Long-term safety and efficacy of topical cyclosporine in 156 children with vernal keratoconjunctivitis

International Journal of Immunopathology and Pharmacology

Volumn 23, Issue 3, 2010, Pages 865-871

  Pucci, Neri ^a   Caputo, R ^a   Mori, F ^a   De Libero, C ^a   Di Grande, L ^a   Massai, C ^a   Bernardini, R ^a   Novembre, E ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Children; Eye drops; Ocular score; Topical cyclosporine; Vernal keratoconjunctivitis

Indexed keywords

CYCLOSPORIN A;

ADOLESCENT; ADULT; AMBULATORY CARE; ARTICLE; BURNING SENSATION; CHILD; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; ENZYME ACTIVITY; FEMALE; FOLLOW UP; HUMAN; KIDNEY FUNCTION; LIVER FUNCTION; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; VERNAL CONJUNCTIVITIS;

EID: 78149235593     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201002300322     Document Type: Article

References (18)

1. Secchi AG, Tognon S, Leonardi A. Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis. Am J Ophtalmol 1990; 110:641-45.
2. Bleik JH, Tabbara KF. Topical cyclosporine in vernal keratoconjunctivitis. Ophtalmology 1991; 98:1679-84.
3. Gupta V, Kumar Sahu P. Topical cyclosporin A in the management of vernal keratoconjunctivitis. Eye 2001; 15:39-41.
4. Pucci N, Novembre E, Cianferoni A, Lombardi E, Bernardini R, Caputo R et al. Efficacy and safety of cyclosporine eye drops in vernal keratoconjunctivitis. Ann Allergy Asthma Immunol 2002; 89:298-303.
5. Perry HD, Donnenfeld ED, Kanellopoulos AJ, Grossman GA. Topical cyclosporine A in the management of post keratoplasty glaucoma. Cornea 1997; 16:284-8.
6. Cabrelle A, Maschio N, Carraro S, et al. Apoptotic effect of cyclosporin A and dexamethasone in malignant cells of patients with B-chronic lymphocytic leukemia. J Biol Regul Homeost Agents 2009; 23:239-50.
7. Holland EJ, Chan CC, Kuwabara T, Palestine AG, Rowsey JJ, Nussenblatt RB. Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis. Am J Ophthalmol 1989; 107:160-66.
8. Borel JF, Baumann G, Chapman I, Donatsch P, Fahr A, Mueller EA, Vigouret JM. In vivo pharmacological effect of cyclosporine and some analogues. Adv Pharmacol 1996; 35:115-246.
9. Pucci N, Novembre E, Lombardi E, et al. Atopy and serum eosinophil cationic protein in 110 white children with vernal keratoconjunctivitis: differences between tarsal and limbal forms. Clin Exp Allergy 2003; 33:325-30.
10. Zamir E, Mechoulam H. Micera A, Levi-Schaffer F, Pe'er J. Inflamed juvenile conjunctival naevus: clinicopathological characterization. Br J Ophthalmol 2002; 86:28-30.
11. Task Force on Blood Pressure Control in Children, National Heart, Lung, and Blood Institute, Bethesda, MD. Report of the Second Task Force on Blood Pressure Control in Children 1987. Pediatrics 1987; 79:1-25.
12. Mendicute J, Aranzasti C, Eder F, Ostolaza JI, Salaberria M. Topical cyclosporin A 2% in the treatment of vernal keratoconjunctivitis. Eye 1997; 11:75-78.
13. El-Asrar AM, Tabbara KF, Geboes K, Missotten L, Desmet V. An immunohistochemical study of topical cyclosporine in vernal keratoconjunctivitis. Am J Ophthalmol 1996; 121:156-61.
14. Doan S, Gabison E, Abitbol O, Gatinel D, Chast F, Hoang-Xuan T. Efficacité de la ciclosporine A en collyre à 2% en tant qu'èpargneur de corticoides dans le traitement de la keratoconjonctivite vernale corticodependante. J Fr Ophthalmol 2007; 30:697-701.
15. BenEzra D, Pe'er J, Brodsky M, Cohen E. Cyclosporine eye drops for the treatment of severe vernal keratoconjunctivitis. Am J Ophthalmol 1986; 101:278-82.
16. Kilic A, Gurler B. Topical 2% cyclosporine A in preservative-free artificial tears for the treatment of vernal keratoconjunctivitis. Can J Ophthalmol 2006; 41:693-8.
17. Spadavecchia L, Fanelli P, Tesse R, et al. Efficacy of 1.25% and 1% topical cyclosporine in the treatment of severe vernal keratoconjunctivitis in childhood. Pediatr Allergy Immunol 2006; 17:527-32.
18. Spadavecchia L, Fanelli P, Tesse R, et al. [Prognosis and treatment of Vernal keratoconjunctivitis in pediatric age: pilot study on 197 patients.] Minerva Pediatr 2010; 62:239-244. (Italian).