Mechanism of inhibition of GluA2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives: Functional consequences of replacing a 7,8-methylenedioxy with a 7,8-ethylenedioxy moiety

Biochemistry

Volumn 51, Issue 8, 2012, Pages 1787-1795

  Qneibi, Mohammad S ^a   Micale, Nicola ^b   Grasso, Silvana ^b   Niu, Li ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA-RECEPTOR; CHANNEL OPENING; DRUG CANDIDATES; INHIBITION CONSTANTS; NEUROLOGICAL DISEASE; RECEPTOR CHANNELS; SOLUTION FLOWS; STRUCTURE ACTIVITY RELATIONSHIPS; TIME RESOLUTION;

PHOTOLYSIS;

SULFUR COMPOUNDS;

1 (4 AMINO 3 CHLOROPHENYL) 3,5 DIHYDRO 7,8 ETHYLENEDIOXY 4H 2,3 BENZODIAZEPIN 4 ONE; 1 (4 AMINOPHENYL) 3,5 DIHYDRO 7,8 ETHYLENEDIOXY 4H 2,3 BENZODIAZEPIN 4 ONE; 1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; AMPA RECEPTOR; BENZODIAZEPINE DERIVATIVE; GLUTAMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; PHOTOLYSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION;

BENZODIAZEPINES; BENZODIAZEPINONES; BINDING SITES; CALCIUM; HEK293 CELLS; HUMANS; KINETICS; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857531031     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2017552     Document Type: Article

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