메뉴 건너뛰기




Volumn 32, Issue SUPPL. 1, 2011, Pages 101-116

Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma

Author keywords

Cytotoxicity; DNA adduct; Ellipticine; Neuroblastoma; Trichostatin A; Valproic acid

Indexed keywords

CYCLOOXYGENASE 1; CYTOCHROME B5; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYTOCHROME P450 3A4; DRUG METABOLITE; ELLIPTICINE; GLYCOPROTEIN P; LACTOPEROXIDASE; PEROXIDASE; PHOSPHORUS 32; TRICHOSTATIN A; VALPROIC ACID;

EID: 84857375705     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (32)

References (76)
  • 2
    • 0023617219 scopus 로고
    • Multimodal action of antitumor agents on DNA: The ellipticine series
    • Auclair C (1987) Multimodal action of antitumor agents on DNA: The ellipticine series. Arch Biochem Biophys 259: 1-14.
    • (1987) Arch Biochem Biophys , vol.259 , pp. 1-14
    • Auclair, C.1
  • 4
    • 0036721055 scopus 로고    scopus 로고
    • Anti-tumor mechanisms of valproate: A novel role for an old drug
    • Blaheta RA and Cinatl J Jr (2002) Anti-tumor mechanisms of valproate: a novel role for an old drug. Med Res Rev 22: 492-511.
    • (2002) Med Res Rev , vol.22 , pp. 492-511
    • Blaheta, R.A.1    Cinatl Jr., J.2
  • 6
    • 0035992780 scopus 로고    scopus 로고
    • Valproate and valproate-analogues: Potent tools to fight against cancer
    • Blaheta RA, Nau H, Michaelis M and Cinatl J Jr (2002) Valproate and valproate-analogues: potent tools to fight against cancer. Curr Med Chem 9: 1417-1433. (Pubitemid 34823024)
    • (2002) Current Medicinal Chemistry , vol.9 , Issue.15 , pp. 1417-1433
    • Blaheta, R.A.1    Nau, H.2    Michaelis, M.3    Cinatl Jr., J.4
  • 7
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • DOI 10.1038/nrd2133, PII NRD2133
    • Bolden JE, Peart MJ and Johnstone RW (2006) Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 5: 769-784. (Pubitemid 44348499)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.9 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 8
    • 1942422695 scopus 로고    scopus 로고
    • DNA adduct formation by the anticancer drug ellipticine and its hydroxy derivatives in human breast adenocarcinoma MCF-7 cells
    • DOI 10.1135/cccc20040603
    • Borek-Dohalska L, Frei E and Stiborova M (2004) DNA adduct formation by the anticancer drug ellipticine and its hydroxy derivatives in human breast adenocarcinoma MCF-7 cells. Collect Czech Chem Commun 69: 603-615. (Pubitemid 38526511)
    • (2004) Collection of Czechoslovak Chemical Communications , vol.69 , Issue.3 , pp. 603-615
    • Borek-Dohalska, L.1    Frei, E.2    Stiborova, M.3
  • 9
    • 2342494314 scopus 로고    scopus 로고
    • Role of hepatocyte nuclear factor 3gamma in the expression of human CYP2C genes
    • DOI 10.1016/j.abb.2004.03.032, PII S0003986104001791
    • Bort R, Gomez-Lechon MJ, Castell JV and Jover R (2004) Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes. Arch Biochem Biophys 426: 63-72. (Pubitemid 38595130)
    • (2004) Archives of Biochemistry and Biophysics , vol.426 , Issue.1 , pp. 63-72
    • Bort, R.1    Gomez-Lechon, M.J.2    Castell, J.V.3    Jover, R.4
  • 10
    • 0037366067 scopus 로고    scopus 로고
    • Neuroblastoma: Biological insights into a clinical enigma
    • Brodeur GM (2003) Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 3: 203-216.
