-
1
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
3
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander, H.M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
4
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7: 11-20.
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
Deberardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
5
-
-
76649102764
-
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
-
Clower CV, et al. The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci U S A 2010; 107: 1894-1899.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 1894-1899
-
-
Clower, C.V.1
-
7
-
-
0026467983
-
Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells
-
Eigenbrodt E, Reinacher M, Scheefers-Borchel U, Scheefers H, Friis R. Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. Crit Rev Oncog 1992; 3, 91-115.
-
(1992)
Crit Rev Oncog
, vol.3
, pp. 91-115
-
-
Eigenbrodt, E.1
Reinacher, M.2
Scheefers-Borchel, U.3
Scheefers, H.4
Friis, R.5
-
8
-
-
0032520197
-
The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate
-
Jurica MS, et al. The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. Structure 1998; 6: 195-210.
-
(1998)
Structure
, vol.6
, pp. 195-210
-
-
Jurica, M.S.1
-
9
-
-
0034451550
-
Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells
-
Mazurek S, et al. Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells. Anticancer Res 2000; 20 5151-5154.
-
(2000)
Anticancer Res
, vol.20
, pp. 5151-5154
-
-
Mazurek, S.1
-
10
-
-
78349269485
-
Human pyruvate kinase M2: A multifunctional protein
-
Gupta V, Bamezai RN. Human pyruvate kinase M2: a multifunctional protein. Protein Sci 2010; 19: 2031-2044.
-
(2010)
Protein Sci
, vol.19
, pp. 2031-2044
-
-
Gupta, V.1
Bamezai, R.N.2
-
11
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk HR, et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008; 452: 230-233.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
-
12
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosinebinding protein
-
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosinebinding protein. Nature 2008; 452: 181-186.
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander, H.M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
13
-
-
75149150660
-
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
-
David CJ, Chen M, Assanah M, Canoll P, Manley JL. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 2010; 463: 364-368.
-
(2010)
Nature
, vol.463
, pp. 364-368
-
-
David, C.J.1
Chen, M.2
Assanah, M.3
Canoll, P.4
Manley, J.L.5
-
14
-
-
82755166890
-
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
-
Anastasiou D, et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 2011; 334: 1278-1828.
-
(2011)
Science
, vol.334
, pp. 1278-1828
-
-
Anastasiou, D.1
-
15
-
-
80053922625
-
Metabolic flux and the regulation of Mammalian cell growth
-
Locasale JW, Cantley LC. Metabolic flux and the regulation of Mammalian cell growth. Cell Metab 2011; 14: 443-451.
-
(2011)
Cell Metab
, vol.14
, pp. 443-451
-
-
Locasale, J.W.1
Cantley, L.C.2
-
16
-
-
21844468220
-
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
-
Dombrauckas JD, Santarsiero BD, Mesecar AD. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry 2005; 44: 9417-9429.
-
(2005)
Biochemistry
, vol.44
, pp. 9417-9429
-
-
Dombrauckas, J.D.1
Santarsiero, B.D.2
Mesecar, A.D.3
-
17
-
-
0012288533
-
Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase
-
Kato H, Fukuda T, Parkison C, McPhie P, Cheng SY. Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase. Proc Natl Acad Sci U S A 1989; 86: 7861-7865.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 7861-7865
-
-
Kato, H.1
Fukuda, T.2
Parkison, C.3
McPhie, P.4
Cheng, S.Y.5
-
18
-
-
0022488438
-
The inhibitory effect of various fatty acids on aerobic glycolysis in Ehrlich ascites tumour cells
-
Marchut E, Guminska M, Kedryna T. The inhibitory effect of various fatty acids on aerobic glycolysis in Ehrlich ascites tumour cells. Acta Biochim Pol 1986; 33: 7-16.
-
(1986)
Acta Biochim Pol
, vol.33
, pp. 7-16
-
-
Marchut, E.1
Guminska, M.2
Kedryna, T.3
-
19
-
-
79958103961
-
Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
-
Mazurek S. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol 2011; 43: 969-980.
