Contribution of nitric oxide synthase (NOS) in blood-brain barrier disruption during acute focal cerebral ischemia in normal rat

Pathophysiology

Volumn 19, Issue 1, 2012, Pages 13-20

  Mohammadi, Mohammad T ^a   Shid Moosavi, S Mostafa ^a   Dehghani, Gholam A ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

BBB; Blood flow; Cerebral ischemia; Nitric oxide; Rat; Reperfusion

Indexed keywords

ARGININE; EVANS BLUE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN WATER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SYNTHESIS; LEFT HEMISPHERE; MALE; MEAN ARTERIAL PRESSURE; MICROVASCULARIZATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; RIGHT HEMISPHERE;

EID: 84857458147     PISSN: 09284680     EISSN: 1873149X     Source Type: Journal    
DOI: 10.1016/j.pathophys.2011.07.003     Document Type: Article

References (40)

1. Hawkins B.T., Davis T.P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 2005, 57:173-185.
2. Belayev L., Busto R., Zhao W., Ginsberg M.D. Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res. 1996, 739:88-96.
3. Yang G.Y., Gong C., Qin Z., Liu X.H., Lorris Betz A. Tumor necrosis factor alpha expression produces increased blood-brain barrier permeability following temporary focal cerebral ischemia in mice. Brain Res. Mol. Brain Res. 1999, 69:135-143.
4. Cipolla M.J., McCall A.L., Lessov N., Porter J.M. Reperfusion decreases myogenic reactivity and alters middle cerebral artery function after focal cerebral ischemia in rats. Stroke 1997, 28:176-180.
5. Fagan S.C., Hess D.C., Hohnadel E.J., Pollock D.M., Ergul A. Targets for vascular protection after acute ischemic stroke. Stroke 2004, 35:2220-2225.
6. Gursoy-Ozdemir Y., Can A., Dalkara T. Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia. Stroke 2004, 35:1449-1453.
7. Gursoy-Ozdemir Y., Bolay H., Saribas O., Dalkara T. Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia. Stroke 2000, 31:1974-1980. discussion 1981.
8. Han F., Shirasaki Y., Fukunaga K. Microsphere embolism-induced endothelial nitric oxide synthase expression mediates disruption of the blood-brain barrier in rat brain. J. Neurochem. 2006, 99:97-106.
9. Tan K.H., Harrington S., Purcell W.M., Hurst R.D. Peroxynitrite mediates nitric oxide-induced blood-brain barrier damage. Neurochem. Res. 2004, 29:579-587.
10. Parathath S.R., Parathath S., Tsirka S.E. Nitric oxide mediates neurodegeneration and breakdown of the blood-brain barrier in tPA-dependent excitotoxic injury in mice. J. Cell Sci. 2006, 119:339-349.
11. Perez-Asensio F.J., Hurtado O., Burguete M.C., Moro M.A., Salom J.B., Lizasoain I., Torregrosa G., Leza J.C., Alborch E., Castillo J., Knowles R.G., Lorenzo P. Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia. Neurobiol. Dis. 2005, 18:375-384.
12. Ding-Zhou L., Marchand-Verrecchia C., Croci N., Plotkine M., Margaill I. l-NAME reduces infarction, neurological deficit and blood-brain barrier disruption following cerebral ischemia in mice. Eur. J. Pharmacol. 2002, 457:137-146.
13. Boje K.M. Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis. Brain Res. 1996, 720:75-83.
14. Dalkara T., Morikawa E., Panahian N., Moskowitz M.A. Blood flow-dependent functional recovery in a rat model of focal cerebral ischemia. Am. J. Physiol. 1994, 267:H678-H683.
15. Morikawa E., Moskowitz M.A., Huang Z., Yoshida T., Irikura K., Dalkara T. l-Arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke 1994, 25:429-435.
16. Morikawa E., Rosenblatt S., Moskowitz M.A. l-Arginine dilates rat pial arterioles by nitric oxide-dependent mechanisms and increases blood flow during focal cerebral ischaemia. Br. J. Pharmacol. 1992, 107:905-907.
17. Zhang F., Casey R.M., Ross M.E., Iadecola C. Aminoguanidine ameliorates and l-arginine worsens brain damage from intraluminal middle cerebral artery occlusion. Stroke 1996, 27:317-323.