    • (2003) Nat Rev Cancer , vol.3 , pp. 203-216
    • Brodeur, G.M.1
  • 14
    • 0033228555 scopus 로고    scopus 로고
    • Bovine seminal ribonuclease selectively kills human multidrug-resistant neuroblastoma cells via induction of apoptosis
    • Cinatl J Jr, Cinatl J, Kotchetkov R, Vogel JU, Woodcock BG, Matousek J, et al. (1999) Bovine seminal ribonuclease selectively kills human multidrug-resistant neuroblastoma cells via induction of apoptosis. Int J Oncol 15: 1001-1009.
    • (1999) Int J Oncol , vol.15 , pp. 1001-1009
    • Cinatl Jr., J.1    Cinatl, J.2    Kotchetkov, R.3    Vogel, J.U.4    Woodcock, B.G.5    Matousek, J.6
  • 16
    • 33749000597 scopus 로고    scopus 로고
    • The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver
    • DOI 10.1038/sj.bjp.0706830, PII 0706830
    • Eyal S, Lamb JG, Smith-Yockman M, Yagen B, Fibach E and Altschuler Y (2006) White HS, Bialer M. The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver. Br J Pharmacol 149: 250-260. (Pubitemid 44453425)
    • (2006) British Journal of Pharmacology , vol.149 , Issue.3 , pp. 250-260
    • Eyal, S.1    Lamb, J.G.2    Smith-Yockman, M.3    Yagen, B.4    Fibach, E.5    Altschuler, Y.6    White, H.S.7    Bialer, M.8
  • 17
    • 0023845568 scopus 로고
    • Binding characteristics of Ah receptors from rats and mice before and after separation from hepatic cytosols - 7-Hydroxyellipticine as a competitive antagonist of cytochrome P-450 induction
    • Fernandez N, Roy M and Lesca P (1988) Binding characteristics of Ah receptors from rats and mice before and after separation from hepatic cytosols. 7-Hydroxyellipticine as a competitive antagonist of cytochrome P-450 induction. Eur J Biochem 172: 585-592. (Pubitemid 18076477)
    • (1988) European Journal of Biochemistry , vol.172 , Issue.3 , pp. 585-592
    • Fernandez, N.1    Roy, M.2    Lesca, P.3
  • 18
    • 0025967232 scopus 로고
    • Alterations in the renal excretion of valproate and its metabolites after chronic treatment
    • Fisher JE, Nau H and Löscher W (1991) Alterations in the renal excretion of valproate and its metabolites after chronic treatment. Epilepsia 32: 146-150.
    • (1991) Epilepsia , vol.32 , pp. 146-150
    • Fisher, J.E.1    Nau, H.2    Löscher, W.3
  • 19
    • 0027104314 scopus 로고
    • Stimulation of topoisomerase II-mediated DNA cleavage by ellipticine derivatives: Structure-activity relationship
    • Fosse P, Rene B, Charra M, Paoletti C and Saucier JM (1992) Stimulation of topoisomerase II-mediated DNA cleavage by ellipticine derivatives: structure-activity relationships. Mol Pharmacol 42: 590-595. (Pubitemid 23027620)
    • (1992) Molecular Pharmacology , vol.42 , Issue.4 , pp. 590-595
    • Fosse, P.1    Rene, B.2    Charra, M.3    Paoletti, C.4    Saucier, J.-M.5
  • 20
    • 0037099292 scopus 로고    scopus 로고
    • Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes
    • DOI 10.1016/S0006-2952(02)01072-9, PII S0006295202010729
    • Frei E, Bieler CA, Arlt VM, Wiessler M and Stiborova M (2002) Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes. Biochem Pharmacol 64: 289-295. (Pubitemid 34775308)
    • (2002) Biochemical Pharmacology , vol.64 , Issue.2 , pp. 289-295
    • Frei, E.1    Bieler, C.A.2    Arlt, V.M.3    Wiessler, M.4    Stiborova, M.5
  • 21
    • 0029015354 scopus 로고
    • Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy
    • Froelich-Ammon SJ, Patchan MW, Osheroff N and Thompson RB (1995) Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy. J Biol Chem 270: 14998-15004.
