Using thyroid hormone in brain-dead donors to maximize the number of organs available for transplantation

Clinical Transplantation

Volumn 21, Issue 3, 2007, Pages 405-409

  Salim, Ali ^a,b   Martin, Matthew ^a   Brown, Carlos ^a   Inaba, Kenji ^a   Roth, Bradley ^a   Hadjizacharia, Pantelis ^a   Mascarenhas, Angela ^b   Rhee, Peter ^a   Demetriades, Demetrios ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b LAC USC MEDICAL CENTER   (United States)

Author keywords

Brain death; Organdonor; Thyroid hormone; Transplantation

Indexed keywords

ADRENALIN; DESMOPRESSIN ACETATE; DOPAMINE; GLUCOSE; INSULIN; LEVOTHYROXINE SODIUM; METHYLPREDNISOLONE SODIUM SUCCINATE; THYROXINE;

ADULT; ARTICLE; BLOOD TRANSFUSION; BRAIN DEATH; CLINICAL PROTOCOL; CONTINUOUS INFUSION; CONTROLLED STUDY; DIABETES INSIPIDUS; DISSEMINATED INTRAVASCULAR CLOTTING; ELECTROLYTE DISTURBANCE; EMERGENCY HEALTH SERVICE; FEMALE; FLUID RESUSCITATION; HEALTH CARE POLICY; HEART MUSCLE ISCHEMIA; HEMODYNAMICS; HORMONAL THERAPY; HUMAN; HUMAN TISSUE; LUNG EDEMA; MALE; MEDICAL RECORD REVIEW; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; THROMBOCYTOPENIA;

ADULT; BRAIN DEATH; CLINICAL PROTOCOLS; FEMALE; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; THYROXINE; TISSUE AND ORGAN HARVESTING; TISSUE DONORS; TRANSPLANTS;

EID: 34248177897     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2007.00659.x     Document Type: Article

References (35)

