Increased levels of angiopoietins 1 and 2 in sputum supernatant in severe refractory asthma

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 67, Issue 3, 2012, Pages 396-402

  Tseliou, E ^a   Bakakos, P ^a   Kostikas, K ^a   Hillas, G ^b   Mantzouranis, K ^a   Emmanouil, P ^a   Simoes, D ^c   Alchanatis, M ^a   Papiris, S ^a   Loukides, S ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b SOTIRIA GENERAL HOSPITAL   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

angiopoietins; asthma; inflammation; severe refractory; vascular remodeling

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; GELATINASE A; INTERLEUKIN 13; INTERLEUKIN 8; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN;

ADULT; ARTICLE; ASTHMA; CONTROLLED STUDY; DISEASE SEVERITY; EOSINOPHIL; FEMALE; HUMAN; INFLAMMATION; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEVERE REFRACTORY ASTHMA; SPUTUM ANALYSIS; SPUTUM LEVEL;

AGED; AIRWAY REMODELING; ANGIOPOIETIN-1; ANGIOPOIETIN-2; ASTHMA; BRONCHIAL HYPERREACTIVITY; CAPILLARY PERMEABILITY; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; RESPIRATORY FUNCTION TESTS; SEVERITY OF ILLNESS INDEX; SPUTUM;

EID: 84857194016     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2011.02768.x     Document Type: Article

References (28)

1. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. Am J Respir Crit Care Med 2000; 162: 2341-2351.
2. Vrugt B, Wilson S, Bron A, Holgate ST, Djukanovic R, Aalbers R,. Bronchial angiogenesis in severe glucocorticoid-dependent asthma. Eur Respir J 2000; 15: 1014-1021.
3. Chanez P, Wenzel SE, Anderson GP, Anto JM, Bel EH, Boulet LP, et al. Severe asthma in adults: what are the important questions? J Allergy Clin Immunol 2007; 119: 1337-1348.
4. Zanini A, Chetta A, Imperatori AS, Spanevello A, Olivieri D,. The role of the bronchial microvasculature in the airway remodelling in asthma and COPD. Respir Res 2010; 11: 132.
5. Walters EH, Soltani A, Reid DW, Ward C,. Vascular remodelling in asthma. Curr Opin Allergy Clin Immunol 2008; 8: 39-43.
6. Papaioannou AI, Kostikas K, Kollia P, Gourgoulianis KI,. Clinical implications for vascular endothelial growth factor in the lung: friend or foe? Respir Res 2006; 7: 128.
7. Hoshino M, Takahashi M, Takai Y, Sim J, Aoike N,. Inhaled corticosteroids decrease vascularity of the bronchial mucosa in patients with asthma. Clin Exp Allergy 2001; 31: 722-730.
8. Goldie RG, Pedersen KE,. Mechanisms of increased airway microvascular permeability: role in airway inflammation and obstruction. Clin Exp Pharmacol Physiol 1995; 22: 387-396.
9. Makinde T, Murphy RF, Agrawal DK,. Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling. Curr Mol Med 2006; 6: 831-841.
10. Kanazawa H,. VEGF, angiopoietin-1 and -2 in bronchial asthma: new molecular targets in airway angiogenesis and microvascular remodeling. Recent Pat Inflamm Allergy Drug Discov 2007; 1: 1-8.
11. Simoes DC, Vassilakopoulos T, Toumpanakis D, Petrochilou K, Roussos C, Papapetropoulos A,. Angiopoietin-1 protects against airway inflammation and hyperreactivity in asthma. Am J Respir Crit Care Med 2008; 177: 1314-1321.
12. Kanazawa H, Nomura S, Asai K,. Roles of angiopoietin-1 and angiopoietin-2 on airway microvascular permeability in asthmatic patients. Chest 2007; 131: 1035-1041.
13. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31: 143-178.
14. Kips JC, Fahy JV, Hargreave FE, Ind PW, in't Veen JC,. Methods for sputum induction and analysis of induced sputum: a method for assessing airway inflammation in asthma. Eur Respir J Suppl 1998; 26: 9S-12S.
15. Grootendorst DC, van den Bos JW, Romeijn JJ, Veselic-Charvat M, Duiverman EJ, Vrijlandt EJ, et al. Induced sputum in adolescents with severe stable asthma. Safety and the relationship of cell counts and eosinophil cationic protein to clinical severity. Eur Respir J 1999; 13: 647-653.
16. Efthimiadis A, Spanevello A, Hamid Q, Kelly MM, Linden M, Louis R, et al. Methods of sputum processing for cell counts, immunocytochemistry and in situ hybridisation. Eur Respir J Suppl 2002; 37: 19s-23s.
17. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 1995; 152: 1107-1136.
18. Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 2000; 161: 309-329.
19. Menzies D, Nair A, Lipworth BJ,. Portable exhaled nitric oxide measurement: comparison with the "gold standard" technique. Chest 2007; 131: 410-414.
20. Kanazawa H, Nomura S, Yoshikawa J,. Role of microvascular permeability on physiologic differences in asthma and eosinophilic bronchitis. Am J Respir Crit Care Med 2004; 169: 1125-1130.
21. Pichiule P, Chavez JC, LaManna JC,. Hypoxic regulation of angiopoietin-2 expression in endothelial cells. J Biol Chem 2004; 279: 12171-12180.
22. Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996; 87: 1171-1180.
23. Feistritzer C, Mosheimer BA, Sturn DH, Bijuklic K, Patsch JR, Wiedermann CJ,. Expression and function of the angiopoietin receptor Tie-2 in human eosinophils. J Allergy Clin Immunol 2004; 114: 1077-1084.
24. Lee KS, Min KH, Kim SR, Park SJ, Park HS, Jin GY, et al. Vascular endothelial growth factor modulates matrixmetalloproteinase-9 expression in asthma. Am J Respir Crit Care Med 2006; 174: 161-170.
25. Broide DH,. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol 2008; 121: 560-570; quiz 571-2.
26. Zanini A, Chetta A, Saetta M, Baraldo S, D'Ippolito R, Castagnaro A, et al. Chymase-positive mast cells play a role in the vascular component of airway remodeling in asthma. J Allergy Clin Immunol 2007; 120: 329-333.
27. Chetta A, Zanini A, Foresi A, Del Donno M, Castagnaro A, D'Ippolito R, et al. Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone. Am J Respir Crit Care Med 2003; 167: 751-757.
28. Feltis BN, Wignarajah D, Reid DW, Ward C, Harding R, Walters EH,. Effects of inhaled fluticasone on angiogenesis and vascular endothelial growth factor in asthma. Thorax 2007; 62: 314-319.