    • (1995) J Biol Chem , vol.270 , pp. 14998-15004
    • Froelich-Ammon, S.J.1    Patchan, M.W.2    Osheroff, N.3    Thompson, R.B.4
  • 22
    • 33947153003 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood
    • DOI 10.1002/ijc.22401
    • Furchert SE, Lanvers-Kaminsky C, Juürgens H, Jung M, Loidl A and Frühwald MC (2007) Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. Int J Cancer 120: 1787-1794. (Pubitemid 46399367)
    • (2007) International Journal of Cancer , vol.120 , Issue.8 , pp. 1787-1794
    • Furchert, S.E.1    Lanvers-Kaminsky, C.2    Jurgens, H.3    Jung, M.4    Loidl, A.5    Fruhwald, M.C.6
  • 23
    • 0030582844 scopus 로고    scopus 로고
    • Analysis of structural requirements for Ah receptor antagonist activity: Ellipticines, flavones, and related compounds
    • Gasiewicz TA, Kende RS, Rucci G, Whitney B and Willey JJ (1996). Analysis of structural requirements for Ah receptor antagonist activity: Ellipticines, flavones, and related compounds. Biochem Pharmacol. 52: 1787-830.
    • (1996) Biochem Pharmacol. , vol.52 , pp. 1787-1830
    • Gasiewicz, T.A.1    Kende, R.S.2    Rucci, G.3    Whitney, B.4    Willey, J.J.5
  • 24
    • 9144249625 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: Effect on glutathione peroxidase and glutathione reductase enzymes
    • DOI 10.1111/j.1365-2125.2004.02210.x
    • Gupta M, Gupta YK, Agarwal S, Aneja S and Kohli K (2004) A randomized, double-blind, placebo controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes. Br J Clin Pharmacol 58: 542-547. (Pubitemid 39540459)
    • (2004) British Journal of Clinical Pharmacology , vol.58 , Issue.5 , pp. 542-547
    • Gupta, M.1    Gupta, Y.K.2    Agarwal, S.3    Aneja, S.4    Kohli, K.5
  • 25
    • 13944280578 scopus 로고    scopus 로고
    • Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells
    • DOI 10.1016/j.bmcl.2005.01.032
    • Hooven LA, Mahadevan B, Keshava C, Johns C, Pereira C, Desai D, et al. (2005) Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells. Bioorg Med Chem Lett 15: 1283-1287. (Pubitemid 40268976)
    • (2005) Bioorganic and Medicinal Chemistry Letters , vol.15 , Issue.5 , pp. 1283-1287
    • Hooven, L.A.1    Mahadevan, B.2    Keshava, C.3    Johns, C.4    Pereira, C.5    Desai, D.6    Amin, S.7    Weston, A.8    Baird, W.M.9
  • 26
    • 0037026635 scopus 로고    scopus 로고
    • Doxorubicin-induced death in neuroblastoma does not involve death receptors in S-type cells and is caspase-independent in N-type cells
    • Hopkins-Donaldson S, Yan P, Bourloud KB, Muhlethaler A, Bodmer JL and Gross N (2002) Doxorubicin-induced death in neuroblastoma does not involve death receptors in S-type cells and is caspase-independent in N-type cells. Oncogene 21: 6132-6137.
    • (2002) Oncogene , vol.21 , pp. 6132-6137
    • Hopkins-Donaldson, S.1    Yan, P.2    Bourloud, K.B.3    Muhlethaler, A.4    Bodmer, J.L.5    Gross, N.6
  • 27
    • 77950829408 scopus 로고    scopus 로고
    • Valproic acid in the complex therapy of malignant tumors
    • Hrebackova J, Hrabeta J and Eckschlager T (2010) Valproic acid in the complex therapy of malignant tumors. Curr Drug Targets 11: 361-379.
