Pαx6 expression in postmitotic neurons mediates the growth of axons in response to SFRP1

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Sebastián Serrano, Alvaro ^a   Sandonis, Africa ^b   Cardozo, Marcos ^b   Rodríguez Tornos, Fernanda M ^a   Bovolenta, Paola ^b   Nieto, Marta ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

NETRIN; SECRETED FRIZZLED RELATED PROTEIN 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR PAX6; EYE PROTEIN; FRIZZLED RELATED PROTEIN-1; HOMEODOMAIN PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; PROTEIN; REPRESSOR PROTEIN;

ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; MOUSE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; NERVE FIBER GROWTH; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA GANGLION CELL; ANIMAL; CYTOLOGY; FOREBRAIN; GENETICS; MITOSIS; NERVE CELL; NERVE FIBER; PHYSIOLOGY; ULTRASTRUCTURE;

ANIMALS; AXONS; EYE PROTEINS; HOMEODOMAIN PROTEINS; MICE; MITOSIS; NEURONS; PAIRED BOX TRANSCRIPTION FACTORS; PROSENCEPHALON; PROTEINS; REPRESSOR PROTEINS; RETINAL GANGLION CELLS;

EID: 84857127199     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031590     Document Type: Article

References (56)

1. Georgala PA, Carr CB, Price DJ, (2011) The role of Pax6 in forebrain development. Dev Neurobiol.
2. Stoykova A, Gruss P, (1994) Roles of Pax-genes in developing and adult brain as suggested by expression patterns. J Neurosci 14: 1395-1412.
3. Marquardt T, Ashery-Padan R, Andrejewski N, Scardigli R, Guillemot F, et al. (2001) Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105: 43-55.
4. Marquardt T, Gruss P, (2002) Generating neuronal diversity in the retina: one for nearly all. Trends Neurosci 25: 32-38.
5. Hsieh YW, Yang XJ, (2009) Dynamic Pax6 expression during the neurogenic cell cycle influences proliferation and cell fate choices of retinal progenitors. Neural Dev 4: 32.
6. Heins N, Malatesta P, Cecconi F, Nakafuku M, Tucker KL, et al. (2002) Glial cells generate neurons: the role of the transcription factor Pax6. Nat Neurosci 5: 308-315.
7. Hack MA, Sugimori M, Lundberg C, Nakafuku M, Gotz M, (2004) Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6. Mol Cell Neurosci 25: 664-678.
8. Ericson J, Rashbass P, Schedl A, Brenner-Morton S, Kawakami A, et al. (1997) Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90: 169-180.
9. Estivill-Torrus G, Pearson H, van Heyningen V, Price DJ, Rashbass P, (2002) Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors. Development 129: 455-466.
10. Ninkovic J, Pinto L, Petricca S, Lepier A, Sun J, et al. (2011) The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin alphaA. Neuron 68: 682-694.
11. Baumer N, Marquardt T, Stoykova A, Ashery-Padan R, Chowdhury K, et al. (2002) Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle. Development 129: 4535-4545.
12. Manuel M, Pratt T, Liu M, Jeffery G, Price DJ, (2008) Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance. BMC Dev Biol 8: 59.
13. Rodger J, King CE, Lukehurst S, Chen PB, Dunlop SA, et al. (2006) Changing Pax6 expression correlates with axon outgrowth and restoration of topography during optic nerve regeneration. Neuroscience 142: 1043-1054.
14. Rodriguez J, Esteve P, Weinl C, Ruiz JM, Fermin Y, et al. (2005) SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor. Nat Neurosci 8: 1301-1309.
15. Bovolenta P, Esteve P, Ruiz JM, Cisneros E, Lopez-Rios J, (2008) Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J Cell Sci 121: 737-746.
16. Trevant B, Gaur T, Hussain S, Symons J, Komm BS, et al. (2008) Expression of secreted frizzled related protein 1, a Wnt antagonist, in brain, kidney, and skeleton is dispensable for normal embryonic development. J Cell Physiol 217: 113-126.
17. de Iongh RU, Abud HE, Hime GR, (2006) WNT/Frizzled signaling in eye development and disease. Front Biosci 11: 2442-2464.
18. Leimeister C, Bach A, Gessler M, (1998) Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family. Mech Dev 75: 29-42.
19. Kim AS, Lowenstein DH, Pleasure SJ, (2001) Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon. Mech Dev 103: 167-172.
20. Cubelos B, Sebastian-Serrano A, Beccari L, Calcagnotto ME, Cisneros E, et al. (2010) Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex. Neuron 66: 523-535.
21. Esteve P, Trousse F, Rodriguez J, Bovolenta P, (2003) SFRP1 modulates retina cell differentiation through a beta-catenin-independent mechanism. J Cell Sci 116: 2471-2481.
22. Alvarez-Rodriguez R, Barzi M, Berenguer J, Pons S, (2007) Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. J Biol Chem 282: 37170-37180.
23. Sanchez-Camacho C, Bovolenta P, (2008) Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons. Development 135: 3531-3541.
24. Black MM, Slaughter T, Fischer I, (1994) Microtubule-associated protein 1b (MAP1b) is concentrated in the distal region of growing axons. J Neurosci 14: 857-870.
