Dermal fibroblasts display similar phenotypic and differentiation capacity to fat-derived mesenchymal stem cells, but differ in anti-inflammatory and angiogenic potential

Vascular Cell

Volumn 3, Issue , 2011, Pages

  Blasi, Antonella ^a   Martino, Carmela ^a   Balducci, Luigi ^a   Saldarelli, Marilisa ^a   Soleti, Antonio ^a   Navone, Stefania ^b   Canzi, Laura ^b   Cristini, Silvia ^b   Invernici, Gloria ^b   Parati, Eugenio ^b   Alessandri, Giulio ^b  

^a Medestea Research and Production Laboratories   (Italy)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALDEHYDE DEHYDROGENASE; ANGIOGENIC FACTOR; ANGIOPOIETIN; BETA1 INTEGRIN; BIOLOGICAL MARKER; CD133 ANTIGEN; CD146 ANTIGEN; CD34 ANTIGEN; CD56 ANTIGEN; CHEMOKINE; ENDOGLIN; HERMES ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; RANTES; SCATTER FACTOR; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN A;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; ANGIOGENESIS; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL EXPANSION; CELL PROLIFERATION; CELL STRAIN U937; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; INHIBITION KINETICS; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MONOCYTE; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SKIN FIBROBLAST; TISSUE REGENERATION;

EID: 79955595037     PISSN: 2045824X     EISSN: None     Source Type: Journal    
DOI: 10.1186/2045-824X-3-5     Document Type: Article

References (41)