    • (2010) Curr Drug Targets , vol.11 , pp. 361-379
    • Hrebackova, J.1    Hrabeta, J.2    Eckschlager, T.3
  • 28
    • 77956329493 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells
    • Hrebackova J, Poljakova J, Eckschlager T, Hrabeta J, Prochazka P, Smutny S et al. (2009) Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells. Interdisc Toxicol 2: 205-210.
    • (2009) Interdisc Toxicol , vol.2 , pp. 205-210
    • Hrebackova, J.1    Poljakova, J.2    Eckschlager, T.3    Hrabeta, J.4    Prochazka, P.5    Smutny, S.6
  • 29
    • 16344377909 scopus 로고    scopus 로고
    • Correlating gene expression with chemical scaffolds of cytotoxic agents: Ellipticines as substrates and inhibitors of MDR1
    • DOI 10.1038/sj.tpj.6500297
    • Huang Y, Blower PE, Yang C, Barbacioru C, Dai Z, Zhang Y, et al. (2005) Correlating gene expression with chemical scaffolds of cytotoxic agents: ellipticines as substrates and inhibitors of MDR1. Pharmacogenomics J 5: 112-125. (Pubitemid 40468118)
    • (2005) Pharmacogenomics Journal , vol.5 , Issue.2 , pp. 112-125
    • Huang, Y.1    Blower, P.E.2    Yang, C.3    Barbacioru, C.4    Dai, Z.5    Zhang, Y.6    Xiao, J.J.7    Chan, K.K.8    Sadee, W.9
  • 31
    • 0035964804 scopus 로고    scopus 로고
    • Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells
    • Kerzee JK and Ramos KS (2001) Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells. Circ Res 89: 573-582.
    • (2001) Circ Res , vol.89 , pp. 573-582
    • Kerzee, J.K.1    Ramos, K.S.2
  • 32
    • 0242610850 scopus 로고    scopus 로고
    • Inhibition of Histone Deacetylase Increases Cytotoxicity to Anticancer Drugs Targeting DNA
    • Kim MS, Blake M, Baek JH, Kohlhagen G, Pommier Yand Carrier F (2003) Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. Cancer Res 63: 7291-7300. (Pubitemid 37413470)
    • (2003) Cancer Research , vol.63 , Issue.21 , pp. 7291-7300
    • Kim, M.S.1    Blake, M.2    Baek, J.H.3    Kohlhagen, G.4    Pommier, Y.5    Carrier, F.6
  • 33
    • 80051552143 scopus 로고    scopus 로고
    • 5 shifts oxidation of anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation metabolites, thereby modulating its pharmacological efficacy
    • 5 shifts oxidation of anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation metabolites, thereby modulating its pharmacological efficacy. Biochem Pharmacol. 82(6): 669-80.
