Sonoporation-mediated anti-angiogenic gene transfer into muscle effectively regresses distant orthotopic tumors

Cancer Gene Therapy

Volumn 19, Issue 3, 2012, Pages 171-180

  Liao, Z K ^a,b   Tsai, K C ^b   Wang, H T ^b   Tseng, S H ^c   Deng, W P ^d   Chen, W S ^c   Hwang, L H ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

anti angiogenic gene therapy; orthotopic tumors; sonoporation; ultrasound

Indexed keywords

ADENOVIRUS VECTOR; CALRETICULIN; DOXORUBICIN; ENDOSTATIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; SONOVUE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC GENE THERAPY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BRAIN TUMOR; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER GENE THERAPY; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; DRUG INTERMITTENT THERAPY; DRUG POTENTIATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER TUMOR; LUNG TUMOR; MALE; MONOTHERAPY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; RAT; SONOPORATION MEDIATED ANTIANGIOGENIC GENE THERAPY; TRANSGENE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR REGRESSION; ULTRASOUND;

ADENOVIRIDAE;

EID: 84857113870     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2011.73     Document Type: Article

References (42)

1. Li YS, Davidson E, Reid CN, McHale AP. Optimising ultrasound-mediated gene transfer (sonoporation) in vitro and prolonged expression of a transgene in vivo: potential applications for gene therapy of cancer. Cancer Lett 2009; 273: 62-69.
2. Newman CM, Bettinger T. Gene therapy progress and prospects: ultrasound for gene transfer. Gene Ther 2007; 14: 465-475. (Pubitemid 46390919)
3. Tachibana K, Uchida T, Ogawa K, Yamashita N, Tamura K. Induction of cell-membrane porosity by ultrasound. Lancet 1999; 353: 1409. (Pubitemid 29192415)
4. Miller MW, Miller DL, Brayman AA. A review of in vitro bioeffects of inertial ultrasonic cavitation from a mechanistic perspective. Ultrasound Med Biol 1996; 22: 1131-1154. (Pubitemid 27024654)
5. Barnett SB, ter Haar GR, ZiskinMC, Nyborg WL, Maeda K, Bang J. Current status of research on biophysical effects of ultrasound. Ultrasound Med Biol 1994; 20: 205-218. (Pubitemid 24148511)
6. Shen ZP, Brayman AA, Chen L, Miao CH. Ultrasound with microbubbles enhances gene expression of plasmid DNA in the liver via intraportal delivery. Gene Ther 2008; 15: 1147-1155.
7. Lawrie A, Brisken AF, Francis SE, Cumberland DC, Crossman DC, Newman CM. Microbubble-enhanced ultrasound for vascular gene delivery. Gene Ther 2000; 7: 2023-2027. (Pubitemid 32036768)
8. Li T, Tachibana K, Kuroki M. Gene transfer with echoenhanced contrast agents: comparison between Albunex, Optison, and Levovist in mice-initial results. Radiology 2003; 229: 423-428. (Pubitemid 37310829)
9. Bekeredjian R, Grayburn PA, Shohet RV. Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine. J Am Coll Cardiol 2005; 45: 329-335. (Pubitemid 40186780)
10. Miller DL, Quddus J. Sonoporation of monolayer cells by diagnostic ultrasound activation of contrast-agent gas bodies. Ultrasound Med Biol 2000; 26: 661-667. (Pubitemid 30336669)
11. Hayashi S, Mizuno M, Yoshida J, Nakao A. Effect of sonoporation on cationic liposome-mediated IFNbeta gene therapy for metastatic hepatic tumors of murine colon cancer. Cancer Gene Ther 2009; 16: 638-643.
12. Bekeredjian R, Chen S, Frenkel PA, Grayburn PA, Shohet RV. Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart. Circulation 2003; 108: 1022-1026. (Pubitemid 37048235)
13. Taniyama Y, Tachibana K, Hiraoka K, Namba T, Yamasaki K, Hashiya N et al. Local delivery of plasmid DNA into rat carotid artery using ultrasound. Circulation 2002; 105: 1233-1239. (Pubitemid 34225826)
14. Koike H, Tomita N, Azuma H, Taniyama Y, Yamasaki K, Kunugiza Y et al. An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney. J Gene Med 2005; 7: 108-116.
15. Miao CH, Brayman AA, Loeb KR, Ye P, Zhou L, Mourad P et al. Ultrasound enhances gene delivery of human factor IX plasmid. Hum Gene Ther 2005; 16: 893-905. (Pubitemid 40982337)
16. Lu QL, Liang HD, Partridge T, Blomley MJ. Microbubble ultrasound improves the efficiency of gene transduction in skeletal muscle in vivo with reduced tissue damage. Gene Ther 2003; 10: 396-405. (Pubitemid 36372447)
17. Wang X, Liang HD, Dong B, Lu QL, Blomley MJ. Gene transfer with microbubble ultrasound and plasmid DNA into skeletal muscle of mice: comparison between commercially available microbubble contrast agents. Radiology 2005; 237: 224-229. (Pubitemid 41346167)
