메뉴 건너뛰기




Volumn 109, Issue 7, 2012, Pages 2642-2647

Trisomy of the G protein-coupled K + channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice

Author keywords

Electrophysiological recordings; Fear conditioning; Neuronal culture; Open field; Sucrose preference

Indexed keywords

G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; GIRK 1 PROTEIN; GIRK 2 PROTEIN; GIRK 3 PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

EID: 84857136099     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1109099109     Document Type: Article
Times cited : (59)

References (56)
  • 3
    • 0022764775 scopus 로고
    • Behavior problems in retarded children with special reference to Down's syndrome
    • Gath A, Gumley D (1986) Behaviour problems in retarded children with special reference to Down's syndrome. Br J Psychiatry 149:156-161. (Pubitemid 16076248)
    • (1986) British Journal of Psychiatry , vol.149 , Issue.AUG. , pp. 156-161
    • Gath, A.1    Gumley, D.2
  • 4
    • 0034597908 scopus 로고    scopus 로고
    • Pain expression and stimulus localisation in individuals with Down's syndrome
    • Hennequin M, Morin C, Feine JS (2000) Pain expression and stimulus localisation in individuals with Down's syndrome. Lancet 356:1882-1887.
    • (2000) Lancet , vol.356 , pp. 1882-1887
    • Hennequin, M.1    Morin, C.2    Feine, J.S.3
  • 6
    • 0242348738 scopus 로고    scopus 로고
    • Mouse models of Down syndrome: How useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions
    • DOI 10.1016/S0378-1119(03)00769-8
    • Gardiner K, Fortna A, Bechtel L, Davisson MT (2003) Mouse models of Down syndrome: How useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions. Gene 318:137-147. (Pubitemid 37338399)
    • (2003) Gene , vol.318 , Issue.1-2 , pp. 137-147
    • Gardiner, K.1    Fortna, A.2    Bechtel, L.3    Davisson, M.T.4
  • 7
    • 67651124806 scopus 로고    scopus 로고
    • Molecular genetic analysis of Down syndrome
    • Patterson D (2009) Molecular genetic analysis of Down syndrome. Hum Genet 126: 195-214.
    • (2009) Hum Genet , vol.126 , pp. 195-214
    • Patterson, D.1
  • 8
    • 0037433652 scopus 로고    scopus 로고
    • Down's syndrome
    • DOI 10.1016/S0140-6736(03)12987-X
    • Roizen NJ, Patterson D (2003) Down's syndrome. Lancet 361:1281-1289. (Pubitemid 36428586)
    • (2003) Lancet , vol.361 , Issue.9365 , pp. 1281-1289
    • Roizen, N.J.1    Patterson, D.2
  • 9
    • 0038687498 scopus 로고    scopus 로고
    • The Neuropsychology of Down Syndrome: Evidence for Hippocampal Dysfunction
    • Pennington BF, Moon J, Edgin J, Stedron J, Nadel L (2003) The neuropsychology of Down syndrome: Evidence for hippocampal dysfunction. Child Dev 74:75-93. (Pubitemid 37244589)
    • (2003) Child Development , vol.74 , Issue.1 , pp. 75-93
    • Pennington, B.F.1    Moon, J.2    Edgin, J.3    Stedron, J.4    Nadel, L.5
  • 10
    • 33745032837 scopus 로고    scopus 로고
    • Mouse models of cognitive disorders in trisomy 21: A review
    • DOI 10.1007/s10519-006-9056-9
    • Sérégaza Z, Roubertoux PL, Jamon M, Soumireu-Mourat B (2006) Mouse models of cognitive disorders in trisomy 21: A review. Behav Genet 36:387-404. (Pubitemid 43876778)
    • (2006) Behavior Genetics , vol.36 , Issue.3 , pp. 387-404
    • Seregaza, Z.1    Roubertoux, P.L.2    Jamon, M.3    Soumireu-Mourat, B.4
  • 11
    • 0027874350 scopus 로고
    • Molecular mapping of twenty-four features of Down syndrome on chromosome 21
    • Delabar JM, et al. (1993) Molecular mapping of twenty-four features of Down syndrome on chromosome 21. Eur J Hum Genet 1:114-124.