    • (2011) Biochem Pharmacol , vol.82 , Issue.6 , pp. 669-680
    • Kotrbova, V.1    Mrazova, B.2    Moserova, M.3    Martinek, V.4    Hodek, P.5    Hudecek, J.6
  • 34
    • 0030803825 scopus 로고    scopus 로고
    • Comparative analysis of different permeabilization methods for the flow cytometry measurement of cytoplasmic myeloperoxidase and lysozyme in normal and leukemic cells
    • DOI 10.1002/(SICI)1097-0320(19970615)30:3<134::AID-CYTO4>3.0.CO;2-L
    • Lanza F, Latorraca A, Moretti S, Castagnari B, Ferrari L and Castoldi G (1997) Comparative analysis of different permeabilization methods for the flow cytometry measurement of cytoplasmic myeloperoxidase and lysozyme in normal and leukemic cells, Cytometry 30: 134-144. (Pubitemid 27296734)
    • (1997) Communications in Clinical Cytometry , vol.30 , Issue.3 , pp. 134-144
    • Lanza, F.1    Latorraca, A.2    Moretti, S.3    Castagnari, B.4    Ferrari, L.5    Castoldi, G.6
  • 35
    • 18144373452 scopus 로고    scopus 로고
    • Valproic acid alters chromatin structure by regulation of chromatin modulation proteins
    • DOI 10.1158/0008-5472.CAN-04-2478
    • Marchion DC, Bicaku E, Daud Al, Sullivan DM and Munster PN (2005a) Valproic acid alters chromatin structure by regulation of chromatin modulation proteins. Cancer Res 65: 3815-3822. (Pubitemid 40616361)
    • (2005) Cancer Research , vol.65 , Issue.9 , pp. 3815-3822
    • Marchion, D.C.1    Bicaku, E.2    Daud, A.I.3    Sullivan, D.M.4    Munster, P.N.5
  • 36
    • 30344443991 scopus 로고    scopus 로고
    • In vivo synergy between topoisomerase II and histone deacetylase inhibitors: Predictive correlates
    • DOI 10.1158/1535-7163.MCT-05-0194
    • Marchion DC, Bicaku E, Daud AI, Sullivan DM and Munster PN (2005b) In vivo synergy between topoisomerase II and histone deacetylase inhibitors: predictive correlates. Mol Cancer Ther 4: 1993-2000. (Pubitemid 43056982)
    • (2005) Molecular Cancer Therapeutics , vol.4 , Issue.12 , pp. 1993-2000
    • Marchion, D.C.1    Bicaku, E.2    Daud, A.I.3    Sullivan, D.M.4    Munster, P.N.5
  • 37
    • 0033034390 scopus 로고    scopus 로고
    • Molecular biology of neuroblastomas
    • Maris JM and Mathay KK (1999) Molecular biology of neuroblastomas. J Clin Oncol 17: 2264-2279.
    • (1999) J Clin Oncol , vol.17 , pp. 2264-2279
    • Maris, J.M.1    Mathay, K.K.2
  • 40
    • 77349123536 scopus 로고    scopus 로고
    • Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells
    • Martinkova E, Dontenwill M, Frei E and Stiborova M (2009). Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells. Neuro Endocrinol Lett. 30 (Suppl): 60-66.
    • (2009) Neuro Endocrinol Lett , vol.30 , Issue.SUPPL. , pp. 60-66
    • Martinkova, E.1    Dontenwill, M.2    Frei, E.3    Stiborova, M.4
  • 41
    • 77955490232 scopus 로고    scopus 로고
    • α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells
    • Martinkova E, Maglott A, Leger, DY, Bonnet D, Stiborova M, Takeda K, et al. (2010). α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int J Cancer 127: 1240-1248.
    • (2010) Int J Cancer , vol.127 , pp. 1240-1248
    • Martinkova, E.1    Maglott, A.2    Leger, D.Y.3    Bonnet, D.4    Stiborova, M.5    Takeda, K.6
  • 42
    • 0019430425 scopus 로고
    • Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea
    • McCormick DL, Adamowski CB, Fiks A and Moon RC (1981) Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea, Cancer Res 41: 1690-1694. (Pubitemid 11114558)
    • (1981) Cancer Research , vol.41 , Issue.5 , pp. 1690-1694
    • McCormick, D.L.1    Adamowski, C.B.2    Fiks, A.3    Moon, R.C.4
  • 44
    • 16644379041 scopus 로고    scopus 로고
    • Valproic acid and interferon-alpha synergistically inhibit neuroblastoma cell growth in vitro and in vivo
    • Michaelis M, Suhan T, Cinatl J, Driever PH and Cinatl J Jr (2004) Valproic acid and interferon-alpha synergistically inhibit neuroblastoma cell growth in vitro and in vivo. Int J Oncol 25: 1795-1799.
