Quantitative and functional diversity of cross-reactive EBV-specific CD8+ T cells in a longitudinal study cohort of lung transplant recipients

Transplantation

Volumn 90, Issue 12, 2010, Pages 1439-1449

  Mifsud, Nicole A ^a   Nguyen, Thi Hoang Oanh ^a   Tait, Brian D ^b   Kotsimbos, Tom C ^a,c  

^a MONASH UNIVERSITY   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c ALFRED HOSPITAL   (Australia)

Author keywords

Cross reactivity; Lung transplant recipients; T cells

Indexed keywords

ALLOANTIGEN; GAMMA INTERFERON; HLA B ANTIGEN; HLA B44 ANTIGEN; HLA B4402 ANTIGEN; HLA B8 ANTIGEN; IMMUNOSUPPRESSIVE AGENT; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; UNCLASSIFIED DRUG;

ADULT; AGED; ALLOIMMUNITY; ANTIGEN EXPRESSION; ARTICLE; BLOOD SAMPLING; CD8+ T LYMPHOCYTE; CELL ISOLATION; CELL SPECIFICITY; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS REACTION; CYTOKINE PRODUCTION; CYTOTOXICITY; EPSTEIN BARR VIRUS; FEMALE; FLOW CYTOMETRY; GRAFT RECIPIENT; HUMAN; HUMAN CELL; IMMUNOPROPHYLAXIS; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; LONGITUDINAL STUDY; LUNG GRAFT REJECTION; LUNG LAVAGE; LUNG TRANSPLANTATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; TREATMENT OUTCOME; VIRUS IMMUNITY; VIRUS REACTIVATION;

B-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; COHORT STUDIES; CROSS REACTIONS; DNA, VIRAL; EPSTEIN-BARR VIRUS INFECTIONS; GENETIC VARIATION; HERPESVIRUS 4, HUMAN; HLA-B ANTIGENS; HLA-B8 ANTIGEN; HUMANS; IMMUNOLOGIC MEMORY; ISOANTIGENS; LUNG TRANSPLANTATION; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; TRANSPLANTATION, HOMOLOGOUS;

EID: 78650826471     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181ff4ff3     Document Type: Article

References (43)

