TCR cross-reactivity and allorecognition: New insights into the immunogenetics of allorecognition

Immunogenetics

Volumn 64, Issue 2, 2012, Pages 77-85

  D'Orsogna, L J ^a,b,c   Roelen, D L ^a   Doxiadis, I I N ^a   Claas, F H J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c PATHWEST LABORATORY MEDICINE   (Australia)

Author keywords

Alloantibodies; Allorecognition; Antiviral immunity; Heterologous immunity; Memory T cells; Tissue specificity

Indexed keywords

HLA ANTIBODY; T LYMPHOCYTE RECEPTOR;

ALLOIMMUNITY; ALLORECOGNITION; ANTIGEN RECOGNITION; CROSS REACTION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOGENETICS; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; REVIEW; VACCINATION; VIRUS INFECTION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; GRAFT VS HOST DISEASE; HLA ANTIGENS; HUMANS; IMMUNOLOGIC MEMORY; ISOANTIBODIES; ISOANTIGENS; MALE; MICE; RECEPTORS, ANTIGEN, T-CELL; THYMUS GLAND; TRANSPLANTATION, HOMOLOGOUS; VIRUS DISEASES;

EID: 84857357111     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-011-0590-0     Document Type: Review

References (70)

1. A Adams M Williams T Jones, et al. 2003 Heterologous immunity provides a potent barrier to transplantation tolerance J Clin Invest 111 1887 1895 12813024 1:CAS:528:DC%2BD3sXkvV2kuro%3D
2. J Alberu L Morales-Buenrostro C de Leo, et al. 2007 A non-allogeneic stimulus triggers the production of de-novo HLA antibodies in healthy adults Transpl Immunol 18 166 171 18005863 10.1016/j.trim.2007.06.001 1:CAS:528:DC%2BD2sXhtlWrs7vP
3. A Amir L D'Orsogna D Roelen, et al. 2010 Allo-HLA reactivity of viral specific memory T cells is common Blood 115 3146 3157 20160165 10.1182/blood-2009-07-234906 1:CAS:528:DC%2BC3cXltlWqsrs%3D
4. Anonymous (2004) Guidelines for vaccination of solid organ transplant candidates and recipients. Am J Transplant, 4 (Suppl 10): 160-163
5. J Archbold W Macdonald J Miles, et al. 2006 Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry J Biol Chem 281 34324 34332 16963442 10.1074/jbc.M606755200 1:CAS:528:DC%2BD28XhtFKgur7M
6. V Argaet C Schimdt S Burrows, et al. 1994 Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus J Exp Med 180 2335 2340 7964506 10.1084/jem.180.6.2335 1:CAS:528:DyaK2MXhtFGmuro%3D
7. A Bankovich K Garcia 2003 Not just any T cell receptor will do Immunity 18 7 11 12530971 10.1016/S1074-7613(02)00517-4 1:CAS:528:DC%2BD3sXnvVyrsg%3D%3D
8. O Borbulevych K Piepenbrink B Gloor, et al. 2009 T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility Immunity 31 885 896 20064447 10.1016/j.immuni.2009.11.003 1:CAS:528:DC%2BC3cXht1Cjs7s%3D
9. J Borst E de Vries H Spits J de Vries A Boylston E Matthews 1987 Complexity of T cell receptor recognition sites for defined alloantigens J Immunol 139 1952 1959 2957443 1:CAS:528:DyaL2sXlvFKju70%3D
10. M Brehm K Daniels B Priyadharshini, et al. 2010 Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity Am J Transplant 10 1738 1748 20659086 10.1111/j.1600-6143.2010.03161.x 1:CAS:528:DC%2BC3cXhtFahsbzN
11. M Brook K Wood N Jones 2006 The impact of memory T cells on rejection and the induction of tolerance Transplantation 82 1 9 16861933 10.1097/01.tp. 0000226082.17507.da
