STR/ort mice, a model for spontaneous osteoarthritis, exhibit elevated levels of both local and systemic inflammatory markers

Comparative Medicine

Volumn 61, Issue 4, 2011, Pages 346-355

  Kyostio Moore, Sirkka ^a   Nambiar, Bindu ^a   Hutto, Elizabeth ^a   Ewing, Patty J ^a   Piraino, Susan ^a   Berthelette, Patricia ^a   Sookdeo, Cathleen ^a   Matthews, Gloria ^a   Armentano, Donna ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; BIOLOGICAL MARKER; CALVASCULIN; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 5; MACROPHAGE INFLAMMATORY PROTEIN 1BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CBA MOUSE; CONTROLLED STUDY; CORRELATION ANALYSIS; COST EFFECTIVENESS ANALYSIS; DISEASE MODEL; DISEASE RESISTANCE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KNEE MENISCUS; LIGAMENT; MALE; MORPHOLOGY; MOUSE; NONHUMAN; OSTEOARTHRITIS; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; SYNOVIUM;

ANALYSIS OF VARIANCE; ANIMALS; BIOLOGICAL MARKERS; CYTOKINES; GLYCOSYLATION END PRODUCTS, ADVANCED; HMGB1 PROTEIN; IMMUNOHISTOCHEMISTRY; JOINTS; MICE; MICE, INBRED STRAINS; OSTEOARTHRITIS; OXIDATIVE STRESS;

