Expiratory threshold loading impairs cardiovascular function in health and chronic heart failure during submaximal exercise

Journal of Applied Physiology

Volumn 101, Issue 1, 2006, Pages 213-227

  Miller, Jordan D ^a,b   Hemauer, Sarah J ^a   Smith, Curtis A ^a   Stickland, Michael K ^a   Dempsey, Jerome A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Blood flow distribution; Cardiac output; Exercise; Expiratory flow limitation; Heart failure

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; BLOOD GAS ANALYSIS; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DOG; EXPIRATORY FLOW; HEART CONDUCTION; HEART FAILURE; HEART OUTPUT; HEART PACING; HEART RATE; HEART STROKE VOLUME; HINDLIMB; INSPIRATORY RESERVE VOLUME; LOADING TEST; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; REST; THORAX PRESSURE; TREADMILL EXERCISE;

ANIMALS; CARDIAC OUTPUT; CARDIAC OUTPUT, LOW; CARDIOVASCULAR SYSTEM; DOGS; EXHALATION; FEMALE; FORCED EXPIRATORY FLOW RATES; HEART RATE; HINDLIMB; INHALATION; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; REGIONAL BLOOD FLOW; RESPIRATORY MECHANICS; STROKE VOLUME; TIME FACTORS;

EID: 33745858991     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00862.2005     Document Type: Article

References (36)

