EP 2 and EP 4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 302, Issue 5, 2012, Pages

  Tajima, Tsuyoshi ^a,b   Murata, Takahisa ^a   Aritake, Kosuke ^c   Urade, Yoshihiro ^c   Michishita, Masaki ^b   Matsuoka, Toshiyuki ^d   Narumiya, Shuh ^d   Ozaki, Hiroshi ^a   Hori, Masatoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIPPON VETERINARY AND LIFE SCIENCE UNIVERSITY   (Japan)

^c OSAKA BIOSCIENCE INSTITUTE   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Inflammation; Intestinal motility; Nitric oxide; Prostaglandins

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; COLONY STIMULATING FACTOR 1; CYCLIC AMP; CYCLOOXYGENASE 2; DIBUTYRYLCYTIDINE 3',5' PHOSPHATE; FORSKOLIN; INDUCIBLE NITRIC OXIDE SYNTHASE; KT 5720; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 4; 3 (4 METHYLSULFONYLPHENYL) 4 PHENYL 5 TRIFLUOROMETHYLISOXAZOLE; 3-(4-METHYLSULFONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE; CARBAZOLE DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR; FLAVONOID; ISOXAZOLE DERIVATIVE; NOS2 PROTEIN, MOUSE; PROSTAGLANDIN E2; PTGER4 PROTEIN, MOUSE; PYRROLE DERIVATIVE; SULFONE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CELL ISOLATION; CELL PHAGOCYTOSIS; CONTROLLED STUDY; ENZYME INDUCTION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; ILEUM; IMMUNOHISTOCHEMISTRY; INTESTINAL DYSMOTILITY; INTESTINE MUSCLE; MACROPHAGE; MALE; MEASUREMENT; MOUSE; MUSCLE TONE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURIFICATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE CONTRACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; GASTROINTESTINAL MOTILITY; METABOLISM; PHYSIOLOGY;

ANIMALS; CARBAZOLES; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; FLAVONOIDS; GASTROINTESTINAL MOTILITY; ILEUM; ISOXAZOLES; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; NITRIC OXIDE SYNTHASE TYPE II; PYRROLES; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; SULFONES; UP-REGULATION;

EID: 84857327414     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00264.2011     Document Type: Article

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