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Volumn 23, Issue SPEC. ISSUE, 2012, Pages 213-217

Cellular control mechanisms that regulate pyruvate kinase M2 activity and promote cancer growth

Author keywords

Alternative splicing; Anabolic glucose metabolism; Glycolysis; Reactive oxygen species

Indexed keywords

CYSTEINE; PYRUVATE KINASE; PYRUVATE KINASE M2; UNCLASSIFIED DRUG;

EID: 84857175147     PISSN: 0970938X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (6)

References (33)
  • 1
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 2
    • 0000459772 scopus 로고
    • Ueber den Stoffwechsel der Tumoren
    • Warburg O, Posener K, Negelein E. Ueber den Stoffwechsel der Tumoren. Biochem Z 1924; 152: 319-344.
    • (1924) Biochem Z , vol.152 , pp. 319-344
    • Warburg, O.1    Posener, K.2    Negelein, E.3
  • 3
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander, H.M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 4
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7: 11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 5
    • 76649102764 scopus 로고    scopus 로고
    • The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
    • Clower CV, et al. The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci U S A 2010; 107: 1894-1899.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1894-1899
    • Clower, C.V.1
  • 6
    • 23044500915 scopus 로고    scopus 로고
    • Pyruvate kinase type M2 and its role in tumor growth and spreading
    • Mazurek S, Boschek CB, Hugo F, Eigenbrodt E. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 2005; 15: 300-308.
    • (2005) Semin Cancer Biol , vol.15 , pp. 300-308
    • Mazurek, S.1    Boschek, C.B.2    Hugo, F.3    Eigenbrodt, E.4
  • 7
    • 0026467983 scopus 로고
    • Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells
    • Eigenbrodt E, Reinacher M, Scheefers-Borchel U, Scheefers H, Friis R. Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. Crit Rev Oncog 1992; 3, 91-115.
    • (1992) Crit Rev Oncog , vol.3 , pp. 91-115
    • Eigenbrodt, E.1    Reinacher, M.2    Scheefers-Borchel, U.3    Scheefers, H.4    Friis, R.5
  • 8
    • 0032520197 scopus 로고    scopus 로고
    • The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate
    • Jurica MS, et al. The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. Structure 1998; 6: 195-210.
    • (1998) Structure , vol.6 , pp. 195-210
    • Jurica, M.S.1
  • 9
    • 0034451550 scopus 로고    scopus 로고
    • Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells
    • Mazurek S, et al. Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells. Anticancer Res 2000; 20 5151-5154.
    • (2000) Anticancer Res , vol.20 , pp. 5151-5154
    • Mazurek, S.1
  • 10
    • 78349269485 scopus 로고    scopus 로고
    • Human pyruvate kinase M2: A multifunctional protein
    • Gupta V, Bamezai RN. Human pyruvate kinase M2: a multifunctional protein. Protein Sci 2010; 19: 2031-2044.
    • (2010) Protein Sci , vol.19 , pp. 2031-2044
    • Gupta, V.1    Bamezai, R.N.2
  • 11
    • 40749163248 scopus 로고    scopus 로고
    • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    • Christofk HR, et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008; 452: 230-233.
    • (2008) Nature , vol.452 , pp. 230-233
    • Christofk, H.R.1
  • 13
    • 75149150660 scopus 로고    scopus 로고
    • HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
    • David CJ, Chen M, Assanah M, Canoll P, Manley JL. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 2010; 463: 364-368.
    • (2010) Nature , vol.463 , pp. 364-368
    • David, C.J.1    Chen, M.2    Assanah, M.3    Canoll, P.4    Manley, J.L.5
  • 14
    • 82755166890 scopus 로고    scopus 로고
    • Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
    • Anastasiou D, et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 2011; 334: 1278-1828.
    • (2011) Science , vol.334 , pp. 1278-1828
    • Anastasiou, D.1
  • 15
    • 80053922625 scopus 로고    scopus 로고
    • Metabolic flux and the regulation of Mammalian cell growth
    • Locasale JW, Cantley LC. Metabolic flux and the regulation of Mammalian cell growth. Cell Metab 2011; 14: 443-451.
    • (2011) Cell Metab , vol.14 , pp. 443-451
    • Locasale, J.W.1    Cantley, L.C.2
  • 16
    • 21844468220 scopus 로고    scopus 로고
    • Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
    • Dombrauckas JD, Santarsiero BD, Mesecar AD. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry 2005; 44: 9417-9429.
    • (2005) Biochemistry , vol.44 , pp. 9417-9429
    • Dombrauckas, J.D.1    Santarsiero, B.D.2    Mesecar, A.D.3
  • 18
    • 0022488438 scopus 로고
    • The inhibitory effect of various fatty acids on aerobic glycolysis in Ehrlich ascites tumour cells