    • (2004) Int J Oncol , vol.25 , pp. 1795-1799
    • Michaelis, M.1    Suhan, T.2    Cinatl, J.3    Driever, P.H.4    Cinatl Jr., J.5
  • 47
    • 57149128596 scopus 로고    scopus 로고
    • Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA
    • Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, et al. (2008). Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA. Neuro Endocrinol Lett. 29: 728-732.
    • (2008) Neuro Endocrinol Lett , vol.29 , pp. 728-732
    • Moserova, M.1    Kotrbova, V.2    Rupertova, M.3    Naiman, K.4    Hudecek, J.5    Hodek, P.6
  • 48
    • 33644909875 scopus 로고    scopus 로고
    • Clinically relevant drug interactions with antiepileptic drugs
    • Perucca E (2006) Clinically relevant drug interactions with antiepileptic drugs. Br J Clin Pharmacol 61: 246-255.
    • (2006) Br J Clin Pharmacol , vol.61 , pp. 246-255
    • Perucca, E.1
  • 50
    • 63149114184 scopus 로고    scopus 로고
    • The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells
    • Poljakova J, Eckschlager T, Hrabeta J, Hrebackova J, Smutny S, Frei E, et al. (2009) The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells. Biochem Pharmacol. 77: 1466-1479.
    • (2009) Biochem Pharmacol. , vol.77 , pp. 1466-1479
    • Poljakova, J.1    Eckschlager, T.2    Hrabeta, J.3    Hrebackova, J.4    Smutny, S.5    Frei, E.6
  • 52
    • 34248662505 scopus 로고    scopus 로고
    • DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells
    • DOI 10.1016/j.canlet.2006.12.037, PII S0304383507000043
    • Poljakova J, Frei E, Gomez JE, Aimova D, Eckschlager T, Hrabeta J, et al. (2007) DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells. Cancer Lett 252: 270-279. (Pubitemid 46809792)
    • (2007) Cancer Letters , vol.252 , Issue.2 , pp. 270-279
    • Poljakova, J.1    Frei, E.2    Gomez, J.E.3    Aimova, D.4    Eckschlager, T.5    Hrabeta, J.6    Stiborova, M.7
  • 53
    • 0030834058 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors
    • Rendic S and Di Carlo FJ (1997) Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 29: 413-580. (Pubitemid 27293618)
    • (1997) Drug Metabolism Reviews , vol.29 , Issue.1-2 , pp. 413-580
    • Rendic, S.1    Di, C.F.J.2
  • 54
    • 0029018808 scopus 로고
    • Effects of the anticonvulsant, valproate, on the expression of components of the cytochrome-P-450-mediated monooxygenase system and glutathione S-transferases
    • Rogiers V, Akrawi M, Vercruysse A, Phillips IR and Shephard EA (1995) Effects of the anticonvulsant, valproate, on the expression of components of the cytochrome-P-450-mediated monooxygenase system and glutathione S-transferases. Eur J Biochem 231: 337-343.
    • (1995) Eur J Biochem , vol.231 , pp. 337-343
    • Rogiers, V.1    Akrawi, M.2    Vercruysse, A.3    Phillips, I.R.4    Shephard, E.A.5
  • 56
    • 34249033131 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular and biological activity as a premise to clinical application
    • Santini V, Gozzini A and Ferrari G (2007) Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application. Curr Drug Metab. 8: 383-393.
    • (2007) Curr Drug Metab. , vol.8 , pp. 383-393
    • Santini, V.1    Gozzini, A.2    Ferrari, G.3
  • 58
    • 0033039024 scopus 로고    scopus 로고
    • Human neuroblastoma: From basic science to clinical debut of cellular oncogenes
    • Schwab M (1999) Human neuroblastoma: from basic science to clinical debut of cellular oncogenes. Naturwissenschaften 86: 71-78.
