Topical ciclosporin in the treatment of vernal keratoconjunctivitis in Rwanda, Central Africa: A prospective, randomised, double-masked, controlled clinical trial

British Journal of Ophthalmology

Volumn 96, Issue 3, 2012, Pages 323-328

  De Smedt, Stefan ^a   Nkurikiye, John ^b   Fonteyne, Yannick ^a   Tuft, Stephen ^c   De Bacquer, Dirk ^d   Gilbert, Clare ^e   Kestelyn, Philippe ^f  

^a Kabgayi Hospital   (Rwanda)

^b KING FAISAL HOSPITAL   (Rwanda)

^c MOORFIELDS EYE HOSPITAL   (United Kingdom)

^d GHENT UNIVERSITY   (Belgium)

^e LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^f GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CROMOGLYCATE DISODIUM; CYCLOSPORIN A; DEXAMETHASONE; OLIVE OIL; PLACEBO;

ADOLESCENT; ADVERSE OUTCOME; APPLICATION SITE BURNING; ARTICLE; CENTRAL AFRICA; CLINICAL FEATURE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RELAPSE; TREATMENT DURATION; TREATMENT OUTCOME; VERNAL CONJUNCTIVITIS; VISUAL ACUITY;

ADMINISTRATION, TOPICAL; ADOLESCENT; CHILD; CONJUNCTIVITIS, ALLERGIC; CYCLOSPORINE; DEXAMETHASONE; DOUBLE-BLIND METHOD; FEMALE; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; OPHTHALMIC SOLUTIONS; PROSPECTIVE STUDIES; RWANDA; TREATMENT OUTCOME; VISUAL ACUITY;

EID: 84857110511     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjophthalmol-2011-300415     Document Type: Article

References (25)

1. Diallo J-S. La limbo-conjonctivite endémique des tropiques. Rev Int Trachome 1976;3-4:71-9.
2. Khan MD, Kundi N, Saeed N, et al. A study of 530 cases of vernal conjunctivitis from the North West Frontier Province of Pakistan. Pakistan J Ophthalmol 1986;2:111-14. (Pubitemid 17216220)
3. BenEzra D, Pe'er J, Brodsky M, et al. Cyclosporine eyedrops for the treatment of severe vernal keratoconjunctivitis. Am J Ophthalmol 1986;101:278-82. (Pubitemid 16132651)
4. Dahan E, Appel R. Vernal keratoconjunctivitis in the black child and its response to therapy. Br J Ophthalmol 1983;67:688-92. (Pubitemid 13007653)
5. Sandford-Smith J. Vernal eye disease in Northern Nigeria. Trop Geogr Med 1979;31:321-8. (Pubitemid 10172551)
6. Resnikoff S, Cornand G, Filliard G, et al. Limbal vernal conjunctivitis in the tropics. Rev Int Trachome 1988;3-4:53-71.
7. Pucci N, Caputo R, Mori F, et al. Long-term safety and efficacy of topical cyclosporine in 156 children with vernal keratoconjunctivitis. Int J Immunopathol Pharmacol 2010;23:865-71.
8. Spadavecchia L, Fanelli P, Tesse R, et al. Efficacy of 1.25% and 1% topical cyclosporine in the treatment of severe vernal keratoconjunctivitis in childhood. Pediatr Allergy Immunol 2006;17:527-32. (Pubitemid 44511088)
9. Pucci N, Novembre E, Cianferoni A, et al. Efficacy and safety of cyclosporine eyedrops in vernal keratoconjunctivitis. Ann Allergy Asthma Immunol 2002;89:298-303.
10. Secchi A, Tognon M, Leonardi A. Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis. Am J Ophthalmol 1990;110:641-5.
11. Bleik J, Tabbara K. Topical cyclosporine in vernal keratoconjunctivitis. Ophthalmology 1991;98:1679-84.
12. Gupta V, Sahun P. Topical cyclosporin A in the management of vernal keratoconjunctivitis. Eye 2001;15:39-41. (Pubitemid 32258214)
13. Akpek EK, Dart JK, Watson S, et al. A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis. Ophthalmology 2004;111:476-82. (Pubitemid 38293102)
14. Schulz K, Altman D, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. Ann Int Med 2010;152:726-32.
15. Bonini S, Bonini S, Lambiase A, et al. Vernal keratoconjunctivitis revisited. A case series of 195 patients with long-term followup. Ophthalmology 2000;107:1157-63.
16. Easty D, Rice N, Jones B. Disodium cromoglycate (Intal) in the treatment of vernal-kerato-conjunctivitis. Trans Ophthal Soc UK 1971;91:491-9.
17. Singh S, Pal V, Dhull CS. Supratarsal injection of corticosteroids in the treatment of refractory vernal keratoconjunctivitis. Indian J Ophthalmol 2001;49:241-5. (Pubitemid 34111877)
18. Nussenblat R, Palestine A. Cyclosporine: immunology, pharmacology and therapeutic uses. Surv Ophthalmol 1986;31:159-69. (Pubitemid 17222027)
19. Whitcup SM, Chan C-C, Luyo DA, et al. Topical cyclosporine inhibits mast cell-mediated conjunctivitis. Invest Ophthalmol Vis Sci 1996;37:2686-93. (Pubitemid 27026553)
20. Kashani S, Mearza AA. Uses and safety profile of ciclosporin in ophthalmology. Expert Opin Drug Saf 2008;7:79-89. (Pubitemid 351222965)
21. Kiliç A, Gürler B. Topical 2% cyclosporine A in preservative-free artificial tears for the treatment of vernal keratoconjunctivitis. Can J Ophthalmol 2006;41:693-8. (Pubitemid 46113021)
22. Ozcan AA, Ersoz TR, Dulger E. Management of severe allergic conjunctivitis with topical cyclosporine 0.05% eye drops. Cornea 2007;26:1035-8. (Pubitemid 47480680)
23. Daniell M, Constantinou M, Vu HT, et al. Randomised controlled trial of topical ciclosporin A in steroid dependent allergic conjunctivitis. Br J Ophthalmol 2006;90:461-4.
24. Hingorani M, Moodaley L, Calder VL, et al. A randomised, placebo-controlled trial of topical cyclosporin A in steroid-dependent atopic keratoconjunctivitis. Ophthalmology 1998;105:1715-20. (Pubitemid 28513525)
25. Tam P, Young A, Cheng L, et al. Topical tacrolimus 0.03% monotherapy for vernal keratoconjunctivitis - case series. Br J Ophthalmol 2010;94:1405-6.