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Volumn 10, Issue 2, 2011, Pages 79-90

The antioxidant N-acetylcysteine in vitro improves several functions of peritoneal leucocytes from old mice approaching their values to those of adult animals

Author keywords

Immunosenescence; Lymphocytes; Macrophages; Mice; N acetylcysteine

Indexed keywords

ACETYLCYSTEINE; SUPEROXIDE;

EID: 84857592086     PISSN: 1214021X     EISSN: 12140287     Source Type: Journal    
DOI: 10.2478/v10136-012-0005-z     Document Type: Article
Times cited : (4)

References (57)
  • 1
  • 2
    • 0018699842 scopus 로고
    • Effects of ascorbate on leukocytes: Part II. Effects of ascorbic acid and calcium and sodium ascorbate on neutrophil phagocytosis and post-phagocytic metabolic activity
    • Anderson R. Effects of ascorbate on leukocytes: Part II. Effects of ascorbic acid and calcium and sodium ascorbate on neutrophil phagocytosis and post-phagocytic metabolic activity. S Afr Med J. 56: 401-404, 1979.
    • (1979) S Afr Med J. , vol.56 , pp. 401-404
    • Anderson, R.1
  • 4
    • 77955863405 scopus 로고    scopus 로고
    • Preserved immune functions and controlled leukocyte oxidative stress in naturally long-lived mice: Possible role of nuclear factor-κ B
    • Arranz L, Caamano J, Lord JM, De la Fuente M. Preserved immune functions and controlled leukocyte oxidative stress in naturally long-lived mice: Possible role of nuclear factor-κ B. J Gerontol Biol Sci. 65A: 941-950, 2010.
    • (2010) J Gerontol Biol Sci. , vol.65 A , pp. 941-950
    • Arranz, L.1    Caamano, J.2    Lord, J.M.3    de la Fuente, M.4
  • 5
    • 0029961237 scopus 로고    scopus 로고
    • Glutathione-dependent modulation of exhausting exercise-induced changes in neutrophil function of rats
    • Atalay M, Marnila P, Lilius EM, Hanninen O, Sen CK. Glutathione-dependent modulation of exhausting exercise-induced changes in neutrophil function of rats. Eur J Appl Physiol. 74: 342-347, 1996.
    • (1996) Eur J Appl Physiol. , vol.74 , pp. 342-347
    • Atalay, M.1    Marnila, P.2    Lilius, E.M.3    Hanninen, O.4    Sen, C.K.5
  • 6
    • 33847640493 scopus 로고    scopus 로고
    • Immunosenescence: Emerging challenges for an ageing population
    • Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology 120: 435-446, 2007.
    • (2007) Immunology , vol.120 , pp. 435-446
    • Aw, D.1    Silva, A.B.2    Palmer, D.B.3
  • 7
    • 0002867219 scopus 로고
    • Interaction between antioxidant vitamin C and E and their effect on immune responses
    • In Miquel J, Quintanilla AT, Weber H (eds.): II. CRC press, Boca Raton
    • Bendich A. Interaction between antioxidant vitamin C and E and their effect on immune responses. In Miquel J, Quintanilla AT, Weber H (eds.): Handbook of Free Radicals and Antioxidants in Biomedicine. II. CRC press, Boca Raton 1989, pp. 153-160.
    • (1989) Handbook of Free Radicals and Antioxidants in Biomedicine , pp. 153-160
    • Bendich, A.1
  • 8
    • 2442743129 scopus 로고    scopus 로고
    • Changes in several functions of murine peritoneal macrophages by N-acetylcysteine and thioproline ingestion. Comparative effect between two strains of mice
    • Blanco B, Ferrnández MD, Correa R, Del Rio M, Guaza C, Hernanz A, De la Fuente M. Changes in several functions of murine peritoneal macrophages by N-acetylcysteine and thioproline ingestion. Comparative effect between two strains of mice. BioFactors. 10: 179-185, 1999.
