Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling

Molecular Pharmacology

Volumn 81, Issue 3, 2012, Pages 401-410

  Yan, Chao ^a   Siegel, David ^a   Newsome, Jeffery ^b   Chilloux, Aurelie ^b   Moody, Christopher J ^b   Ross, David ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYMETHYL 5 METHOXY 1 METHYL 3[(4 NITROPHENOXY) METHYL] INDOLE 4,7 DIONE; 5 METHOXY 1 METHYL 3[(2,4,6 TRIFLUOROPHENOXY) METHYL] INDOLE 4,7 DIONE; ANTINEOPLASTIC AGENT; APOPTOSIS SIGNAL REGULATING KINASE 1; GLUTATHIONE; GLUTATHIONE DISULFIDE; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; SELENOCYSTEINE; STRESS ACTIVATED PROTEIN KINASE; THIOL DERIVATIVE; THIOREDOXIN REDUCTASE 1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL FREE SYSTEM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PANCREAS CANCER; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; HUMANS; INDOLEQUINONES; OXIDATION-REDUCTION; PANCREATIC NEOPLASMS; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 84857386778     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.076091     Document Type: Article

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