1. Multilineage potential of adult human mesenchymal stem cells. Pittenger MF Mackay AM, Beck SC Jaiswal RK, Douglas R Mosca JD, Moorman MA Simonetti DW, Craig S Marshak DR, Science 1999 284 143 147 10.1126/science.284.5411.143 10102814 (Pubitemid 29282067)
2. Pluripotency of mesenchymal stem cells derived from adult marrow. Jiang Y Jahagirdar BN, Reinhardt RL Schwartz RE, Keene CD Ortiz-Gonzalez XR, Reyes M Lenvik T, Lund T Blackstad M, Du J Aldrich S, Lisberg A Low WC, Largaespada DA Verfaillie CM, Nature 2002 418 42 D49 10.1038/nature00870 (Pubitemid 34742565)
3. Human adipose tissue is a source of multipotent stem cells. Zuk PA Zhu M, Ashjian P De Ugarte DA, Huang JI Mizuno H, Alfonso ZC Fraser JK, Benhaim P Hedrick MH, Mol Biol Cell 2002 13 4279 4295 10.1091/mbc.E02-02-0105 12475952 (Pubitemid 35471185)
4. Isolation and identification of mesenchymal stem cells from human fetal pancreas. Hu Y Liao L Wang Q Ma L, Ma G Jiang X, Zhao RC, J Lab Clin Med 2003 141 342 349 10.1016/S0022-2143(03)00022-2 12761478 (Pubitemid 36578102)
5. 5-Aza-2'-deoxycytidine treatment induces skeletal myogenic differentiation of mouse dental pulp stem cells. Nakatsuka R Nozaki T, Uemura Y Matsuoka Y, Sasaki Y Shinohara M, Ohura K Sonoda Y, Arch Oral Biol 2010 55 350 357 10.1016/j.archoralbio.2010.03.003 20362276
6. A perivascular origin for mesenchymal stem cells in multiple human organs. Crisan M Yap S Casteilla L Chen CW, Corselli M Park TS, Andriolo G Sun B, Zheng B Zhang L, Norotte C Teng PN, Traas J Schugar R, Deasy BM Badylak S, Buhring HJ Giacobino JP, Lazzari L Huard J, Péault B, Cell Stem Cell 2008 3 301 313 10.1016/j.stem.2008.07.003 18786417
7. Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle. Yoshimura H Muneta T, Nimura A Yokoyama A, Koga H Sekiya I, Cell Tissue Res 2007 327 449 462 10.1007/s00441-006-0308-z 17053900 (Pubitemid 46232315)
8. Isolation of stromal stem cells from human adipose tissue. Boquest AC Shahdadfar A, Brinchmann JE Collas P, Methods Mol Biol 2006 325 35 46 16761717
9. A method for removal of fibroblasts from human tissue culture system. Linge C Green MR Brooks RF, Exp Cell Res 1989 185 519 528 10.1016/0014-4827(89) 90320-0 2689198 (Pubitemid 20014187)
10. Multilineage differentiation potential of human dermal skin-derived fibroblasts. Lorenz K Sicker M Schmelzer E Rupf T, Salvetter J Schulz-Siegmund M, Bader A, Exp Dermatol 2008 17 925 932 10.1111/j.1600-0625.2008.00724.x 18557932
11. The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors. Gronthos S Graves SE, Ohta S Simmons PJ, Blood 1994 84 4164 4173 7994030 (Pubitemid 24371919)
12. Isolation and characterization of resident mesenchymal stem cells in human glomeruli. Bruno S Bussolati B, Grange C Collino F, di Cantogno LV Herrera MB, Biancone L Tetta C, Segoloni G Camussi G, Stem Cells Dev 2009 18 867 880 10.1089/scd.2008.0320 19579288
13. Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Sorrentino A Ferracin M, Castelli G Biffoni M, Tomaselli G Baiocchi M, Fatica A Negrini M, Peschle C Valtieri M, Exp Hematol 2008 36 1035 1046 10.1016/j.exphem.2008.03.004 18504067
14. Comparative characteristics of mesenchymal stem cellsfrom human bone marrow, adipose tissue, and umbilical cord blood. Wagner W Wein F Seckinger A, Exp Hematol 2005 33 1402 1416 10.1016/j.exphem.2005.07.003 16263424 (Pubitemid 41541969)
15. Omentum-derived stromal cells improve myocardial regeneration in pig post-infarcted heart through a potent paracrine mechanism. De Siena R Balducci L, Blasi A Montanaro MG, Saldarelli M Saponaro V, Martino C Logrieco G, Soleti A Fiobellot S, Madeddu P Rossi G, Ribatti D Crovace A, Cristini S Invernici G, Parati EA Alessandri G, Exp Cell Res 2010 316 1804 1815 10.1016/j.yexcr.2010.02. 009 20156437
16. Aldehyde dehydrogenase as a marker for stem cells. Moreb JS, Curr Stem Cell Res Ther 2008 3 237 246 10.2174/157488808786734006 19075754
17. Phenotypic and functional characteristics of tumour-derived microvascular endothelial cells. Alessandri G Chirivi RG, Fiorentini S Dossi R, Bonardelli S Giulini SM, Zanetta G Landoni F, Graziotti PP Turano A, Caruso A Zardi L, Giavazzi R Bani MR, Clin Exp Metastasis 1999 17 655 662 10.1023/A:1006738901839 10919710 (Pubitemid 30450187)
18. Matrigel: basement membrane matrix with biological activity. Kleinman HK Martin GR, Semin Cancer Biol 2005 15 378 386 10.1016/j.semcancer.2005.05.004 15975825 (Pubitemid 41140305)
19. Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells. Steingen C Brenig F, Baumgartner L Schmidt J, Schmidt A Bloch W, J Mol Cell Cardiol 2008 44 1072 1084 10.1016/j.yjmcc.2008.03.010 18462748
20. Molecular mechanism and function of CD40/CD40L engagement in the immune system. Elgueta R Benson MJ, de Vries VC Wasiuk A, Guo Y Noelle RJ, Immunol Rev 2009 229 152 172 10.1111/j.1600-065X.2009.00782.x 19426221
