메뉴 건너뛰기




Volumn 56, Issue 3, 2012, Pages 1491-1501

MpeR regulates the mtr efflux locus in Neisseria gonorrhoeae and modulates antimicrobial resistance by an iron-responsive mechanism

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPTEROATE SYNTHASE; IRON; MEMBRANE PROTEIN; OLIGONUCLEOTIDE; PROTEIN MPER; PROTEIN MTRF; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84857151617     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.06112-11     Document Type: Article
Times cited : (25)

References (39)
  • 1
    • 0023032272 scopus 로고
    • Human immune response to iron-repressible outer membrane proteins of Neisseria meningitidis
    • Black JR, Dyer DW, Thompson MK, Sparling PF. 1986. Human immune response to iron-repressible outer membrane proteins of Neisseria meningitidis. Infect. Immun. 54:710-713. (Pubitemid 17186440)
    • (1986) Infection and Immunity , vol.54 , Issue.3 , pp. 710-713
    • Black, J.R.1    Dyer, D.W.2    Thompson, M.K.3    Sparling, P.F.4
  • 5
    • 84857155819 scopus 로고    scopus 로고
    • TonB-dependent transporters expressed by Neisseria gonorrhoeae
    • Cornelissen CN, Hollander A. 2011. TonB-dependent transporters expressed by Neisseria gonorrhoeae. Front. Microbiol. 2:117.
    • (2011) Front. Microbiol. , vol.2 , pp. 117
    • Cornelissen, C.N.1    Hollander, A.2
  • 8
    • 21844455487 scopus 로고    scopus 로고
    • Identification of the iron-responsive genes of Neisseria gonorrhoeae by microarray analysis in defined medium
    • DOI 10.1128/JB.187.14.4865-4874.2005
    • Ducey TF, Carson MB, Orvis J, Stintzi AP, Dyer DW. 2005. Identification of the iron-responsive genes of Neisseria gonorrhoeae by microarray analysis in defined medium. J. Bacteriol. 187:4865-4874. (Pubitemid 40962203)
    • (2005) Journal of Bacteriology , vol.187 , Issue.14 , pp. 4865-4874
    • Ducey, T.F.1    Carson, M.B.2    Orvis, J.3    Stintzi, A.P.4    Dyer, D.W.5
  • 9
    • 79961061063 scopus 로고    scopus 로고
    • Identification of the in vitro target of an iron-responsive AraC-like protein from Neisseria meningitidis that is in a regulatory cascade with fur
    • Fantappie L, Scarlato V, Delany I. 2011. Identification of the in vitro target of an iron-responsive AraC-like protein from Neisseria meningitidis that is in a regulatory cascade with Fur. Microbiology 157:2235-2247.
    • (2011) Microbiology , vol.157 , pp. 2235-2247
    • Fantappie, L.1    Scarlato, V.2    Delany, I.3
  • 10
    • 34347372857 scopus 로고    scopus 로고
    • Differential regulation of ponA and pilMNOPQ expression by the MtrR transcriptional regulatory protein in Neisseria gonorrhoeae
    • DOI 10.1128/JB.00286-07
    • Folster JP, Dhulipala V, Nicholas RA, Shafer WM. 2007. Differential regulation of ponA and pilMNOPQ expression by the MtrR transcriptional regulatory protein in Neisseria gonorrhoeae. J. Bacteriol. 189:4569-4577. (Pubitemid 47025568)
    • (2007) Journal of Bacteriology , vol.189 , Issue.13 , pp. 4569-4577
    • Folster, J.P.1    Dhulipala, V.2    Nicholas, R.A.3    Shafer, W.M.4
  • 11
    • 58149520026 scopus 로고    scopus 로고
    • MtrR modulates rpoH expression and levels of antimicrobial resistance in Neisseria gonorrhoeae
    • Folster JP, et al. 2009. MtrR modulates rpoH expression and levels of antimicrobial resistance in Neisseria gonorrhoeae. J. Bacteriol. 191:287-297.
    • (2009) J. Bacteriol. , vol.191 , pp. 287-297
    • Folster, J.P.1
  • 12
    • 18944382290 scopus 로고    scopus 로고
    • Regulation of mtrF expression in Neisseria gonorrhoeae and its role in high-level antimicrobial resistance
    • DOI 10.1128/JB.187.11.3713-3720.2005
    • Folster JP, Shafer WM. 2005. Regulation of mtrF expression in Neisseria gonorrhoeae and its role in high-level antimicrobial resistance. J. Bacteriol. 187:3713-3720. (Pubitemid 40705575)
    • (2005) Journal of Bacteriology , vol.187 , Issue.11 , pp. 3713-3720
    • Folster, J.P.1    Shafer, W.M.2
  • 13
    • 0030015825 scopus 로고    scopus 로고
    • Use of a non-selective transformation technique to construct a multiply restriction/modification-deficient mutant of Neisseria gonorrhoeae
    • Gunn JS, Stein DC. 1996. Use of a non-selective transformation technique to construct a multiply restriction/modification-deficient mutant of Neisseria gonorrhoeae. Mol. Gen. Genet. 251:509-517.