18. Salom J.B., Orti M., Centeno J.M., Torregrosa G., Alborch E. Reduction of infarct size by the NO donors sodium nitroprusside and spermine/NO after transient focal cerebral ischemia in rats. Brain Res. 2000, 865:149-156.
19. Dawson D.A. Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome. Cerebrovasc. Brain Metab. Rev. 1994, 6:299-324.
20. Unterberg A.W., Stover J., Kress B., Kiening K.L. Edema and brain trauma. Neuroscience 2004, 129:1021-1029.
21. Thiel V.E., Audus K.L. Nitric oxide and blood-brain barrier integrity. Antioxid. Redox Signal. 2001, 3:273-278.
22. Deb P., Sharma S., Hassan K.M. Pathophysiologic mechanisms of acute ischemic stroke: an overview with emphasis on therapeutic significance beyond thrombolysis. Pathophysiology 2010, 17:197-218.
23. Lecrux C., Nicole O., Chazalviel L., Catone C., Chuquet J., MacKenzie E.T., Touzani O. Spontaneously hypertensive rats are highly vulnerable to AMPA-induced brain lesions. Stroke 2007, 38:3007-3015.
24. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20:84-91.
25. Vakili A., Nekoeyan A.A., Dehghani G.A. l-NAME and 7-nitroindazole reduces brain injuries in transient focal cerebral ischemia in the rat. Iran J. Med. Sci. 2004, 29:109-115.
26. Huang Z., Huang P.L., Panahian N., Dalkara T., Fishman M.C., Moskowitz M.A. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 1994, 265:1883-1885.
27. Panahpour H., Nekoeyan A.A., Dehghani G.A. Inhibition of angiotensin-converting enzyme reduces cerebral infarction size in experimental-induced focal cerebral ischemia in the rat. Iran J. Med. Sci. 2007, 32:12-17.
28. Swanson R.A., Morton M.T., Tsao-Wu G., Savalos R.A., Davidson C., Sharp F.R. A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow Metab. 1990, 10:290-293.
29. Gerriets T., Stolz E., Walberer M., Muller C., Kluge A., Bachmann A., Fisher M., Kaps M., Bachmann G. Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging. Stroke 2004, 35:566-571.
30. Simpkins A.N., Rudic R.D., Roy S., Tsai H.J., Hammock B.D., Imig J.D. Soluble epoxide hydrolase inhibition modulates vascular remodeling. Am. J. Physiol. Heart Circ. Physiol. 2010, 298:H795-H806.
31. Awad A.S. Role of AT1 receptors in permeability of the blood-brain barrier in diabetic hypertensive rats. Vascul. Pharmacol. 2006, 45:141-147.
32. Mikawa S., Kinouchi H., Kamii H., Gobbel G.T., Chen S.F., Carlson E., Epstein C.J., Chan P.H. Attenuation of acute and chronic damage following traumatic brain injury in copper, zinc-superoxide dismutase transgenic mice. J. Neurosurg. 1996, 85:885-891.
33. Iadecola C., Pelligrino D.A., Moskowitz M.A., Lassen N.A. Nitric oxide synthase inhibition and cerebrovascular regulation. J. Cereb. Blood Flow Metab. 1994, 14:175-192.
34. Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci. 1997, 20:132-139.
35. Margaill I., Allix M., Boulu R.G., Plotkine M. Dose- and time-dependence of l-NAME neuroprotection in transient focal cerebral ischaemia in rats. Br. J. Pharmacol. 1997, 120:160-163.
36. Mark K.S., Davis T.P. Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation. Am. J. Physiol. Heart Circ. Physiol. 2002, 282:H1485-H1494.
37. Xu M., Su W., Xu Q.P. Aquaporin-4 and traumatic brain edema. Chin. J. Traumatol. 2010, 13:103-110.
38. Nag S., Picard P., Stewart D.J. Expression of nitric oxide synthases and nitrotyrosine during blood-brain barrier breakdown and repair after cold injury. Lab. Invest. 2001, 81:41-49.
39. Rodriguez-Yanez M., Castellanos M., Blanco M., Millan M., Nombela F., Sobrino T., Lizasoain I., Leira R., Serena J., Davalos A., Castillo J. Micro- and macroalbuminuria predict hemorrhagic transformation in acute ischemic stroke. Neurology 2006, 67:1172-1177.
40. Nag S., Picard P., Stewart D.J. Increased immunolocalization of nitric oxide synthases during blood-brain barrier breakdown and cerebral edema. Acta Neurochir. Suppl. 2000, 76:65-68.