Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

Journal of Polymer Research

Volumn 19, Issue 3, 2012, Pages

  Ngadaonye, Jude I ^a   Geever, Luke M ^a   Cloonan, Martin O ^b   Higginbotham, Clement L ^a  

^a Athletic Rehabilitation Therapy Ireland   (Ireland)

^b Atlantic Technological University Sligo   (Ireland)

Author keywords

Drug release; Hydrogels; Poly(N,N diethylacrylamide); Pulsatile; Thermo responsive

Indexed keywords

CHLORINE COMPOUNDS; DIFFERENTIAL SCANNING CALORIMETRY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FREE RADICALS; HYDROGELS; HYDROPHILICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYMERIZATION; TARGETED DRUG DELIVERY; URANIUM METALLOGRAPHY;

CONTROLLED DRUG DELIVERY SYSTEMS; DRUG RELEASE; MODULATED DIFFERENTIAL SCANNING CALORIMETRY; N ,N-DIMETHYLACRYLAMIDE; POLY(N , N-DIETHYLACRYLAMIDE); PULSATILE; SOLUTION POLYMERISATION; THERMO-RESPONSIVE;

CONTROLLED DRUG DELIVERY;

EID: 84857482371     PISSN: 10229760     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10965-012-9822-8     Document Type: Article

References (60)