    • (1993) Eur J Hum Genet , vol.1 , pp. 114-124
    • Delabar, J.M.1
  • 12
    • 0039357820 scopus 로고    scopus 로고
    • + channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons
    • DOI 10.1016/S0896-6273(00)80381-5
    • Lüscher C, Jan LY, Stoffel M, Malenka RC, Nicoll RA (1997) G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron 19:687-695. (Pubitemid 27430754)
    • (1997) Neuron , vol.19 , Issue.3 , pp. 687-695
    • Luscher, C.1    Jan, L.Y.2    Stoffel, M.3    Malenka, R.C.4    Nicoll, R.A.5
  • 13
    • 67649482679 scopus 로고    scopus 로고
    • New sites of action for GIRK and SK channels
    • Luján R, Maylie J, Adelman JP (2009) New sites of action for GIRK and SK channels. Nat Rev Neurosci 10:475-480.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 475-480
    • Luján, R.1    Maylie, J.2    Adelman, J.P.3
  • 14
    • 0024730134 scopus 로고
    • Twelfth Gaddum memorial lecture. Drug receptors and the inhibition of nerve cells
    • North RA (1989) Twelfth Gaddum memorial lecture. Drug receptors and the inhibition of nerve cells. Br J Pharmacol 98:13-28.
    • (1989) Br J Pharmacol , vol.98 , pp. 13-28
    • North, R.A.1
  • 15
    • 0029664508 scopus 로고    scopus 로고
    • 4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes
    • Werner P, Hussy N, Buell G, Jones KA, North RA (1996) D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes. Mol Pharmacol 49:656-661. (Pubitemid 26117149)
    • (1996) Molecular Pharmacology , vol.49 , Issue.4 , pp. 656-661
    • Werner, P.1    Hussy, N.2    Buell, G.3    Jones, K.A.4    North, R.A.5
  • 16
    • 0023132940 scopus 로고
    • + channel in heart
    • DOI 10.1038/325321a0
    • Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE (1987) The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature 325:321-326. (Pubitemid 17053169)
    • (1987) Nature , vol.325 , Issue.6102 , pp. 321-326
    • Logothetis, D.E.1    Kurachi, Y.2    Galper, J.3
  • 18
    • 77951498231 scopus 로고    scopus 로고
    • Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease
    • Lüscher C, Slesinger PA (2010) Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nat Rev Neurosci 11:301-315.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 301-315
    • Lüscher, C.1    Slesinger, P.A.2
  • 19
    • 0029075809 scopus 로고
    • Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2
    • Smith DJ, Zhu Y, Zhang J, Cheng JF, Rubin EM (1995) Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics 27:425-434.
    • (1995) Genomics , vol.27 , pp. 425-434
    • Smith, D.J.1    Zhu, Y.2    Zhang, J.3    Cheng, J.F.4    Rubin, E.M.5
  • 20
    • 7744237268 scopus 로고    scopus 로고
    • Functional analysis of genes implicated in Down syndrome: 1. Cognitive abilities in mice transpolygenic for Down Syndrome Chromosomal Region-1 (DCR-1)
    • DOI 10.1007/s10519-004-5584-3
    • Chabert C, et al. (2004) Functional analysis of genes implicated in Down syndrome: 1. Cognitive abilities in mice transpolygenic for Down Syndrome Chromosomal Region-1 (DCR-1). Behav Genet 34:559-569. (Pubitemid 39463125)
    • (2004) Behavior Genetics , vol.34 , Issue.6 , pp. 559-569
    • Chabert, C.1    Jamon, M.2    Cherfouh, A.3    Duquenne, V.4    Smith, D.J.5    Rubin, E.6    Roubertoux, P.L.7
  • 24
    • 49749120046 scopus 로고    scopus 로고
    • Selective breeding for differential saccharin intake as an animal model of drug abuse
    • Carroll ME, Morgan AD, Anker JJ, Perry JL, Dess NK (2008) Selective breeding for differential saccharin intake as an animal model of drug abuse. Behav Pharmacol 19: 435-460.
    • (2008) Behav Pharmacol , vol.19 , pp. 435-460
    • Carroll, M.E.1    Morgan, A.D.2    Anker, J.J.3    Perry, J.L.4    Dess, N.K.5
  • 25
    • 78650431997 scopus 로고    scopus 로고
    • A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery
    • Neufeld-Cohen A, et al. (2010) A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery. Proc Natl Acad Sci USA 107: 19020-19025.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 19020-19025
    • Neufeld-Cohen, A.1
  • 26
    • 67651036860 scopus 로고    scopus 로고
    • Aneuploidy: From a physiological mechanism of variance to Down syndrome
    • Dierssen M, Herault Y, Estivill X (2009) Aneuploidy: From a physiological mechanism of variance to Down syndrome. Physiol Rev 89:887-920.