    • (1996) Mol. Gen. Genet. , vol.251 , pp. 509-517
    • Gunn, J.S.1    Stein, D.C.2
  • 14
    • 0028906903 scopus 로고
    • Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system
    • Hagman KE, et al. 1995. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology 141(Pt 3):611-622.
    • (1995) Microbiology , vol.141 , Issue.PART 3 , pp. 611-622
    • Hagman, K.E.1
  • 15
    • 0029078189 scopus 로고
    • Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae
    • Hagman KE, Shafer WM. 1995. Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae. J. Bacteriol. 177:4162-4165.
    • (1995) J. Bacteriol. , vol.177 , pp. 4162-4165
    • Hagman, K.E.1    Shafer, W.M.2
  • 16
    • 84855724118 scopus 로고    scopus 로고
    • The iron-repressed, AraC-like regulator MpeR activates expression of fetA in Neisseria gonorrhoeae
    • Hollander A, Mercante AD, Shafer WM, Cornelissen CN. 2011. The iron-repressed, AraC-like regulator MpeR activates expression of fetA in Neisseria gonorrhoeae. Infect. Immun. 79:4764-4776.
    • (2011) Infect. Immun. , vol.79 , pp. 4764-4776
    • Hollander, A.1    Mercante, A.D.2    Shafer, W.M.3    Cornelissen, C.N.4
  • 17
    • 0342899995 scopus 로고    scopus 로고
    • The epidemiology of global antibiotic resistance among Neisseria gonorrhoeae and Haemophilus ducreyi
    • Ison CA, Dillon JA, Tapsall JW. 1998. The epidemiology of global antibiotic resistance among Neisseria gonorrhoeae and Haemophilus ducreyi. Lancet 351(Suppl 3):8-11. (Pubitemid 128643729)
    • (1998) Lancet , vol.351 , Issue.SUPPL.3 , pp. 8-11
    • Ison, C.A.1    Dillon, J.-A.R.2    Tapsall, J.W.3
  • 18
    • 3343012046 scopus 로고    scopus 로고
    • Remarkable increase in central Japan in 2001-2002 of Neisseria gonorrhoeae isolates with decreased susceptibility to penicillin, tetracycline, oral cephalosporins, and fluoroquinolones
    • DOI 10.1128/AAC.48.8.3185-3187.2004
    • Ito M, et al. 2004. Remarkable increase in central Japan in 2001-2002 of Neisseria gonorrhoeae isolates with decreased susceptibility to penicillin, tetracycline, oral cephalosporins, and fluoroquinolones. Antimicrob. Agents Chemother. 48:3185-3187. (Pubitemid 38989201)
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , Issue.8 , pp. 3185-3187
    • Ito, M.1    Yasuda, M.2    Yokoi, S.3    Ito, S.-I.4    Takahashi, Y.5    Ishihara, S.6    Maeda, S.-I.7    Deguchi, T.8
  • 19
    • 73849136751 scopus 로고    scopus 로고
    • Transcriptional and functional analysis of the Neisseria gonorrhoeae fur regulon
    • Jackson LA, et al. 2010. Transcriptional and functional analysis of the Neisseria gonorrhoeae Fur regulon. J. Bacteriol. 192:77-85.