EID: 84857485744     PISSN: 15320820     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Aigner T, Fundel K, Saas J, Gebhard PM, Haag J, Weiss T, Zien A, Obermayer F, Zimmer R, Bartnik E. 2006. Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 54:3533-3544. (Pubitemid 44737165)
2. Ameye LG, Young MF. 2006. Animal models of osteoarthritis: lessons learned while seeking the "Holy Grail". Curr Opin Rheumatol 18:537-547. (Pubitemid 44200342)
3. Ayral X, Pickering EH, Woodworth TG, Mackillop N, Dougados M. 2005. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis-results of a 1-year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage 13:361-367. (Pubitemid 40631281)
4. Basta G, Lazzerini G, Massaro M, Simoncini T, Tanganelli P, Fu C, Kislinger T, Stern DM, Schmidt AM, DeCaterina R. 2002. Advanced glycation end-products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses. Circulation 105:816-822. (Pubitemid 34174921)
5. Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. 2005. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis 64:1263-1267. (Pubitemid 41206240)
6. Binder CJ, Hartvigsen K, Chang MK, Miller M, Broide D, Palinski W, Curtiss LK, Corr M, Witztum JL. 2004. IL5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114:427-437. (Pubitemid 39071615)
7. Blom AB, van Lent PL, Libregts S, Holthuysen AE, van der Kraan PM, van Rooijen N, van der Berg WB. 2007. Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis. Arthritis Rheum 56:147-157. (Pubitemid 46106187)
8. Cecil DL, Johnson K, Rediske J, Lotz M, Schmidt AM, Terkeltaub R. 2005. Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products. J Immunol 175:8296-8302. (Pubitemid 41798395)
9. Chambers MG, Bayliss MT, Mason RM. 1997. Chondrocyte cytokine and growth factor expression in murine osteoarthritis. Osteoarthritis Cartilage 5:301-308. (Pubitemid 27396023)
10. Chambers MG, Kuffner T, Cowan SK, Cheah KS, Mason RM. 2002. Expression of collagen and aggrecan genes in normal and osteoarthritic murine knee joints. Osteoarthritis Cartilage 10:51-61. (Pubitemid 34110790)
11. Chou MY, Hartvigsen K, Hansen LF, Fogelstrand L, Shaw PX, Boullier A, Binder CJ, Witztum JL. 2008. Oxidation-specific epitopes are important targets of innate immunity. J Intern Med 263:479-488. (Pubitemid 351533561)
12. DeGroot J, Verzijl N, Wenting-van Wijk MJ, Jacobs KM, Van El B, Van Roermund PM, Bank RA, Bijlsma JW, TeKoppele JM, Lafeber FP. 2004. Accumulation of advanced glycation end-products as a molecular mechanism for aging as a risk factor in osteoarthritis. Arthritis Rheum 50:1207-1215. (Pubitemid 38480831)
13. Ding KH, Wang ZZ, Hamrick MW, Deng ZB, Zhou L, Kang B, Yan SL, She JX, Stern DM, Isales CM, Mi QS. 2006. Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes-related bone loss. Biochem Biophys Res Commun 340:1091-1097. (Pubitemid 43083390)
14. 2-generation by mononuclear phagocytes in diabetes. J Leukoc Biol 81:520-527.
15. Flannelly J, Chambers MG, Dudhia J, Hembry RM, Murphy G, Mason RM, Bayliss MT. 2002. Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis. Osteoarthritis Cartilage 10:722-733. (Pubitemid 34993960)
16. Franke S, Sommer M, Ruster C, Bondeva T, Marticke J, Hofmann G, Hein G, Wolf G. 2009. Advanced glycation end-products induce cell-cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells. Arthritis Res Ther 11:R136.
17. Garcia-Arnandis I, Guillen M, Gomar F, Pelletier J, Martel-Pelletier J, Alcaraz M. 2010. High-mobility group box 1 potentiates the proinflammatory effects of interleukin 1β in osteoarthritic synoviocytes. Arthritis Res Ther 12:R165.
18. Huebner JL, Kraus VB. 2006. Assessment of the utility of biomarkers of osteoarthritis in the guinea pig. Osteoarthritis Cartilage 14:923-930. (Pubitemid 44138673)
19. Jaeger K, Selent C, Jaehme W, Mahr S, Goebel U, Ibrahim S, Vollmar B, Mueller-Hilke B. 2008. The genetics of osteoarthritis in STR/ort mice. Osteoarthritis Cartilage 16:607-614. (Pubitemid 351524697)
20. Klingelhöfer J, Senolt L, Baslund B, Nielsen GH, Skibhoj I, Pavelka K, Neidhart M, Gay S, Ambartsumian N, Hansen BS, Petersen J, Lukanidin E, Grigorian M. 2007. Upregulation of metastasis-promoting S100A4 (Mts1) in rheumatoid arthritis: putative involvement in the pathogenesis of rheumatoid arthritis. Arthritis Rheum 56:779-789. (Pubitemid 46399425)
21. Kokkola R, Sundberg E, Ulfgren AK, Palmblad K, Li J, Wang H, Ulloa L, Yang H, Yan XJ, Furle R, Chiorazzi N, Tracey KJ, Andersson U, Harris HE. 2002. High-mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum 46:2598-2603. (Pubitemid 36118922)
22. Lementowski PW, Zelicof SB. 2008. Obesity and osteoarthritis. Am J Orthop 37:148-151.
23. Licastro F, Candore G, Lio D, Porcellini E, Colonna-Romano G, Franceschi C, Caruso C. 2005. Innate immunity and inflammation in aging: a key for understanding age-related diseases. Immun Ageing 2:8-22.
