A randomized, placebo-controlled trial of topical cyclosporin A in steroid-dependent atopic keratoconjunctivitis

Ophthalmology

Volumn 105, Issue 9, 1998, Pages 1715-1720

  Hingorani, Melanie ^a,b,c   Moodaley, Lalitha ^a   Calder, Virginia L ^b   Buckley, Roger J ^a   Lightman, Susan ^a,b  

^a MOORFIELDS EYE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NONE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; PLACEBO;

ADULT; ALLERGIC REACTION; ARTICLE; ATOPY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KERATOCONJUNCTIVITIS; MALE; MEDIATOR RELEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; T LYMPHOCYTE SUBPOPULATION; TOPICAL DRUG ADMINISTRATION; VISUAL IMPAIRMENT;

EID: 0031732498     PISSN: 01616420     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-6420(98)99043-1     Document Type: Article

References (22)

1. Colby K, Dohlman C. Vernal keratoconjunctivitis. Int Ophthalmol Clin 1996;36:15-20.
2. Akova YA, Rodriguez A, Foster CS. Atopic keratoconjunctivitis. Ocular Immunology and Inflammation 1994;2:125-44.
3. Buckley RJ. Vernal keratoconjunctivitis. Int Ophthalmol Clin 1989;28:303-8.
4. Foster CS, Calonge M. Atopic keratoconjunctivitis. Ophthalmology 1990;97:992-1000.
5. Hingorani M, Lightman S. Therapeutic options in ocular allergic disease. Drugs 1995;50:208-21.
6. Jaanus SD. Anti-inflammatory drugs. In: Bartlett JD, Jaanus SD, eds. Clinical ocular pharmacology, 2nd ed. Boston: Butterworths, 1989;163-97.
7. Metz DP, Bacon AS, Holgate S, Lightman SL. Phenotypic characterization of T cells infiltrating the conjunctiva in chronic allergic eye disease. J Allergy Clin Immunol 1996; 98:686-96.
8. Calder V, Hingorani M, Metz D, Lightman SL. T cell cytokine production in ocular allergic diseases. Journal of Allergy and Clinical Immunology 1998;100:817-22.
9. Borel JF, Baumann G, Chapman I, et al. In vivo pharmacological effects of ciclosporin and some analogues. Adv Pharmacol 1996;35:115-246.
10. Secchi AG, Tognon MS, Leonardi A. Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis. Am J Ophthalmol 1990;110:641-5.
11. Secchi AG, Tognon MS, Leonardi A. Topical cyclosporine-A in the treatment of vernal and other immunologically mediated keratoconjunctivitis. In: Usui M, Ohno S, Aoki K, eds. Ocular Immunology Today: Proceedings of the 5th Int'l Symposium on the Immunology and Immunopathology of the Eye, Tokyo, March 13-15, 1990. Amsterdam; New York: Excerpta Medica; New York, New York: Elsevier Science Pub Co., 1990; 37-42.
12. Bleik JH, Tabbara KF. Topical cyclosporine in vernal keratoconjunctivitis. Ophthalmology 1991;98:1679-84.
13. BenEzra D, Pe'er J, Brodsky M, Cohen E. Cyclosporine eyedrops for the treatment of severe vernal keratoconjunctivitis. Am J Ophthalmol 1986;101:278-82.
14. BenEzra D, Matamoros N, Cohen E. Treatment of severe vernal keratoconjunctivitis with cyclosporine A eyedrops. Transplant Proc 1988;20(2 Suppl 2):644-9.
15. BenEzra D. The role of cyclosporin eye drops in ocular inflammatory diseases. Ocular Immunology and Inflammation 1993;1:159-62.
16. Hoang-Xuan T, Prisant O, Hannouche D, Robin H. Systemic cyclosporine A in severe atopic keratoconjunctivitis. Ophthalmology 1997;104:1300-5.
17. Power WJ, Mullaney P, Farrell M, Collum LM. Effect of topical cyclosporin A on conjunctival T cells in patients with secondary Sjögren's syndrome. Cornea 1993;12:507-11.
18. Holland EJ, Chan C-C, Kuwabara T, et al. Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis. Am J Ophthalmol 1989;107:160-6.
19. Holland EJ, Olsen TW, Ketcham JM, et al. Topical cyclosporin A in the treatment of anterior segment inflammatory disease. Cornea 1993;12:413-9.
20. Liegner JT, Yee RW, Wild JH. Topical cyclosporine therapy for ulcerative keratitis associated with rheumatoid arthritis. Am J Ophthalmol 1990;109:610-2.
21. Zierhut M, Thiel HJ, Weidle EG, et al. Topical treatment of severe corneal ulcers with cyclosporin A. Graefes Arch Clin Exp Ophthalmol 1989;227:30-5.
22. Belin MW, Bouchard CS, Frantz S, Chmielinska J. Topical cyclosporine in high-risk corneal transplants. Ophthalmology 1989;96:1144-50.