Osteopontin Deficiency Suppresses Tumor Necrosis Factor-α-Induced Apoptosis in Chondrocytes

Cartilage

Volumn 3, Issue 1, 2012, Pages 79-85

  Yumoto, K ^a   Nifuji, A ^a   Rittling, S R ^b   Tsuchiya, Y ^c   Kon, S ^d   Uede, T ^d   Denhardt, D T ^b   Hemmi, H ^a   Notomi, T ^a   Hayata, T ^a   Ezura, Y ^a   Nakamoto, T ^a   Noda, M ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b RUTGERS UNIVERSITY   (United States)

^c Immuno Biological Laboratories Co Ltd   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

animal models general; biomechanics general; chondrocytes cells; chondrogenesis cells

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; CASPASE 3; LACTATE DEHYDROGENASE; OSTEOPONTIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MONOLAYER CULTURE; MOUSE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOPONTIN DEFICIENCY; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; WILD TYPE;

EID: 84857127387     PISSN: 19476035     EISSN: 19476043     Source Type: Journal    
DOI: 10.1177/1947603511421502     Document Type: Article

References (16)

1. Yumoto K,Rittling SR,Nifuji A,Uede T,Denhardt DT,Noda M, et al.Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.Proc Natl Acad Sci U S A. 2002;99 (7): 4556-61.
2. Seemayer CA,Distler O,Kuchen S,Muller-Ladner U,Michel BA,Neidhart M, et al.Rheumatoid arthritis: new developments in the pathogenesis with special reference to synovial fibroblasts.Z Rheumatol. 2001;60 (5): 309-18.
3. Kim HA,Song YW.Apoptotic chondrocyte death in rheumatoid arthritis.Arthritis Rheum. 1999;42 (7): 1528-37.
4. Schuerwegh AJ,Dombrecht EJ,Stevens WJ,Van Offel JF,Bridts CH,De Clerck LS.Influence of pro-inflammatory (IL-1 alpha, IL-6, TNF-alpha, IFN-gamma) and anti-inflammatory (IL-4) cytokines on chondrocyte function.Osteoarthritis Cartilage. 2003;11 (9): 681-7.
5. Rittling SR,Matsumoto HN,McKee MD,Nanci A,Noda M,Denhardt DT, et al.Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro.J Bone Miner Res. 1998;13 (7): 1101-11.
6. Yagi K,Nifuji A,Shinomiya K,Nakashima K,DeCrombrugghe B,Noda M, et al.Bone morphogenetic protein-2 enhances osterix gene expression in chondrocytes.J Cell Biochem. 2003;88 (6): 1077-83.
7. Le Stunff H,Auger R,Kanellopoulos J,Raymond MN.The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes.J Biol Chem. 2004;279 (17): 16918-26.
8. Yatsugi N,Tsukazaki T,Osaki M,Koji T,Yamashita S,Shindo H.Apoptosis of articular chondrocytes in rheumatoid arthritis and osteoarthritis: correlation of apoptosis with degree of cartilage destruction and expression of apoptosis-related proteins of p53 and c-myc.J Orthop Sci. 2000;5 (2): 150-6.
9. Kuhn K,Shikhman AR,Lotz M.Role of nitric oxide, reactive oxygen species, and p38 MAP kinase in the regulation of human chondrocyte apoptosis.J Cell Physiol. 2003;197 (3): 379-87.
10. Yamamoto N,Sakai F,Kon S,Seki N,Fujii T,Uede T, et al.Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis.J Clin Invest. 2003;112 (2): 181-8.
11. Asou Y,Rittling SR,Shinomiya K,Nifuji A,Denhardt DT,Noda M, et al.Osteopontin facilitates angiogenesis, accumulation of osteoclasts, and resorption in ectopic bone.Endocrinology. 2001;142 (3): 1325-32.
12. Ashkar S,Weber GF,Rittling SR,Denhardt DT,Glimcher MJ,Cantor H, et al.Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity.Science. 2000;287 (5454): 860-4.
13. Gravallese EM.Osteopontin: a bridge between bone and the immune system.J Clin Invest. 2003;112 (2): 147-9.
14. Zhu B,Suzuki K,Goldberg HA,Rittling SR,Denhardt DT,Sodek J, et al.Osteopontin modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: evidence of a role for an intracellular form of osteopontin.J Cell Physiol. 2004;198 (1): 155-67.
15. Chabas D,Baranzini SE,Rittling SR,Denhardt DT,Oksenberg JR,Steinman L, et al.The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science. 2001;294 (5547): 1731-5.
16. Potter MR,Rittling SR,Denhardt DT,Roper RJ,Teuscher C,Weis JJ, et al.Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi. Infect Immun. 2002;70 (3): 1372-81.