    • (2009) Physiol Rev , vol.89 , pp. 887-920
    • Dierssen, M.1    Herault, Y.2    Estivill, X.3
  • 27
    • 0034076609 scopus 로고    scopus 로고
    • Emotion circuits in the brain
    • LeDoux JE (2000) Emotion circuits in the brain. Annu Rev Neurosci 23:155-184.
    • (2000) Annu Rev Neurosci , vol.23 , pp. 155-184
    • LeDoux, J.E.1
  • 28
    • 0035930587 scopus 로고    scopus 로고
    • Characterization of the mechanism underlying the reversal of long term potentiation by low frequency stimulation at hippocampal CA1 synapses
    • Huang CC, Liang YC, Hsu KS (2001) Characterization of the mechanism underlying the reversal of long term potentiation by low frequency stimulation at hippocampal CA1 synapses. J Biol Chem 276:48108-48117.
    • (2001) J Biol Chem , vol.276 , pp. 48108-48117
    • Huang, C.C.1    Liang, Y.C.2    Hsu, K.S.3
  • 29
    • 58849165705 scopus 로고    scopus 로고
    • Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels
    • Chung HJ, Qian X, Ehlers M, Jan YN, Jan LY (2009) Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Proc Natl Acad Sci USA 106:629-634.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 629-634
    • Chung, H.J.1    Qian, X.2    Ehlers, M.3    Jan, Y.N.4    Jan, L.Y.5
  • 30
    • 58849118419 scopus 로고    scopus 로고
    • G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation
    • Chung HJ, et al. (2009) G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation. Proc Natl Acad Sci USA 106: 635-640.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 635-640
    • Chung, H.J.1
  • 31
    • 19544393555 scopus 로고    scopus 로고
    • Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: A model of Down syndrome
    • DOI 10.1016/j.neulet.2005.03.031, PII S0304394005003253
    • Costa AC, Grybko MJ (2005) Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: A model of Down syndrome. Neurosci Lett 382:317-322. (Pubitemid 40733644)
    • (2005) Neuroscience Letters , vol.382 , Issue.3 , pp. 317-322
    • Costa, A.C.S.1    Grybko, M.J.2
  • 32
    • 65949098892 scopus 로고    scopus 로고
    • The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome
    • Belichenko NP, et al. (2009) The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci 29:5938-5948.
    • (2009) J Neurosci , vol.29 , pp. 5938-5948
    • Belichenko, N.P.1
  • 33
    • 44349122904 scopus 로고    scopus 로고
    • Speeding of miniature excitatory post-synaptic currents in Ts65Dn cultured hippocampal neurons
    • Best TK, Cho-Clark M, Siarey RJ, Galdzicki Z (2008) Speeding of miniature excitatory post-synaptic currents in Ts65Dn cultured hippocampal neurons. Neurosci Lett 438: 356-361.
    • (2008) Neurosci Lett , vol.438 , pp. 356-361
    • Best, T.K.1    Cho-Clark, M.2    Siarey, R.J.3    Galdzicki, Z.4
  • 34
    • 4644250821 scopus 로고    scopus 로고
    • Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome
    • Kleschevnikov AM, et al. (2004) Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci 24:8153-8160.
    • (2004) J Neurosci , vol.24 , pp. 8153-8160
    • Kleschevnikov, A.M.1
  • 35
    • 0029114706 scopus 로고
    • A mouse model for Down syndrome exhibits learning and behaviour deficits
    • Reeves RH, et al. (1995) A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat Genet 11:177-184.
