Pulsed-high intensity focused ultrasound enhanced tPA mediated thrombolysis in a novel in vivo clot model, a pilot study

Thrombosis Research

Volumn 121, Issue 2, 2007, Pages 193-202

  Stone, Michael J ^a,b   Frenkel, Victor ^a   Dromi, Sergio ^a   Thomas, Peter ^a   Lewis, Ryan P ^a   Li, King C P ^a   Horne III, McDonald ^a   Wood, Bradford J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Clot model; High intensity focused ultrasound (HIFU); Rabbit ear vein; Thrombolysis; Tissue plasminogen activator (tPA)

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

ANGIOGRAPHY; ANIMAL EXPERIMENT; ARTICLE; BLOOD CLOT LYSIS; BLOOD CLOTTING; BLOOD VESSEL WALL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HEMODYNAMICS; HIGH INTENSITY FOCUSED ULTRASOUND; IN VIVO STUDY; MONOTHERAPY; NEUTROPHIL; NONHUMAN; PHLEBOGRAPHY; PRIORITY JOURNAL; RABBIT; RECANALIZATION;

ANIMALS; FEMALE; FIBRINOLYTIC AGENTS; MODELS, ANIMAL; PILOT PROJECTS; RABBITS; THROMBOLYTIC THERAPY; THROMBOSIS; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME; ULTRASONIC THERAPY; ULTRASONICS;

EID: 36348972180     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2007.03.023     Document Type: Article

References (36)