    • (1999) Naturwissenschaften , vol.86 , pp. 71-78
    • Schwab, M.1
  • 59
    • 0027953894 scopus 로고
    • High-field NMR and restrained molecular modeling studies on a DNA heteroduplex containing a modified apurinic abasic site in the form of covalently linked 9-aminoellipticine
    • Singh MP, Hill GC, Peoch D, Rayner B, Inabach JL and Lown JW (1994) High-field NMR and restrained molecular modeling studies on a DNA heteroduplex containing a modified apurinic abasic site in the form of covalently linked 9-aminoellipticine. Biochemistry 33: 10271-10285. (Pubitemid 24281792)
    • (1994) Biochemistry , vol.33 , Issue.34 , pp. 10271-10285
    • Singh, M.P.1    Hill, G.C.2    Peoc'h, D.3    Rayner, B.4    Imbach, J.-L.5    Lown, J.W.6
  • 60
    • 38649108546 scopus 로고    scopus 로고
    • Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH:Cytochrome P450 reductase null mouse
    • DOI 10.1016/j.taap.2007.09.017, PII S0041008X07004231
    • Stiborova M, Arlt VM, Henderson CJ, Wolf CR, Kotrbova V, Moserova M, et al. (2008). Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse. Toxicol Appl Pharmacol. 226: 318-27. (Pubitemid 351172414)
    • (2008) Toxicology and Applied Pharmacology , vol.226 , Issue.3 , pp. 318-327
    • Stiborova, M.1    Arlt, V.M.2    Henderson, C.J.3    Wolf, C.R.4    Kotrbova, V.5    Moserova, M.6    Hudecek, J.7    Phillips, D.H.8    Frei, E.9
  • 61
    • 0035894174 scopus 로고    scopus 로고
    • The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts
    • DOI 10.1016/S0006-2952(01)00806-1, PII S0006295201008061
    • Stiborova M, Bieler CA, Wiessler M and Frei E (2001).The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts. Biochem Pharmacol. 62: 1675-1684. (Pubitemid 34033654)
    • (2001) Biochemical Pharmacology , vol.62 , Issue.12 , pp. 1675-1684
    • Stiborova, M.1    Bieler, C.A.2    Wiessler, M.3    Frei, E.4
  • 64
    • 0037108678 scopus 로고    scopus 로고
    • Sudan I is a potential carcinogen for humans: Evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes
    • Stiborova M, Martinek V, Rydlova H, Hodek P and Frei E (2002). Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes. Cancer Res 62: 5678-5684. (Pubitemid 35204721)
    • (2002) Cancer Research , vol.62 , Issue.20 , pp. 5678-5684
    • Stiborova, M.1    Martinek, V.2    Rydlova, H.3    Hodek, P.4    Frei, E.5
  • 65
    • 17644405812 scopus 로고    scopus 로고
    • Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers
    • DOI 10.1016/j.canlet.2004.07.036
    • Stiborova M, Martinek V, Rydlova H, Koblas T and Hodek P (2005). Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers. Cancer Lett. 220: 145-154. (Pubitemid 40568771)
    • (2005) Cancer Letters , vol.220 , Issue.2 , pp. 145-154
    • Stiborova, M.1    Martinek, V.2    Rydlova, H.3    Koblas, T.4    Hodek, P.5
  • 66
  • 67
    • 79952796704 scopus 로고    scopus 로고
    • Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: Additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney. Neuro Endocrino
    • Stiborova M, Moserova M, Mrazova B, Kotrbova V and Frei E (2010) Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney. Neuro Endocrino. Lett 31 (Suppl. 2): 26-35.
    • (2010) Lett , vol.31 , Issue.SUPPL. 2 , pp. 26-35
    • Stiborova, M.1    Moserova, M.2    Mrazova, B.3    Kotrbova, V.4    Frei, E.5
  • 68
    • 33845624680 scopus 로고    scopus 로고
    • Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine
    • DOI 10.1002/ijc.22247
    • Stiborova M, Poljakova J, Ryslava H, Dracinsky M, Eckschlager T and Frei E (2007a). Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine. Int J Cancer 120: 243-251. (Pubitemid 44956832)
    • (2007) International Journal of Cancer , vol.120 , Issue.2 , pp. 243-251
    • Stiborova, M.1    Poljakova, J.2    Ryslava, H.3    Dracinsky, M.4    Eckschlager, T.5    Frei, E.6
  • 69
    • 34248652696 scopus 로고    scopus 로고
    • Formation and persistence of DNA adducts of anticancer drug ellipticine in rats
    • DOI 10.1016/j.tox.2007.03.026, PII S0300483X07002065
    • Stiborova M, Rupertova M, Aimova D, Ryslava H and Frei E (2007b) Formation and persistence of DNA adducts of anticancer drug ellipticine in rats. Toxicology 236: 50-60. (Pubitemid 46777068)
    • (2007) Toxicology , vol.236 , Issue.1-2 , pp. 50-60
    • Stiborova, M.1    Rupertova, M.2    Aimova, D.3    Ryslava, H.4    Frei, E.5
  • 70
    • 78649447922 scopus 로고    scopus 로고
    • Cytochrome P450and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency
    • Stiborova M, Rupertova M and Frei E (2011) Cytochrome P450and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency. Biochim Biophys Acta 1814: 175-185.
    • (2011) Biochim Biophys Acta , vol.1814 , pp. 175-185
    • Stiborova, M.1    Rupertova, M.2    Frei, E.3
  • 73
    • 12244292673 scopus 로고    scopus 로고
    • Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans
    • DOI 10.1021/tx0200818
    • Stiborova M, Stiborova-Rupertova M, Borek-Dohalska L, Wiessler M and Frei E (2003b) Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans. Chem Res Toxicol. 16: 38-47. (Pubitemid 36139409)
    • (2003) Chemical Research in Toxicology , vol.16 , Issue.1 , pp. 38-47
    • Stiborova, M.1    Stiborova-Rupertova, M.2    Borek-Dohalska, L.3    Wiessler, M.4    Frei, E.5
  • 74
    • 31844434762 scopus 로고    scopus 로고
    • Differentiation, proliferation and adhesion of human neuroblastoma cells after treatment with retinoic acid
    • Voigt A, Hartmann P and Zintl F (2000) Differentiation, proliferation and adhesion of human neuroblastoma cells after treatment with retinoic acid. Cell Adhes Commun 7: 423-440. (Pubitemid 30265258)
    • (2000) Cell Adhesion and Communication , vol.7 , Issue.5 , pp. 423-440
    • Voigt, A.1    Hartmann, P.2    Zintl, F.3
  • 75
    • 0035515634 scopus 로고    scopus 로고
    • In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: Preferential inhibition of cytochrome P450 2C9 (CYP2C9)
    • Wen X, Wang JS, Kivistö KT, Neuvonen PJ and Backman JT (2001) In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9). Br J Clin Pharmacol 52: 547-553.
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 547-553
    • Wen, X.1    Wang, J.S.2    Kivistö, K.T.3    Neuvonen, P.J.4    Backman, J.T.5
  • 76
    • 33847701595 scopus 로고    scopus 로고
    • Thrombospondin-1 peptide ABT-510 combined with valproic acid is an effective antiangiogenesis strategy in neuroblastoma
    • DOI 10.1158/0008-5472.CAN-06-2595
    • Yang Q, Tian Y, Liu S, Zeine R, Chlenski A, Salwen HR, et al. 2007. Thrombospondin-1 peptide ABT-510 combined with valproic acid is an effective antiangiogenesis strategy in neuroblastoma. Cancer Res 67: 1716-1724. (Pubitemid 46383398)
    • (2007) Cancer Research , vol.67 , Issue.4 , pp. 1716-1724
    • Yang, Q.1    Tian, Y.2    Liu, S.3    Zeine, R.4    Chlenski, A.5    Salwen, H.R.6    Henkin, J.7    Cohn, S.L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.