Transcriptional and post-transcriptional regulation of βIII-tubulin protein expression in relation with cell cycle-dependent regulation of tumor cells

International Journal of Oncology

Volumn 40, Issue 3, 2012, Pages 695-702

  Shibazaki, Masahiko ^a   Maesawa, Chihaya ^a   Akasaka, Kiyomi ^a   Kasai, Shuya ^a   Yasuhira, Shinji ^a   Kanno, Kiminori ^a   Nakayama, Ikue ^a   Sugiyama, Toru ^a   Wakabayasi, Go ^a   Masuda, Tomoyuki ^a   Mori, Nozomu ^b  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

III tubulin; Cell cycle; Epigenetics; RE 1; REST

Indexed keywords

BETA TUBULIN; BETA3 TUBULIN; CYCLIN B1; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL GROWTH; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SEQUENCE; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TRANSCRIPTION REGULATION; TUMOR CELL;

CELL DIVISION; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; EPIGENOMICS; G2 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HELA CELLS; HUMANS; INTRONS; PROTEASOME ENDOPEPTIDASE COMPLEX; REPRESSOR PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; TUBULIN; UBIQUITIN;

EID: 84857155659     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1291     Document Type: Article

References (42)

1. Gray S and Levine M: Transcriptional repression in development. Curr Opin Cell Biol 8: 358-364, 1996. (Pubitemid 26179216)
2. Downing KH: Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics. Annu Rev Cell Dev Biol 16: 89-111, 2000.
3. Jordan MA and Wilson L: Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 10: 123-130, 1998. (Pubitemid 28066130)
4. Kavallaris M, Kuo DY, Burkhart CA, et al: Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes. J Clin Invest 100: 1282-1293, 1997. (Pubitemid 27386315)
5. Orr GA, Verdier-Pinard P, McDaid H and Horwitz SB: Mechanisms of Taxol resistance related to microtubules. Oncogene 22: 7280-7295, 2003. (Pubitemid 37487160)
6. Katsetos CD, Herman MM and Mork SJ: Class III beta-tubulin in human development and cancer. Cell Motil Cytoskeleton 55: 77-96, 2003. (Pubitemid 36627260)
7. Chen ZF, Paquette AJ and Anderson DJ: NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nat Genet 20: 136-142, 1998. (Pubitemid 28455445)
8. Svendsen CN, Bhattacharyya A and Tai YT: Neurons from stem cells: preventing an identity crisis. Nat Rev Neurosci 2: 831-834, 2001. (Pubitemid 33674064)
9. Draberova E, Lukas Z, Ivanyi D, Viklicky V and Draber P: Expression of class III beta-tubulin in normal and neoplastic human tissues. Histochem Cell Biol 109: 231-239, 1998. (Pubitemid 28114287)
10. Jouhilahti EM, Peltonen S and Peltonen J: Class III beta-tubulin is a component of the mitotic spindle in multiple cell types. J Histochem Cytochem 56: 1113-1119, 2008.
11. Desai A and Mitchison TJ: Microtubule polymerization dynamics. Annu Rev Cell Dev Biol 13: 83-117, 1997. (Pubitemid 28034521)
12. Oakley BR: An abundance of tubulins. Trends Cell Biol 10: 537-542, 2000.
13. Sharp DJ, Rogers GC and Scholey JM: Microtubule motors in mitosis. Nature 407: 41-47, 2000.
14. Mori N and Morii H: SCG10-related neuronal growth-associated proteins in neural development, plasticity, degeneration, and aging. J Neurosci Res 70: 264-273, 2002. (Pubitemid 35222361)
15. Walczak CE: Microtubule dynamics and tubulin interacting proteins. Curr Opin Cell Biol 12: 52-56, 2000.
16. Starita LM, Horwitz AA, Keogh MC, Ishioka C, Parvin JD and Chiba N: BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II. J Biol Chem 280: 24498-24505, 2005. (Pubitemid 40934535)
17. Kim JH, Choi HJ, Kim B, et al: Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis. Nat Cell Biol 8: 631-639, 2006. (Pubitemid 43827357)
18. Luo RX, Postigo AA and Dean DC: Rb interacts with histone deacetylase to repress transcription. Cell 92: 463-473, 1998. (Pubitemid 28101110)