    • (1995) Nat Genet , vol.11 , pp. 177-184
    • Reeves, R.H.1
  • 37
    • 0032729863 scopus 로고    scopus 로고
    • Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome
    • DOI 10.1016/S0028-3908(99)00083-0, PII S0028390899000830
    • Siarey RJ, et al. (1999) Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. Neuropharmacology 38:1917-1920. (Pubitemid 29509730)
    • (1999) Neuropharmacology , vol.38 , Issue.12 , pp. 1917-1920
    • Siarey, R.J.1    Carlson, E.J.2    Epstein, C.J.3    Balbo, A.4    Rapoport, S.I.5    Galdzicki, Z.6
  • 38
    • 0031414807 scopus 로고    scopus 로고
    • Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome
    • DOI 10.1016/S0028-3908(97)00157-3, PII S0028390897001573
    • Siarey RJ, Stoll J, Rapoport SI, Galdzicki Z (1997) Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome. Neuropharmacology 36: 1549-1554. (Pubitemid 28085914)
    • (1997) Neuropharmacology , vol.36 , Issue.11-12 , pp. 1549-1554
    • Siarey, R.J.1    Stoll, J.2    Rapoport, S.I.3    Galdzicki, Z.4
  • 39
    • 21344435258 scopus 로고    scopus 로고
    • Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome
    • DOI 10.1016/j.neuropharm.2005.02.012, PII S0028390805000833
    • Siarey RJ, Villar AJ, Epstein CJ, Galdzicki Z (2005) Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome. Neuropharmacology 49:122-128. (Pubitemid 40910022)
    • (2005) Neuropharmacology , vol.49 , Issue.1 , pp. 122-128
    • Siarey, R.J.1    Villar, A.J.2    Epstein, C.J.3    Galdzicki, Z.4
  • 40
    • 0033407499 scopus 로고    scopus 로고
    • Motor dysfunction in a mouse model for Down syndrome
    • DOI 10.1016/S0031-9384(99)00178-X, PII S003193849900178X
    • Costa AC, Walsh K, Davisson MT (1999) Motor dysfunction in a mouse model for Down syndrome. Physiol Behav 68:211-220. (Pubitemid 30009803)
    • (1999) Physiology and Behavior , vol.68 , Issue.1-2 , pp. 211-220
    • Costa, A.C.S.1    Walsh, K.2    Davisson, M.T.3
  • 41
    • 23744473479 scopus 로고    scopus 로고
    • Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome
    • DOI 10.1016/j.bbr.2005.04.016, PII S0166432805001853
    • Martínez-Cué C, et al. (2005) Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome. Behav Brain Res 163:174-185. (Pubitemid 41138051)
    • (2005) Behavioural Brain Research , vol.163 , Issue.2 , pp. 174-185
    • Martinez-Cue, C.1    Rueda, N.2    Garcia, E.3    Davisson, M.T.4    Schmidt, C.5    Florez, J.6
  • 42
    • 43649094588 scopus 로고    scopus 로고
    • Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test
    • DOI 10.1038/sj.npp.1301535, PII 1301535
    • Costa AC, Scott-McKean JJ, Stasko MR (2008) Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test. Neuropsychopharmacology 33: 1624-1632. (Pubitemid 351684704)
    • (2008) Neuropsychopharmacology , vol.33 , Issue.7 , pp. 1624-1632
    • Costa, A.C.S.1    Scott-McKean, J.J.2    Stasko, M.R.3
  • 43
    • 0033756144 scopus 로고    scopus 로고
    • Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome
    • Sago H, et al. (2000) Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr Res 48:606-613.
    • (2000) Pediatr Res , vol.48 , pp. 606-613
    • Sago, H.1
  • 44
    • 0026847039 scopus 로고
    • Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans
    • Squire LR (1992) Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans. Psychol Rev 99:195-231.
    • (1992) Psychol Rev , vol.99 , pp. 195-231
    • Squire, L.R.1
  • 45
    • 0029064090 scopus 로고
    • Damage limited to the hippocampal region produces long-lasting memory impairment in monkeys
    • Alvarez P, Zola-Morgan S, Squire LR (1995) Damage limited to the hippocampal region produces long-lasting memory impairment in monkeys. J Neurosci 15:3796-3807.
