The Menkes copper transporter is required for the activation of tyrosinase

Human Molecular Genetics

Volumn 9, Issue 19, 2000, Pages 2845-2851

  Petris, Michael J ^a,b   Strausak, Daniel ^a   Mercer, Julian F B ^a  

^a DEAKIN UNIVERSITY   (Australia)

^b University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ASPARTIC ACID; CARRIER PROTEIN; COPPER; CYTOCHROME C OXIDASE; DOPAMINE BETA MONOOXYGENASE; MELANIN; MONOPHENOL MONOOXYGENASE; PROTEIN LYSINE 6 OXIDASE; RECOMBINANT ENZYME;

ARTICLE; CELL MEMBRANE TRANSPORT; CELLULAR DISTRIBUTION; CHELATION; CONTROLLED STUDY; COPPER DEFICIENCY; COPPER METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; FIBROBLAST; GENE MUTATION; GENETIC RECOMBINATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR TRANSPORT; MAMMAL CELL; MELANOGENESIS; MENKES SYNDROME; PATHOGENESIS; PIGMENTATION; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSPORT KINETICS; X CHROMOSOME LINKAGE;

MAMMALIA;

EID: 0034703872     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.19.2845     Document Type: Article

References (33)

1. A sex-linked recessive disorder with retardation of growth, peculiar hair, and focal cerebral and cerebellar degeneration
2. The metabolic and molecular basis of inherited disease
3. Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase
4. Isolation of a partial candidate gene for Menkes disease by postional cloning
5. Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein
6. Uptake and efflux of copper-64 in Menkes-disease and normal continuous lymphoid cell lines
7. Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux
8. Functional analysis and intracellular localization of the human Menkes protein (MNK) stably expressed from a cDNA construct in Chinese hamster ovary cells (CHO-K1)
9. Immunocytochemical localization of the Menkes copper transporter (ATP7A) to the trans compartment of the Golgi complex
10. Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: A novel mechanism of regulated trafficking
11. Biochemical characterization and intracellular localization of the Menkes disease protein
12. Tyrosinase: A comprehensive review of its mechanism
13. Functional analysis of alternatively spliced tyrosinase gene transcripts
14. Mutational analysis of copper binding by human tyrosinase
15. Induction of pigmentation in mouse fibroblasts by expression of human tyrosinase cDNA
16. Mutations at critical N-glycosylation sites reduce tyrosinase activity by altering folding and quality control
17. Promotion of tyrosinase folding in COS 7 cells by calnexin
18. Correction of the copper transport defect of Menkes patient fibroblasts by expression of the Menkes and Wilson ATPases
19. A cytoplasmic sequence in human tyrosinase defines a second class of di-leucine-based sorting signals for late endosomal and lysosomal delivery
20. DNA enhances melanogenesis
21. CPX-type ATPases: A class of P-type ATPases that pump heavy metals
22. Sequence, mapping and disruption of CCC2, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants and encodes a P-type ATPase belonging to the Cu(2+)-ATPase subfamily
23. The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake
24. Functional expression of the Menkes disease protein reveals common biochemical mechanisms among the copper-transporting P-type ATPases
25. Caenorhabditis elegans cDNA for a Menkes/Wilson disease gene homologue and its function in a yeast CCC2 gene deletion mutant
26. Tyrosinase folding and copper loading in vivo: A crucial role for calnexin and alpha-glucosidase II
27. Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase
28. Unusual copper-induced sensitization of the biological damage due to superoxide radicals
29. The copper chaperone for superoxide dismutase
30. HAH1 is a copper-binding protein with distinct amino acid residues mediating copper homeostasis and antioxidant defense
31. The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal
32. Immunophenotyping of melanomas for tyrosinase: Implications for vaccine development
33. Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein