Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Pankhurst, Michael W ^a,b   Gell, David A ^a   Butler, Chris W ^a   Kirkcaldie, Matthew T K ^c   West, Adrian K ^a   Chung, Roger S ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c UNIVERSITY OF TASMANIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; COMPLEMENTARY DNA; CORTICOSTERONE; LIVER PROTEIN; MESSENGER RNA; METALLOTHIONEIN I; METALLOTHIONEIN II; PROTEIN ANTIBODY; UC1 METALLOTHIONEIN ANTIBODY; UNCLASSIFIED DRUG; ZINC; ANTIBODY; METALLOTHIONEIN; METALLOTHIONEIN 1, MOUSE; METALLOTHIONEIN-1, MOUSE; MT2 PROTEIN, MOUSE; TISSUE EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BRAIN HOMOGENATE; BRAIN INJURY; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOSTERONE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENE INACTIVATION; KNOCKOUT MOUSE; LIVER HOMOGENATE; LIVER LEVEL; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOP CODON; WILD TYPE; ZINC METABOLISM; ZINC SEQUESTRATION; ANIMAL; BLOOD; BRAIN; COLD; GENETICS; IMMUNOLOGY; LIVER; METABOLISM; PATHOLOGY; RADIOIMMUNOASSAY; REPRODUCIBILITY; STANDARD; STATISTICAL MODEL;

ANIMALS; ANTIBODIES; BRAIN; BRAIN INJURIES; COLD TEMPERATURE; CORTICOSTERONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; LIVER; LOGISTIC MODELS; METALLOTHIONEIN; MICE; RADIOIMMUNOASSAY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SPECTROPHOTOMETRY, ATOMIC; TISSUE EXTRACTS; ZINC;

EID: 84857146501     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031185     Document Type: Article

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