    • (1999) BioFactors. , vol.10 , pp. 179-185
    • Blanco, B.1    Ferrnández, M.D.2    Correa, R.3    del Rio, M.4    Guaza, C.5    Hernanz, A.6    de la Fuente, M.7
  • 9
    • 0343841187 scopus 로고
    • The chemotaxis effect of mixtures of antibody and antigen on polymorphonuclear leukocytes
    • Boyden SV. The chemotaxis effect of mixtures of antibody and antigen on polymorphonuclear leukocytes. J Exp Med. 115: 453-466, 1962.
    • (1962) J Exp Med. , vol.115 , pp. 453-466
    • Boyden, S.V.1
  • 10
    • 0026043122 scopus 로고
    • Antioxidant activity and other mechanisms of thiol involved in chemoprevention of mutation and cancer
    • De Flora S, Izzoti A, D'Agostini F, Cesarone CF. Antioxidant activity and other mechanisms of thiol involved in chemoprevention of mutation and cancer. Am J Med. 91: 122-130, 1991.
    • (1991) Am J Med. , vol.91 , pp. 122-130
    • De Flora, S.1    Izzoti, A.2    D'Agostini, F.3    Cesarone, C.F.4
  • 11
    • 0021871082 scopus 로고
    • Changes in the macrophage function with aging
    • De la Fuente M. Changes in the macrophage function with aging. Comp Biochem Physiol. 81A: 935-938, 1985.
    • (1985) Comp Biochem Physiol. , vol.81 A , pp. 935-938
    • de la Fuente, M.1
  • 12
    • 0036049037 scopus 로고    scopus 로고
    • Effects of antioxidants on immune system ageing
    • De la Fuente M. Effects of antioxidants on immune system ageing. Eur J Clin Nutr. 56: S5-S8, 2002.
    • (2002) Eur J Clin Nutr. , vol.56
    • de la Fuente, M.1
  • 13
    • 57149096659 scopus 로고    scopus 로고
    • Role of neuroimmunomodulation in aging
    • De la Fuente M. Role of neuroimmunomodulation in aging. Neuroimmunomodulation. 15: 213-223, 2008.
    • (2008) Neuroimmunomodulation. , vol.15 , pp. 213-223
    • de la Fuente, M.1
  • 14
    • 79951883392 scopus 로고    scopus 로고
    • Murine models of premature ageing for the study of diet-induced immune changes. Improvement of leukocyte functions in two strains of old prematurely ageing mice by dietary supplementation with sulphur-containing antioxidants
    • De la Fuente M. Murine models of premature ageing for the study of diet-induced immune changes. Improvement of leukocyte functions in two strains of old prematurely ageing mice by dietary supplementation with sulphur-containing antioxidants. Proc Nutr Soc. 69: 651-659, 2010.
    • (2010) Proc Nutr Soc. , vol.69 , pp. 651-659
    • de la Fuente, M.1
  • 15
    • 70449431387 scopus 로고    scopus 로고
    • An update of the oxidation-inflammation theory of aging. The involvement of the immune system in oxi-inflamm-aging
    • De la Fuente M, Miquel J. An update of the oxidation-inflammation theory of aging. The involvement of the immune system in oxi-inflamm-aging. Curr Pharm Des. 15: 3003-3026, 2009.
    • (2009) Curr Pharm Des. , vol.15 , pp. 3003-3026
    • de la Fuente, M.1    Miquel, J.2
  • 16
    • 0033953297 scopus 로고    scopus 로고
    • Antioxidants as modulators of immune function
    • De la Fuente M, Victor VM. Antioxidants as modulators of immune function. Immunol Cell Biol. 78: 49-54, 2000.
    • (2000) Immunol Cell Biol. , vol.78 , pp. 49-54
    • de la Fuente, M.1    Victor, V.M.2
  • 17
    • 0033860424 scopus 로고    scopus 로고
    • Changes in macrophage and lymphocyte functions in guinea-pigs after different amounts of vitamin E ingestion
    • De la Fuente M, Carazo M, Correa R, Del Rio M. Changes in macrophage and lymphocyte functions in guinea-pigs after different amounts of vitamin E ingestion. Brit J Nutr. 84: 25-29, 2000.