18. Taniyama Y, Tachibana K, Hiraoka K, Aoki M, Yamamoto S, Matsumoto K et al. Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Ther 2002; 9: 372-380. (Pubitemid 34414035)
19. Hauff P, Seemann S, Reszka R, Schultze-Mosgau M, Reinhardt M, Buzasi T et al. Evaluation of gas-filled microparticles and sonoporation as gene delivery system: feasibility study in rodent tumor models. Radiology 2005; 236: 572-578. (Pubitemid 41023442)
20. Manome Y, Nakamura M, Ohno T, Furuhata H. Ultrasound facilitates transduction of naked plasmid DNA into colon carcinoma cells in vitro and in vivo. Hum Gene Ther 2000; 11: 1521-1528. (Pubitemid 30670604)
21. Yamashita Y, Shimada M, Tachibana K, Harimoto N, Tsujita E, Shirabe K et al. In vivo gene transfer into muscle via electro-sonoporation. Hum Gene Ther 2002; 13: 2079-2084. (Pubitemid 35417352)
22. Ribatti D, Vacca A, Dammacco F. The role of the vascular phase in solid tumor growth: a historical review. Neoplasia 1999; 1: 293-302.
23. Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005; 438: 932-936. (Pubitemid 43093958)
24. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285: 1182-1186.
25. Duvshani-Eshet M, Benny O, Morgenstern A, Machluf M. Therapeutic ultrasound facilitates antiangiogenic gene delivery and inhibits prostate tumor growth. Mol Cancer Ther 2007; 6: 2371-2382. (Pubitemid 47294765)
26. Tsai KC, Liao ZK, Yang SJ, Lin WL, Shieh MJ, Hwang LH et al. Differences in gene expression between sonoporation in tumor and in muscle. J Gene Med 2009; 11: 933-940.
27. Tai KF, Chen PJ, Chen DS, Hwang LH. Concurrent delivery of GM-CSF and endostatin genes by a single adenoviral vector provides a synergistic effect on the treatment of orthotopic liver tumors. J Gene Med 2003; 5: 386-398.
28. Lee YL, Ye YL, Yu CI, Wu YL, Lai YL, Ku PH et al. Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma. Hum Gene Ther 2001; 12: 2065-2079.
29. Chang CJ, Chen YH, Huang KW, Cheng HW, Chan SF, Tai KF et al. Combined GM-CSF and IL-12 gene therapy synergistically suppresses the growth of orthotopic liver tumors. Hepatology 2007; 45: 746-754.
30. Huang KW, Huang YC, Tai KF, Chen BH, Lee PH, Hwang LH. Dual therapeutic effects of interferon-alpha gene therapy in a rat hepatocellular carcinoma model with liver cirrhosis. Mol Ther 2008; 16: 1681-1687.
31. Tseng SH, Chen Y, Chang CJ, Tai KF, Lin SM, Hwang LH. Induction of T-cell apoptosis in rats by genetically engineered glioma cells expressing granulocyte-macrophage colony-stimulating factor and B7. 1. Clin Cancer Res 2005; 11: 1639-1649. (Pubitemid 40315249)
32. Chen HW, Lee JY, Huang JY, Wang CC, Chen WJ, Su SF et al. Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Res 2008; 68: 7428-7438.
33. Kulke MH, Bergsland EK, Ryan DP, Enzinger PC, Lynch TJ, Zhu AX et al. Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors. J Clin Oncol 2006; 24: 3555-3561. (Pubitemid 46630526)
34. Celik I, Surucu O, Dietz C, Heymach JV, Force J, Hoschele I et al. Therapeutic efficacy of endostatin exhibits a biphasic dose-response curve. Cancer Res 2005; 65: 11044-11050. (Pubitemid 41713375)
35. Cho HM, Rosenblatt JD, Kang YS, Iruela-Arispe ML, Morrison SL, Penichet ML et al. Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein. Mol Cancer Ther 2005; 4: 956-967. (Pubitemid 40909078)
36. Hansma AH, Broxterman HJ, van der Horst I, Yuana Y, Boven E, Giaccone G et al. Recombinant human endostatin administered as a 28-day continuous intravenous infusion, followed by daily subcutaneous injections: a phase I and pharmacokinetic study in patients with advanced cancer. Ann Oncol 2005; 16: 1695-1701. (Pubitemid 41510146)
37. Thomas JP, Arzoomanian RZ, Alberti D, Marnocha R, Lee F, Friedl A et al. Phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors. J Clin Oncol 2003; 21: 223-231. (Pubitemid 46606150)
38. Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62. (Pubitemid 40093472)
39. Huber PE, Bischof M, Jenne J, Heiland S, Peschke P, Saffrich R et al. Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. Cancer Res 2005; 65: 3643-3655. (Pubitemid 40616341)
40. Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 2004; 64: 3731-3736. (Pubitemid 38697278)
41. Ma J, Waxman DJ. Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther 2008; 7: 3670-3684.
42. Huang KW, Wu HL, Lin HL, Liang PC, Chen PJ, Chen SH et al. Combining antiangiogenic therapy with immunotherapy exerts better therapeutical effects on large tumors in a woodchuck hepatoma model. Proc Natl Acad Sci USA 2010; 107: 14769-14774.