    • (2010) J. Bacteriol. , vol.192 , pp. 77-85
    • Jackson, L.A.1
  • 20
    • 0141446140 scopus 로고    scopus 로고
    • A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection
    • DOI 10.1128/IAI.71.10.5576-5582.2003
    • Jerse AE, et al. 2003. A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection. Infect. Immun. 71:5576-5582. (Pubitemid 37205608)
    • (2003) Infection and Immunity , vol.71 , Issue.10 , pp. 5576-5582
    • Jerse, A.E.1    Sharma, N.D.2    Simms, A.N.3    Crow, E.T.4    Snyder, L.A.5    Shafer, W.M.6
  • 21
    • 0344666702 scopus 로고    scopus 로고
    • FarR Regulates the farAB-Encoded Efflux Pump of Neisseria gonorrhoeae via an MtrR Regulatory Mechanism
    • DOI 10.1128/JB.185.24.7145-7152.2003
    • Lee EH, Rouquette-Loughlin C, Folster JP, Shafer WM. 2003. FarR regulates the farAB-encoded efflux pump of Neisseria gonorrhoeae via an MtrR regulatory mechanism. J. Bacteriol. 185:7145-7152. (Pubitemid 37509830)
    • (2003) Journal of Bacteriology , vol.185 , Issue.24 , pp. 7145-7152
    • Lee, E.-H.1    Rouquette-Loughlin, C.2    Folster, J.P.3    Shafer, W.M.4
  • 22
    • 0032782869 scopus 로고    scopus 로고
    • The farAB-encoded efflux pump mediates resistance of gonococci to long-chained antibacterial fatty acids
    • DOI 10.1046/j.1365-2958.1999.01530.x
    • Lee EH, Shafer WM. 1999. The farAB-encoded efflux pump mediates resistance of gonococci to long-chained antibacterial fatty acids. Mol. Microbiol. 33:839-845. (Pubitemid 29392663)
    • (1999) Molecular Microbiology , vol.33 , Issue.4 , pp. 839-845
    • Lee, E.H.1    Shafer, W.M.2
  • 23
    • 78449263982 scopus 로고    scopus 로고
    • The gonococcus fights back: Is this time a knock out?
    • Lewis DA. 2010. The gonococcus fights back: is this time a knock out? Sex. Transm. Infect. 86:415-421.
    • (2010) Sex. Transm. Infect. , vol.86 , pp. 415-421
    • Lewis, D.A.1
  • 24
    • 0030798952 scopus 로고    scopus 로고
    • The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae
    • Lucas CE, Balthazar JT, Hagman KE, Shafer WM. 1997. The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae. J. Bacteriol. 179:4123-4128. (Pubitemid 27291039)
    • (1997) Journal of Bacteriology , vol.179 , Issue.13 , pp. 4123-4128
    • Lucas, C.E.1    Balthazar, J.T.2    Hagman, K.E.3    Shafer, W.M.4
  • 26
    • 0027244956 scopus 로고
    • Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells
    • Menard R, Sansonetti PJ, Parsot C. 1993. Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells. J. Bacteriol. 175:5899-5906. (Pubitemid 23277438)
    • (1993) Journal of Bacteriology , vol.175 , Issue.18 , pp. 5899-5906
    • Menard, R.1    Sansonetti, P.J.2    Parsot, C.3
  • 27
    • 0028364451 scopus 로고
    • Regulation of the permeability of the gonococcal cell envelope by the mtr system
    • DOI 10.1111/j.1365-2958.1994.tb00354.x
    • Pan W, Spratt BG. 1994. Regulation of the permeability of the gonococcal cell envelope by the mtr system. Mol. Microbiol. 11:769-775. (Pubitemid 24197469)
    • (1994) Molecular Microbiology , vol.11 , Issue.4 , pp. 769-775
    • Pan, W.1    Spratt, B.G.2
  • 28
    • 0021264835 scopus 로고
    • Identification of an envelope mutation (env-10) resulting in increased antibiotic susceptibility and pyocin resistance in a clinical isolate of Neisseria gonorrhoeae
    • Shafer WM, Guymon LF, Lind I, Sparling PF. 1984. Identification of an envelope mutation (env-10) resulting in increased antibiotic susceptibility and pyocin resistance in a clinical isolate of Neisseria gonorrhoeae. Antimicrob. Agents Chemother. 25:767-769. (Pubitemid 14112045)
    • (1984) Antimicrobial Agents and Chemotherapy , vol.25 , Issue.6 , pp. 767-769
    • Shafer, W.M.1    Guymon, L.F.2    Lind, I.3    Sparling, P.F.4
  • 29
    • 0032539553 scopus 로고    scopus 로고
    • Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family
    • DOI 10.1073/pnas.95.4.1829
    • Shafer WM, Qu X, Waring AJ, Lehrer RI. 1998. Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family. Proc. Natl. Acad. Sci. U. S. A. 95:1829-1833. (Pubitemid 28103479)
    • (1998) Proceedings of the National Academy of Sciences of the United States of America , vol.95 , Issue.4 , pp. 1829-1833
    • Shafer, W.M.1    Qu, X.-D.2    Waring, A.J.3    Lehrer, R.I.4
  • 30
    • 0028828941 scopus 로고
    • Construction of a translational lacZ fusion system to study gene regulation in Neisseria gonorrhoeae
    • Silver LE, Clark VL. 1995. Construction of a translational lacZ fusion system to study gene regulation in Neisseria gonorrhoeae. Gene 166:101-104.