1. Estenne M, Hertz MI. Bronchiolitis obliterans after human lung transplantation. Am J Respir Crit Care Med 2002; 166: 440.
2. Estenne M, Maurer JR, Boehler A, et al. Bronchiolitis obliterans syndrome 2001: An update of the diagnostic criteria. J Heart Lung Transplant 2002; 21: 297.
3. Boehler A, Estenne M. Post-transplant bronchiolitis obliterans. Eur Respir J 2003; 22: 1007.
4. Ison MG. Influenza, including the novel H1N1, in organ transplant patients. Curr Opin Infect Dis 2010; 23: 365.
5. Liu M, Mallory GB, Schecter MG, et al. Long-term impact of respiratory viral infection after pediatric lung transplantation. Pediatr Transplant 2010; 14: 431.
6. Burrows SR, Khanna R, Silins SL, et al. The influence of antiviral T-cell responses on the alloreactive repertoire. Immunol Today 1999; 20: 203.
7. Welsh RM, Selin LK. No one is naive: The significance of heterologous T-cell immunity. Nat Rev Immunol 2002; 2: 417.
8. Adams AB, Pearson TC, Larsen CP. Heterologous immunity: An overlooked barrier to tolerance. Immunol Rev 2003; 196: 147.
9. Adams AB, Williams MA, Jones TR, et al. Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest 2003; 111: 1887.
10. Mariuzza RA, Poljak RJ. The basics of binding: Mechanisms of antigen recognition and mimicry by antibodies. Curr Opin Immunol 1993; 5: 50.
11. Oldstone MB. Molecular mimicry and autoimmune disease. Cell 1987; 50: 819.
12. Merkenschlager M, Terry L, Edwards R, et al. Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: Implications for differential CD45 expression in T cell memory formation. Eur J Immunol 1988; 18: 1653.
13. Lombardi G, Sidhu S, Daly M, et al. Are primary alloresponses truly primary? Int Immunol 1990; 2: 9.
14. Macedo C, Orkis EA, Popescu I, et al. Contribution of naive and memory T-cell populations to the human alloimmune response. Am J Transplant 2009; 9: 2057.
15. Lindahl KF, Wilson DB. Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors. J Exp Med 1977; 145: 508.
16. Suchin EJ, Langmuir PB, Palmer E, et al. Quantifying the frequency of alloreactive T cells in vivo: New answers to an old question. J Immunol 2001; 166: 973.
17. Baker RJ, Hernandez-Fuentes MP, Brookes PA, et al. The role of the allograft in the induction of donor-specific T cell hyporesponsiveness. Transplantation 2001; 72: 480.
18. Ashwell JD, Chen C, Schwartz RH. High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules. J Immunol 1986; 136: 389.
19. Hislop AD, Annels NE, Gudgeon NH, et al. Epitope-specific evolution of human CD8(-) T cell responses from primary to persistent phases of Epstein-Barr virus infection. J Exp Med 2002; 195: 893.
20. Levitsky V, de Campos-Lima PO, Frisan T, et al. The clonal composition of a peptide-specific oligoclonal CTL repertoire selected in response to persistent EBV infection is stable over time. J Immunol 1998; 161: 594.
21. Maecker HT, Maino VC. Analyzing T-cell responses to cytomegalovirus by cytokine flow cytometry. Hum Immunol 2004; 65: 493.
22. Benninger-Doring G, Pepperl S, Deml L, et al. Frequency of CD8(-) T lymphocytes specific for lytic and latent antigens of Epstein-Barr virus in healthy virus carriers. Virology 1999; 264: 289.
23. Burrows SR, Khanna R, Burrows JM, et al. An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: Implications for graft-versushost disease. J Exp Med 1994; 179: 1155.
24. Burrows SR, Silins SL, Cross SM, et al. Human leukocyte antigen phenotype imposes complex constraints on the antigen-specific cytotoxic T lymphocyte repertoire. Eur J Immunol 1997; 27: 178.
25. Elkington R, Walker S, Crough T, et al. Ex vivo profiling of CD8-Tcell responses to human cytomegalovirus reveals broad and multispecific reactivities in healthy virus carriers. J Virol 2003; 77: 5226.
26. Koelle DM, Chen HB, McClurkan CM, et al. Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles. Blood 2002; 99: 3844.
27. Gamadia LE, Remmerswaal EB, Surachno S, et al. Cross-reactivity of cytomegalovirus-specific CD8- T cells to allo-major histocompatibility complex class I molecules. Transplantation 2004; 77: 1879.
28. Rist M, Smith C, Bell MJ, et al. Cross-recognition of HLA DR4 alloantigen by virus-specific CD8- T cells: A new paradigm for self-/nonselfrecognition. Blood 2009; 114: 2244.
29. Amir AL, D'Orsogna LJ, Roelen DL, et al. Allo-HLA reactivity of virusspecific memory T cells is common. Blood 2010; 115: 3146.
30. Cainelli F, Vento S. Infections and solid organ transplant rejection: A cause-and-effect relationship? Lancet Infect Dis 2002; 2: 539.
31. Westall GP, Brooks AG, Kotsimbos T. CD8- T-cell maturation following lung transplantation: The differential impact of CMV and acute rejection. Transpl Immunol 2007; 18: 186.
32. Westall GP, Michaelides A, Williams TJ, et al. Bronchiolitis obliterans syndrome and early human cytomegalovirus DNAaemia dynamics after lung transplantation. Transplantation 2003; 75: 2064.
33. Argaet VP, Schmidt CW, Burrows SR, et al. Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. J Exp Med 1994; 180: 2335.
34. Turner SJ, Doherty PC, McCluskey J, et al. Structural determinants of T-cell receptor bias in immunity. Nat Rev Immunol 2006; 6: 883.
35. Wynn KK, Fulton Z, Cooper L, et al. Impact of clonal competition for peptide-MHC complexes on the CD8- T-cell repertoire selection in a persistent viral infection. Blood 2008; 111: 4283.
36. Burrows SR, Silins SL, Moss DJ, et al. T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen. J Exp Med 1995; 182: 1703.
37. D'Orsogna LJ, Amir AL, Zoet YM, et al. New tools to monitor the impact of viral infection on the alloreactive T-cell repertoire. Tissue Antigens 2009; 74: 290.
38. Macdonald WA, Chen Z, Gras S, et al. T cell allorecognition via molecular mimicry. Immunity 2009; 31: 897.
39. Mifsud NA, Purcell AW, Chen W, et al. Immunodominance hierarchies and gender bias in direct T(CD8)-cell alloreactivity. Am J Transplant 2008; 8: 121.
40. Westall G, Kotsimbos T, Brooks A. CMV-specific CD8 T-cell dynamics in the blood and the lung allograft reflect viral reactivation following lung transplantation. Am J Transplant 2006; 6: 577.
41. Kotsimbos AT, Sinickas V, Glare EM, et al. Quantitative detection of human cytomegalovirus DNA in lung transplant recipients. Am J Respir Crit Care Med 1997; 156: 1241.
42. Macdonald WA, Purcell AW, Mifsud NA, et al. A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition. J Exp Med 2003; 198: 679.
43. Nguyen TH, Sullivan LC, Kotsimbos TC, et al. Cross-presentation of HCMVchimeric protein enables generation and measurement of polyclonal T cells. Immunol Cell Biol 2010; 88: 676.