21. CD40 expression by human fibroblasts. Fries KM Sempowski GD, Gaspari AA Blieden T, Looney RJ Phipps RP, Clin Immunol Immunopathol 1995 77 42 51 10.1016/0090-1229(95)90135-3 7554483
22. Adiponectin: a link between excess adiposity and associated comorbidities? Ukkola O Santaniemi M, J Mol Med 2002 80 696 702 10.1007/s00109-002-0378-7 12436346 (Pubitemid 35352035)
23. Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats. Tanaka F Tominaga K, Ochi M Tanigawa T, Watanabe T Fujiwara Y, Ohta K Oshitani N, Higuchi K Arakawa T, Life Sci 2008 83 771 779 10.1016/j.lfs.2008.09. 016 18950645
24. Identification of IL-10 and TGF-beta transcripts involved in the inhibition of T-lymphocyte proliferation during cell contact with human mesenchymal stem cells. Nasef A Chapel A Mazurier C Bouchet S, Lopez M Mathieu N, Sensebé L Zhang Y, Gorin NC Thierry D, Fouillard L, Gene Expr 2007 13 217 226 10.3727/000000006780666957 17605296 (Pubitemid 47024153)
25. In vivo transmigrated monocytes from patients with stable coronary artery disease have a reduced expression of CD11b. Paulsson JM Dadfar E Held C Jacobson SH, Lundahl J, Clin Exp Immunol 2008 153 196 204 10.1111/j.1365-2249. 2008.03676.x 18460014 (Pubitemid 351989155)
26. Adult rat mesenchymal stem cells differentiate into neuronal-like phenotype and express a variety of neuro-regulatory molecules in vitro. Jiang J Lv Z, Gu Y Li J, Xu L Xu W, Lu J Xu J, Neurosci Res 2010 66 46 52 10.1016/j.neures.2009.09.1711 19808065
27. Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G. Nasef A Mathieu N Chapel A Frick J, François S Mazurier C, Boutarfa A Bouchet S, Gorin NC Thierry D, Fouillard L, Transplantation 2007 84 231 237 10.1097/01.tp.0000267918.07906.08 17667815 (Pubitemid 47205757)
28. Trophic molecules derived from human mesenchymal stem cells enhance survival, function, and angiogenesis of isolated islets after transplantation. Park KS Kim YS, Kim JH Choi B, Kim SH Tan AH, Lee MS Lee MK, Kwon CH Joh JW, Kim SJ Kim KW, Transplantation 2010 89 509 517 20125064
29. Why are MSCs therapeutic? New data: new insight. Caplan AI, J Pathol 2009 217 318 324 10.1002/path.2469 19023885
30. Dilution of human mesenchymal stem cells with dermal fibroblasts and the effects on in vitro and in vivo osteochondrogenesis. Lennon DP Haynesworth SE Arm DM Baber MA, Caplan AI, Dev Dyn 2000 219 50 62 10.1002/1097-0177(2000)9999: 9999<::AID-DVDY1037>3.0.CO;2-7 10974671 (Pubitemid 30667123)
31. Human Bone-Marrow And Adipose Tissue Mesenchymal Stem Cells: A User's Guide. Mosna F Sensebé L Krampera M, Stem Cells Dev 2010 19 1449 1470 10.1089/scd.2010.0140 20486777
32. Minimal criteria for defining multipotent mesenchymal stromal cells. Dominici M Le Blanc K, Mueller I Slaper-Cortenbach I, Marini F Krause D, Cytotherapy 2006 8 315 317 10.1080/14653240600855905 16923606
33. Immune cell proliferation is suppressed by the interferon-gamma-induced indoleamine 2,3-dioxygenase expression of fibroblasts populated in collagen gel (FPCG). Sarkhosh K Tredget EE Karami A Uludag H, Iwashina T Kilani RT, Ghahary A, J Cell Biochem 2003 90 206 217 10.1002/jcb.10593 12938169 (Pubitemid 37052322)
34. Extracellular matrix deposition by fibroblasts is necessary to promote capillary-like tube formation in vitro. Berthod F Germain L, Tremblay N Auger FAJ, Cell Physiol 2006 207 491 498 10.1002/jcp.20584
35. In vitro reconstruction of a human capillary-like network in a tissue-engineered skin equivalent. Black AF Berthod F L'heureux N Germain L, Auger FA, FASEB J 1998 12 1331 1340 9761776 (Pubitemid 28475574)
36. A tissue-engineered endothelialized dermis to study the modulation of angiogenic and angiostatic molecules on capillary-like tube formation in vitro. Hudon V Berthod F, Black AF Damour O, Germain L Auger FA, Br J Dermatol 2003 148 1094 1104 10.1046/j.1365-2133.2003.05298.x 12828735 (Pubitemid 36819207)
37. Bone marrow-derived stem cells in wound healing: a review. Wu Y Wang J, Scott PG Tredget EE, Wound Repair Regen 2008 16 582 10.1111/j.1524-475X.2008. 00406.x
38. The role of the Angiopoietins in vascular morphogenesis. Thomas M Augustin HG, Angiogenesis 2009 12 125 37 10.1007/s10456-009-9147-3 19449109
39. All MSCs are pericytes? Caplan AI, Cell Stem Cell 2008 3 229 230 10.1016/j.stem.2008.08.008 18786406
40. Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. Covas DT Panepucci RA Fontes AM Silva WA Jr, Orellana MD Freitas MC, Neder L Santos AR, Peres LC Jamur MC, Zago MA, Exp Hematol 2008 36 642 654 10.1016/j.exphem.2007.12.015 18295964
41. TNF-alfa enhances engraftment of mesenchymal stem cells into infracted myocardium. Kim YS Park HJ, Hong MH kang PM, Morgan JP Jeong MH, Cho JG Park JC, Ahn Y, Front Biosci 2009 14 2845 2856 10.2741/3417 19273239