Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging

Magnetic Resonance in Medical Sciences

Volumn 10, Issue 3, 2011, Pages 169-176

  Matsushita, Taro ^a   Kusakabe, Yoshinori ^a   Kitamura, Akihiro ^a   Okada, Sakie ^a   Murase, Kenya ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Blood oxygenation level dependent MRI; Gentamicin induced nephrotoxicity; Hydrogen rich water; Oxygen consumption; Rat

Indexed keywords

CREATININE; GENTAMICIN; HYDROGEN; OXYGEN; WATER;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BLOOD; CHEMICALLY INDUCED DISORDER; KIDNEY DISEASE; MALE; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; SPRAGUE DAWLEY RAT; UREA NITROGEN BLOOD LEVEL;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD UREA NITROGEN; CREATININE; GENTAMICINS; HYDROGEN; KIDNEY DISEASES; MAGNETIC RESONANCE IMAGING; MALE; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; WATER;

EID: 84857389973     PISSN: 13473182     EISSN: 18802206     Source Type: Journal    
DOI: 10.2463/mrms.10.169     Document Type: Article

References (27)

1. Humes HD. Aminoglycoside nephrotoxicity. Kidney Int 1988; 33:900-911.
2. Ali BH. Gentamicin nephrotoxicity in humans and animals: some recent research. Gen Pharmacol 1995; 26:1477-1487.
3. Walker PD, Barri Y, Shah SV. Oxidant mechanisms in gentamicin nephrotoxicity. Ren Fail 1999; 21:433-442.
4. Roberts CK, Sindhu KK. Oxidative stress and metabolic syndrome. Life Sci 2009; 84:705-712.
5. Ben Ismail TH, Ali BH, Bashir AA. Influence of iron, deferoxamine and ascorbic acid on gentami-cin-induced nephrotoxicity in rats. Gen Pharmacol 1994; 25:1249-1252.
6. Ali BH, Al-Qarawi AA, Mousa HM. The effect of calcium load and the calcium channel blocker ver-apamil on gentamicin nephrotoxicity in rats. Food Chem Toxicol 2002; 40:1843-1847.
7. Banday AA, Farooq N, Priyamvada S, Yusufi AN, Khan F. Time dependent effects of gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues. Life Sci 2008; 82:450-459.
8. Ali BH, Al-Salam S, Al-Husseini I, Nemmar A. Comparative protective effect of N-acetyl cysteine and tetramethylpyrazine in rats with gentamicin nephrotoxicity. J Appl Toxicol 2009; 29:302-307.
9. Khan SA, Priyamvada S, Farooq N, Khan S, Khan MW, Yusufi AN. Protective effect of green tea extract on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Pharmacol Res 2009; 59:254-262.
10. Ozbek E, Ilbey YO, Simsek A, Cekmen M, Mete F, Somay A. Rosiglitazone, peroxisome prolifera-tor receptor-gamma agonist, ameliorates gentami-cin-induced nephrotoxicity in rats. Int Urol Nephrol 2010; 42:579-587.
11. Hsu DZ, Liu CT, Li YH, Chu PY, Liu MY. Protective effect of daily sesame oil supplement on gentamicin-induced renal injury in rats. Shock 2010; 33:88-92.
12. Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007; 13:688-694.
13. Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol 2009; 64: 753-761.
14. Kitamura A, Kobayashi S, Matsushita T, Miyazaki S, Fujinawa H, Murase K. Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography. Br J Radiol 2010; 83:509-514.
15. Prasad PV, Edelman RR, Epstein FH. Noninva-sive evaluation of intrarenal oxygenation with BOLD MRI. Circulation 1996; 94:3271-3275.
16. Priatna A, Epstein FH, Spokes K, Prasad PV. Evaluation of changes in intrarenal oxygenation in rats using multiple gradient-recalled echo (mGRE) sequence. J Magn Reson Imaging 1999; 9:842-846.
17. Ries M, Basseau F, Tyndal B, et al. Renal discusion and BOLD MRI in experimental diabetic nephropathy. Blood oxygen level-dependent. J Magn Reson Imaging 2003; 17:104-113.
18. Djamali A, Sadowski EA, Muehrer RJ, et al. BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction. Am J Physiol Renal Physiol 2007; 292:F513-F522.
19. dos Santos EA, Li LP, Ji L, Prasad PV. Early changes with diabetes in renal medullary hemo-dynamics as evaluated by fiberoptic probes and BOLD magnetic resonance imaging. Invest Radiol 2007; 42:157-162.
20. Kusakabe Y, Matsushita T, Honda S, Okada S, Murase K. Using BOLD imaging to measure renal oxygenation dynamics in rats injected with diuretics. Magn Reson Med Sci 2010; 9:187-194.
21. Prasad PV, Priatna A, Spokes K, Epstein FH. Changes in intrarenal oxygenation as evaluated by BOLD MRI in a rat kidney model for radiocon-trast nephropathy. J Magn Reson Imaging 2001; 13:744-747.
22. Jeong JY, Kim SH, Sim JS, et al. MR findings of renal cortical necrosis. J Comput Assist Tomogr 2002; 26:232-236.
23. +-ATPase in rat kidney cells. Acta Physiol Scand 1991; 141:27-34.
24. Sayed AA. Proanthocyanidin protects against cisplatin-induced nephrotoxicity. Phytother Res 2009; 23:1738-1741.
25. Sauer H, Wartenberg M, Hescheler J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Bio-chem 2001; 11:173-186.
26. Patil CR, Jadhav RB, Singh PK, Mundada S, Patil PR. Protective effect of oleanolic acid on gentami-cin induced nephrotoxicity in rats. Phytother Res 2010; 24:33-37.
27. Hottendorf GH, Barnett D, Gordon LL, Christen-sen EF, Madissoo H. Nonparallel nephrotoxicity dose-response curves of aminoglycosides. An-timicrob Agents Chemother 1981; 19:1024-1028.