1. Pfaffenberger S., Devcic-Kuhar B., Kastl S.P., et al. Ultrasound thrombolysis. Thromb Haemost 94 (2005) 26-36
2. Mitragotri S. Healing sound: the use of ultrasound in drug delivery and other therapeutic applications. Nat Rev Drug Discov 4 (2005) 255-260
3. Tachibana K. Enhancement of fibrinolysis with ultrasound energy. J Vasc Interv Radiol 3 (1992) 299-303
4. Hong A.S., Chae J.S., Dubin S.B., et al. Ultrasonic clot disruption: an in vitro study. Am Heart J 120 (1990) 418-422
5. Rosenschein U., Bernstein J.J., DiSegni E., et al. Experimental ultrasonic angioplasty: disruption of atherosclerotic plaques and thrombi in vitro and arterial recanalization in vivo. J Am Coll Cardiol 15 (1990) 711-717
6. Rosenschein U., Gaul G., Erbel R., Amann F., et al. Percutaneous transluminal therapy of occluded saphenous vein grafts. Circulation 99 (1999) 26-29
7. Cintas P., Nguyen F., Boneu B., et al. Enhancement of enzymatic fibrinolysis with 2-mHz ultrasound and microbubbles. J Thromb Haemost 2 (2004) 1163-1166
8. Frenkel V., Kimmel E., and Iger Y. Ultrasound-induced cavitation damage to external epithelia of fish skin. Ultrasound Med Biol 25 (1999) 1295-1303
9. Kennedy J.E. High-intensity focused ultrasound n treatment of solid tumors. Nat Rev Cancer 5 (2005) 321-327
10. Miller D.L., and Song J. Tumor growth reduction and DNA transfer by cavitation-enhanced high intensity focused ultrasound in vivo. Ultrasound Med Biol 29 (2003) 887-893
11. Nightingale K., Soo M.S., Nightingale R., et al. Acoustic radiation force impulse imaging: in vivo demonstration of clinical feasibility. Ultrasound Med Biol 28 (2002) 227-235
12. Lizzi F.L., Muratore R., Deng C.X., et al. Radiation-force technique to monitor lesions during ultrasonic therapy. Ultrasound Med Biol 29 (2003) 1593-1605
13. Frenkel V., and Li K.C.P. Potential role of pulsed-high intensity focused ultrasound in gene therapy. Future Oncol 2 (2006) 111-119
14. Yuh E.L., Shulman S.G., Mehta S.A., et al. Delivery of a systemic chemotherapeutic agent to tumors using focused ultrasound: a study in a murine model. Radiology 234 (2005) 431-437
15. Dittmar K., Xie J., Hunter F., et al. Pulsed-HIFU facilitated local gene delivery with systemically injected naked DNA in a mouse squamous cell carcinoma model: initial experience. Radiology 235 (2005) 541-546
16. Frenkel V., Etherington A., Greene M., et al. Delivery of liposomal Doxorubicin (doxil) in a breast cancer tumor model: investigation of potential enhancement by pulsed-high intensity focused ultrasound exposure. Acad Radiol 4 (2006) 469-479
17. Frenkel V., Oberoi J., Stone M.J., et al. Pulsed-high intensity focused ultrasound (HIFU) enhances thrombolysis in an in vitro model. Radiology 239 (2006) 86-93
18. Stone M.J., Frenkel V., Oberoi J., et al. Pulsed-high intensity focused ultrasound (HIFU)-enhanced thrombolysis in vitro: proof of concept and investigation of mechanism. Proceedings of the 91st meeting of the Radiological Society of North America. Chicago, IL (2005)
19. Shebuski R., Bush L., Gagnon A., et al. Development and applications of animal models of thrombosis. Methods Mol Med 93 (2004) 175-219
20. Jeske W., Iqbal O., Fareed J., et al. A survey of venous thrombosis models. Methods Mol Med 93 (2004) 221-237
21. Agnelli G., Buchanan M.R., Fernandez F., et al. Sustained thrombolysis with DNA-recombinant tissue type plasminogen activator in rabbits. Blood 66 (1985) 399-401
22. Diamond S.L., and Anand S. Inner clot diffusion and permeation during fibrinolysis. Biophys J 65 (1993) 2622-2643
23. Braaten J.V., Gross R.A., and Francis C.W. Ultrasound reversibly disaggregates fibrin fibres. Thromb Haemost 78 (1997) 1063-1068
24. Siddiqi F., Blinc A., Braaten J.V., and Francis C.W. Ultrasound increases flow through fibrin gels. Thromb Haemost 73 (1995) 495-498
25. Francis C.W., Blinc A., Lee S., and Cox C. Ultrasound accelerates transport of recombinant tissue plasminogen activator into clots. Ultrasound Med Biol 21 (1995) 419-424
26. Cohen M.G., Tuero E., Bluguermann J., et al. Transcutaneous ultrasound-facilitated coronary thrombolysis during acute myocardial infarction. Am J Cardiol 92 (2003) 454-457
27. Alexandrov A.V., Molina C.A., Grotta J.C., et al. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med 351 (2004) 2170-2178
28. Molina C.A., Ribo M., Rubiera M., et al. Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke 37 (2006) 425-429
29. Qureshi A.I., Luft A.R., Sharma M., et al. Prevention and treatment of thromboembolic and ischemic complications associated with endovascular procedures: part I-pathophysiological and pharmacological features. Neurosurgery 46 (2000) 1344-1359
30. Atar S., Luo H., Nagai T., et al. Arterial thrombus dissolution in vivo using a transducer-tipped, high-frequency ultrasound catheter and local low-dose urokinase delivery. J Endovasc Ther 8 (2001) 282-290
31. Sakharov D.V., Hekkenberg R.T., and Rijken D.C. Acceleration of fibrinolysis by high-frequency ultrasound: the contribution of acoustic streaming and temperature rise. Thromb Res 100 (2000) 333-340
32. Shlamovitz G.Z., Matz IakobishvilliZ., et al. In vitro ultrasound augmented clot dissolution-what is the optimal timing of ultrasound application?. Cardiovasc Drugs Ther 16 (2002) 521-526
33. Sheikov N., McDannold N., Vykhodtseva N., et al. Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med Biol 30 (2004) 979-989
34. Kimmel E. Cavitation bioeffects. Crit Rev Biomed Eng 34 2 (2006) 105-161
35. Larson T.R., Bostwick D.G., and Corica A. Temperature-correlated histopathologic changes following microwave thermoablation of obstructive tissue in patients with benign prostatic hyperplasia. Urology 47 (1996) 463-469
36. Hwang J.H., Brayman A.A., Reidy M.A., et al. Vascular effects induced by combined 1-MHz ultrasound and microbubble contrast agent treatments in vivo. Ultrasound Med Biol 31 (2005) 553-564