12. S Burrows R Khanna J Burrows D Moss 1994 An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-vs-host disease J Exp Med 179 1155 1161 7511682 10.1084/jem.179.4.1155 1:CAS:528:DyaK2cXhvV2itbs%3D
13. S Burrows S Silins D Moss, et al. 1995 T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility antigen J Exp Med 182 1703 1715 7500015 10.1084/jem.182.6. 1703 1:CAS:528:DyaK2MXpslymtLg%3D
14. S Burrows S Silins R Khanna, et al. 1997 Cross-reactive memory T cells for Epstein-Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex-bound peptide by T cells and its role in alloreactivity Eur J Immunol 27 1726 1736 9247584 10.1002/eji.1830270720 1:CAS:528:DyaK2sXks1Clt7Y%3D
15. S Burrows R Khanna S Silins D Moss 1999 The influence of antiviral T-cell responses on the alloreactive repertoire Immunol Today 20 203 207 10322297 10.1016/S0167-5699(98)01429-7 1:CAS:528:DyaK1MXjtFSju74%3D
16. J Byrne J Butler M Cooper 1988 Differential activation requirements for virgin and memory T cells J Immunol 141 3249 3257 2972769 1:STN:280: DyaL1M%2FjsFCgtA%3D%3D
17. J Cai P Terasaki N Anderson, et al. 2009 Intact HLA not beta2m-free heavy chain-specific HLA class I antibodies are predictive of graft failure Transplantation 88 226 230 19623018 10.1097/TP.0b013e3181ac6198 1:CAS:528:DC%2BD1MXovVSgtbk%3D
18. L Colf A Bankovich N Hanick, et al. 2007 How a single T cell receptor recognizes both self and foreign MHC Cell 129 135 146 17418792 10.1016/j.cell.2007.01.048 1:CAS:528:DC%2BD2sXkvVeltLY%3D
19. L D'Orsogna A Amir Y Zoet, et al. 2009 New tools to monitor the impact of viral infection on the alloreactive T-cell repertoire Tissue Antigens 74 290 297 19624615 10.1111/j.1399-0039.2009.01311.x
20. L D'Orsogna D Roelen I Doxiadis F Claas 2010 Alloreactivity from human viral specific memory T-cells Transpl Immunol 23 149 155 20600900 10.1016/j.trim.2010.06.008
21. L D'Orsogna D Roelen E van der Meer-Prins, et al. 2011 Tissue specificity of cross-reactive allogeneic responses by EBV EBNA3A specific memory T cells Transplantation 91 494 500 21242884 10.1097/TP.0b013e318207944c
22. L D'Orsogna D Roelen I Doxiadis F Claas 2011 Screening of viral specific T-cell lines for HLA alloreactivity prior to adoptive immunotherapy may prevent GvHD Transpl Immunol 24 141 21167283 10.1016/j.trim.2010.12.001
23. L D'Orsogna N van Besouw E van der Meer-Prins, et al. 2011 Vaccine induced allo-HLA reactive memory T cells in a kidney transplantation candidate Transplantation 91 645 651 21283063 10.1097/TP.0b013e318208c071
24. L Danziger-Isakov L Cherkassky H Siegel, et al. 2010 Effects of influenza immunization on humoral and cellular alloreactivity in humans Transplantation 89 838 844 20179666 10.1097/TP.0b013e3181ca56f8
25. J Deckers J Boonstra S van der Kooij M Daha F van der Woude 1997 Tissue-specific characteristics of cytotoxic graft-infiltrating T cells during renal allograft rejection Transplantation 64 178 181 9233724 10.1097/00007890-199707150-00034 1:STN:280:DyaK2szns12msQ%3D%3D
