Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4+T cell-mediated colitis in mice

Gastroenterology

Volumn 142, Issue 3, 2012, Pages 582-591.e8

  Liao, Gongxian ^a   Detre, Cynthia ^a   Berger, Scott B ^a   Engel, Pablo ^c   De Waal Malefyt, Rene ^d   Herzog, Roland W ^e   Bhan, Atul K ^b   Terhorst, Cox ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF BARCELONA   (Spain)

^d MERCK RESEARCH LABORATORIES   (United States)

^e UNIVERSITY OF FLORIDA   (United States)

Author keywords

IBD; Immune Regulation; Inflammation; TNF

Indexed keywords

CD45RB ANTIGEN; GAMMA INTERFERON; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL MATURATION; CELL SURFACE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE ACTIVITY; EFFECTOR CELL; ENTEROCOLITIS; HISTOPATHOLOGY; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LIGAND BINDING; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFER; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; WILD TYPE;

EID: 84857526681     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.11.031     Document Type: Article

References (32)

1. J. Shimizu, S. Yamazaki, T. Takahashi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance Nat Immunol 3 2002 135 142
2. K. Ko, S. Yamazaki, K. Nakamura Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells J Exp Med 202 2005 885 891
3. R.W. van Olffen, N. Koning, K.P. van Gisbergen GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo J Immunol 182 2009 7490 7500
4. G. Liao, S. Nayak, J.R. Regueiro GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells Int Immunol 22 2010 259 270
5. M. Azuma Role of the glucocorticoid-induced TNFR-related protein (GITR)-GITR ligand pathway in innate and adaptive immunity Crit Rev Immunol 30 2010 547 557
6. A. Vecchiarelli, E. Pericolini, E. Gabrielli The GITRL-GITR system alters TLR-4 expression on DC during fungal infection Cell Immunol 257 2009 13 22
7. L. Santucci, M. Agostini, S. Bruscoli GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice Gut 56 2007 52 60
8. U. Grohmann, C. Volpi, F. Fallarino Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy Nat Med 13 2007 579 586
9. Y. Kamimura, H. Iwai, J. Piao The glucocorticoid-induced TNF receptor-related protein (GITR)-GITR ligand pathway acts as a mediator of cutaneous dendritic cell migration and promotes T cell-mediated acquired immunity J Immunol 182 2009 2708 2716
10. T.S. Heng, M.W. Painter The Immunological Genome Project: networks of gene expression in immune cells Nat Immunol 9 2008 1091 1094
11. H.H. Shin, B.S. Kwon, H.S. Choi Recombinant glucocorticoid induced tumour necrosis factor receptor (rGITR) induced COX-2 activity in murine macrophage Raw 264.7 cells Cytokine 19 2002 187 192
12. H.S. Lee, H.H. Shin, B.S. Kwon Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) increased MMP-9 activity in murine macrophage J Cell Biochem 88 2003 1048 1056
13. M.W. Steinberg, O. Turovskaya, R.B. Shaikh A crucial role for HVEM and BTLA in preventing intestinal inflammation J Exp Med 205 2008 1463 1476
14. S. Ronchetti, G. Nocentini, C. Riccardi Role of GITR in activation response of T lymphocytes Blood 100 2002 350 352
15. E. Bettelli, Y. Carrier, W. Gao Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 441 2006 235 238
16. Y.P. de Jong, A.C. Abadia-Molina, A.R. Satoskar Development of chronic colitis is dependent on the cytokine MIF Nat Immunol 2 2001 1061 1066
17. S.J. Simpson, G.A. Hollander, E. Mizoguchi Expression of pro-inflammatory cytokines by TCR alpha beta+ and TCR gamma delta+ T cells in an experimental model of colitis Eur J Immunol 27 1997 17 25
18. G. Liao, M. Zhang, E.W. Harhaj Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation J Biol Chem 279 2004 26243 262450
19. A.L. Mellor, D.B. Keskin, T. Johnson Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses J Immunol 168 2002 3771 3776
20. F. Powrie, R. Correa-Oliveira, S. Mauze Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity J Exp Med 179 1994 589 600
21. F. Powrie, M.W. Leach, S. Mauze Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C B-17 scid mice Int Immunol 5 1993 1461 1471
22. C. Mottet, H.H. Uhlig, F. Powrie Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells J Immunol 170 2003 3939 3943
23. E.M. Shevach, G.L. Stephens The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? Nat Rev Immunol 6 2006 613 618
24. H.H. Uhlig, B.S. McKenzie, S. Hue Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology Immunity 25 2006 309 318
25. H. Hadeiba, T. Sato, A. Habtezion CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease Nat Immunol 9 2008 1253 1260
26. J.L. Coombes, K.R. Siddiqui, C.V. Arancibia-Carcamo A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism J Exp Med 204 2007 1757 1764
27. O. Annacker, J.L. Coombes, V. Malmstrom Essential role for CD103 in the T cell-mediated regulation of experimental colitis J Exp Med 202 2005 1051 1061
28. E. Jaensson, H. Uronen-Hansson, O. Pabst Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans J Exp Med 205 2008 2139 2149
29. K. Liu, M.C. Nussenzweig Origin and development of dendritic cells Immunol Rev 234 2010 45 54
30. K.R. Siddiqui, S. Laffont, F. Powrie E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis Immunity 32 2010 557 567
31. M. Fujimoto, M. Nakano, F. Terabe The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells J Immunol 186 2011 32 40
32. S. Dominitzki, M.C. Fantini, C. Neufert Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells J Immunol 179 2007 2041 2045