Poly(N-isopropylacrylamide) copolymers for constant temperature controlled drug delivery

International Journal of Pharmaceutics

Volumn 273, Issue 1-2, 2004, Pages 109-119

  Eeckman, F ^a   Moes A J ^a   Amighi, K ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Compression coated tablets; Controlled drug release; Poly(N isopropylacrylamide); Salting out effect; Thermosensitive copolymers

Indexed keywords

COPOLYMER; POLY(N ISOPROPYLACRYLAMIDE); SODIUM SULFATE; THEOPHYLLINE;

ARTICLE; CONTROLLED DRUG RELEASE; DRUG COATING; DRUG SOLUBILITY; DRUG SYNTHESIS; HEAT SENSITIVITY; PHASE TRANSITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TABLET; TEMPERATURE DEPENDENCE;

ACRYLIC RESINS; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG DELIVERY SYSTEMS; KINETICS; MOLECULAR WEIGHT; PARTICLE SIZE; SOLUBILITY; SULFATES; TABLETS, ENTERIC-COATED; TEMPERATURE;

EID: 1542298887     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.12.013     Document Type: Article

References (22)

1. Brasel C.S., Peppas N.A. Pulsatile local delivery of thrombolytic and antithrombotic agents using poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels. J. Contr. Rel. 39:1996;57-64.
2. Durand A., Hourdet D. Thermoassociative graft copolymers based on poly(N-isopropylacrylamide): effect of added co-solutes on the rheological behaviour. Polymer. 41:2000;545-555.
3. Eeckman F., Amighi K., Moës A.J. Effect of some physiological and non-physiological compounds on the phase transition temperature of thermoresponsive polymers intended for oral controlled-drug delivery. Int. J. Pharm. 222:2001;259-270.
4. Eeckman F., Moës A.J., Amighi K. Evaluation of a new controlled-drug delivery concept based on the use of thermoresponsive polymers. Int. J. Pharm. 241:2002;113-125.
5. Eeckman, F., Moës, A.J., Amighi, K., 2004. Synthesis and characterisation of thermosensitive copolymers for oral controlled drug delivery. Eur. Polym. J., in press.
6. Feil H., Bae H., Feijen J., Kim S.W. Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers. Macromolecules. 26:1993;2496-2500.
7. Fujishige S., Kubota K., Ando I. Phase transition of aqueous solutions of poly(N-isopropylacrylamide) and poly(N-isopropylmethacrylamide). J. Phys. Chem. 93:1989;3311-3313.
8. Hahn M., Görnitz E., Dautzenberg H. Synthesis and properties of ionically modified polymers with LCST behavior. Macromolecules. 31:1998;5616-5623.
9. Heskins M., Guillet J.E. Solutions properties of poly(N- isopropylacrylamide). J. Macromol. Sci.-Chem. A2:1968;1441-1455.
10. Ichikawa H., Fukumori Y. A novel positively thermosensitive controlled-release microcapsule with membrane of nano-sized poly(N- isopropylacrylamide) gel dispersed in ethylcellulose matrix. J. Contr. Rel. 63:2000;107-119.
11. Idziak I., Avoce D., Lessard D., Gravel D., Zhu X.X. Thermosensitivity of aqueous solutions of poly(N,N-diethylacrylamide). Macromolecules. 32:1999;1260-1263.
12. Kolchob T., Kimura S., Imanishi Y. Thermoresponsive release from poly(glucone)-block-poly(sar) microcapsules with surface-grafting of poly(N-isopropylacrylamide). J. Contr. Rel. 50:1998;205-214.
13. Kubota K., Fujishige S., Ando I. Single chain transition of poly(N-isopropylacrylamide) in water. J. Phys. Chem. 94:1990;5154-5158.
14. Okano T., Bae Y.H., Jacobs H., Kim S.W. Thermally on-off switching polymers for drug permeation and release. J. Contr. Rel. 11:1990;255-265.
15. Platé N.A., Lebedeva T.L., Valuev L.I. Lower critical solution temperature in aqueous solutions of N-alkyl-substituted polyacrylamides. Polym. J. 31:1999;21-27.
16. Schild H.G. Poly(N-isopropylacrylamide): experiment, theory and application. Prog. Polym. Sci. 17:1992;163-249.
17. Schild H.G., Tirrell D.A. Microcalorimetric detection of lower critical solution temperature in aqueous polymer solution. J. Phys. Chem. 94:1990;4352-4356.
18. Schild H.G., Tirrell D.A. Interaction of poly(N-isopropylacrylamide) with sodium n-alkyl sulfates in aqueous solution. Langmuir. 7:1991;665-671.
19. Wu C., Zhou S. Volume phase of transition of swollen gels: discontinuous or continuous? Macromolecules. 30:1997;574-576.
20. Xue W., Champ S., Huglin M.B. Thermoreversible swelling behaviour of hydrogels based on N-isopropylacrylamide with a zwitterionic comonomer. Eur. Polym. J. 37:2001;869-875.
21. Yoshida R., Sakai K., Okano T., Sakurai Y. Drug release profiles in the shrinking process of thermoresponsive poly(N-isopropylacrylamide-co-alkyl methacrylate) gels. Ind. Eng. Chem. Res. 31:1992;2339-2345.
22. Zhang X.-Z., Zhuo R.-X., Cui J.-Z., Zhang J.-T. A novel thermo-responsive drug delivery system with positive controlled-release. Int. J. Pharm. 235:2002;43-50.