24. Livshits G, Zhai G, Hart DJ, Kato BS, Wang H, Williams FM, Spector TD. 2009. Interleukin 6 is a significant predictor of radiographic knee osteoarthritis: the Chingford Study. Arthritis Rheum 60:2037-2045.
25. Loeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, Bursch LS, Yan SD. 2005. Articular chondrocytes express the receptor for advanced glycation end-products: potential role in osteoarthritis. Arthritis Rheum 52:2376-2385. (Pubitemid 41117422)
26. Mason RM, Chambers MG, Flannelly J, Gaffen JD, Dudhia J, Bayliss MT. 2001. The STR/ort mouse and its use as a model of osteoarthritis. Osteoarthritis Cartilage 9:85-91. (Pubitemid 32229257)
27. Pearle AD, Scanzello CR, George S, Mandl LA, DiCarlo EF, Peterson M, Sculco TP, Crow MK. 2007. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis Cartilage 15:516-523. (Pubitemid 46667712)
28. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E, Ben-Neriah Y. 2004. NFκB functions as a tumor promoter in inflammation-associated cancer. Nature 431:461-466. (Pubitemid 39329586)
29. Pischon N, Heng N, Bernimoulin JP, Kieber BM, Willich SN, Pischon T. 2007. Obesity, inflammation, and periodontal disease. J Dent Res 86:400-409.
30. Pisetsky DS, Erlandsson-Harris H, Andesson U. 2008. Highmobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther 10:209-219.
31. Pullerits R, Jonsson IM, Verdrengh M, Bokarewa M, Andersson U, Erlandsson-Harris H, Tarkowski A. 2003. High-mobility group box chromosomal protein 1, a DNA-binding cytokine, induces arthritis. Arthritis Rheum 48:1693-1700. (Pubitemid 36682378)
32. Ramasamy R, Vannucci SJ, Yan SS, Herold K, Yan SF, Schmidt AM. 2005. Advanced glycation end-products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology 15:16R-28R. (Pubitemid 41417992)
33. Regan E, Flannelly J, Bowler R, Tran K, Nicks M, Carbone BD, Glueck D, Heijnen H, Mason R, Crapo J. 2005. Extracellular superoxide dismutase and oxidant damage in osteoarthritis. Arthritis Rheum 52:3479-3491. (Pubitemid 41612214)
34. Santana RB, Xu L, Chase HB, Amar S, Graves DT, Trackman PC. 2003. A role for advanced glycation end-products in diminished bone healing in type 1 diabetes. Diabetes 52:1502-1510. (Pubitemid 36666207)
35. Sarukawa J, Takahashi M, Doi M, Suzuki D, Nagano A. 2010. A longitudinal analysis of urinary biochemical markers and bone mineral density in STR/ort mice as a model of spontaneous osteoarthritis. Arthritis Rheum 62:463-471.
36. Sarzi-Puttini P, Cimmino MA, Scarpa R, Caporali R, Parazzini A, Atzeni F, Canesi B. 2005. Osteoarthritis: an overview of the disease and its treatment strategies. Semin Arthritis Rheum 35:1-10. (Pubitemid 41097249)
37. Schmidt AM, Yan SD, Yan SF, Stern DM. 2001. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 108:949-955. (Pubitemid 32946067)
38. Sokoloff L, Mickelsen O, Silverstein E, Jay GE Jr, Yamamoto RS. 1960. Experimental obesity and osteoarthritis. Am J Physiol 198:765-770.
39. Steenvoorden MM, Huizinga TW, Verzijl N, Bank RA, Ronday HK, Luning HA, Lafeber FP, Toes RE, DeGroot J. 2006. Activation of receptor for advanced glycation end-products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes. Arthritis Rheum 54:253-263. (Pubitemid 43122210)
40. Sunahori K, Yamamura M, Yamana J, Takasugi K, Kawashima M, Makino H. 2006. Increased expression of receptor for advanced glycation end-products by synovial tissue macrophages in rheumatoid arthritis. Arthritis Rheum 54:97-104. (Pubitemid 43122192)
41. Taniguchi N, Kawahara K, Yone K, Hashiguchi T, Yamakuchi M, Goto M, Inoue K, Yamada S, Ijiri K, Matsunaga S, Nakajima T, Komiya S, Maruyma I. 2003. High-mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine. Arthritis Rheum 48:971-981. (Pubitemid 36418239)
42. Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H. 2007. Stage-specific secretion of HMGB1 in cartilage regulates endochondrial ossification. Mol Cell Biol 27:5650-5663. (Pubitemid 47257823)
43. Uchida K, Urabe K, Naruse K, Ogawa Z, Mabuchi K, Itoman M. 2009. Hyperlipidemia and hyperinsulinemia in the spontaneous osteoarthritis mouse model, STR/ort. Exp Anim 58:181-187.
44. Walton M. 1978. A spontaneous ankle deformity in an inbred strain of mouse. J Pathol 124:189-194. (Pubitemid 8317724)
45. Walton M. 1979. Patella displacement and osteoarthrosis of the knee joint in mice. J Pathol 127:165-172. (Pubitemid 9187139)
46. Watters JW, Chen C, Pickarski M, Wesolowski GA, Zhuo Y, Hayami T, Wang W, Szumiloski J, Phillips RL, Duong LT. 2007. Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/ort mice. Arthritis Rheum 56:2999-3009. (Pubitemid 47502747)
47. Yammani RR, Carlson CS, Bresnick AR, Loeser RF. 2006. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: role of the receptor for advanced glycation end-products. Arthritis Rheum 54:2901-2911. (Pubitemid 44497769)
48. Zhou Z, Immel D, Xi CX, Bierhaus A, Feng X, Mei L, Nawroth P, Stern DM, Xiong WC. 2006. Regulation of osteoclast function and bone mass by RAGE. J Exp Med 203:1067-1080.