1. Abel FL and Waldhausen JA. Effects of anesthesia and artificial ventilation on caval flow and cardiac output. J Appl Physiol 25: 479-484, 1968.
2. Angell James JE. The effects of changes of extramural, 'intrathoracic', pressure on aortic arch baroreceptors. J Physiol 214: 89-103, 1971.
3. Barclay JK. A delivery-independent blood flow effect on skeletal muscle fatigue. J Appl Physiol 61: 1084-1090, 1986.
4. Bjurstedt H, Rosenhamer G, Lindborg B, and Hesser CM. Respiratory and circulatory responses to sustained positive-pressure breathing and exercise in man. Acta Physiol Scand 105: 204-214, 1979.
5. Braunwald E, Binion JT, Morgan WL Jr, and Sarnoff SJ Alterations in central blood volume and cardiac output induced by positive pressure breathing and counteracted by metaraminol (aramine). Circ Res 5: 670-675, 1957.
6. Cabanes L, Costes F, Weber S, Regnard J, Benvenuti C, Castaigne A, Guerin F, and Lockhart A. Improvement in exercise performance by inhalation of methoxamine in patients with impaired left ventricular function. N Engl J Med 326: 1661-1665, 1992.
7. Folkow B, Gaskell P, and Waaler BA. Blood flow through limb muscles during heavy rhythmic exercise. Acta Physiol Scand 80: 61-72, 1970.
8. Genovese J, Huberfeld S, Tarasiuk A, Moskowitz M, and Scharf SM. Effects of CPAP on cardiac output in pigs with pacing-induced congestive heart failure. Am J Respir Crit Care Med 152: 1847-1853, 1995.
9. 2 max in women. Med Sci Sports Exerc 32: 1101-1108, 2000.
10. Iandelli I, Aliverti A, Kayser B, Dellaca R, Cala SJ, Duranti R, Kelly S, Scano G, Sliwinski P, Yan S, Macklem PT, and Pedotti A. Determinants of exercise performance in normal men with externally imposed expiratory flow limitation. J Appl Physiol 92: 1943-1952, 2002.
11. Johnson BD, Beck KC, Olson LJ, O'Malley KA, Allison TG, Squires RW, and Gau GT. Ventilatory constraints during exercise in patients with chronic heart failure. Chest 117: 321-332, 2000.
12. Johnson BD, Reddan WG, Seow KC, and Dempsey JA. Mechanical constraints on exercise hyperpnea in a fit aging population. Am Rev Respir Dis 143: 968-977, 1991.
13. Johnson BD, Saupe KW, and Dempsey JA. Mechanical constraints on exercise hyperpnea in endurance athletes. J Appl Physiol 73: 874-886, 1992.
14. Johnson BD, Seow KC, Pegelow DF, and Dempsey JA. Adaptation of the inert gas FRC technique for use in heavy exercise. J Appl Physiol 68: 802-809, 1990.
15. Lai-Fook SJ. Stress distribution in the lung. In: The Lung: Scientific Foundations (2nd ed.), edited by Crystal RG, West JB, Weibel ER, and Barnes PJ. Philadelphia, PA: Lippincott-Raven, 1997, p. 1177-1186.
16. Liebman PR, Patten MT, Manny J, Shepro D, and Hechtman HB. The mechanism of depressed cardiac output on positive end-expiratory pressure (PEEP). Surgery 83: 594-598, 1978.
17. Lloyd TC. Respiratory system compliance as seen from the cardiac fossa. J Appl Physiol 53: 57-62, 1982.
18. Magnusson G, Kaijser L, Sylven C, Karlberg KE, Isberg B, and Saltin B. Peak skeletal muscle perfusion is maintained in patients with chronic heart failure when only a small muscle mass is exercised. Cardiovasc Res 33: 297-306, 1997.
19. Mancini D, Donchez L, and Levine S. Acute unloading of the work of breathing extends exercise duration in patients with heart failure. J Am Coll Cardiol 29: 590-596, 1997.
20. Manny J, Grindlinger G, Mathe AA, and Hechtman HB. Positive end-expiratory pressure, lung stretch, and decreased myocardial contractility. Surgery 84: 127-133, 1978.
21. Miller JD, Pegelow DF, Jacques AJ, and Dempsey JA. Skeletal muscle pump vs. respiratory muscle pump: modulation of venous return from the locomotor limb in humans. J Physiol 563: 925-943, 2005.
22. Mitchell JH, Kaufman MP, and Iwamoto GA. The exercise pressor reflex: its cardiovascular effects, afferent mechanisms, and central pathways. Annu Rev Physiol 45: 229-242, 1983.
23. Mitchell JR, Sas R, Zuege DJ, Doig CJ, Smith ER, Whitelaw WA, Tyberg JV, and Belenkie I. Ventricular interaction during mechanical ventilation in closed-chest anesthetized dogs. Can J Cardiol 21: 73-81, 2005.
24. Musch TI. Elevated diaphragmatic blood flow during submaximal exercise in rats with chronic heart failure. Am J Physiol Heart Circ Physiol 265: H1721-H1726, 1993.
25. O'Donnell DE. Ventilatory limitations in chronic obstructive pulmonary disease. Med Sci Sports Exerc 33: S647-655, 2001.
26. O'Donnell DE, Bertley JC, Chau LK, and Webb KA. Qualitative aspects of exertional breathlessness in chronic airflow limitation: pathophysiologic mechanisms. Am J Respir Crit Care Med 155: 109-115, 1997.
27. O'Donnell DE, D'Arsigny C, Fitzpatrick M, and Webb KA. Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation. Am J Respir Crit Care Med 166: 663-668, 2002.
28. O'Donnell DE, D'Arsigny C, Raj S, Abdollah H, and Webb KA. Ventilatory assistance improves exercise endurance in stable congestive heart failure. Am J Respir Crit Care Med 160: 1804-1811, 1999.
29. O'Donnell DE, Lam M, and Webb KA. Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158: 1557-1565, 1998.
30. Olafsson S and Hyatt RE. Ventilatory mechanics and expiratory flow limitation during exercise in normal subjects. J Clin Invest 48: 564-573, 1969.
31. 2 max in the exercise-trained human quadriceps. J Appl Physiol 86: 1048-1053, 1999.
32. Rodman JR, Henderson KS, Smith CA, and Dempsey JA. Cardiovascular effects of the respiratory muscle metaboreflexes in dogs: rest and exercise. J Appl Physiol 16: 16, 2003.
33. Rowell LB. Passive effects of gravity. In: Human Cardiovascular Control. New York: Oxford University Press, 1993, p. 3-36.
34. Stark-Leyva KN, Beck KC, and Johnson BD. Influence of expiratory loading and hyperinflation on cardiac output during exercise. J Appl Physiol 96: 1920-1927, 2004.
35. Sullivan MJ and Cobb FR. Central hemodynamic response to exercise in patients with chronic heart failure. Chest 101: 340S-346S, 1992.
36. Sullivan MJ, Knight JD, Higginbotham MB, and Cobb FR. Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Muscle blood flow is reduced with maintenance of arterial perfusion pressure. Circulation 80: 769-781, 1989.