Antimalarial evaluation and docking studies of hybrid phenylthiazolyl-1,3,5-triazine derivatives: A novel and potential antifolate lead for Pf-DHFR-TS inhibition

Experimental Parasitology

Volumn 130, Issue 3, 2012, Pages 292-299

  Gahtori, Prashant ^a,b   Ghosh, Surajit K ^b   Parida, Pratap ^b   Prakash, Anil ^c   Gogoi, Kabita ^c   Bhat, Hans Raj ^d   Singh, Udaya Pratap ^d  

^a UTTARAKHAND TECHNICAL UNIVERSITY   (India)

^b DIBRUGARH UNIVERSITY   (India)

^c REGIONAL MEDICAL RESEARCH CENTRE   (India)

^d SAM HIGGINBOTTOM UNIVERSITY OF AGRICULTURE   (India)

Author keywords

1,3,5 Triazine; Antifolate; Antimalarial; Docking

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; CHLORCYCLOGUANIL; CHLORPROGUANIL; CLOCIGUANIL; CYCLOGUANIL; FOLIC ACID ANTAGONIST; LIGAND; PHENYLTHIAZOLYL 1,3,5 TRIAZINE DERIVATIVE; PROGUANIL; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG STRUCTURE; IN VITRO STUDY; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR HYBRIDIZATION; NONHUMAN; PLASMODIUM FALCIPARUM; PREDICTION; PRIORITY JOURNAL; SCORING SYSTEM; STRUCTURE ACTIVITY RELATION; WILD TYPE;

ANTIMALARIALS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID ANTAGONISTS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

PLASMODIUM FALCIPARUM;

EID: 84857458484     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2011.12.014     Document Type: Article

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