Dimeric α-Cobratoxin X-ray structure: Localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors

Journal of Biological Chemistry

Volumn 287, Issue 9, 2012, Pages 6725-6734

  Osipov, Alexey V ^a   Rucktooa, Prakash ^b   Kasheverov, Igor E ^a,c   Filkin, Sergey Yu ^a   Starkov, Vladislav G ^a   Andreeva, Tatyana V ^a   Sixma, Titia K ^b   Bertrand, Daniel ^d   Utkin, Yuri N ^a,c   Tsetlin, Victor I ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c Syneuro   (Russian Federation)

^d HiQScreen   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COBRA VENOM; CYTOTOXINS; MODE OF BINDING; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHR); NONCOVALENT; PROTOMERS; SELECTIVE REDUCTION; SOLUTION STRUCTURES; X-RAY STRUCTURE;

ACTIVATION ANALYSIS; SULFUR COMPOUNDS; TOBACCO;

DIMERS;

BUNGAROTOXIN; BUNGAROTOXIN RECEPTOR; COBROTOXIN; CYSTEINE; CYTOTOXIN; DISULFIDE; NICOTINIC RECEPTOR;

ANIMAL CELL; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR RECOGNITION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR BINDING; TOXIN STRUCTURE; X RAY CRYSTALLOGRAPHY; XENOPUS;

ALKYLATION; BINDING SITES; COBRA NEUROTOXIN PROTEINS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DISULFIDES; MODELS, CHEMICAL; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RADIOLIGAND ASSAY; RECEPTORS, NICOTINIC;

NAJA KAOUTHIA;

EID: 84857483839     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.322313     Document Type: Article

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