Wolbachia and its implications for the immunopathology of filariasis

Endocrine, Metabolic and Immune Disorders - Drug Targets

Volumn 12, Issue 1, 2012, Pages 53-56

  Genchi, Claudio ^a   Kramer, Laura H ^b   Sassera, Davide ^a   Bandi, Claudio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

Filarial nematodes; PAMPs; Reproductive parasite; Symbiosis; Wolbachia

Indexed keywords

ANTIBIOTIC AGENT; DOXYCYCLINE; IVERMECTIN; TETRACYCLINE;

AEDES AEGYPTI; ANTIPROTOZOAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; DIROFILARIA IMMITIS; ENDOSYMBIONT; FEMINIZATION; FILARIA; FILARIASIS; HOST PARASITE INTERACTION; IMMUNOMODULATION; IMMUNOPATHOLOGY; LYMPHATIC FILARIASIS; NONHUMAN; ONCHOCERCA VOLVULUS; PARASITE SURVIVAL; PARASITE TRANSMISSION; PARASITE VECTOR; WOLBACHIA;

EID: 84857135321     PISSN: 18715303     EISSN: 22123873     Source Type: Journal    
DOI: 10.2174/187153012799279108     Document Type: Article

References (34)

1. Basanez, M.G.; Pion, S.D.S.; Churcher, T.S.; Breitling, L.P.; Little, M.P. and Boussinesq, M. (2006) River blindness: A success story under threat? PloS Med., 3, 1454-1460.
2. Remme, J.H.F.; Feenstra, P.; Lever, P.R.; Medici, A.; Morel, C.; Noma, M.; Ramaiah, K. D.; Richards, F.; Seketeli, A.; Schmunis, G.; Brakel, W.H.V. and Vassall, A. (2006) Tropical diseases targeted for elimination: Chagas disease, lymphatic filariasis, onchocerciasis, and leprosy. Disease control priorities in developing countries, (2nd Ed.), 433-449.
3. Ichimori, K. and Crump, A. (2005) Pacific collaboration to eliminate lymphatic filariasis. Trends Parasitol., 21, 441-444.
4. Orihel, T.C. and Eberhard, M.L. (1998) Zoonotic filariasis. Clin. Microbiol. Rev., 11, 366-381.
5. Pampiglione, S. and Rivasi, F. (2000) Human dirofilariasis due to Dirofilaria (Nochtiella) repens: an update of world literature from 1995 to 2000. Parassitologia, 42, 231-254.
6. McCall, J.W.; Genchi, C.; Kramer, L.; Guerrero, J.; Dzimianski, M.T.; Supakorndej, P.; Mansour, A.M.; McCall, S.D.; Supakorndej, N.; Grandi, G. and Carson, B. (2008) Heartworm and Wolbachia: Therapeutic implications. Vet. Parasitol., 158, 204-214.
7. Genchi, C.; Cody, R.; Pengo, G.; Buscher, G.; Cavalleri, D.; Bucci, V. and Junquera, P. (2004) Efficacy of a single milbemycin oxime administration in combination with praziquantel against experimentally induced heartworm (Dirofilaria immitis) infection in cats. Vet. Parasitol., 122, 287-292.
8. Bandi, C.; Trees, A.J. and Brattig, N.W. (2001) Wolbachia in filarial nematodes: evolutionary aspects and implications for the pathogenesis and treatment of filarial diseases. Vet. Parasitol., 98, 215-238.
9. Dumler, J.S.; Barbet, A.F.; Bekker, C.P.; Dasch, G.A.; Palmer, G.H.; Ray, S.C.; Rikihisa, Y. and Rurangirwa, F.R. (2001) Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol., 51, 2145-2165.
10. Werren, J.H.; Baldo, L. and Clark, M.E. (2008) Wolbachia: master manipulators of invertebrate biology. Nat. Rev. Microbiol., 6, 741-751.
11. Taylor, M.J.; Bandi, C. and Hoerauf, A. (2005) Wolbachia bacterial endosymbionts of filarial nematodes. Adv. Parasitol., 60, 248-286.
12. Kremer, N.; Voronin, D.; Charif, D.; Mavingui, P.; Mollereau, B. and Vavre F. (2009) Wolbachia interferes with ferritin expression and iron metabolism in insects. PLoS Pathog., 5, e1000630.
13. Teixeira, L.; Ferreira, A. and Ashburner, M. (2008) The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster. PLoS Biol., 6, e2.
14. Kambris, Z.; Cook, P.E.; Phuc, H.K. and Sinkins, S.P. (2009) Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. Science, 326, 134-136.
15. Kambris, Z.; Blagborough, A.M.; Pinto, S.B.; Blagrove, M.S.; Godfray, H.C.; Sinden, R.E. and Sinkins, S.P. (2010) Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae. PLoS Pathog., 6 10.
16. Enserink, M. (2010) Australia to Test 'Mosquito Vaccine' Against Human Disease. Science, 330, 1460-1461.
17. Bandi, C.; McCall, J.W.; Genchi, C.; Corona, S.; Venco, L. and Sacchi, L. (1999) Effects of tetracycline on the filarial worms Brugia pahangi and Dirofilaria immitis and their bacterial endosymbionts Wolbachia. Int. J. Parasitol., 29, 357-364.