    • (2000) Brit J Nutr. , vol.84 , pp. 25-29
    • de la Fuente, M.1    Carazo, M.2    Correa, R.3    del Rio, M.4
  • 18
    • 0036486754 scopus 로고    scopus 로고
    • The amount of thiolic antioxidant ingestion needed to improve the immune functions is higher in aged than in adult mice
    • De la Fuente M, Guayerbas N, Catalán MP, Victor VM, Miquel J. The amount of thiolic antioxidant ingestion needed to improve the immune functions is higher in aged than in adult mice. Free Radic Res. 36: 119-126, 2002.
    • (2002) Free Radic Res. , vol.36 , pp. 119-126
    • de la Fuente, M.1    Guayerbas, N.2    Catalán, M.P.3    Victor, V.M.4    Miquel, J.5
  • 20
    • 21744437451 scopus 로고    scopus 로고
    • Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence
    • De la Fuente M, Hernanz A, Guayerbas N, Puerto M, Alvarez P, Alvarado C. Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence. Cell Mol Biol. 50: OL683-OL690, 2004b.
    • (2004) Cell Mol Biol. , vol.50
    • de la Fuente, M.1    Hernanz, A.2    Guayerbas, N.3    Puerto, M.4    Alvarez, P.5    Alvarado, C.6
  • 21
    • 24144436152 scopus 로고    scopus 로고
    • The immune system in the oxidation stress conditions of aging and hypertension. Favorable effects of antioxidants and physical exercise
    • De la Fuente M, Hernanz A, Vallejo MC. The immune system in the oxidation stress conditions of aging and hypertension. Favorable effects of antioxidants and physical exercise. Antioxid Redox Signal 7: 1356-1366, 2005.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1356-1366
    • de la Fuente, M.1    Hernanz, A.2    Vallejo, M.C.3
  • 23
    • 84855222570 scopus 로고    scopus 로고
    • Strategies to improve the functions and redox state of the immune system in aged subjects
    • De la Fuente M, Cruces J, Hernandez O, Ortega E. Strategies to improve the functions and redox state of the immune system in aged subjects. Curr Pharm Des. 17: 3966-3983, 2011a.
    • (2011) Curr Pharm Des. , vol.17 , pp. 3966-3983
    • de la Fuente, M.1    Cruces, J.2    Hernandez, O.3    Ortega, E.4
  • 24
    • 79955807799 scopus 로고    scopus 로고
    • Sulfur-containing antioxidants increase in vitro several functions of lymphocytes from mice
    • De la Fuente M Hernanz A, Viniegra S, Miquel J. Sulfur-containing antioxidants increase in vitro several functions of lymphocytes from mice. Int Immunopharmacol. 11: 661-669, 2011b.
    • (2011) Int Immunopharmacol. , vol.11 , pp. 661-669
    • de la Fuente, M.1    Hernanz, A.2    Viniegra, S.3    Miquel, J.4
  • 26
    • 57649148545 scopus 로고    scopus 로고
    • N-acetylcysteine for antioxidant therapy: Pharmacology and clinical utility
    • Dodd S, Dean O, Copolov DL, Malhi GS, Berk M. N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility. Expert Opin Biol Ther. 8: 1955-1962, 2008.
    • (2008) Expert Opin Biol Ther. , vol.8 , pp. 1955-1962
    • Dodd, S.1    Dean, O.2    Copolov, D.L.3    Malhi, G.S.4    Berk, M.5
  • 27
    • 0036977353 scopus 로고    scopus 로고
    • Aging-related changes in the thiol/disulfide redox state: Implications for the use of thiol antioxidants
    • Dröge W. Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants. Exp Gerontol. 37: 1333-1345, 2002.
    • (2002) Exp Gerontol. , vol.37 , pp. 1333-1345
    • Dröge, W.1
  • 28
    • 33745247801 scopus 로고    scopus 로고
    • Oxidative stress and ageing: Is ageing a cysteine deficiency syndrome?
    • Dröge W. Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos Trans R Soc B. 360: 2355-2372, 2005.
    • (2005) Philos Trans R Soc B. , vol.360 , pp. 2355-2372
    • Dröge, W.1
  • 29
    • 0034537186 scopus 로고    scopus 로고
    • Glutathione and immune function
    • Dröge W, Breikreuz R. Glutathione and immune function. Proc Nutr Soc. 59: 595-600, 2000.
