Effects of cationic hydroxyethyl cellulose on glucose metabolism and obesity in a diet-induced obesity mouse model

Journal of Diabetes

Volumn 4, Issue 1, 2012, Pages 85-94

  Young, Scott A ^a   Hung, Shao Ching ^a   Anderson, William H K ^a   Albers, David R ^a   Langhorst, Marsha L ^a   Yokoyama, Wallace ^b  

^a DOW CHEMICAL COMPANY   (United States)

^b WESTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

Diabetes mellitus; Diet induced obese mice; Insulin resistance; Metabolic syndrome; Soluble dietary fiber

Indexed keywords

ADIPONECTIN; ANTIOBESITY AGENT; BILE ACID; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYETHYLCELLULOSE; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SATURATED FATTY ACID; STEROL; TRANS FATTY ACID; TRIACYLGLYCEROL; UNSATURATED FATTY ACID; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG SCREENING; FECES; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HORMONE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID LIVER LEVEL; LIVER WEIGHT; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION;

ADIPONECTIN; ANIMALS; CELLULOSE; DISEASE MODELS, ANIMAL; GLUCOSE; INSULIN; LEPTIN; LIPIDS; MALE; MICE; MICE, INBRED C57BL; OBESITY; WEIGHT GAIN;

EID: 84857408565     PISSN: 17530393     EISSN: 17530407     Source Type: Journal    
DOI: 10.1111/j.1753-0407.2011.00157.x     Document Type: Article

References (35)

1. Barness LA, Opitz JM, Gilbert-Barness E. Obesity: Genetic, molecular, and environmental aspects. Am J Med Genet A. 2007; 143A: 3016-34.
2. World Health Organization. Controlling the Global Obesity Epidemic. 2011. Available from: (accessed 15 February 2011).
3. Bray G. Medical consequences of obesity. J Clin Endocrinol Metab. 2004; 89: 2583-9.
4. Narayan K, Boyle J, Thompson T et al. Lifetime risk for diabetes mellitus in the United States. JAMA. 2003; 290: 1884-90.
5. Ershoff BH, Wells AF. Effects of gum guar, locust bean gum and carrageenan on liver cholesterol of cholesterol fed rats. Proc Soc Exp Biol Med. 1962; 110: 580-2.
6. Sprecher DL, Harris BV, Goldberg AC et al. Efficacy of psyllium in reducing serum cholesterol levels in the hypercholesterolemic patients on high- or low-fat diets. Ann Intern Med. 1993; 119: 545-54.
7. Jenkins DJA, Marchie A, Augustin LSA, Ros E, Kendall CWC. Viscous dietary fibre and metabolic effects. Clin Nutr Suppl. 2004; 1: 39-49.
8. Kim SY, Song HJ, Lee YY, Cho K-H, Roh YK. Biomedical issues of dietary fiber beta-glucan. J Korean Med Sci. 2006; 21: 781-9.
9. Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: A meta-analysis. Am J Clin Nutr. 1999; 69: 30-42.
10. Gallaher DD, Hassel GA, Lee K-J. Relationships between viscosity of hydroxypropyl methylcellulose and plasma cholesterol in hamsters. J Nutr. 1993; 123: 1732-8.
11. Maki KC, Davidson MH, Torri S et al. High-molecular-weight hydroxypropylmethylcellulose taken with or between meals is hypocholesterolemic in adult men. J Nutr. 2000; 130: 1705-10.
12. Maki KC, Davidson MH, Malik KC, Albrecht HH, O'Mullane J, Daggy BP. Cholesterol lowering with high-viscosity hydroxypropylmethylcellulose. Am J Cardiol. 1999; 84: 1198-203.
13. Hung SC, Bartley G, Young SA et al. Dietary fiber improves lipid homeostasis and modulates adipocytokines in hamsters. J Diabetes. 2009; 1: 194-206.
14. Hung S-C, Anderson WHK, Albers DR, Langhorst ML, Young SA. Effect of hydroxypropyl methylcellulose on obesity and glucose metabolism in a diet-induced obesity mouse model. J Diabetes. 2011; 3: 1-10.
15. Winzell MS, Abrén B. The high-fat diet-fed mouse: A model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes. 2004; 53(Suppl.): S215-9.
16. Surwit RS, Wang S, Petro AE et al. Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. Proc Natl Acad Sci USA. 1998; 95: 4061-5.
17. Surwit RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN. Diet-induced type II diabetes in C57BL/6J mice. Diabetes. 1988; 37: 1163-7.
18. Collins S, Martin TL, Surwit RS, Robidoux J. Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: Physiological and molecular characteristics. Physiol Behav. 2004; 81: 243-8.
19. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. Definition of metabolic syndrome. Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition. Circulation. 2004; 109: 433-8.
20. Bartley GE, Yokoyama W, Young SA et al. Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters. J Nutr. 2010; 140: 1255-60.
21. American Oil Chemists Society (AOCS). Preparation of Methyl Esters of Long-chain Fatty Acids From Sampling and Analysis of Commercial Fats and Oils. Official Method. AOCS, Champaign, 1997.
22. Hong YJ, Turowski M, Lin JT, Yokoyama WH. Simultaneous characterization of bile acid, sterols, and determination of acylglycerides in feces from soluble cellulose-fed hamsters using HPLC with evaporative light-scattering detection and APCI-MS. J Agric Food Chem. 2007; 55: 9750-7.
23. Gallaher DD, Hassel CA, Lee KJ, Gallaher CM. Viscosity and fermentability as attributes of dietary fiber responsible for the hypocholesterolemic effect in hamsters. J Nutr. 1993; 123: 244-52.
24. Hidebrandt AL, Kelly-Sullivan DM, Black SC. Antiobesity effects of chronic annabinoid CB1 receptor anatagonist treatment in diet-induced obese mice. Eur J Pharmacol. 2003; 462: 125-32.
25. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S. Contribution of intraabdominal fat accumulation to the impairment of glucose and lipid metabolism. Metabolism. 1987; 36: 54-9.
26. Farooqi S. Partial leptin deficiency and human adiposity. Nature. 2001; 414: 34-5.
27. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004; 24: 29-33.
28. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem. 1996; 271: 10697-703.
29. Hotta K, Funahashi T, Arita Y et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol. 2000; 20: 1595-9.
30. Bonnard C, Durand A, Vidal H, Rieusset J. Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice. Diabetes Metab. 2008; 34: 52-61.
31. Winzell MS, Nogueiras R, Dieguez C, Ahren B. Dual action of adiponectin on insulin secretion in insulin-resistant mice. Biochem Biophys Res Commun. 2004; 321: 154-60.
32. Kobayshi M, Ikegami H, Fujisawa T et al. Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin. Diabetes. 2007; 56: 239-47.
33. Ahren B, Mansson S, Gingerich RL, Havel PJ. Regulation of plasma leptin in mice: Influence of age, high-fat diet, and fasting. Am J Physiol. 1997; 273: R113-20.
34. Surwit RS, Petro AE, Parekh P, Vollins S. Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. Diabetes. 1997; 46: 1516-20.
35. Havel PJ, Kasim-Karakas S, Mueller W, Johnson PR, Gingerich RL, Stern JS. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: Effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab. 1996; 81: 4406-13.