18. Hoerauf, A.; Nissen-Pähle, K.; Schmetz, C.; Henkle-Dührsen, K.; Blaxter, M.L.; Büttner, D.W.; Gallin, M.Y.; Al-Qaoud, K.M.; Lucius, R. and Fleischer, B. (1999) Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility. J. Clin. Invest., 103, 11-18.
19. Langworthy, N.G.; Renz, A.; Mackenstedt, U.; Henkle-Dührsen, K.; de Bronsvoort, M.B.; Tanya, V.N.; Donnelly, M.J. and Trees A.J. (2000) Macrofilaricidal activity of tetracycline against the filarial nematode Onchocerca ochengi: elimination of Wolbachia precedes worm death and suggests a dependent relationship. Proc. Biol. Sci., 267, 1063-1069.
20. Casiraghi, M.; McCall, J.W.; Simoncini, L.; Kramer, L.H.; Sacchi, L.; Genchi, C., Werren, J.H. and Bandi, C. (2002) Tetracycline treatment and sex-ratio distortion: a role for Wolbachia in the moulting of filarial nematodes? Int. J. Parasitol., 32, 1457-1468.
21. Hoerauf, A. (2009) Mansonella perstans--the importance of an endosymbiont. N. Engl. J. Med., 361, 1502-1504.
22. Bazzocchi, C.; Mortarino, M.; Grandi, G.; Kramer, L.H.; Genchi, C.; Bandi, C.; Genchi, M.; Sacchi, L. and McCall, J.W. (2008). Combined ivermectin and doxycycline treatment has. microfilaricidal and adulticidal activity against Dirofilaria immitis. in experimentally infected dogs. Int. J. Parasitol., 38, 1401-1410.
23. Foster, J.; Ganatra, M.; Kamal, I.; Ware, J.; Makarova, K.; Ivanova, N.; Bhattacharyya, A.; Kapatral, V.; Kumar, S.; Posfai, J.; Vincze, T.; Ingram, J.; Moran L.; Lapidus, A.; Omelchenko, M.; Kyrpides, N.; Ghedin, E.; Wang, S.; Goltsman, E.; Joukov, V.; Ostrovskaya, O.; Tsukerman, K.; Mazur, M.; Comb.; Koonin, E. and Slatko, B. (2005) The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode. PLoS Biol., 3, e121.
24. Wu, B.; Novelli, J.; Foster, J.; Vaisvila, R.; Conway, L.; Ingram, J.; Ganatra, M.; Rao, A. U.; Hamza, I. and Slatko, B. (2009) The heme biosynthetic pathway of the obligate Wolbachia endosymbiont of Brugia malayi as a potential anti-filarial drug target. Plos Negl. Trop. Dis., 3, 7.
25. Bazzocchi, C.; Ceciliani, F.; McCall, J.W.; Ricci, I.; Genchi, C. and Bandi, C. (2000) Antigenic role of the endosymbionts of filarial nematodes: IgG response against the Wolbachia surface protein in cats infected with Dirofilaria immitis. Proc. Biol. Sci., 267, 2511-2516.
26. Brattig, N.W.; Bazzocchi, C.; Kirschning, C.J.; Reiling, N.; Buttner, D.W.; Ceciliani, F.; Geisinger, F.; Hochrein, H.; Ernst, M.; Wagner, H.; Bandi, C. and Hoerauf, A. (2004) The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4. J. Immunol., 73, 437-445.
27. Cross, H.F.; Haarbrink, M.; Egerton, G.; Yazdanbakhsh, M. and Taylor, M.J. (2001) Severe reactions to filarial chemotherapy and release of Wolbachia endosymbionts into blood. Lancet, 358, 1873-1875.
28. Brattig, N.W.; Buttner, D.W. and Hoerauf, A. (2001) Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria. Microb. Infect., 3, 439-446.
29. Bazzocchi, C.; Genchi, C.; Paltrinieri, S.; Lecchi, C.; Mortarino, M. and Bandi, C. (2003) Immunological role of the endosymbionts of Dirofilaria immitis: the Wolbachia surface protein activates canine neutrophils with production of IL-8. Vet. Parasitol., 117, 73-83.
30. Hise, A.G.; Gillette-Ferguson, I. and Pearlman, E. (2004) The role of endosymbiotic Wolbachia bacteria in filarial disease. Cell Microbiol., 6, 97-104.
31. Mand, S.; Pfarr, K.; Sahoo, P.K.; Satapathy, A.K.; Specht, S.; Klarmann, U.; Debrah, A.Y.; Ravindran B. and Hoerauf, A. (2009) Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine. Am. J. Trop. Med. Hyg., 81, 702-711.
32. O'Connor, R.A.; Jenson, J.S.; Osborne, J. and Devaney, E. (2003) An enduring association? Microfilariae and immunosupression in lymphatic filariasis. Trends Parasitol., 19, 565-570.
33. Bazzocchi, C.; Comazzi, S.; Santoni, R.; Bandi, C.; Genchi, C. And Mortarino, M. (2007) Wolbachia surface protein (WSP) inhibits apoptosis in human neutrophils. Parasite Immunol., 29, 73-79.
34. Hansen, R.D.; Trees, A.J.; Bah, G.S.; Hetzel, U.; Martin C.; Bain, O.; Tanya V.N. and Makepeace A. (2010) Worm's best friend: recruitment of neutrophils by Wolbachia confounds eosinophil degranulation against the filarial nematode Onchocerca ochengi. Proc. Biol. Sci., 278, 2293-2302.