    • (1995) J Neurosci , vol.15 , pp. 3796-3807
    • Alvarez, P.1    Zola-Morgan, S.2    Squire, L.R.3
  • 46
    • 34247498748 scopus 로고    scopus 로고
    • Memory consolidation or transformation: Context manipulation and hippocampal representations of memory
    • DOI 10.1038/nn1880, PII NN1880
    • Winocur G, MoscovitchM, SekeresM(2007) Memory consolidation or transformation: Context manipulation and hippocampal representations of memory. Nat Neurosci 10: 555-557. (Pubitemid 46652438)
    • (2007) Nature Neuroscience , vol.10 , Issue.5 , pp. 555-557
    • Winocur, G.1    Moscovitch, M.2    Sekeres, M.3
  • 47
    • 0042932365 scopus 로고    scopus 로고
    • Stability of retrieved memory: Inverse correlation with trace dominance
    • DOI 10.1126/science.1086881
    • Eisenberg M, Kobilo T, Berman DE, Dudai Y (2003) Stability of retrieved memory: Inverse correlation with trace dominance. Science 301:1102-1104. (Pubitemid 37022313)
    • (2003) Science , vol.301 , Issue.5636 , pp. 1102-1104
    • Eisenberg, M.1    Kobilo, T.2    Berman, D.E.3    Dudai, Y.4
  • 48
    • 33751537736 scopus 로고    scopus 로고
    • G protein-activated inwardly rectifying potassium channels as potential therapeutic targets
    • DOI 10.2174/138161206779010468
    • Kobayashi T, Ikeda K (2006) G protein-activated inwardly rectifying potassium channels as potential therapeutic targets. Curr Pharm Des 12:4513-4523. (Pubitemid 44835160)
    • (2006) Current Pharmaceutical Design , vol.12 , Issue.34 , pp. 4513-4523
    • Kobayashi, T.1    Ikeda, K.2
  • 49
    • 77955150592 scopus 로고    scopus 로고
    • Altered neurotransmission in the mesolimbic reward system of Girk mice
    • Arora D, et al. (2010) Altered neurotransmission in the mesolimbic reward system of Girk mice. J Neurochem 114:1487-1497.
    • (2010) J Neurochem , vol.114 , pp. 1487-1497
    • Arora, D.1
  • 50
    • 0342806880 scopus 로고    scopus 로고
    • + channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain
    • Liao YJ, Jan YN, Jan LY (1996) Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain. J Neurosci 16:7137-7150. (Pubitemid 26382891)
    • (1996) Journal of Neuroscience , vol.16 , Issue.22 , pp. 7137-7150
    • Liao, Y.J.1    Jan, Y.N.2    Jan, L.Y.3
  • 51
    • 34249651674 scopus 로고    scopus 로고
    • Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model
    • Harashima C, et al. (2006) Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model. Cell Mol Neurobiol 26:719-734.
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 719-734
    • Harashima, C.1
  • 52
    • 30144433373 scopus 로고    scopus 로고
    • Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: A model of Down syndrome
    • DOI 10.1002/cne.20844
    • Harashima C, et al. (2006) Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: A model of Down syndrome. J Comp Neurol 494:815-833. (Pubitemid 43054228)
    • (2006) Journal of Comparative Neurology , vol.494 , Issue.5 , pp. 815-833
    • Harashima, C.1    Jacobowitz, D.M.2    Witta, J.3    Borke, R.C.4    Best, T.K.5    Siarey, R.J.6    Galdzicki, Z.7
  • 53
    • 0033571910 scopus 로고    scopus 로고
    • A role for extracellular adenosine in time-dependent reversal of long-term potentiation by low-frequency stimulation at hippocampal CA1 synapses
    • Huang CC, Liang YC, Hsu KS (1999) A role for extracellular adenosine in time-dependent reversal of long-term potentiation by low-frequency stimulation at hippocampal CA1 synapses. J Neurosci 19:9728-9738.
    • (1999) J Neurosci , vol.19 , pp. 9728-9738
    • Huang, C.C.1    Liang, Y.C.2    Hsu, K.S.3
  • 54
    • 77956389608 scopus 로고    scopus 로고
    • NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1
    • Guetg N, et al. (2010) NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1. Proc Natl Acad Sci USA 107: 13924-13929.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 13924-13929
    • Guetg, N.1
  • 55
    • 78049400024 scopus 로고    scopus 로고
    • Mouse models of cognitive disabilities in trisomy 21 (Down syndrome)
    • Roubertoux PL, Carlier M (2010) Mouse models of cognitive disabilities in trisomy 21 (Down syndrome). Am J Med Genet C Semin Med Genet 154C:400-416.
    • (2010) Am J Med Genet C Semin Med Genet , vol.154 C , pp. 400-416
    • Roubertoux, P.L.1    Carlier, M.2
  • 56
    • 79959584954 scopus 로고    scopus 로고
    • Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation
    • Regev L, et al. (2011) Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation. Mol Psychiatry 16:714-728.
    • (2011) Mol Psychiatry , vol.16 , pp. 714-728
    • Regev, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.