Ocular surface epithelial thickness evaluation with spectral-domain optical coherence tomography

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 12, 2011, Pages 9116-9123

  Francoz, Marlène ^a,b   Karamoko, Issouf ^a   Baudouin, Christophe ^a,c,d   Labbé, Antoine ^a,c,d  

^a CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^b UNIVERSITÉ JEAN MONNET   (France)

^c LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; EYE DROPS;

ADULT; AGED; ARTICLE; B SCAN; CLINICAL ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; CORNEA; CORNEA LIMBUS; DISEASE SEVERITY; DRY EYE; FEMALE; GLAUCOMA; HUMAN; INTRAOCULAR HYPERTENSION; MALE; OCULAR SURFACE DISEASE; OCULAR SURFACE EPITHELIUM THICKNESS; PRIORITY JOURNAL; QUESTIONNAIRE; SCANNING LASER OPHTHALMOSCOPE; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; TEAR FILM; VISUAL SYSTEM PARAMETERS; COMPARATIVE STUDY; CORNEA EPITHELIUM; DRUG EFFECT; EPITHELIUM CELL; HISTOLOGY; INTRAOCULAR PRESSURE; MIDDLE AGED; OPTICAL COHERENCE TOMOGRAPHY; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; CONJUNCTIVA; DRY EYE SYNDROMES; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; FEMALE; GLAUCOMA; HUMANS; INTRAOCULAR PRESSURE; LIMBUS CORNEAE; MALE; MIDDLE AGED; OCULAR HYPERTENSION; QUESTIONNAIRES; TOMOGRAPHY, OPTICAL COHERENCE; YOUNG ADULT;

EID: 84857099675     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7988     Document Type: Article

References (54)

1. Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5:108-152.
2. Singh R, Joseph A, Umapathy T, Tint NL, Dua HS. Impression cytology of the ocular surface. Br J Ophthalmol. 2005;89:1655-1659.
3. Zhivov A, Stachs O, Kraak R, Stave J, Guthoff RF. In vivo confocal microscopy of the ocular surface. Ocul Surf. 2006;4:81-93.
4. Baudouin C, Labbe A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res. 2010;29:312-334.
5. McLaren JW, Nau CB, Erie JC, Bourne WM. Corneal thickness measurement by confocal microscopy, ultrasound, and scanning slit methods. Am J Ophthalmol. 2004;137:1011-1020.
6. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science. 1991;254:1178-1181.
7. Haque S, Jones L, Simpson T. Thickness mapping of the cornea and epithelium using optical coherence tomography. Optom Vis Sci. 2008;85:E963-E976.
8. Sin S, Simpson TL. The repeatability of corneal and corneal epithelial thickness measurements using optical coherence tomography. Optom Vis Sci. 2006;83:360-365.
9. Feng Y, Simpson TL. Comparison of human central cornea and limbus in vivo using optical coherence tomography. Optom Vis Sci. 2005;82:416-419.
10. Wang J, Fonn D, Simpson TL, Sorbara L, Kort R, Jones L. Topographical thickness of the epithelium and total cornea after overnight wear of reverse-geometry rigid contact lenses for myopia reduction. Invest Ophthalmol Vis Sci. 2003;44:4742-4746.
11. Wang J, Fonn D, Simpson TL, Jones L. The measurement of corneal epithelial thickness in response to hypoxia using optical coherence tomography. Am J Ophthalmol. 2002;133:315-319.
12. Feng Y, Varikooty J, Simpson TL. Diurnal variation of corneal and corneal epithelial thickness measured using optical coherence tomography. Cornea. 2001;20:480-483.
13. Radhakrishnan S, Rollins AM, Roth JE, et al. Real-time optical coherence tomography of the anterior segment at 1310 nm. Arch Ophthalmol. 2001;119:1179-1185.
14. Izatt JA, Hee MR, Swanson EA, et al. Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography. Arch Ophthalmol. 1994;112:1584-1589.
15. Feng Y, Simpson TL. Corneal, limbal, and conjunctival epithelial thickness from optical coherence tomography. Optom Vis Sci. 2008;85:E880-E883.
16. Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol. 2000;118:615-621.
17. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5:75-92.
18. Tao A, Wang J, Chen Q, et al. Topographical thickness of Bowman's layer determined by ultra-high resolution spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2011; 52:3901-3907.
19. Labbe A, Brignole-Baudouin F, Baudouin C. Ocular surface investigations in dry eye [in French]. J Fr Ophtalmol. 2007;30:76-97.
20. Maldonado MJ, Ruiz-Oblitas L, Munuera JM, Aliseda D, Garcia-Layana A, Moreno-Montanes J. Optical coherence tomography evaluation of the corneal cap and stromal bed features after laser in situ keratomileusis for high myopia and astigmatism. Ophthalmology. 2000;107:81-87; discussion 8.
21. Niederer RL, Perumal D, Sherwin T, McGhee CN. Age-related differences in the normal human cornea: a laser scanning in vivo confocal microscopy study. Br J Ophthalmol. 2007;91:1165-1169.
22. Mustonen RK, McDonald MB, Srivannaboon S, Tan AL, Doubrava MW, Kim CK. Normal human corneal cell populations evaluated by in vivo scanning slit confocal microscopy. Cornea. 1998;17: 485-492.
23. Zheng T, Xu J. Age-related changes of human limbus on in vivo confocal microscopy. Cornea. 2008;27:782-786.
24. Patel DV, Sherwin T, McGhee CN. Laser scanning in vivo confocal microscopy of the normal human corneoscleral limbus. Invest Ophthalmol Vis Sci. 2006;47:2823-2827.
25. Utheim TP, Raeder S, Olstad OK, et al. Comparison of the histology, gene expression profile, and phenotype of cultured human limbal epithelial cells from different limbal regions. Invest Ophthalmol Vis Sci. 2009;50:5165-5172.
26. Shortt AJ, Secker GA, Munro PM, Khaw PT, Tuft SJ, Daniels JT. Characterization of the limbal epithelial stem cell niche: novel imaging techniques permit in vivo observation and targeted biopsy of limbal epithelial stem cells. Stem Cells. 2007;25:1402-1409.
27. Wiley L, SundarRaj N, Sun TT, Thoft RA. Regional heterogeneity in human corneal and limbal epithelia: an immunohistochemical evaluation. Invest Ophthalmol Vis Sci. 1991;32:594-602.
28. Zhu W, Hong J, Zheng T, Le Q, Xu J, Sun X. Age-related changes of human conjunctiva on in vivo confocal microscopy. Br J Ophthalmol. 2010;94:1448-1453.
29. Abdel-Khalek LM, Williamson J, Lee WR. Morphological changes in the human conjunctival epithelium. I. In the normal elderly population. Br J Ophthalmol. 1978;62:792-799.
30. Reinoso R, Calonge M, Castellanos E, et al. Differential cell proliferation, apoptosis, and immune response in healthy and evaporative-type dry eye conjunctival epithelia. Invest Ophthalmol Vis Sci. 2011;52:4819-4828.
31. Brignole F, Pisella PJ, Goldschild M, De Saint Jean M, Goguel A, Baudouin C. Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Invest Ophthalmol Vis Sci. 2000;41:1356-1363.
32. Erdelyi B, Kraak R, Zhivov A, Guthoff R, Nemeth J. In vivo confocal laser scanning microscopy of the cornea in dry eye. Graefes Arch Clin Exp Ophthalmol. 2007;245:39-44.
33. Villani E, Galimberti D, Viola F, Mapelli C, Ratiglia R. The cornea in Sjogren's syndrome: an in vivo confocal study. Invest Ophthalmol Vis Sci. 2007;48:2017-2022.
34. Tuominen IS, Konttinen YT, Vesaluoma MH, Moilanen JA, Helinto M, Tervo TM. Corneal innervation and morphology in primary Sjogren's syndrome. Invest Ophthalmol Vis Sci. 2003;44:2545-2549.
35. Martone G, Frezzotti P, Tosi GM, et al. An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology. Am J Ophthalmol. 2009;147:725-735, e1.
36. Wakamatsu TH, Sato EA, Matsumoto Y, et al. Conjunctival in vivo confocal scanning laser microscopy in patients with Sjogren syndrome. Invest Ophthalmol Vis Sci. 2010;51:144-150.
37. Schwartz GS, Holland EJ. Iatrogenic limbal stem cell deficiency. Cornea. 1998;17:31-37.
38. Schlotzer-Schrehardt U, Dietrich T, Saito K, et al. Characterization of extracellular matrix components in the limbal epithelial stem cell compartment. Exp Eye Res. 2007;85:845-860.
39. Cotsarelis G, Cheng SZ, Dong G, Sun TT, Lavker RM. Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell. 1989;57:201-209.
40. Puangsricharern V, Tseng SC. Cytologic evidence of corneal diseases with limbal stem cell deficiency. Ophthalmology. 1995;102: 1476-1485.
41. Dua HS, Azuara-Blanco A. Limbal stem cells of the corneal epithelium. Surv Ophthalmol. 2000;44:415-425.
42. De Nicola R, Labbe A, Amar N, Dupas B, Baudouin C. In vivo confocal microscopy and ocular surface diseases: anatomical-clinical correlations [in French]. J Fr Ophtalmol. 2005;28:691-698.
43. Schwartz GS, Holland EJ. Iatrogenic limbal stem cell deficiency: when glaucoma management contributes to corneal disease. J Glaucoma. 2001;10:443-445.
44. Kunert KS, Tisdale AS, Gipson IK. Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine. Arch Ophthalmol. 2002;120: 330-337.
45. Jones DT, Monroy D, Ji Z, Pflugfelder SC. Alterations of ocular surface gene expression in Sjogren's syndrome. Adv Exp Med Biol. 1998;438:533-536.
46. Lopin E, Deveney T, Asbell PA. Impression cytology: recent advances and applications in dry eye disease. Ocul Surf. 2009;7:93-110.
47. Kojima T, Matsumoto Y, Dogru M, Tsubota K. The application of in vivo laser scanning confocal microscopy as a tool of conjunctival in vivo cytology in the diagnosis of dry eye ocular surface disease. Mol Vis. 2010;16:2457-2464.
48. Nelson JD. Impression cytology. Cornea. 1988;7:71-81.
49. Tseng SC. Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology. 1985;92:728-733.
50. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998;17:584-589.
51. Nuzzi R, Vercelli A, Finazzo C, Cracco C. Conjunctiva and subconjunctival tissue in primary open-angle glaucoma after long-term topical treatment: an immunohistochemical and ultrastructural study. Graefes Arch Clin Exp Ophthalmol. 1995;233:154-162.
52. Sherwood MB, Grierson I, Millar L, Hitchings RA. Long-term morphologic effects of antiglaucoma drugs on the conjunctiva and Tenon's capsule in glaucomatous patients. Ophthalmology. 1989; 96:327-335.
53. Broadway DC, Grierson I, O'Brien C, Hitchings RA. Adverse effects of topical antiglaucoma medication, I: the conjunctival cell profile. Arch Ophthalmol. 1994;112:1437-1445.
54. Guthoff RF, Zhivov A, Stachs O. In vivo confocal microscopy, an inner vision of the cornea-a major review. Clin Experiment Ophthalmol. 2009;37:100-117.