25. Haubst N, Berger J, Radjendirane V, Graw J, Favor J, et al. (2004) Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development. Development 131: 6131-6140.
26. Bahr M, (2000) Live or let die- retinal ganglion cell death and survival during development and in the lesioned adult CNS. Trends Neurosci 23: 483-490.
27. Ouyang J, Shen YC, Yeh LK, Li W, Coyle BM, et al. (2006) Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells. Invest Ophthalmol Vis Sci 47: 2397-2407.
28. Pak W, Hindges R, Lim YS, Pfaff SL, O'Leary DD, (2004) Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding. Cell 119: 567-578.
29. Erkman L, Yates PA, McLaughlin T, McEvilly RJ, Whisenhunt T, et al. (2000) A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system. Neuron 28: 779-792.
30. Garcia-Frigola C, Carreres MI, Vegar C, Herrera E, (2007) Gene delivery into mouse retinal ganglion cells by in utero electroporation. BMC Dev Biol 7: 103.
31. de la Torre JR, Hopker VH, Ming GL, Poo MM, Tessier-Lavigne M, et al. (1997) Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC. Neuron 19: 1211-1224.
32. Deiner MS, Kennedy TE, Fazeli A, Serafini T, Tessier-Lavigne M, et al. (1997) Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. Neuron 19: 575-589.
33. Van Raay TJ, Vetter ML, (2004) Wnt/frizzled signaling during vertebrate retinal development. Dev Neurosci 26: 352-358.
34. Chuman Y, Uren A, Cahill J, Regan C, Wolf V, et al. (2004) Identification of a peptide binding motif for secreted frizzled-related protein-1. Peptides 25: 1831-1838.
35. Bovolenta P, (2005) Morphogen signaling at the vertebrate growth cone: a few cases or a general strategy? J Neurobiol 64: 405-416.
36. Nural HF, Mastick GS, (2004) Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain. J Comp Neurol 479: 399-409.
37. Jones L, Lopez-Bendito G, Gruss P, Stoykova A, Molnar Z, (2002) Pax6 is required for the normal development of the forebrain axonal connections. Development 129: 5041-5052.
38. Nikoletopoulou V, Plachta N, Allen ND, Pinto L, Gotz M, et al. (2007) Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells lacking Pax6. Cell Stem Cell 1: 529-540.
39. Kania A, Jessell TM, (2003) Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A:EphA interactions. Neuron 38: 581-596.
40. Wilson SI, Shafer B, Lee KJ, Dodd J, (2008) A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors. Neuron 59: 413-424.
41. Sabatier C, Plump AS, Le M, Brose K, Tamada A, et al. (2004) The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell 117: 157-169.
42. Herrera E, Brown L, Aruga J, Rachel RA, Dolen G, et al. (2003) Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell 114: 545-557.
43. Lee R, Petros TJ, Mason CA, (2008) Zic2 regulates retinal ganglion cell axon avoidance of ephrinB2 through inducing expression of the guidance receptor EphB1. J Neurosci 28: 5910-5919.
44. Williams SE, Mann F, Erskine L, Sakurai T, Wei S, et al. (2003) Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. Neuron 39: 919-935.
45. Molyneaux BJ, Arlotta P, Hirata T, Hibi M, Macklis JD, (2005) Fezl is required for the birth and specification of corticospinal motor neurons. Neuron 47: 817-831.
46. Chen B, Schaevitz LR, McConnell SK, (2005) Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc Natl Acad Sci U S A 102: 17184-17189.
47. Britanova O, de Juan Romero C, Cheung A, Kwan KY, Schwark M, et al. (2008) Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron 57: 378-392.
48. Alcamo EA, Chirivella L, Dautzenberg M, Dobreva G, Farinas I, et al. (2008) Satb2 regulates callosal projection neuron identity in the developing cerebral cortex. Neuron 57: 364-377.
49. Arlotta P, Molyneaux BJ, Chen J, Inoue J, Kominami R, et al. (2005) Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron 45: 207-221.
50. Castellani V, Chedotal A, Schachner M, Faivre-Sarrailh C, Rougon G, (2000) Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance. Neuron 27: 237-249.
51. Carcea I, Ma'ayan A, Mesias R, Sepulveda B, Salton SR, et al. (2011) Flotillin-mediated endocytic events dictate cell type-specific responses to semaphorin 3A. J Neurosci 30: 15317-15329.
52. Holm PC, Mader MT, Haubst N, Wizenmann A, Sigvardsson M, et al. (2007) Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon. Mol Cell Neurosci 34: 99-119.
53. Osumi N, Hirota A, Ohuchi H, Nakafuku M, Iimura T, et al. (1997) Pax-6 is involved in the specification of hindbrain motor neuron subtype. Development 124: 2961-2972.
54. Frowein J, Campbell K, Gotz M, (2002) Expression of Ngn1, Ngn2, Cash1, Gsh2 and Sfrp1 in the developing chick telencephalon. Mech Dev 110: 249-252.
55. Mao W, Wordinger RJ, Clark AF, (2010) Focus on molecules: SFRP1. Exp Eye Res 91: 552-553.
56. Augustine C, Gunnersen J, Spirkoska V, Tan SS, (2001) Place- and time-dependent expression of mouse sFRP-1 during development of the cerebral neocortex. Mech Dev 109: 395-397.