Pulsed focused ultrasound-induced displacements in confined in vitro blood clots

IEEE Transactions on Biomedical Engineering

Volumn 59, Issue 3, 2012, Pages 842-851

  Wright, Cameron C ^a,b   Hynynen, Kullervo ^a,b   Goertz, David E ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b Canada   (Canada)

Author keywords

Ischemic stroke; thrombolysis; tissue plasminogen activator (tPA); ultrasound

Indexed keywords

ACOUSTIC POWER; ACOUSTIC RADIATION; AXIAL DIRECTION; AXIAL STRAIN; BLOOD CLOTS; CLINICAL TRIAL; EXPOSURE CONDITIONS; FOCAL ZONES; FOCUSED ULTRASOUND; HIGH-FREQUENCY ULTRASOUND IMAGING; IN-VITRO; ISCHEMIC STROKES; LINEAR RELATIONSHIPS; MECHANISM OF ACTION; PEAK VALUES; RECOVERY TIME; TEMPORAL AND SPATIAL DYNAMICS; TEMPORAL DISPLACEMENT; THROMBOLYSIS; TIME TO PEAK; TISSUE PLASMINOGEN ACTIVATOR; TISSUE PLASMINOGEN ACTIVATOR (TPA); TRANSMIT POWER; VESSEL PHANTOM;

ACOUSTIC WAVE PROPAGATION; BLOOD; TISSUE; ULTRASONIC IMAGING;

ULTRASONICS;

ACOUSTICS; ARTICLE; BLOOD CLOT; IN VITRO STUDY; NONHUMAN; RABBIT; THROMBUS; ULTRASOUND;

ANIMALS; PHANTOMS, IMAGING; RABBITS; THROMBOSIS; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TRANSDUCERS; ULTRASONIC THERAPY;

EID: 84857522873     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2011.2180904     Document Type: Article

References (41)

