Effect of diet supplementation with N-acetylcysteine on leucocyte functions in prematurely aging mice

Journal of Applied Biomedicine

Volumn 3, Issue 4, 2005, Pages 199-205

  Guayerbas, Noelia ^a   Puerto, Marta ^a   Alvarado, Carmen ^a   De la Fuente, Mónica ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Antioxidant; Glutathione; Leucocytes; Lymphoproliferation; N acetylcysteine

Indexed keywords

ACETYLCYSTEINE; CONCANAVALIN A; FREE RADICAL; GLUTATHIONE; INTERLEUKIN 1BETA; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CYTOKINE RELEASE; DIET SUPPLEMENTATION; FEMALE; IMMUNE RESPONSE; LEUKOCYTE FUNCTION; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; OXIDATIVE STRESS; PREMATURE AGING; PROTEIN CONTENT; PROTEIN SECRETION; SENESCENCE; SHORT COURSE THERAPY;

ANIMALIA;

EID: 32044450320     PISSN: 1214021X     EISSN: 12140287     Source Type: Journal    
DOI: 10.32725/jab.2005.026     Document Type: Article

References (27)

1. Aspinall R.: Longevity and immune response. Biogerontology 1:273-278, 2000.
2. Bruunsgaard H., Pedersen M., Pedersen B.K.: Aging and proinflammatory cytokines, Curr. Opin. Hematol. 8:131-136, 2001.
3. Chandra R.K.: Nutrition and immunology: from the clinic to cellular biology and back again. Proc. Nutr. Soc. 58:681-683, 1999.
4. De la Fuente M.: Effects of antioxidants on immune system ageing. Eur J Clin Nutr. 56:1-4, 2002.
5. De la Fuente M., Álvarez P., Alvarado C. et al.: A diet supplemented with thiolic antioxidants decreases the oxidative stress in peritoneal leucocytes from prematurely ageing mice. Free Radic Res. 37:53, 2003a.
6. De la Fuente M., Hernanz A., Medina S. et al.: Characterization of monoaminergic systems in brain regions of prematurely ageing mice. Neurochem. Int. 43:165-172, 2003b.
7. Dröge W.: Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants. Exp. Gerontol. 37:1333-1345, 2002.
8. Ferrández M.D., Correa R., Del Río M., De la Fuente M.: Effects in vitro of several antioxidants on the natural killer function of aging mice. Exp. Gerontol. 34:675-685, 1999.
9. Franklin R.A., Li Y.M., Arkins S., Kelley K.W.: Glutathione augments in vitro proliferative responses of lymphocytes to Concanavalin A to a greater degree in old than in young rats. J. Nutr. 120:1710-1717, 1990.
10. Golsdstone S.D., Hunt N.H.: Redox regulation of the mitogen-activated protein kinase pathway during lymphocyte activation. Biochim. Biophys. Acta 1355:353-360, 1997.
11. Guayerbas N., Sánchez A.I., Gamallo A. et al.: Mouse performance in an exploratory activity test as a longevity biomarker. Tur-Marí J.A. and Orellana-Muriana J.M. (eds), Animal Research Welfare. A partnership, Laboratory Animals Ltd, London 2000, pp. 159-161.
12. Guayerbas N., Catalán M.P., Víctor V.M. et al.: Relation of behavior and macrophage function with the life span in a murine model of premature immunosenescence. Behav. Brain Res. 134:41-48, 2002a.
13. Guayerbas N., Puerto M., Víctor V.M. et al.: Leucocyte function and life span in a murine model of premature immunosenescence. Exp. Gerontol. 37:249-256, 2002b.
14. Guayerbas N., De la Fuente M.: An impairment of phagocytic function is linked to a shorter life span in two strains of prematurely aging mice. Dev. Comp. Immunol. 27:339-350, 2003.
15. Guevara A.G., Guilvard E., Borges M.M. et al.: N-acetylcysteine and glutathione modulate the behaviour of Trypanosoma cruzi experimental infection. Immunol. Lett. 71:79-83, 2000.
16. Hernanz A., Fernández-Vivancos E. et al.: Changes in the intracellular homocysteine and glutathione content associated with aging. Life Sci. 67:1317-1324, 2000.
17. Knight J.A.: Review: free radicals, antioxidants, and the immune system. Annu. Clin. Lab. Sci. 30:145-157, 2000.
18. Medina S., Del Río M., Hernanz A., De la Fuente M.: Age-related changes in the neuropeptide Y effects of murine lymphoproliferation and interleukin-2 production. Peptides 21:1403-1409, 2000.
19. Pieri C., Moroni F., Recchioni R.: Glutathione influences the proliferation as well as the extent of mitochondrial activation in rat splenocytes. Cell Immunol. 145:210-217, 1992
20. Puerto M., Guayerbas N., Víctor V.M., De la Fuente M.: Effects of the N-acetylcysteine on macrophage and lymphocyte functions in a mouse model of premature ageing. Pharmacol. Biochem. Behav. 73:797-804, 2002.
21. Sekhon B., Sekhon C., Khan M. et al.: N-Acetylcysteine protects against injury in a rat model of focal cerebral ischemia. Brain Res. 971:1-8, 2003.
22. Víctor V.M., Guayerbas N., Garrote D. et al.: Modulation of murine macrophage function by N-acetylcysteine in a model of endotoxic shock. BioFactors 10:347-357, 1999.
23. Víctor V.M., Rocha M., De la Fuente M.: N-acetylcysteine protects mice from lethal endotoxemia by regulating the redox state of immune cells. Free Radic. Res. 37:919-929, 2003.
24. Víctor V.M., Rocha M., De la Fuente M.: Immune cells: free radicals and antioxidants in sepsis. Int. Immunopharmacol. 4(3):327-347, 2004.
25. Viora M., Quaranta M.G., Straface E. et al.: Redox imbalance and immune functions: opposite effects of oxidized low-density lipoproteins and N-acetylcysteine. Immunology 104:431-438, 2001.
26. Viveros M.P., Fernández B., Guayerbas N., De la Fuente M.: Behavioral characterization of a mouse model of premature immunosenescence. J. Neuroimmunol. 114:80-88, 2001.
27. Wayne S.J., Rhyme R.L., Garry P.J., Goodwin J.S.: Cell-mediated immunity as a predictor of morbility and mortality in subjects over 60. J. Gerontol. 45:45-48, 1990.