1. Bussemer T, Peppas NA, Bodmeier R (2003) Evaluation of the swelling, hydration and rupturing properties of the swelling layer of a rupturable pulsatile drug delivery system. Eur J Pharm Bio-pharm 56:261-270 (Pubitemid 37072111)
2. Belgamwar VS, Gaikwad MV, Patil GB, Surana S (2008) Pulsatile drug delivery system. Asian J Pharm: July-September 141-145.
3. Lalwani A, Santani DD (2007) Pulsatile drug delivery systems. Indian J. Pharm. Sci. July-August 489-497. (Pubitemid 350099012)
4. Liu HY, Zhu XX (1999) Lower critical solution temperatures of N-substituted acrylamide copolymers in aqueous solutions. Polymer 40:6985-6990 (Pubitemid 29434893)
5. Shibanuma T, Aoki T, Sanui K, Ogata N, Kikuchi A, Sakurai V, Okano T (2000) Thermosensitive phase-separation behaviour of poly (acrylic acid)-graft-poly (N, N-dimethylacrylamide) aqueous solution. Macromolecules 33:444-450 (Pubitemid 30541911)
6. Panayiotou M, Freitag R (2005) Influence of the synthesis conditions and ionic additives on the swelling behaviour of thermo-responsive polyalkylacrylamide hydrogels. Polymer 46:6777-6785 (Pubitemid 41125139)
7. Chen J, Liu M, Liu H, Ma L (2009) Synthesis, swelling and drug release behaviour of poly (N, N-diethylacrylamide-co-N-hydroxy-methyl acrylamide) hydrogel. Mater Sci Eng C 29:2116-2123
8. Bromberg LE, Ron ES (1998) Adv Drug Deliv Rev 31:197-221
9. Qiu Y, Park K (2001) Adv Drug Deliv Rev 53:321-339
10. Panayiotou M, Pöhner C, Vandevyver C, Wandrey C, Hilbrig F, Freitag R (2007) Synthesis and characterisation of thermo-responsive poly ('-diethylacrylamide) microgels. React Funct Polym 67:807-819 (Pubitemid 47302395)
11. Eeckman F, Moes AJ, Amighi K (2004) Poly (N-isopropylacryla-mide) copolymers for constant temperature controlled drug delivery. Int J Pharm 273:109-119 (Pubitemid 38317045)
12. Devine DM, Geever LM, Higginbotham CL (2005) Drug release from a N-vinyl pyrrolidinone/Aacrylic acid lubricious hydrophilic coating. J Mater Sci 40:3429-3436 (Pubitemid 41130178)
13. Geever LM, Mínguez CM, Devine DM, Nugent M J D, Kennedy JE, Lyons JG, Hanley A, Devery S, Tomkins PT, Higginbotham CL (2007) The synthesis, swelling behaviour and rheological properties of chemically crosslinked thermosensitive copolymers based on N-isopropylacrylamide. J Mater Sci 42:4136-4148 (Pubitemid 47142167)
14. Geever LM, Nugent M J D, Higginbotham CL (2007) The effect of salts and pH buffer solutions on the phase transition temperature and swelling of thermoresponsive pseudogels based on N-isopro-pylacrylamide. J Mater Sci 42:9845-9854 (Pubitemid 47476490)
15. Geever LM, Cooney CC, Devine DM, Devery S, Nugent M J D, Higginbotham CL (2008) Negative temperature sensitive hydro-gels in controlled drug delivery. Macromol Symp 266:53-58
16. Devine DM, Devery SM, Lyons JG, Geever LM, Kennedy JE, Higginbotham CL (2006) Multifunctional poly (vinyl pyrrolidi-none)-polyacrylic acid copolymer hydrogels for biomedical applications. Int J Pharm 326:50-59 (Pubitemid 44647746)
17. Geever LM, Cooney CC, Lyons JG, Kennedy JE, Nugent M J D, Devery S, Higginbotham CL (2008) Characterisation and controlled drug release from novel drug-loaded hydrogels. Eur J Pharm Biopharm 69:1147-1159
18. Kennedy JE, Lyons JG, Geever LM, Higginbotham CL (2009) Synthesis and characterisation of styrene butadiene-g-acrylic acid for potential use in biomedical applications. Mater Sci Eng C 29:1655-1661
19. Ngadaonye JI, Cloonan MO, Geever LM, Higginbotham CL (2011) Synthesis and characterisation of thermo-sensitive terpoly-mer hydrogels for drug delivery applications. J Polym Res. Published online 23 June 2011, doi:10.1007/s10965- 011-9644-0.
20. Lyons JG, Geever LM, Nugent M J D, Kennedy JE, Higginbotham CL (2009) Development and characterisation of an agar-polyvinyl alcohol blend hydrogel. Journal of the Mechanical Behaviour of Biomedical Materials 2:485-493
21. Geever LM, Lyons JG, Higginbotham CL (2011) Photopolymer-isation and characterisation of negative temperature sensitive hydrogels based on N-N-diethylacrylamide. J Mater Sci 46:509-517
22. Studer K, Decker C, Beck E, Schwalm R (2003) Prog Org Coat 48:101-111
23. Rasool N, Yasin T, Heng J Y Y, Akhter Z (2010) Synthesis and characterization of novel pH, ionic strength and temperature-sensitive hydrogel for insulin delivery. Polymer 51:1687-1693
24. Chen J, Liu M, Liu H, Ma L, Gao C, Zhu S, Zhang S (2010) Synthesis and properties of thermo-and pH-sensitive poly (dia-llyldimethylammonium chloride)/poly (N, N-diethylacrylamide) semi-IPN hydrogel. Chem Eng J 159:247-256
25. Hiratani H, Alvarez-Lorenzo C (2004) The nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol drug delivery system. Biomaterials 25:1105-1113 (Pubitemid 37393300)
26. Babu VR, Hosamani KM, Aminabhavi TM (2008) Preparation and in-vitro release of chlorothiazide novel pH-sensitive chitosan-N, N-dimethylacrylamide semi-interpenetrating network micro-spheres. Carbohydr Polym 71:208-217 (Pubitemid 350100814)
27. Luo Y-L, Wei Q-B, Xu F, Chen Y-S, Fan L-H, Zhang C-H (2009) Assembly, characterization and swelling kinetics of Ag nanopar-ticles in PDMAA-g-PVA hydrogel networks. Mater Chem Phys 118:329-336
28. Szaraz I, Forsling W (2000) A spectroscopic study of the solvation 1-vinyl-2-pyrrolidone and poly (1-vinyl-2-pyrrollidone) in different solvents. Polymer 41:4831-4839 (Pubitemid 30193110)
29. Sun SF (1998) Physical chemistry of macromolecules, basic principles and issues. Wiley, New York, pp 400-415
30. Liu H, Liu M, Ma L, Chen J (2009) Thermo-and pH-sensitive comb-type grafted poly (N, N-diethylacrylamide-co-acrylic acid) hydrogels with rapid response behaviours. Eur Polym J 45:2060-2067
