Mutation in the CPC motif-containing 6th transmembrane domain affects intracellular localization, trafficking and copper transport efficiency of ATP7A protein in mosaic mutant mice - An animal model of Menkes disease

Metallomics

Volumn 4, Issue 2, 2012, Pages 197-204

  Lenartowicz, Małgorzata ^a   Grzmil, Paweł ^a,b   Shoukier, Moneef ^b   Starzyński, Rafał ^c   Marciniak, Marcin ^a   Lipiński, Paweł ^c  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c INSTITUTE OF GENETICS AND ANIMAL BREEDING   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; CELL MEMBRANES; COPPER; CYTOLOGY; GENES; PHYSIOLOGY; PROTEINS; TRACE ELEMENTS;

ANIMAL MODEL; BINDING COPPER; COPPER ACCUMULATION; COPPER CONCENTRATION; COPPER HOMEOSTASIS; COPPER TRANSPORT; INTRACELLULAR LOCALIZATION; KIDNEY CELLS; LIVING ORGANISMS; MOLECULAR DEFECTS; MOUSE MODELS; MUTANT MICE; NEURODEGENERATIVE DISORDERS; NUCLEOTIDE EXCHANGE; SMALL INTESTINE; TRANS-GOLGI NETWORK; TRANS-MEMBRANE DOMAINS;

MAMMALS;

ARGININE; COPPER; CYTOSINE; GUANINE; MEMBRANE PROTEIN; MENKES PROTEIN; PROLINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN; CELL ISOLATION; CELL MIGRATION; CONTROLLED STUDY; COPPER DEFICIENCY; COPPER METABOLISM; EXON; FEMALE; GENE FUNCTION; GENE MUTATION; HEART; INTRACELLULAR TRANSPORT; KIDNEY; KIDNEY CELL; LIVER; MALE; MENKES SYNDROME; MOSAICISM; MOUSE; MOUSE MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SMALL INTESTINE;

EID: 84857293506     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c1mt00134e     Document Type: Article

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