26. J Deckers M Daha S van der Kooij F van der Woude 1998 Epithelial and endothelial-cell specificity of renal graft infiltrating T cells Clin Transplant 12 285 291 9686321 1:STN:280:DyaK1czltV2gug%3D%3D
27. El-Awar N, Terasaki P, Nguyen A et al (2008) Epitopes of HLA antibodies found in sera of normal healthy males and cord blood. Clin Transpl 199-214
28. L Ely S Burrows A Purcell, et al. 2008 T-cells behaving badly: structural insights into alloreactivity and autoimmunity Curr Opin Immunol 20 575 580 18678247 10.1016/j.coi.2008.07.006 1:CAS:528:DC%2BD1cXhtVyltbfE
29. G Feng T Chan K Wood A Bushell 2009 Donor reactive regulatory T cells Curr Opin Organ Transplant 14 432 438 19448539 10.1097/MOT.0b013e32832c58f1
30. K Fleischhauer D Avila F Vilbois, et al. 1994 Characterization of natural peptide ligands for HLA-B*4402 and -B*4403: implications for peptide involvement in allorecognition of a single amino acid change in the HLA-B44 heavy chain Tissue Antigens 44 311 317 7878657 10.1111/j.1399-0039.1994. tb02401.x 1:CAS:528:DyaK2MXivFSntbo%3D
31. K Flynn A Mullbacher 1996 Memory alloreactive cytotoxic T cells do not require costimulation for activation in vitro Immunol Cell Biol 74 413 420 8912004 10.1038/icb.1996.71 1:CAS:528:DyaK28XmvFKmsb4%3D
32. R Francis G Feng T Tha-In, et al. 2011 Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells Eur J Immunol 41 726 738 21243638 10.1002/eji.201040509 1:CAS:528:DC%2BC3MXit1ehsbs%3D
33. J Gaston A Rickinson M Epstein 1983 Cross-reactivity of self-HLA-restricted Epstein-Barr virus-specific cytotoxic T lymphocytes for allo-HLA determinants J Exp Med 158 1804 1821 6196431 10.1084/jem.158.6.1804 1:STN:280:DyaL2c%2FmtlCitg%3D%3D
34. D Golshayan J Wyss M Buckland, et al. 2010 Differential role of naïve and memory CD4+ T-cell subsets in primary alloresponses Am J Transplant 10 1749 1759 20659087 10.1111/j.1600-6143.2010.03180.x 1:CAS:528:DC%2BC3cXhtFahsbzO
35. S Gras S Burrows L Kjer-Nielsen, et al. 2009 The shaping of T cell receptor recognition by self-tolerance Immunity 30 193 203 19167249 10.1016/j.immuni.2008.11.011 1:CAS:528:DC%2BD1MXltFSmsb0%3D
36. D Gray P Matzinger 1991 T cell memory is short lived in the absence of antigen J Exp Med 174 969 974 1834764 10.1084/jem.174.5.969 1:CAS:528: DyaK3MXmtVGqsr8%3D
37. A Greisemer E Sorenson M Hardy 2010 The role of the thymus in tolerance Transplantation 90 465 474 10.1097/TP.0b013e3181e7e54f
38. D Hamann P Baars M Rep, et al. 1997 Phenotypic and functional separation of memory and effector human CD8+ T cells J Exp Med 186 1407 1418 9348298 10.1084/jem.186.9.1407 1:STN:280:DyaK1c%2Fht1aitg%3D%3D
39. W Heath L Sherman 1991 Cell-type-specific recognition of allogeneic cells by alloreactive cytotoxic T cells: a consequence of peptide-dependent allorecognition Eur J Immunol 21 153 159 1991485 10.1002/eji.1830210123 1:CAS:528:DyaK3MXht1SisLs%3D
40. J Herman V Jongeneel D Kuznetsov P Coulie 1999 Differences in the recognition by CTL of peptides presented by the HLA-B*4402 and the HLA-B*4403 molecules which differ by a single amino acid Tissue Antigens 53 111 121 10090611 10.1034/j.1399-0039.1999.530201.x 1:CAS:528: DyaK1MXhvVSnsbc%3D