1. United Network for Organ Sharing. Available at: http://www.optn.org/ latestData/rptData.asp (accessed on August 6, 2006).
2. Organ Donation Breakthrough Collaborative. Available at: http://www.organdonationnow.org (accessed on August 6, 2006).
3. Salim A, Velmahos GC, Brown C et al. Aggressive organ donor management significantly increases the number of organs available for transplantation. J Trauma 2005: 58: 991.
4. Salim A, Vassiliu P, Velmahos GC et al. The role of thyroid hormone administration in potential organ donors. Arch Surg 2001: 136: 1377.
5. Macoviak JA, McDougall IR, Bayer MF et al. Significance of thyroid dysfunction in human cardiac allograft procurement. Transplantation 1987: 43: 824.
6. Mariot J, Sadoune LO, Jacob F et al. Hormone levels, hemodynamic, and metabolism in brain dead organ donors. Transplant Proc 1995: 27: 793.
7. Randell TT, Hockerstedt KAV. Triiodothyronine treatment is not indicated in brain-dead multiorgan donors: A controlled study. Transplant Proc 1993: 25: 1552.
8. Power BM, Van Heerden PV. The physiological changes associated with brain death: Current concepts and implications for treatment of the brain dead organ donor. Anaesth Intensive Care 1995: 23: 26.
9. 3) and cardiovascular therapeutics: A review. J Card Surg 1992: 7: 363.
10. Novitzky D, Wicomb WN, Cooper DKC et al. Electrocardiographic, hemodynamic and endocrine changes during experimental brain death in the Chacma baboon. J Heart Transplant 1984: 4: 63.
11. Cooper DKC, Novitzky D, Wicomb WN. The pathophysiological effects of brain death on potential donor organs, with particular reference to the heart. Ann R Coll Surg Engl 1989: 71: 261.
12. Novitzky D, Wicomb WN, Cooper DKC et al. Prevention of myocardial injury during brain death by total cardiac sympathectomy in the Chacma baboon. Ann Thorac Surg 1986: 41: 520.
13. Wicomb WN, Cooper DKC, Lanza RP et al. The effects of brain death and 24 hours storage of hypothermic perfusion on donor heart function in the pig. J Thorac Cardiovasc Surg 1986; 491: 896.
14. Novitzky D, Wicomb WN, Cooper DKC et al. Improved cardiac function following hormonal therapy in brain dead pigs: Relevance to organ donation. Heart Transplant Cryobiol 1987: 24: 1.
15. Novitzky D, Cooper DKC, Morrell D, Isaacs S. Change from aerobic to anaerobic metabolism after brain death, and reversal following triiodothyronine therapy. Transplantation 1988: 45: 32.
16. Novitzky D, Cooper DKC, Reichart B. Hemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors. Transplantation 1987: 43: 852.
17. Masson E, Thicoipe M, Latapie MJ, Maurette P. Thyroid function in brain-dead donors. Transplant Int 1990: 3: 226.
18. Novitzky D. Triiodothyronine replacement, the euthyroid sick syndrome, and organ transplantation. Transplant Proc 1991: 23: 2460.
19. Garcia-Fages LC, Antolin M, Cabrer C et al. Effects of substitutive triiodothyronine therapy on intracellular nucleotide levels in donor organs. Transplant Proc 1991: 23: 2495.
20. Rosendale JD, Kauffman HM, Mc Bride MAet al. Aggressive pharmacologic donor management results in more transplanted organs. Transplantation 2003: 75: 482.
21. Wheeldon DR, Potter CD, Oduro A et al. Transforming the "unacceptable" donor: Outcomes from the adoption of a standardized donor management technique. J Heart Lung Transplant 1995: 14: 734.
22. Wheeldon DR, Potter CD, Jonas M et al. Using "unsuitable" hearts for transplantation. Eur J Cardiothorac Surg 1994: 8: 7.
23. Robertson KM, Hramiak IM, Gelb AW. Endocrine changes and hemodynamic stability after brain death. Transplant Proc 1989: 21: 1197.
24. Goarin JP, Cohen S, Riou B et al. The effects of triiodothyronine on hemodynamic status and cardiac function in potential heart donors. Anesth Analg 1996: 83: 41.
25. Karayalcin K, Umana JP, Harrison JD et al. Donor thyroid function does not affect outcome in orthotopic liver transplantation. Transplantation 1994: 57: 669.
26. Szostek M, Gaciong Z, Danielelewicz R et al. Influence of thyroid function in brain stem death donors on kidney allograft function. Transplant Proc 1997: 29: 3354.
27. Walhers T, Fieguth HG, Jurmann M et al. Does hormone depletion of organ donors impair myocardial function after cardiac transplantation? Transplan Proc 1988: 20: 792.
28. 4 for managing hemodynamically unstable donors: Clinical experience of Colorado organ recovery systems. Transplant Manage 1990: 2: 13.
29. Orlowski JP. Evidence that thyroxine (T4) is effective as a hemodynamic rescue agent in management of organ donors. Transplantation 1993: 55: 959.
30. Novitzky D, Cooper DK, Swanepoel A. Inotropic effect of triiodothyronine in low cardiac output following cardioplegic arrest and cardiopulmonary bypass: An initial experience in patients undergoing open-heart surgery. Eur J Cardiothorac Surg 1989: 3: 140.
31. Novitzky D, Cooper DK, Barton CI et al. Triiodothyronine as an inotropic agent after open-heart surgery. J Thorac Cardiovasc Surg 1989: 98: 972.
32. Zaroff JG, Rosengard BR, Armstrong WF et al. Consensus conference report: Maximizing use of organs recovered from the cadaver donor: cardiac recommendations. Circulation 2002: 106: 836.
33. Rosendale JD, Dean JR. Organ donation in the United States. Clin Transplant 2002: 93.
34. Cooper DKC, Basker M. Physiologic changes following brain death. Transplant Proc 1999: 31: 1001.
35. Zuppa AF, Nadkarni V, Davis L et al. The effect of a thyroid hormone infusion on vasopressor support in critically ill children with cessation of neurologic function. Crit Care Med 2004: 32: 2318.