    • (2000) Proc Nutr Soc. , vol.59 , pp. 595-600
    • Dröge, W.1    Breikreuz, R.2
  • 30
    • 0027976888 scopus 로고
    • Decrease of hypochlorous acid and hydroxyl radical generated by stimulated human neutrophils: Comparisons in vitro of some thiol-containing drugs
    • Gressier B, Cabanis A, Lebegue S, Brunet C, Dine T, Luyckx M, Cazin M, Cazin JC. Decrease of hypochlorous acid and hydroxyl radical generated by stimulated human neutrophils: comparisons in vitro of some thiol-containing drugs. Methods Find Exp Clin Pharmacol. 16: 9-13, 1994.
    • (1994) Methods Find Exp Clin Pharmacol. , vol.16 , pp. 9-13
    • Gressier, B.1    Cabanis, A.2    Lebegue, S.3    Brunet, C.4    Dine, T.5    Luyckx, M.6    Cazin, M.7    Cazin, J.C.8
  • 31
    • 0037151259 scopus 로고    scopus 로고
    • Relation of behaviour and macrophage function to life span in a murine model of premature immunosenescence
    • Guayerbas N, Catalán M, Victor VM, Miquel M, De la Fuente M. Relation of behaviour and macrophage function to life span in a murine model of premature immunosenescence Brain Behav Res. 134: 41-48, 2002a.
    • (2002) Brain Behav Res. , vol.134 , pp. 41-48
    • Guayerbas, N.1    Catalán, M.2    Victor, V.M.3    Miquel, M.4    de la Fuente, M.5
  • 32
    • 0036400371 scopus 로고    scopus 로고
    • A diet supplemented with thiolic antioxidants improves leukocyte function in two strains of prematurely ageing mice
    • Guayerbas N, Puerto M, Ferrandez MD, De la Fuente M. A diet supplemented with thiolic antioxidants improves leukocyte function in two strains of prematurely ageing mice. Clin Exp Pharmacol Physiol. 29: 1009-1014, 2002b.
    • (2002) Clin Exp Pharmacol Physiol. , vol.29 , pp. 1009-1014
    • Guayerbas, N.1    Puerto, M.2    Ferrandez, M.D.3    de la Fuente, M.4
  • 33
    • 21744449796 scopus 로고    scopus 로고
    • Improvement of the macrophage functions in premature ageing mice by a diet supplemented with thiolic antioxidants
    • Guayerbas N, Puerto M, Alvarez P, De la Fuente M. Improvement of the macrophage functions in premature ageing mice by a diet supplemented with thiolic antioxidants. Cell Mol Biol. 50: OL677-OL681, 2004.
    • (2004) Cell Mol Biol. , vol.50
    • Guayerbas, N.1    Puerto, M.2    Alvarez, P.3    de la Fuente, M.4
  • 34
    • 32044450320 scopus 로고    scopus 로고
    • Effect of diet supplementation with N-acetylcysteine on leukocyte functions in prematurely ageing mice
    • Guayerbas N, Puerto M, Alvarado C, De la Fuente M. Effect of diet supplementation with N-acetylcysteine on leukocyte functions in prematurely ageing mice. J Appl Biomed. 3: 199-205, 2005.
    • (2005) J Appl Biomed. , vol.3 , pp. 199-205
    • Guayerbas, N.1    Puerto, M.2    Alvarado, C.3    de la Fuente, M.4
  • 35
    • 59249102083 scopus 로고    scopus 로고
    • The wandering of a free radical
    • Halliwell B. The wandering of a free radical. Free Radic Biol Med. 46: 531-542, 2009.
    • (2009) Free Radic Biol Med. , vol.46 , pp. 531-542
    • Halliwell, B.1
  • 36
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 2: 298-300, 1956.
    • (1956) J Gerontol. , vol.2 , pp. 298-300
    • Harman, D.1
  • 37
    • 0025345560 scopus 로고
    • Effect of age, culture media and lymphocyte presence in ascorbate content of peritoneal macrophages from mice and guinea pigs during phagocytosis
    • Hernanz A, Collazos ME, De la Fuente M. Effect of age, culture media and lymphocyte presence in ascorbate content of peritoneal macrophages from mice and guinea pigs during phagocytosis. Int Arch Allergy Appl Immunol. 91: 166-170, 1990.