41. S Jiang D Golshayan J Tsang, et al. 2006 In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance Int Immunopharmacol 6 1879 1882 17161340 10.1016/j.intimp.2006.07.025 1:CAS:528:DC%2BD28Xht12ksbfK
42. I Katerinis K Hadaya R Duquesnoy, et al. 2011 De novo anti-HLA antibody after pandemic H1N1 and seasonal influenza immunization in kidney transplant recipients Am J Transplant 11 1727 1733 21672157 10.1111/j.1600-6143.2011.03604. x 1:CAS:528:DC%2BC3MXhtFOqtbbK
43. V Kleim L Fricke T Wollbrink, et al. 2008 Improvement in long-term renal graft survival due to CMV prophylaxis with oral ganciclovir: results of a randomized clinical trial Am J Transplant 8 975 983 10.1111/j.1600-6143.2007. 02133.x
44. W Macdonald Z Chen S Gras, et al. 2009 T cell recognition via molecular mimicry Immunity 31 897 908 20064448 10.1016/j.immuni.2009.09.025 1:CAS:528:DC%2BC3cXht1Cjs7g%3D
45. C Macedo A Orkis I Popescu, et al. 2009 Contribution of naïve and memory T-cell populations to the human alloimmune response Am J Transplant 9 2057 2066 19624567 10.1111/j.1600-6143.2009.02742.x 1:CAS:528:DC%2BD1MXht1ansrjK
46. P Marrack J Kappler 1988 T cells can distinguish between allogeneic major histocompatibility complex products on different cell types Nature 332 840 843 3258650 10.1038/332840a0 1:STN:280:DyaL1c7ovFenuw%3D%3D
47. D Mason 1998 A very high level of cross-reactivity is an essential feature of the T-cell receptor Immunol Today 19 428 429 10.1016/S0167-5699(98) 01299-7
48. J Melenhorst A Leen C Bollard M Quigley D Price C Rooney, et al. 2010 Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects Blood 116 4700 4702 20709906 10.1182/blood-2010-06-289991 1:CAS:528:DC%2BC3cXhsFGgtbnN
49. N Mifsud T Nguyen B Tait T Kotsimbos 2010 Quantitative and functional diversity of cross-reactive EBV-specific CD8+ T cells in a longitudinal study cohort of lung transplant recipients Transplantation 90 1439 1449 21042237 10.1097/TP.0b013e3181ff4ff3
50. A Miltenburg M Meijer-Paape M Daha, et al. 1989 Donor-specific lysis of human proximal tubular epithelial cells by renal allograft-infiltrating lymphocytes Transplantation 48 296 302 2502871 10.1097/00007890-198908000-00022 1:STN:280:DyaL1Mzjt1Oquw%3D%3D
51. I Molina B Huber 1990 The expression of tissue-specific self-peptide is required for allorecognition J Immunol 144 2082 2088 1968923 1:CAS:528:DyaK3cXhvFKgtro%3D
52. L Morales-Buenrostro P Terasaki L Marino-Vazquez, et al. 2008 "Natural" human leukocyte antigen antibodies found in nonalloimmunized healthy males Transplantation 86 1111 1115 18946350 10.1097/TP.0b013e318186d87b 1:CAS:528:DC%2BD1cXht1OksrrE
53. K Nagahama E Nishimura S Sakaguchi 2007 Induction of tolerance by adoptive transfer of Treg cells Methods Mol Biol 380 431 442 17876110 10.1007/978-1-59745-395-0-27 1:CAS:528:DC%2BD2sXot1agu7k%3D
54. J Pearl J Parris D Hale S Hoffman W Bernstein K McCoy, et al. 2005 Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion Am J Transplant 5 465 474 15707400 10.1111/j.1600-6143.2005.00759.x 1:CAS:528:DC%2BD2MXivFSisb0%3D
