Targeted catalytic inactivation of angiotensin converting enzyme by lisinopril-coupled transition-metal chelates

Journal of the American Chemical Society

Volumn 134, Issue 7, 2012, Pages 3396-3410

  Joyner, Jeff C ^a   Hocharoen, Lalintip ^a   Cowan, J A ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b MetalloPharm LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN-CONVERTING ENZYME; CARBODIIMIDE HYDROCHLORIDES; CATALYTIC TURNOVER; CONCENTRATION-DEPENDENT; COORDINATION COMPLEX; ETHYLENEDIAMINETETRAACETIC ACID; FLUOROGENIC SUBSTRATE; INHIBITORY CONCENTRATION; LISINOPRIL; LYSINE SIDE CHAINS; METAL CENTERS; METAL CHELATE; NEGATIVE CHARGE; NITRILOTRIACETIC ACID; PRE-INCUBATION; PROTEIN OXIDATION; REACTIVE METALS; REDUCTION POTENTIAL; SECOND-ORDER RATE CONSTANTS; SIDE CHAIN MODIFICATIONS; TIME-DEPENDENT; TRIPEPTIDE;

AMIDES; AMINO ACIDS; COBALT; COORDINATION REACTIONS; COPPER COMPOUNDS; ENZYMES; IRON COMPOUNDS; RATE CONSTANTS;

CHELATION;

BRADYKININ; CHELATE; COBALT; COPPER; DIPEPTIDYL CARBOXYPEPTIDASE; EDETIC ACID; IRON; LISINOPRIL; LYSINE; NICKEL; NITRILOTRIACETIC ACID; TETRAXETAN; TRANSITION ELEMENT; TRIPEPTIDE;

ARTICLE; BINDING AFFINITY; CATALYSIS; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; OXIDATION REDUCTION POTENTIAL; PROTEIN CLEAVAGE;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CATALYSIS; CHELATING AGENTS; HUMANS; LISINOPRIL; MODELS, MOLECULAR; PEPTIDYL-DIPEPTIDASE A; TRANSITION ELEMENTS;

EID: 84857382200     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja208791f     Document Type: Article

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