    • (1990) Int Arch Allergy Appl Immunol. , vol.91 , pp. 166-170
    • Hernanz, A.1    Collazos, M.E.2    de la Fuente, M.3
  • 38
    • 0034604524 scopus 로고    scopus 로고
    • Changes in the intracellular homocysteine and glutathione content associated with aging
    • Hernanz A, Fernández-Vivancos E, Montiel C, Vázquez JJ, Arnalich F. Changes in the intracellular homocysteine and glutathione content associated with aging. Life Sci. 67: 1317-1324, 2000.
    • (2000) Life Sci. , vol.67 , pp. 1317-1324
    • Hernanz, A.1    Fernández-Vivancos, E.2    Montiel, C.3    Vázquez, J.J.4    Arnalich, F.5
  • 39
    • 0842324563 scopus 로고    scopus 로고
    • Infection as a cause of age-related morbidity and mortality
    • High KP. Infection as a cause of age-related morbidity and mortality. Ageing Res Rev. 3: 1-14, 2004.
    • (2004) Ageing Res Rev. , vol.3 , pp. 1-14
    • High, K.P.1
  • 40
    • 0031959417 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha regulates the gene expression of macrophage migration inhibitory factor through tyrosine kinasedependent pathway in 3T3-L1 adipocytes
    • Hirokawa J, Sakaue S, Furuya Y, Ishii J, Hasegawa A, Tagami S, Kawakami Y, Sakai M, Nishi S, Nishihira J. Tumor necrosis factor-alpha regulates the gene expression of macrophage migration inhibitory factor through tyrosine kinasedependent pathway in 3T3-L1 adipocytes. J Biochem. 123: 733-739, 1998.
    • (1998) J Biochem. , vol.123 , pp. 733-739
    • Hirokawa, J.1    Sakaue, S.2    Furuya, Y.3    Ishii, J.4    Hasegawa, A.5    Tagami, S.6    Kawakami, Y.7    Sakai, M.8    Nishi, S.9    Nishihira, J.10
  • 41
    • 0029684007 scopus 로고    scopus 로고
    • Antiviral and immunomodulatory activities of ascorbic acid
    • Jariwalla RJ, Harakeh S: Antiviral and immunomodulatory activities of ascorbic acid. Subcell Biochem. 25: 213-231, 1996.
    • (1996) Subcell Biochem. , vol.25 , pp. 213-231
    • Jariwalla, R.J.1    Harakeh, S.2
  • 43
    • 0034050669 scopus 로고    scopus 로고
    • Review: Free Radicals, Antioxidants, and immune system
    • Knight JA. Review: Free Radicals, Antioxidants, and immune system. Ann Clin Lab Sci. 30: 145-158, 2000.
    • (2000) Ann Clin Lab Sci. , vol.30 , pp. 145-158
    • Knight, J.A.1
  • 44
    • 27144536591 scopus 로고    scopus 로고
    • Sleep-disordered breathing and cerebrovascular disease: A mechanistic approach
    • Lavie L. Sleep-disordered breathing and cerebrovascular disease: a mechanistic approach. Neurol Clin. 23: 1059-1075, 2005.
    • (2005) Neurol Clin. , vol.23 , pp. 1059-1075
    • Lavie, L.1
  • 45
    • 69149098551 scopus 로고    scopus 로고
    • N-acetylcysteine: Multiple clinical applications
    • Millea PJ. N-acetylcysteine: multiple clinical applications. Am Fam Physician. 80: 265-269, 2009.
    • (2009) Am Fam Physician. , vol.80 , pp. 265-269
    • Millea, P.J.1
  • 46
    • 0031964919 scopus 로고    scopus 로고
    • An update on the oxygen stressmitochondrial mutation theory of aging: Genetic and evolutionary implications
    • Miquel J. An update on the oxygen stressmitochondrial mutation theory of aging: genetic and evolutionary implications. Exp Gerontol. 33: 113-126, 1998.
    • (1998) Exp Gerontol. , vol.33 , pp. 113-126
    • Miquel, J.1
  • 48
    • 22844450557 scopus 로고    scopus 로고
    • Effect of thiolic antioxidants on in vitro mouse peritoneal macrophage functions
    • Pomaki M, Mota MJ, De la Fuente M, Berger J, Effect of thiolic antioxidants on in vitro mouse peritoneal macrophage functions. Comp Clin Path. 13: 176-181, 2005.
