A sensitive method for determination of platycodin D in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study

Planta Medica

Volumn 78, Issue 3, 2012, Pages 244-251

  Pei, Lixia ^a   Bao, Yuanwu ^a   Ma, Lei ^b   Wang, Qiqi ^b   Ye, Yiyi ^a   Han, Xianghui ^a   Liu, Sheng ^a   Chen, Xiuping ^c  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY OF MACAU   (Macao)

Author keywords

Campanulaceae; LC MS MS; pharmacokinetics; platycodin D; Platycodon grandiflorum A. DC; tubeimoside I

Indexed keywords

METHANOL; PLANT EXTRACT; PLATYCODIN; TRITERPENOID; TUBEIMOSIDE I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CHROMATOGRAPHY, LIQUID; MALE; PLANT EXTRACTS; PLATYCODON; RATS; SAPONINS; TANDEM MASS SPECTROMETRY; TRITERPENES;

CAMPANULACEAE; PLATYCODON GRANDIFLORUM; RATTUS;

EID: 84857236211     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1280372     Document Type: Article

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