55. M Rist C Smith M Beil, et al. 2009 Cross-recognition of HLA-DR4 alloantigen by virus-specific CD8+ T-cells: a new paradigm for self/non-self recognition Blood 114 2244 2253 19617574 10.1182/blood-2009-05-222596 1:CAS:528:DC%2BD1MXhtFOgtrfO
56. H Schild O Rotzschke H Kalbacher H Rammensee 1990 Limit of T cell tolerance to self-proteins by peptide presentation Science 247 1587 1589 2321019 10.1126/science.2321019 1:CAS:528:DyaK3cXitFCrsL4%3D
57. L Selin M Brehm 2007 Frontiers in nephrology: heterologous immunity, T cell cross-reactivity and alloreactivity J Am Soc Nephrol 18 2268 2277 17634431 10.1681/ASN.2007030295 1:CAS:528:DC%2BD2sXpslersr8%3D
58. D Umetsu E Yunis Y Matsui H Jabara R Geha 1985 HLA-DR4-associated alloreactivity of an HLA-DR3-restricted tetanus toxoid-specific T-cell clone: inhibition of both reactivities by an alloantiserum Eur J Immunol 15 356 361 3157581 10.1002/eji.1830150410 1:STN:280:DyaL2M7nvFOnuw%3D%3D
59. F van der Woude M Daha A Miltenburg, et al. 1990 Renal allograft-infiltrated lymphocytes and proximal tubular cells: further analysis of donor-specific lysis Hum Immunol 28 186 192 2351568 10.1016/0198-8859(90) 90018-K
60. V Venturi D Price D Douek M Davenport 2008 The molecular basis for public T-cell responses? Nat Rev Immunol 8 231 238 18301425 10.1038/nri2260 1:CAS:528:DC%2BD1cXisVKjsrk%3D
61. T Wang L Chen E Ahmed, et al. 2008 Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes J Immunol 180 5991 5999 18424719 1:CAS:528:DC%2BD1cXkvVCjsL4%3D
62. S Webb J Sprent 1986 T cells with multiple specificities Int Rev Immunol 1 151 10.3109/08830188609056605
63. R Welsh L Selin 2002 No one is naïve: the significance of heterologous T-cell immunity Nat Rev Immunol 2 417 426 12093008 1:CAS:528:DC%2BD38Xksl2murY%3D
64. R Welsh T Markees B Woda, et al. 2000 Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody J Virol 74 2210 2218 10666251 10.1128/JVI.74.5.2210-2218.2000 1:CAS:528:DC%2BD3cXhtF2kt78%3D
65. A Whitelegg L Barber 2004 The structural basis of T-cell allorecognition Tissue Antigens 63 101 108 14705981 10.1111/j.1399-0039.2004.00188.x 1:CAS:528:DC%2BD2cXhs1SnsLw%3D
66. H Yang R Welsh 1986 Induction of alloreactive cytotoxic T cells by acute virus infection of mice J Immunol 136 1186 1193 2418107 1:STN:280: DyaL287htleqsw%3D%3D
67. B Yard F Claas M Paape, et al. 1994 Recognition of a tissue-specific polymorphism by graft infiltrating T-cell clones isolated from a renal allograft with acute rejection Nephrol Dial Transplant 9 805 810 7970123 1:STN:280:DyaK2M%2FmtVWlsQ%3D%3D
68. Y Yin R Marluzza 2009 The multiple mechanisms of T cell receptor cross-reactivity Immunity 31 849 851 20064442 10.1016/j.immuni.2009.12.002 1:CAS:528:DC%2BC3cXht1Cjsrc%3D
69. Z Yi-qun J van Neervan A Kasran M de Boer J Ceuppens 1996 Differential requirements for co-stimulatory signals from B7 family members by resting versus recently activated memory T cells towards soluble recall antigens Int Immunol 8 37 44 8671587 10.1093/intimm/8.1.37 1:STN:280:DyaK28zisVOnsQ%3D%3D
70. J Zerrahn W Held D Raulet 1997 The MHC reactivity of the T cell repertoire prior to positive and negative selection Cell 88 627 636 9054502 10.1016/S0092-8674(00)81905-4 1:CAS:528:DyaK2sXhvVSitL4%3D