Effects of PB190 and PB212, new σ receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells

Pharmacological Reports

Volumn 63, Issue 6, 2011, Pages 1564-1568

  Skuza, Grazyna ^a   Szymańska, Magdalena ^a   Budziszewska, Bogusława ^a,b   Abate, Carmen ^c   Berardi, Francesco ^c  

^a POLISH ACADEMY OF SCIENCES   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

Fibroblast cells; Glucocorticoid mediated gene transcription; PB190; PB212; Selective ligands

Indexed keywords

GLUCOCORTICOID RECEPTOR; PB 121 LIGAND; PB 190 LIGAND; SIGMA RECEPTOR LIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CAT GENE; CONTROLLED STUDY; ENDOCRINE SYSTEM; FIBROBLAST; GENE; GENE ACTIVITY; MOUSE; NONHUMAN; PROTEIN FUNCTION;

EID: 84857491489     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(11)70722-8     Document Type: Article

References (32)

1. Barden N: Implication of the hypothalamic-pituitary adrenal axis in the physiopathology of depression. J Psychiatry Neurosci, 2004, 29, 185-193.
2. Berardi F, Ferorelli S, Abate C, Pedone MP, Colabufo NA, Contino M, Perrone R: Methyl substitution on the piperidine ring of N-[ω-(6- methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the σ1 receptor. J Med Chem, 2005, 48, 8237-8244. (Pubitemid 43032532)
3. Berardi F, Ferorelli S, Colabufo NA, Leopoldo M, Perrone R, Tortorella V: A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[ω-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites. Bioorg Med Chem, 2001, 9, 1325-1335. (Pubitemid 32453291)
4. Bermack JE, Debonnel G: The role of sigma receptors in depression. J Pharmacol Sci, 2005, 97, 317-336. (Pubitemid 40515745)
5. Budziszewska B: Effect of antidepressant drug on the hypothalamic- pituitary-adrenal axis activity and glucocorticoid receptor function. Pol J Pharmacol, 2002, 54, 343-349.
6. Budziszewska B, Jaworska-Feil L, Kajta M, Lasoń W: Antidepressant drugs inhibit glucocorticoid receptor mediated gene transcription - a possible mechanism. Br J Pharmacol, 2000, 130, 1385-1393. (Pubitemid 30488604)
7. Ferorelli S, Abate C, Colabufo NA, Niso M, Inglese C, Berardi F, Perrone R: Design and evaluation of naphtholand carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies. J Med Chem, 2007, 50, 4648-4655. (Pubitemid 47463239)
8. Fishback JA, Robson MJ, Xu YT, Matsumoto RR: Sigma receptors: potential targets for a new class of antidepressant drug. Pharmacol Ther, 2010, 127, 271-282.
9. Heuser IJ, Schweiger U, Gotthardt U, Schmider J, Lammers CH, Dettling M, Yassouridis A, Holsboer F: Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects. Am J Psychiatry, 1996, 153, 93-99. (Pubitemid 26026163)
10. Holsboer F: The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology, 2000, 23, 477-501.
11. Holsboer F, Barden N: Antidepressants and hypothalamic- pituitary-adrenocortical regulation. Endocr Rev, 1996, 17, 187-205.
12. Holsboer F, Gerken A, Stalla GK, Müller OA: ACTH, cortisol, and corticosterone output after ovine corticotropin- releasing factor challenge during depression and after recovery. Biol Psychiatry, 1985, 20, 276-286. (Pubitemid 16036393)
13. Kikuchi-Utsumi K, Nakaki T: Chronic treatment with a selective ligand for the sigma-1 receptor chaperone, SA4503, up-regulates BDNF protein levels in the rat hippocampus. Neurosci Lett, 2008, 440, 19-22.
14. Leonard BE: The potential contribution of sigma receptors to antidepressant actions. In: Antidepressants: New Pharmacological Strategies. Ed. Skolnick P, Humana Press, Totowa, 1997, 159-172.
15. Linkowski P, Mendlewicz J, LeClerc R, Brasseur M, Hubain P, Goldstein J, Copinschi G, Van Cauter E: The 24-hour profile of ACTH and cortisol in major depressive illness. J Clin Endocrinol Metab, 1985, 61, 429-438. (Pubitemid 15243950)
16. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem, 1951, 193, 265-275.
17. 1 Receptor subtype is involved in the relief of behavioral despair in the mouse forced swimming test. Eur J Pharmacol, 1996, 312, 267-271.
18. Maurice T, Su TP: The pharmacology of sigma-1 receptors. Pharmacol Ther, 2009, 124, 195-206.
19. Nemeroff CB, Widerlov E, Bisette G, Walleus H, Karlsson I, Eklund K, Kilts CD et al.: Elevated concentrations of CSF corticotropin releasing factor-like immunoreactivity in depressed patients. Science, 1984, 226, 1342-1344. (Pubitemid 15215592)
20. Pariante CM, Miller AH: Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry, 2001, 49, 391-404. (Pubitemid 32234301)
21. Pariante CM, Pearce BD, Pisell TL, Owens MJ, Miller AH: Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine. Mol Pharmacol, 1997, 52, 571-581. (Pubitemid 27443978)
22. Piwowarska J, Wrzosek M, Radziwoń-Zaleska M, Ryszewska- Pokraśniewicz B, Skalski M, Matsumoto H, Biernacka-Bazyluk A et al.: Serum cortisol concentration in patients with major depression after treatment with clomipramine. Pharmacol Rep, 2009, 61, 604-611.
23. Sabino V, Cottone P, Parylak SL, Steardo L, Zorrilla EP: Sigma-1 receptor knockout mice display a depressivelike phenotype. Behav Brain Res, 2009, 198, 472-476.
24. Skuza G: Potential antidepressant activity of sigma ligands. Pol J Pharmacol, 2003, 55, 923-934.
25. 1A receptor agonist in the forced swimming test in rats. Pharmacol Rep, 2007, 59, 773-777.
26. Skuza G, Rogóż Z: Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice. Pharmacol Rep, 2009, 61, 1179-1183.
27. Skuza G, Rogóż Z, Szymańska M, Budziszewska B: Effects of selective sigma receptor ligands on glucocorticoid receptor-mediated gene transcription in LMCAT cells. Pharmacol Rep, 2008, 60, 889-895.
28. Takebayashi M, Hayashi T, Su TP: Nerve growth factorinduced neurite sprouting in PC12 cells involves sigma-1 receptors: implications for antidepressants. J Pharmacol Exp Ther, 2002, 303, 1227-1237. (Pubitemid 35424409)
29. 1 (σ1)-receptor in the acute behavioral effects of antidepressants. J Pharmacol Sci, 2011, 115, 279-292.
30. Volz HP, Stoll KD: Clinical trials with sigma ligands. Pharmacopsychiatry, 2004, 37, Suppl 3, S214-220.
31. Wang J, Mack AL, Coop A, Matsumoto RR: Novel sigma (σ) receptor agonists produce antidepressant-like effects in mice. Eur Neuropsychopharmacol, 2007, 17, 708-716. (Pubitemid 47419291)
32. Yagasaki Y, Numakawa T, Kumamaru E, Hayashi T, Su TP, Kunugi H: Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factorinduced signaling for glutamate release. J Biol Chem, 2006, 281, 12941-12949. (Pubitemid 43855387)