19. Toyoshima F, Moriguchi T, Wada A, Fukuda M and Nishida E: Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint. EMBO J 17: 2728-2735, 1998. (Pubitemid 28227119)
20. Sarli V and Giannis A: Inhibitors of mitotic kinesins: next-generation antimitotics. Chem Med Chem 1: 293-298, 2006. (Pubitemid 43700287)
21. Knoll R, Christ W, Muller-Oerlinghausen B and Coper H: Formation of chlorpromazine sulphoxide and monodesmethylchlorpromazine by microsomes of small intestine. Naunyn Schmiedebergs Arch Pharmacol 297: 195-200, 1977. (Pubitemid 8062134)
22. Andres ME, Burger C, Peral-Rubio MJ, et al: CoREST: a functional corepressor required for regulation of neural-specific gene expression. Proc Natl Acad Sci USA 96: 9873-9878, 1999. (Pubitemid 29398825)
23. Ferrandina G, Zannoni GF, Martinelli E, et al: Class III beta-tubulin overexpression is a marker of poor clinical outcome in advanced ovarian cancer patients. Clin Cancer Res 12: 2774-2779, 2006.
24. Gan PP, Pasquier E and Kavallaris M: Class III beta-tubulin mediates sensitivity to chemotherapeutic drugs in non small cell lung cancer. Cancer Res 67: 9356-9363, 2007. (Pubitemid 47535925)
25. Hasegawa S, Miyoshi Y, Egawa C, et al: Prediction of response to docetaxel by quantitative analysis of class I and III beta-tubulin isotype mRNA expression in human breast cancers. Clin Cancer Res 9: 2992-2997, 2003. (Pubitemid 36993258)
26. Rosell R, Scagliotti G, Danenberg KD, et al: Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer. Oncogene 22: 3548-3553, 2003. (Pubitemid 36765314)
27. Seve P, Isaac S, Tredan O, et al: Expression of class III {beta}-tubulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy. Clin Cancer Res 11: 5481-5486, 2005. (Pubitemid 41060824)
28. Baas PW: Microtubules and axonal growth. Curr Opin Cell Biol 9: 29-36, 1997.
29. Kimble M, Dettman RW and Raff EC: The beta 3-tubulin gene of Drosophila melanogaster is essential for viability and fertility. Genetics 126: 991-1005, 1990.
30. Banerjee A, Roach MC, Trcka P and Luduena RF: Increased microtubule assembly in bovine brain tubulin lacking the type III isotype of beta-tubulin. J Biol Chem 265: 1794-1799, 1990.
31. Panda D, Miller HP, Banerjee A, Luduena RF and Wilson L: Microtubule dynamics in vitro are regulated by the tubulin isotype composition. Proc Natl Acad Sci USA 91: 11358-11362, 1994. (Pubitemid 24356343)
32. Katsetos CD, Draberova E, Smejkalova B, et al: Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells. Neurochem Res 32: 1387-1398, 2007. (Pubitemid 46988201)
33. Chong JA, Tapia-Ramirez J, Kim S, et al: REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80: 949-957, 1995.
34. Lunyak VV and Rosenfeld MG: No rest for REST: REST/NRSF regulation of neurogenesis. Cell 121: 499-501, 2005. (Pubitemid 40720001)
35. Schoenherr CJ and Anderson DJ: The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267: 1360-1363, 1995.
36. Guardavaccaro D, Frescas D, Dorrello NV, et al: Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature 452: 365-369, 2008. (Pubitemid 351430786)
37. Westbrook TF, Hu G, Ang XL, et al: SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 452: 370-374, 2008. (Pubitemid 351430796)
38. Frescas D and Pagano M: Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer 8: 438-449, 2008. (Pubitemid 351744963)
39. Coulson JM: Transcriptional regulation: cancer, neurons and the REST. Curr Biol 15: R665-R668, 2005.
40. Coulson JM, Edgson JL, Woll PJ and Quinn JP: A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker. Cancer Res 60: 1840-1844, 2000. (Pubitemid 30207641)
41. Su X, Gopalakrishnan V, Stearns D, et al: Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol 26: 1666-1678, 2006.
42. Westbrook TF, Martin ES, Schlabach MR, et al: A genetic screen for candidate tumor suppressors identifies REST. Cell 121: 837-848, 2005. (Pubitemid 40806416)