    • (1995) Gene , vol.166 , pp. 101-104
    • Silver, L.E.1    Clark, V.L.2
  • 32
    • 0037238497 scopus 로고    scopus 로고
    • Divergence and transcriptional analysis of the division cell wall (dcw) gene cluster in Neisseria spp
    • Snyder LA, Shafer WM, Saunders NJ. 2003. Divergence and transcriptional analysis of the division cell wall (dcw) gene cluster in Neisseria spp. Mol. Microbiol. 47:431-442.
    • (2003) Mol. Microbiol. , vol.47 , pp. 431-442
    • Snyder, L.A.1    Shafer, W.M.2    Saunders, N.J.3
  • 33
    • 0016743709 scopus 로고
    • Inheritance of low-level resistance to penicillin, tetracycline, and chloramphenicol in Neisseria gonorrhoeae
    • Sparling PF, Sarubbi FA, Jr, Blackman E. 1975. Inheritance of low-level resistance to penicillin, tetracycline, and chloramphenicol in Neisseria gonorrhoeae. J. Bacteriol. 124:740-749.
    • (1975) J. Bacteriol. , vol.124 , pp. 740-749
    • Sparling, P.F.1    Sarubbi Jr., F.A.2    Blackman, E.3
  • 34
    • 0037254049 scopus 로고    scopus 로고
    • Identification of a cell envelope protein (MtrF) involved in hydrophobic antimicrobial resistance in Neisseria gonorrhoeae
    • DOI 10.1093/jac/dkg031
    • Veal WL, Shafer WM. 2003. Identification of a cell envelope protein (MtrF) involved in hydrophobic antimicrobial resistance in Neisseria gonorrhoeae. J. Antimicrob. Chemother. 51:27-37. (Pubitemid 36163824)
    • (2003) Journal of Antimicrobial Chemotherapy , vol.51 , Issue.1 , pp. 27-37
    • Veal, W.L.1    Shafer, W.M.2
  • 35
    • 70350725944 scopus 로고    scopus 로고
    • Increase in reported gonorrhoea cases in Sweden, 2001-2008
    • Velicko I, Unemo M. 2009. Increase in reported gonorrhoea cases in Sweden, 2001-2008. Euro Surveill. 14:19315.
    • (2009) Euro Surveill. , vol.14 , pp. 19315
    • Velicko, I.1    Unemo, M.2
  • 36
    • 39149112789 scopus 로고    scopus 로고
    • Regulation of the MtrC-MtrD-MtrE efflux-pump system modulates the in vivo fitness of Neisseria gonorrhoeae
    • DOI 10.1086/522964
    • Warner DM, Folster JP, Shafer WM, Jerse AE. 2007. Regulation of the MtrC-MtrD-MtrE efflux-pump system modulates the in vivo fitness of Neisseria gonorrhoeae. J. Infect. Dis. 196:1804-1812. (Pubitemid 351411941)
    • (2007) Journal of Infectious Diseases , vol.196 , Issue.12 , pp. 1804-1812
    • Warner, D.M.1    Folster, J.P.2    Shafer, W.M.3    Jerse, A.E.4
  • 37
    • 52649131941 scopus 로고    scopus 로고
    • Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE efflux pump system confer different levels of antimicrobial resistance and in vivo fitness
    • Warner DM, Shafer WM, Jerse AE. 2008. Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE efflux pump system confer different levels of antimicrobial resistance and in vivo fitness. Mol. Microbiol. 70:462-478.
    • (2008) Mol. Microbiol. , vol.70 , pp. 462-478
    • Warner, D.M.1    Shafer, W.M.2    Jerse, A.E.3
  • 38
    • 33746774864 scopus 로고    scopus 로고
    • Sexually transmitted diseases treatment guidelines, 2006
    • Workowski KA, Berman SM. 2006. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recommend. Rep. 55:1-94.
    • (2006) MMWR Recommend. Rep. , vol.55 , pp. 1-94
    • Workowski, K.A.1    Berman, S.M.2
  • 39
    • 43049134177 scopus 로고    scopus 로고
    • Emerging antimicrobial resistance in Neisseria gonorrhoeae: Urgent need to strengthen prevention strategies
    • Workowski KA, Berman SM, Douglas JM, Jr. 2008. Emerging antimicrobial resistance in Neisseria gonorrhoeae: urgent need to strengthen prevention strategies. Ann. Intern. Med. 148:606-613. (Pubitemid 351669134)
    • (2008) Annals of Internal Medicine , vol.148 , Issue.8 , pp. 606-613
    • Workowski, K.A.1    Berman, S.M.2    Douglas Jr., J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.