Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)- 1-phenylethanol derivatives

European Journal of Medicinal Chemistry

Volumn 49, Issue , 2012, Pages 334-342

  De Vita, Daniela ^a   Scipione, Luigi ^a   Tortorella, Silvano ^a   Mellini, Paolo ^a   Di Rienzo, Barbara ^a   Simonetti, Giovanna ^b   D'Auria, Felicia Diodata ^b   Panella, Simona ^b   Cirilli, Roberto ^c   Di Santo, Roberto ^a   Palamara, Anna Teresa ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Antifungal imidazoles; Candida albicans species; Enantiomers separation; Human monocytic cell line; Non albicans Candida species

Indexed keywords

1 (4 CHLOROPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYL (2,6 DICHLOROPYRIDIN 4 YL)CARBAMATE; 1 (4 CHLOROPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYL 3 (TRIFLUOROMETHYL)BENZOATE; 1 (4 CHLOROPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYL [(4 PROPAN 2 YL)PHENYL]CARBAMATE; 1 (4 CHLOROPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYL BIPHENYL 4 CARBOXYLATE; 1 (4 CHLOROPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYL PHENOXYACETATE; 1 (4 FLUOROPHENYL) 2 (1H IMIDAZOL 1 YL) 1 PHENYLETHYL [4 (PROPAN 2 YL)PHENYL]CARBAMATE; 1 (4 FLUOROPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYL 3 (TRIFLUOROMETHYL)BENZOATE; 1 (4 FLUOROPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYL BIPHENYL 4 CARBOXYLATE; 1 (4 FLUOROPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYL PHENOXYACETATE; 1 (4 TRIFLUOROPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYL 3 (TRIFLUOROMETHYL)BENZOATE; 2 (1H IMIDAZOL 1 YL) 1 PHENYLETHANOL DERIVATIVE; 2 (1H IMIDAZOL 1 YL) 1 PHENYLETHYL 3 (TRIFLUOROMETHYL)BENZOATE; 2 (1H IMIDAZOL 1 YL) 1 PHENYLETHYL 4 (TRIFLUOROMETHYL)BENZOATE; 2 (1H IMIDAZOL 1 YL) 1 PHENYLETHYL [4 (PROPAN 2 YL)PHENYL]CARBAMATE; 2 (1H IMIDAZOL 1 YL) 1 PHENYLETHYL BIPHENYL 4 CARBOXYLATE; 2 (1H IMIDAZOL 1 YL)ETHANOL; ANTIFUNGAL AGENT; CARBAMIC ACID DERIVATIVE; ESTER DERIVATIVE; FLUCONAZOLE; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA; CANDIDA ALBICANS; CANDIDA KRUSEI; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOMER; FUNGAL STRAIN; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; MONOCYTE; NONHUMAN; RACEMIC MIXTURE;

ANTIFUNGAL AGENTS; CANDIDA; CANDIDA ALBICANS; CANDIDIASIS; CELL LINE; HUMANS; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; PHENYLETHYL ALCOHOL;

EID: 84857239066     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.034     Document Type: Article

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