Pulmonary system limitations to endurance exercise performance in humans

Experimental Physiology

Volumn 97, Issue 3, 2012, Pages 311-318

  Amann, Markus ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYHEMOGLOBIN;

AEROBIC CAPACITY; ALTITUDE; ARTERIAL OXYGEN SATURATION; ATHLETE; BREATHING MUSCLE; CONFERENCE PAPER; ENDURANCE TRAINING; EXERCISE; FATIGUE; HEART OUTPUT; HUMAN; LEG BLOOD FLOW; MUSCLE FATIGUE; OXYGEN TRANSPORT; QUADRICEPS FEMORIS MUSCLE; RESPIRATORY SYSTEM; SEX DIFFERENCE; THORAX PRESSURE; VASOCONSTRICTION;

EID: 84857600025     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2011.058800     Document Type: Conference Paper

References (50)

1. Aaron EA, Seow KC, Johnson BD & Dempsey JA (1992). Oxygen cost of exercise hyperpnea: implications for performance. J Appl Physiol 72, 1818-1825.
2. Amann M (2011). Central and peripheral fatigue: interaction during cycling exercise in humans. Med Sci Sports Exerc 43, 2039-2045.
3. Amann M, Blain GM, Proctor LT, Sebranek JJ, Pegelow DF & Dempsey JA (2011). Implications of group III and IV muscle afferents for high-intensity endurance exercise performance in humans. J Physiol 589, 5299-5309.
4. Amann M & Calbet JA (2008). Convective oxygen transport and fatigue. J Appl Physiol 104, 861-870.
5. Amann M, Eldridge MW, Lovering AT, Stickland MK, Pegelow DF & Dempsey JA (2006). Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J Physiol 575, 937-952.
6. Amann M, Pegelow DF, Jacques AJ & Dempsey JA (2007). Inspiratory muscle work in acute hypoxia influences locomotor muscle fatigue and exercise performance of healthy humans. Am J Physiol Regul Integr Comp Physiol 293, R2036-R2045.
7. Amann M, Proctor LT, Sebranek JJ, Pegelow DF & Dempsey JA (2009). Opioid-mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humans. J Physiol 587, 271-283.
8. Buskirk ER, Kollias J, Akers RF, Prokop EK & Reategui EP (1967). Maximal performance at altitude and on return from altitude in conditioned runners. J Appl Physiol 23, 259-266.
9. Dempsey JA, Hanson PG & Henderson KS (1984). Exercise-induced arterial hypoxaemia in healthy human subjects at sea level. J Physiol 355, 161-175.
10. Dempsey JA, Sheel AW, St Croix CM & Morgan BJ (2002). Respiratory influences on sympathetic vasomotor outflow in humans. Respir Physiol Neurobiol 130, 3-20.
11. Dempsey JA & Wagner PD (1999). Exercise-induced arterial hypoxemia. J Appl Physiol 87, 1997-2006.
12. Gallagher CG & Younes M (1989). Effect of pressure assist on ventilation and respiratory mechanics in heavy exercise. J Appl Physiol 66, 1824-1837.
13. Guenette JA, Diep TT, Koehle MS, Foster GE, Richards JC & Sheel AW (2004). Acute hypoxic ventilatory response and exercise-induced arterial hypoxemia in men and women. Respir Physiol Neurobiol 143, 37-48.
14. Guenette JA, Witt JD, McKenzie DC, Road JD & Sheel AW (2007). Respiratory mechanics during exercise in endurance-trained men and women. J Physiol 581, 1309-1322.
15. Harms CA, Babcock MA, McClaran SR, Pegelow DF, Nickele GA, Nelson WB & Dempsey JA (1997). Respiratory muscle work compromises leg blood flow during maximal exercise. J Appl Physiol 82, 1573-1583.
16. Harms CA, McClaran SR, Nickele GA, Pegelow DF, Nelson WB & Dempsey JA (1998a). Exercise-induced arterial hypoxaemia in healthy young women. J Physiol 507, 619-628.
17. 2max in women. Exerc Sci Med Sport 32, 1101-1108.
18. Harms CA & Stager JM (1995). Low chemoresponsiveness and inadequate hyperventilation contribute to exercise-induced hypoxemia. J Appl Physiol 79, 575-580.
19. Harms CA, Wetter TJ, McClaran SR, Pegelow DF, Nickele GA, Nelson WB, Hanson P & Dempsey JA (1998b). Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise. J Appl Physiol 85, 609-618.
20. Harms CA, Wetter TJ, St Croix CM, Pegelow DF & Dempsey JA (2000b). Effects of respiratory muscle work on exercise performance. J Appl Physiol 89, 131-138.
21. Hill JM (2000). Discharge of group IV phrenic afferent fibers increases during diaphragmatic fatigue. Brain Res 856, 240-244.
22. Holmgren A & Linderholm H (1958). Oxygen and carbon dioxide tensions of arterial blood during heavy and exhaustive exercise. Acta Physiol Scand 44, 203-215.
23. Hopkins SR, Barker RC, Brutsaert TD, Gavin TP, Entin P, Olfert IM, Veisel S & Wagner PD (2000). Pulmonary gas exchange during exercise in women: effects of exercise type and work increment. J Appl Physiol 89, 721-730.
24. Hopkins SR & Harms CA (2004). Gender and pulmonary gas exchange during exercise. Exerc Sport Sci Rev 32, 50-56.
25. Hopkins SR & McKenzie DC (1989). Hypoxic ventilatory response and arterial desaturation during heavy work. J Appl Physiol 67, 1119-1124.
26. Johnson BD, Aaron EA, Babcock MA & Dempsey JA (1996). Respiratory muscle fatigue during exercise: implications for performance. Med Sci Sports Exerc 28, 1129-1137.
27. Johnson BD, Saupe KW & Dempsey JA (1992). Mechanical constraints on exercise hyperpnea in endurance athletes. J Appl Physiol 73, 874-886.
28. Koskolou MD & McKenzie DC (1994). Arterial hypoxemia and performance during intense exercise. Eur J Appl Physiol Occup Physiol 68, 80-86.
29. Krishnan B, Zintel T, McParland C & Gallagher CG (1996). Lack of importance of respiratory muscle load in ventilatory regulation during heavy exercise in humans. J Physiol 490, 537-550.
30. Lumb A & Nunn JF (2000). Nunn's Applied Respiratory Physiology. Butterworth-Heinemann, Oxford.
31. McClaran SR, Harms CA, Pegelow DF & Dempsey JA (1998). Smaller lungs in women affect exercise hyperpnea. J Appl Physiol 84, 1872-1881.
32. Manohar M (1986). Blood flow to the respiratory and limb muscles and to abdominal organs during maximal exertion in ponies. J Physiol 377, 25-35.
33. Marciniuk D, McKim D, Sanii R & Younes M (1994). Role of central respiratory muscle fatigue in endurance exercise in normal subjects. J Appl Physiol 76, 236-241.
34. Miller JD, Hemauer SJ, Smith CA, Stickland MK & Dempsey JA (2006). Expiratory threshold loading impairs cardiovascular function in health and chronic heart failure during submaximal exercise. J Appl Physiol 101, 213-227.
35. Miller JD, Smith CA, Hemauer SJ & Dempsey JA (2007). The effects of inspiratory intrathoracic pressure production on the cardiovascular response to submaximal exercise in health and chronic heart failure. Am J Physiol Heart Circ Physiol 292, H580-H592.
36. Musch TI (1993). Elevated diaphragmatic blood flow during submaximal exercise in rats with chronic heart failure. Am J Physiol Heart Circ Physiol 265, H1721-H1726.
37. Nielsen HB, Bredmose PP, Strømstad M, Volianitis S, Quistorff B & Secher NH (2002). Bicarbonate attenuates arterial desaturation during maximal exercise in humans. J Appl Physiol 93, 724-731.
38. Powers SK, Dodd S, Lawler J, Landry G, Kirtley M, McKnight T & Grinton S (1988). Incidence of exercise induced hypoxemia in elite endurance athletes at sea level. Eur J Appl Physiol Occup Physiol 58, 298-302.
39. Powers SK, Lawler J, Dempsey JA, Dodd S & Landry G (1989). Effects of incomplete pulmonary gas exchange on VO2 max. J Appl Physiol 66, 2491-2495.
40. Rasmussen J, Hanel B, Diamant B & Secher NH (1991). Muscle mass effect on arterial desaturation after maximal exercise. Med Sci Sports Exerc 23, 1349-1352.
41. Romer LM, Haverkamp HC, Lovering AT, Pegelow DF & Dempsey JA (2006a). Effect of exercise-induced arterial hypoxemia on quadriceps muscle fatigue in healthy humans. Am J Physiol Regul Integr Comp Physiol 290, R365-R375.
42. Romer LM, Lovering AT, Haverkamp HC, Pegelow DF & Dempsey JA (2006b). Effect of inspiratory muscle work on peripheral fatigue of locomotor muscles in healthy humans. J Physiol 571, 425-439.
43. St Croix CM, Morgan BJ, Wetter TJ & Dempsey JA (2000). Fatiguing inspiratory muscle work causes reflex sympathetic activation in humans. J Physiol 529, 493-504.
44. Squires RW & Buskirk ER (1982). Aerobic capacity during acute exposure to simulated altitude, 914 to 2286 meters. Med Sci Sports Exerc 14, 36-40.
45. Stark-Leyva KN, Beck KC & Johnson BD (2004). Influence of expiratory loading and hyperinflation on cardiac output during exercise. J Appl Physiol 96, 1920-1927.
46. Thoden JS, Dempsey JA, Reddan WG, Birnbaum ML, Forster HV, Grover RF & Rankin J (1969). Ventilatory work during steady-state response to exercise. Fed Proc 28, 1316-1321.
47. Wasserman K, Van Kessel AL & Burton GG (1967). Interaction of physiological mechanisms during exercise. J Appl Physiol 22, 71-85.
48. Wetter TJ, Harms CA, Nelson WB, Pegelow DF & Dempsey JA (1999). Influence of respiratory muscle work on and leg blood flow during submaximal exercise. J Appl Physiol 87, 643-651.
49. Williams JH, Powers SK & Stuart MK (1986). Hemoglobin desaturation in highly trained athletes during heavy exercise. Med Sci Sports Exerc 18, 168-173.
50. 2 on exercise tolerance in man. Med Sci Sports Exerc 12, 380-384.