Cross-linking of protein crystals as an aid in the generation of binary protein-ligand crystal complexes, exemplified by the human PDE10a-papaverine structure

Acta Crystallographica Section D: Biological Crystallography

Volumn 65, Issue 8, 2009, Pages 872-874

  Andersen, Ole Andreas ^a   Schönfeld, Dorian Leo ^a   Toogood Johnson, Ian ^a   Felicetti, Brunella ^a   Albrecht, Claudia ^b   Fryatt, Tara ^a   Whittaker, Mark ^a   Hallett, David ^a   Barker, John ^a  

^a EVOTEC UK LTD   (United Kingdom)

^b EVOTEC AG   (Germany)

Author keywords

Cross linking; Hydrolases; Papaverine; Phosphodiesterase

Indexed keywords

CROSS LINKING REAGENT; GLUTARALDEHYDE; LIGAND; MULTIPROTEIN COMPLEX; PAPAVERINE; PDE10A PROTEIN, HUMAN; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR;

ARTICLE; CHEMISTRY; CRYSTALLIZATION; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

CROSS-LINKING REAGENTS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; GLUTARAL; HUMANS; LIGANDS; MULTIPROTEIN COMPLEXES; PAPAVERINE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 68349137530     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444909017855     Document Type: Article

References (11)

1. Chappie, T. A., Humphrey, J. M., Allen, M. P., Estep, K. G., Fox, C. B., Lebel, L. A., Liras, S., Marr, E. S., Menniti, F. S., Pandit, J., Schmidt, C. J., Tu, M., Williams, R. D. & Yang, F. V. (2007). J. Med. Chem. 50, 182-185.
2. Emsley, P. & Cowtan, K. (2004). Acta Cryst. D60, 2126-2132.
3. Evans, P. (2006). Acta Cryst. D62, 72-82.
4. Leslie, A. G. W. (2006). Acta Cryst. D62, 48-57.
5. Lugnier, C. (2006). Pharmacol. Ther. 109, 366-398.
6. Lusty, C. J. (1999). J. Appl. Cryst. 32, 106-112.
7. Murshudov, G. N., Vagin, A. A. & Dodson, E. J. (1997). Acta Cryst. D53, 240-255.
8. Siuciak, J. A., Chapin, D. S., Harms, J. F., Lebel, L. A., McCarthy, S. A., Chambers, L., Shrikhande, A., Wong, S., Menniti, F. S. & Schmidt, C. J. (2006). Neuropharmacology, 51, 386-396.
9. Vagin, A. & Teplyakov, A. (1997). J. Appl. Cryst. 30, 1022-1025.
10. Wang, H., Liu, Y., Hou, J., Zheng, M., Robinson, H. & Ke, H. (2007). Proc. Natl Acad. Sci. USA, 104, 5782-5787.
11. Wine, Y., Cohen-Hadar, N., Freeman, A. & Frolow, F. (2007). Biotechnol. Bioeng. 98, 711-718.