1. H.Luo, T.Nishioka, M. C. Fishbein, B. Cercek, J. S. Forrester, C. J. Kim, H.Berglund, and R. G. Siegel, "Transcutaneous ultrasound augments lysis of arterial thrombi in vivo," Circulation, vol. 94, pp. 775-778, 1996. (Pubitemid 26289235)
2. Y. Birnbaum, H.Luo, T. Nagai, M. C. Fishbein, T. M. Peterson, S. Li, D. Kricsfeld, T. R. Porter, and R. G. Siegel, "Noninvasive in vivo clot dissolution without a thrombolytic drug: Recanalization of thrombosed iliofemoral arteries by transcutaneous ultrasound combined with intravenous infusion of microbubbles," Circulation, vol. 97, pp. 130-134, 1998. (Pubitemid 28124667)
3. W. C. Culp, T. R. Porter, F. Xie, T. C. Goertzen, T. C. McCowan, B. N. Vonk, and B. T. Baxter, "Microbubble potentiated ultrasound as a method of declotting thrombosed dialysis grafts: Experimental studies in dogs," Cardiovas. Intervent. Radiol., vol. 24, pp. 307-312, 2001.
4. T. R. Porter, R. F. LeVeen, R. Fox, A. Kricsfeld, and F. Xie, "Thrombolysis enhancement with perfluorocarbon-exposed sonicated dextrose albumin microubbles," Amer. Heart J., vol. 132, pp. 964-968, 1996. (Pubitemid 26372752)
5. A. D. Maxwell, C. A. Cain, A. P. Duryea, L. Q. Yuan, H.S. Gurm, and Z. Xu, "Noninvasive thrombolysis using pulsed ultrasound cavitation therapy-histotripsy," Ultrasound Med. Biol., vol. 35, pp. 1982-1994, 2001.
6. S. Pfaffenberger, "Ultrasound thrombolysis," Thromb. Haemost., vol. 94, pp. 26-36, 2005. (Pubitemid 40974701)
7. R.Medel, R.W. Crowley, M. S. Mckisic, A. S. Dumont, and N. F. Kassell, "Sonothrombolysis:An emergingmodality for the management of stroke," Neurosurgery, vol. 65, pp. 979-993, 2009.
8. A. Blinc, C. W. Francis, J. L. Trunowski, and E. L. Cartensen, "Characterization of ultrasound-potentiated fibrinolysis in vitro," Blood, vol. 81, pp. 2636-2643, 1993. (Pubitemid 23147567)
9. C.W. Francis, A. Blinc, S. Lee, and C. Cox, "Ultrasound accelerates transport of recombinant tissue plasminogen activator into clots," Ultrasound Med. Biol., vol. 21, pp. 419-424, 1995.
10. S. Behrens, K. Spengos, M. Daffertshofer, H.Schroeck, C. E. Dempfle, and M. Hennerici, "Transcranial ultrasound-improved thrombolysis: Diagnostic versus therapeutic ultrasound," Ultrasound Med. Biol., vol. 27, pp. 1683-1689, 2001. (Pubitemid 34143129)
11. B. Devcic-Kuhar, S. Pfaffenberger, L. Gherardini, C. Mayer, M. Groschi, C. Kaun, E. Benes, E. Tschachler, K. Huber, G. Maurer, J. Wojta, and M. Gottsauner-Wolf, "Ultrasound affects distribution of plasminogen and tissue-type plasminogen activator in whole blood clots in vitro," Thromb. Haemost., vol. 92, pp. 980-985, 2004. (Pubitemid 39545519)
12. A. V. Alexandrov, C. A. Molina, J. C. Grotta, Z. Garami, S. R. Ford, J. Alvarez-Sabin, J. Montaner,M. Saqqur, A. Demchuk, L. Moye,M. Hill, and A. Wojner, "Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke," New Engl. J. Med., vol. 351, pp. 2170-2178, 2004. (Pubitemid 39507629)
13. C. K. Holland, S. S. Vaidya, S. Datta, C. C. Coussios, and G. J. Shaw, "Ultrasound-enhanced tissue plasminogen activator thrombolysis in an in vitro porcine clot model," Thromb. Res., vol. 121, pp. 663-673, 2008. (Pubitemid 351308146)
14. C. Baron, J. F. Aubry, M. Tanter, S. Meairs, and M. Fink, "Simulation of intracranial acoustic fields in clinical trials of sonothrombolysis," Ultrasound Med. Biol., vol. 35, pp. 1148-1158, 2009.
15. J. Song and K. Hynynen, "Feasibility of using lateral mode coupling method for a large scale ultrasound phase array for noninvasive transcranial therapy," IEEE Trans. Biomed. Eng., vol. 57, no. 1, pp. 124-133, Jan. 2010.
16. N. McDannold, G. T. Clement, P. Black, F. Jolesz, and K. Hynynen, "Transcranial magnetic resonance imaging-guided focused ultrasound surgery of brain tumors: Initial findings in 3 patients," Neurosurgery, vol. 66, pp. 323-332, 2006.
17. M. Pernot, J. F. Aubry, M. Tanter, J. L. Thomas, and M. Fink, "High power transcranial beam steering for ultrasonic brain therapy," Phys.Med. Biol., vol. 48, pp. 2577-2589, 2003. (Pubitemid 37069368)
18. C. T. Clement, J. Sun, T. Giesecke, and K. Hynynen, "A hemisphere array for non-invasive ultrasound brain therapy and surgery," Phys. Med. Biol., vol. 45, pp. 3707-3719, 2002.
19. V. Frenkel, J. Oberoi, M. J. Stone, M. Park, C. Deng, B. J. Wood, Z. Neeman, M. Horne, and K. Li, "Pulsed high-intensity focused ultrasound enhances thrombolysis in an in vitro model," Radiology, vol. 239, pp. 86-93, 2006.
20. M. J. Stone, V. Frenkel, S. Dromi, P. Thomas, R. Lewis, K. Li, M. Horne, and B. J. Wood, "Pulsed-high intensity focused ultrasound enhanced tPA mediated thrombolysis in a novel in vivo clot model, a pilot study," Thromb. Res., vol. 121, pp. 193-202, 2007. (Pubitemid 350141674)