    • Marchut E, Guminska M, Kedryna T. The inhibitory effect of various fatty acids on aerobic glycolysis in Ehrlich ascites tumour cells. Acta Biochim Pol 1986; 33: 7-16.
    • (1986) Acta Biochim Pol , vol.33 , pp. 7-16
    • Marchut, E.1    Guminska, M.2    Kedryna, T.3
  • 19
    • 79958103961 scopus 로고    scopus 로고
    • Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
    • Mazurek S. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol 2011; 43: 969-980.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 969-980
    • Mazurek, S.1
  • 20
    • 64049099095 scopus 로고    scopus 로고
    • Thyroid hormone mimetics: Potential applications in atherosclerosis, obesity and type 2 diabetes
    • Baxter JD, Webb P. Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov 2009; 8: 308-320.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 308-320
    • Baxter, J.D.1    Webb, P.2
  • 21
    • 0014429058 scopus 로고
    • The regulation of pyruvate kinase of Escherichia coli by fructose diphosphate and adenylic acid
    • Maeba P, Sanwal BD. The regulation of pyruvate kinase of Escherichia coli by fructose diphosphate and adenylic acid. J Biol Chem 1968; 243: 448-450.
    • (1968) J Biol Chem , vol.243 , pp. 448-450
    • Maeba, P.1    Sanwal, B.D.2
  • 22
    • 63649159793 scopus 로고    scopus 로고
    • Shotgun redox proteomics identifies specifically modified cysteines in key metabolic enzymes under oxidative stress in Saccharomyces cerevisiae
    • McDonagh B, Ogueta S, Lasarte G, Padilla CA, Barcena JA. Shotgun redox proteomics identifies specifically modified cysteines in key metabolic enzymes under oxidative stress in Saccharomyces cerevisiae. J Proteomics 2009; 72: 677-689.
    • (2009) J Proteomics , vol.72 , pp. 677-689
    • McDonagh, B.1    Ogueta, S.2    Lasarte, G.3    Padilla, C.A.4    Barcena, J.A.5
  • 23
    • 34548588380 scopus 로고    scopus 로고
    • Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: Insights into the progression of this dementing disorder
    • Butterfield DA, Sultana R. Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder. J Alzheimers 2007; Dis 12: 61-72.
    • (2007) J Alzheimers , vol.12 , pp. 61-72
    • Butterfield, D.A.1    Sultana, R.2
  • 24
    • 2542469551 scopus 로고    scopus 로고
    • Protein disulfide bond formation in the cytoplasm during oxidative stress
    • Cumming RC, et al. Protein disulfide bond formation in the cytoplasm during oxidative stress. J Biol Chem 2004; 279: 21749-21758.
    • (2004) J Biol Chem , vol.279 , pp. 21749-21758
    • Cumming, R.C.1
  • 25
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?
    • Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 2009; 8: 579-591.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 26
    • 80051923932 scopus 로고    scopus 로고
    • Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
    • Possemato R, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 2011; 476: 346-350.
    • (2011) Nature , vol.476 , pp. 346-350
    • Possemato, R.1
  • 27
    • 0023829928 scopus 로고
    • Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma
    • Snell K, Natsumeda Y, Eble JN, Glover JL, Weber G. Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma. Br J Cancer 1988; 57: 87-90.
    • (1988) Br J Cancer , vol.57 , pp. 87-90
    • Snell, K.1    Natsumeda, Y.2    Eble, J.N.3    Glover, J.L.4    Weber, G.5
  • 28
    • 80052258995 scopus 로고    scopus 로고
    • Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
    • Locasale JW et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet 2011; 43: 869-874.
    • (2011) Nat Genet , vol.43 , pp. 869-874
    • Locasale, J.W.1
  • 29
    • 77449131347 scopus 로고    scopus 로고
    • Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
    • Hitosugi T, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal 2009; 2: ra73.
    • (2009) Sci Signal , vol.2
    • Hitosugi, T.1
  • 30
    • 79959371914 scopus 로고    scopus 로고
    • Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperonemediated autophagy and promotes tumor growth
    • Lv L, et al. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperonemediated autophagy and promotes tumor growth. Mol Cell 2011; 42: 719-730.
    • (2011) Mol Cell , vol.42 , pp. 719-730
    • Lv, L.1
  • 32
    • 4644265292 scopus 로고    scopus 로고
    • Faecal tumour M2 pyruvate kinase: A new, sensitive screening tool for colorectal cancer
    • Hardt PD, et al. Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer. Br J Cancer 2004; 91: 980-984.
    • (2004) Br J Cancer , vol.91 , pp. 980-984
    • Hardt, P.D.1
  • 33
    • 77249154640 scopus 로고    scopus 로고
    • Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
    • Boxer MB, et al. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem 2010; 53: 1048-1055.
    • (2010) J Med Chem , vol.53 , pp. 1048-1055
    • Boxer, M.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.