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 969-980
-
-
Mazurek, S.1
-
20
-
-
64049099095
-
Thyroid hormone mimetics: Potential applications in atherosclerosis, obesity and type 2 diabetes
-
Baxter JD, Webb P. Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov 2009; 8: 308-320.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 308-320
-
-
Baxter, J.D.1
Webb, P.2
-
21
-
-
0014429058
-
The regulation of pyruvate kinase of Escherichia coli by fructose diphosphate and adenylic acid
-
Maeba P, Sanwal BD. The regulation of pyruvate kinase of Escherichia coli by fructose diphosphate and adenylic acid. J Biol Chem 1968; 243: 448-450.
-
(1968)
J Biol Chem
, vol.243
, pp. 448-450
-
-
Maeba, P.1
Sanwal, B.D.2
-
22
-
-
63649159793
-
Shotgun redox proteomics identifies specifically modified cysteines in key metabolic enzymes under oxidative stress in Saccharomyces cerevisiae
-
McDonagh B, Ogueta S, Lasarte G, Padilla CA, Barcena JA. Shotgun redox proteomics identifies specifically modified cysteines in key metabolic enzymes under oxidative stress in Saccharomyces cerevisiae. J Proteomics 2009; 72: 677-689.
-
(2009)
J Proteomics
, vol.72
, pp. 677-689
-
-
McDonagh, B.1
Ogueta, S.2
Lasarte, G.3
Padilla, C.A.4
Barcena, J.A.5
-
23
-
-
34548588380
-
Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: Insights into the progression of this dementing disorder
-
Butterfield DA, Sultana R. Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder. J Alzheimers 2007; Dis 12: 61-72.
-
(2007)
J Alzheimers
, vol.12
, pp. 61-72
-
-
Butterfield, D.A.1
Sultana, R.2
-
24
-
-
2542469551
-
Protein disulfide bond formation in the cytoplasm during oxidative stress
-
Cumming RC, et al. Protein disulfide bond formation in the cytoplasm during oxidative stress. J Biol Chem 2004; 279: 21749-21758.
-
(2004)
J Biol Chem
, vol.279
, pp. 21749-21758
-
-
Cumming, R.C.1
-
25
-
-
67650071137
-
Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?
-
Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 2009; 8: 579-591.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 579-591
-
-
Trachootham, D.1
Alexandre, J.2
Huang, P.3
-
26
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato R, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 2011; 476: 346-350.
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
-
27
-
-
0023829928
-
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma
-
Snell K, Natsumeda Y, Eble JN, Glover JL, Weber G. Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma. Br J Cancer 1988; 57: 87-90.
-
(1988)
Br J Cancer
, vol.57
, pp. 87-90
-
-
Snell, K.1
Natsumeda, Y.2
Eble, J.N.3
Glover, J.L.4
Weber, G.5
-
28
-
-
80052258995
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
-
Locasale JW et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet 2011; 43: 869-874.
-
(2011)
Nat Genet
, vol.43
, pp. 869-874
-
-
Locasale, J.W.1
-
29
-
-
77449131347
-
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
-
Hitosugi T, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal 2009; 2: ra73.
-
(2009)
Sci Signal
, vol.2
-
-
Hitosugi, T.1
-
30
-
-
79959371914
-
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperonemediated autophagy and promotes tumor growth
-
Lv L, et al. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperonemediated autophagy and promotes tumor growth. Mol Cell 2011; 42: 719-730.
-
(2011)
Mol Cell
, vol.42
, pp. 719-730
-
-
Lv, L.1
-
32
-
-
4644265292
-
Faecal tumour M2 pyruvate kinase: A new, sensitive screening tool for colorectal cancer
-
Hardt PD, et al. Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer. Br J Cancer 2004; 91: 980-984.
-
(2004)
Br J Cancer
, vol.91
, pp. 980-984
-
-
Hardt, P.D.1
-
33
-
-
77249154640
-
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
-
Boxer MB, et al. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem 2010; 53: 1048-1055.
-
(2010)
J Med Chem
, vol.53
, pp. 1048-1055
-
-
Boxer, M.B.1
|