21. D. V. Sakharov, R. T. Hekkenberg, and D. C. Rijken, "Acceleration of fibrinolysis by high-frequency ultrasound: The contribution of acoustic streaming and temperature rise," Thromb. Res., vol. 100, pp. 333-340, 2000.
22. G. J. Shaw, A. Dhamija, N. Bavani, and K. R. Holland, "Arrhenius temperature dependence of in vitro tissue plasminogen activator thrombolysis," Phys. Med. Biol., vol. 52, pp. 2953-2967, 2000.
23. V. M. Nahirnyak, S. W. Yoon, and C. K. Holland, "Acousto-mechanical and thermal properties of clotted blood," J. Acoust. Soc. Amer., vol. 119, pp. 3766-3772, 2006. (Pubitemid 43886352)
24. M. Rubiera, M. Ribo, R. Delgado-Mederos, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, J. Alvarez-Sabin, and C. A. Molina, "Do bubble characteristics affect recanalization in stroke patients treated with microbubble-enhanced sonothrombolysis?," Ultrasound Med. Biol., vol. 34, pp. 1573-1577, 2008.
25. G. Jones, F. Hunter, H.A. Hancock, A. Kapoor, M. J. Stone, B. J. Wood, J. Xie, M. R. Dreher, and V. Frenkel, "In vitro investigations into enhancement of tPA bioavailability in whole blood clots using pulsed-high intensity focused ultrasound exposures," IEEE Trans. Biomed. Eng., vol. 57, no. 1, pp. 33-36, Jan. 2010.
26. D.W. Rickey, P. A. Picot, D. A. Christopher, and A. Fenster, "A wall-less vessel phantom for Doppler ultrasound studies," Ultrasound Med. Biol., vol. 21, pp. 1163-1176, 1995.
27. K. Hynynen, "The threshold for thermally significant cavitation in dog's thigh muscle in vivo," Ultrasound Med. Biol., vol. 17, pp. 157-169, 1991.
28. Acoustic Output Measurement Standard for Diagnostic Ultrasound Equipment, AIUM/NEMA UD2-1998, 1998.
29. T. Loupas, J. T. Power, and R. W. Gill, "An axial velocity estimator for ultrasound blood flow imaging, based on a full evaluation of the Doppler equation by means of two-dimensional autocorrelation approach," IEEE Trans. Ultrason., Ferroelectr., Freq. Control, vol. 42, no. 4, pp. 672-688, Jul. 1995.
30. X. M. Lai, H.Torp, and K. Kristoffersen, "An extended autocorrelation method for estimation of blood flow velocity," IEEE Trans. Ultrason., Ferroelectr. Freq. Control, vol. 44, no. 6, pp. 1332-1342, Nov. 1997. (Pubitemid 127771327)
31. A. P. Sarvazyan, O. V. Rudenko, S. D. Swanson, J. B. Fowlkes, and S. Y. Emilianov, "Shear wave elasticity imaging: A new ultrasonic technology of medical diagnostics," Ultrasound Med. Biol., vol. 24, pp. 1419-1435, 1998. (Pubitemid 29003664)
32. J. Bercoff, M. Tanter, and M. Fink, "Supersonic shear imaging: A new technique for soft tissue elasticity mapping," IEEE Trans. Ultrason., Ferroelectr. Freq. Control, vol. 51, no. 4, pp. 396-409, Apr. 2004.
33. M. L. Palmeri, J. J. Dahl, K. D. Frinkley, and K. R. Nightingale, "Quantifying hepatic shear modulus in vivo using acoustic radiation force," Ultrasound Med. Biol., vol. 34, pp. 546-558, 2008. (Pubitemid 351417692)
34. K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, "On the feasibility of remote palpation using acoustic radiation force," J. Acoust. Soc. Amer., vol. 110, pp. 625-634, 2001. (Pubitemid 32642598)
35. K. R. Nightingale, M. S. Soo, R. W. Nightingale, and G. E. Trahey, "Acoustic radiation force impulse imaging: In vivo demonstration of clinical feasibility," Ultrasound Med. Biol., vol. 28, pp. 227-235, 2002. (Pubitemid 34286420)
36. H.A. Hancock, L. H.Smith, J. Cuesta, A. K. Durrani, M. Angstadt, M. L. Palmeri, E. Kimmel, and V. Frenkel, "Investigations into pulsed highintensity focused ultrasound-enhanced delivery: Preliminary evidence for a novel mechanism," Ultrasound Med. Biol., vol. 35, pp. 1722-1736, 2009.
37. F. A. Duck, Physical Properties of Tissue: A Comprehensive Reference Book. London, U.K.: Academic, 1990.
38. M. L. Palmeri, S. A. McAleavey, K. L. Fong, G. E. Trahey, and K. R. Nightingale, "Dynamic mechanical response of elastic spherical inclusions to impulsive acoustic radiation force excitation," IEEE Trans. Ultrason., Ferroelectr. Freq. Control, vol. 53, no. 11, pp. 2065-2079, Nov. 2006. (Pubitemid 46104005)
39. U. Hamhaber, V. A. Grieshaber, J. H.Nagel, and U. Klose, "Comparison of quantitative shearwave MR-elastography with mechanical compression tests," Magn. Reson. Med., vol. 49, pp. 71-77, 2003. (Pubitemid 36042335)
40. M. Couade, M. Pernot, C. Prada, E. Messas, J. Emmerich, P. Bruneval, A. Criton, M. Fink, and M. Tanter, "Quantitative assessment of arterial wall biomechanical properties using shear wave imaging," Ultrasound Med. Biol., vol. 36, pp. 1662-1676, 2010.
41. J. Heikkila, T. Karjalainen,M. Vauhkonen, and K. Hynynen, "Simulations of local harmonic motion on a blood vessel wall induced by an acoustic radiation force used in ultrasound elastography," Phys.Med. Biol., vol. 51, pp. 4587-4601, 2006. (Pubitemid 44362516)