    • (2005) Comp Clin Path. , vol.13 , pp. 176-181
    • Pomaki, M.1    Mota, M.J.2    de la Fuente, M.3    Berger, J.4
  • 49
    • 0036829586 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on macrophage and lymphocyte functions in a mouse model of premature ageing
    • Puerto M, Guayerbas N, Victor VM, De la Fuente M. Effects of N-acetylcysteine on macrophage and lymphocyte functions in a mouse model of premature ageing. Pharmacol Biochem Behav. 73: 797-804, 2002.
    • (2002) Pharmacol Biochem Behav. , vol.73 , pp. 797-804
    • Puerto, M.1    Guayerbas, N.2    Victor, V.M.3    de la Fuente, M.4
  • 50
    • 0036257519 scopus 로고    scopus 로고
    • N-acetylcysteine improves in vitro the function of macrophages from mice with endotoxin-induced oxidative stress
    • Victor VM, De la Fuente M. N-acetylcysteine improves in vitro the function of macrophages from mice with endotoxin-induced oxidative stress. Free Radic Res. 36: 33-45, 2002.
    • (2002) Free Radic Res. , vol.36 , pp. 33-45
    • Victor, V.M.1    de la Fuente, M.2
  • 51
    • 0037245316 scopus 로고    scopus 로고
    • Immune cells redox state from mice with endotoxin-induced oxidative stress. Involvement of NF-κB
    • Victor VM, De la Fuente M. Immune cells redox state from mice with endotoxin-induced oxidative stress. Involvement of NF-κB. Free Radic Res. 37: 19-27, 2003.
    • (2003) Free Radic Res. , vol.37 , pp. 19-27
    • Victor, V.M.1    de la Fuente, M.2
  • 53
    • 35148901006 scopus 로고    scopus 로고
    • Fostering antioxidant defences: Up-regulation of antioxidant genes or antioxidant supplementation?
    • Viña J, Gomez-Cabrera MC, Borras C. Fostering antioxidant defences: up-regulation of antioxidant genes or antioxidant supplementation? Br J Nutr. 98: S36-S40, 2007.
    • (2007) Br J Nutr. , vol.98
    • Viña, J.1    Gomez-Cabrera, M.C.2    Borras, C.3
  • 54
    • 37049027109 scopus 로고    scopus 로고
    • A model of premature ageing in mice based on altered stress-related behavioural response and immunosenescence
    • Viveros MP, Arranz L, Hernanz A, Miquel J, De la Fuente M. A model of premature ageing in mice based on altered stress-related behavioural response and immunosenescence. Neuroimmunomodulation. 14: 157-162, 2007.
    • (2007) Neuroimmunomodulation. , vol.14 , pp. 157-162
    • Viveros, M.P.1    Arranz, L.2    Hernanz, A.3    Miquel, J.4    de la Fuente, M.5
  • 55
    • 0025213974 scopus 로고
    • Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60
    • Wayne SL, Rhyne RL, Garry PJ, Goodwin JS. Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60. J Gerontol. 45: M45-48, 1990.
    • (1990) J Gerontol. , vol.45
    • Wayne, S.L.1    Rhyne, R.L.2    Garry, P.J.3    Goodwin, J.S.4
  • 56
    • 0027390329 scopus 로고
    • Superoxide as an intracellular radical sink
    • Winterbourn CC. Superoxide as an intracellular radical sink. Free Radic Biol Med. 14: 85-90, 1993.
    • (1993) Free Radic Biol Med. , vol.14 , pp. 85-90
    • Winterbourn, C.C.1
  • 57
    • 62749186719 scopus 로고    scopus 로고
    • Dose effect of oxidative stress on signal transduction in aging
    • Yoon SO, Yun CH, Cheng AS. Dose effect of oxidative stress on signal transduction in aging. Mech Ageing Dev. 50: 1-8, 2002.
    • (2002) Mech Ageing Dev. , vol.50 , pp. 1-8
    • Yoon, S.O.1    Yun, C.H.2    Cheng, A.S.3


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