31. Wang YX, He F, Zhuo RX (2006) Synthesis and characterisation of amphiphilic block copolymer containing PVP and poly (5-ben-zyloxytrimethylene carbonate). Chin Chem Lett 17(2):239-243
32. Perrino MP, Navarro R, Tarjados MG, Gallardo A, Reinecke H (2010) A novel route to substitute poly (vinyl pyrrolidone) s via simple functionalization of 1-vinyl-2-pyrrolidone in the 3-position by ring-opening reactions. Eur Polym J 46(7):1557-1562
33. De Queiroz A A A, Gallardo A, Roman JS (2000) Vinylpyrrolidone-N-N- dimethylacrylamide water soluble copolymers: synthesis, physical-chemical properties and proteic interactions. Biomaterials 21:1631-1643 (Pubitemid 30347306)
34. Franceschini A, Abramson S, Mancini V, Bresson B, Chassenieux C, Lequeux N (2007) New covalent bonded polymer-calcium silicate hydrate composites. J Mater Chem 17(9):913-922
35. Yan L-F, Tao W (2008) Graft copolymerization of N, N-dimethylacrylamide to cellulose in homogeneous media using atom transfer radical polymerization for hemocompatibility. J Biomed Sci Eng 1:37-43
36. Albarghouthi MN, Buchholz BA, Doherty E A S, Bogdan FM, Zhou H, Barron AE (2001) Impact of polymer hydrophobicity on the properties and performance of DNA sequencing matrices for capillary electrophoresis. Electrophoresis 22:737-747 (Pubitemid 32208431)
37. Silva M E S R, Dutra ER, Mano V, Machado JC (2000) Polym Degrad Stab 67:491-495
38. Chiantore O, Costa L, Guaita M (1982) Glass temperatures of acrylamide polymers. Makromol Chem Rapid Comm 3:303-309
39. Nichifor M, Zhu X X X (2003) Copolymers of N-alkylacrylamides and styrene as new thermosensitive materials. Polymer 44:3053-3060 (Pubitemid 36460365)
40. Brandrup J, Immergut EH (1975) Polymer handbook. Wiley, New York, pp 111-155
41. Dermici S, Alaslan A, Caykara T (2009) Preparation, characterisation and surface pK (a) values of poly (N-vinyl-2-pyrrolidone)/chitosan blend films. Appl Surf Sci 255:5979-5983
42. Liu HL, Liu MZ, Jin SP, Chen SL (2008) Polym Int 57:1165
43. Gan L-H, Cai W, Tam KC (2001) Studies of phase transition of aqueous solution of poly (N, N-diethylacrylamide-co-acrylic acid) by differential scanning calorimetry and spectrophotometry. Eur Polym J 37:1773-1778 (Pubitemid 32594532)
44. Panayiotou M, Freitag R (2005) Synthesis and characterisation of stimuli-responsive poly (N, N-diethylacrylamide) hydrogels. Polymer 46:615-621 (Pubitemid 40091755)
45. Park TG, Hoffman AS (1993) Sodium chloride-induced phase transition in non-ionic poly (N-isopropylacrylamide) gel. Macro-molecules 26:5045-5048
46. Eeckman F, Amighi K, Moes AJ (2001) Effect of some physiological and non-physiological compounds on the phase transition temperature of thermoresponsive polymers intended for oral controlled-drug delivery applications. Int J Pharm 222:259-270 (Pubitemid 32568369)
47. Iyer G, Tillekeratne L M V, Coleman MR, Nadarajah A (2008) Equilibrium swelling behavior of thermally responsive metal affinity hydrogels, Part I: Compositional effects. Polymer 49:3737-3743
48. Wu JY, Liu SQ, Heng PW, Yang YY (2005) Evaluating proteins release from, and their interactions with, thermosensitive poly (N-isopropylacrylamide) hydrogels. J Control Release 102:361-372 (Pubitemid 40093759)
49. Ferry JD (1980) Viscoelastic properties of polymers, 3rd edn. Wiley, New York
50. Save NS, Jassal M, Agrawal KA (2003) Stimuli sensitive copolymer poly (N-tert-butylacrylamide-ran-acrylamide): processing into thin films and their transitional behaviour. Polymer 44:7979-7988 (Pubitemid 38155922)
51. Zhang JT, Bhat R, Jandt KD (2009) Temperature-sensitive PVA/PNIPAAm semi-IPN hydrogels with enhanced responsive properties. Acta Biomaterialia 5:488-497
52. Zhang JT, Huang SW, Cheng SX, Zhuo RX (2004) Preparation and properties of poly (N-isopropylacrylamide)/poly (N-isopropyla-crylamide) interpenetrating polymer networks for drug delivery. J Polym Sci Part A: Polym Chem 42:1249-1254
53. Gupta P, Vermani K, Garg S (2002) Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discov Today 7:569
54. Zhang J-T, Keller TF, Bhat R, Garipcan B, Jandt KD (2010) A novel two-level micro-structured poly (N-isopropylacrylamide) hydrogel for controlled release. Acta Biomater 6:3890-3898
55. Wang ZC, Xu X-D, Chen C-S, Wang G-R, Wang B, Zhang X-Z, Zhuo R-X (2008) Study on novel hydrogels based on thermosensitive PNIPAAm with pH-sensitive PDMAEMA grafts. Colloids Surf B Biointerfaces 67:245-252
56. Okano T, Bae YH, Jacobs H, Kim SW (1990) Thermally on-off switching polymers for drug permeation and release. J Control Release 11:255-265 (Pubitemid 20070103)
57. Bae YH, Okano T, Kim SW (1991) "On-off thermocontrol of solute transport. I. Temperature dependence of swelling of N-isopropylacrylamide networks modified with hydrophobic components in water. Pharm Res 8(4):531-537
58. Reza S, Quadir MA, Haider SS (2003) Comparative evaluation of plastic, hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery. J Pharm Pharmaceut Sci 6(2):282-291 (Pubitemid 37207234)
59. Sousa RG, Prior-Cabanillas A, Quijada-Garrido I, Barrales-Rienda JM (2005) Dependence of copolymer composition, swelling history, and drug concentration on the loading of diltiazem hydrochloride (DIL. HCl) into poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels and its release behaviour from hydrogels slabs. J Control Release 102:595-606 (Pubitemid 40170203)
60. Hong-Ying L, Xi-Tian P, Xiao-Lin Z, Wen-Sheng H, Jian-Guo C (2010) Pharmacokinetics of aminophylline delivered to the small intestine and colon using remote controlled capsules. Chin Med J 123(3):320-325