TLR4-MyD88 signalling: A molecular target for alcohol actions

British Journal of Pharmacology

Volumn 165, Issue 5, 2012, Pages 1316-1318

  Pandey, Subhash C ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

alcohol; hippocampus; motor impairment; MyD88; neuroinflammation; NF B; sedation; TLR4

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; ALCOHOL; HISTONE ACETYLTRANSFERASE; HISTONE H3; HISTONE H4; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MINOCYCLINE; MYELOID DIFFERENTIATION FACTOR 88; NALOXONE; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 4;

ALCOHOLISM; AMYGDALOID NUCLEUS; DRUG ACTIVITY; ENZYME ACTIVITY; EPIGENETICS; GENE PRODUCT; HISTONE ACETYLATION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MOTOR DYSFUNCTION; MYD88 GENE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SEDATION; SIGNAL TRANSDUCTION; TLR4 GENE;

ANIMALS; ETHANOL; HYPNOTICS AND SEDATIVES; MALE; MOTOR NEURONS; MYELOID DIFFERENTIATION FACTOR 88; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84857065837     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01695.x     Document Type: Review

References (14)

1. Alfonso-Loeches S, Pascual-Lucas M, Blanco AM, Sanchez-Vera I, Guerri C, (2010). Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage. J Neurosci 30: 8285-8295.
2. Blednov YA, Bergeson SE, Walker D, Ferreira VM, Kuziel WA, Harris RA, (2005). Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. Behav Brain Res 165: 110-125.
3. Blednov YA, Benavidez JM, Geil C, Perra S, Morikawa H, Harris RA, (2011). Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice. Brain Behav Immun 25: S92-S105.
4. Crews FT, Zou J, Qin L, (2011). Inductions of innate immune genes in brain create the neurobiology of addiction. Brain Behav Immun 25: S4-S12.
5. Drugan RC, Wiedholz LM, Holt A, Kent S, Christianson JP, (2007). Environmental and immune stressors enhance alcohol-induced motor ataxia in rat. Pharmacol Biochem Behav 86: 125-131.
6. Ferreiro DU, Komives EA, (2010). Molecular mechanisms of system control of NF-κB signaling by IkBα. Biochemistry 49: 1560-1567.
7. Koob GF, (2003). Alcoholism: allostasis and beyond. Alcohol Clin Exp Res 27: 232-243.
8. Laird MH, Rhee SH, Perkins DJ, Medvedev AE, Piao W, Fenton MJ, et al,. (2009). TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol 85: 966-977.
9. A α2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala. Proc Natl Acad Sci USA 108: 4465-4470.
10. Okvist A, Johansson S, Kuzmin A, Bazov I, Merino-Martinez R, Ponomarev I, et al,. (2007). Neuroadaptations in human chronic alcoholics: dysregulation of the NF-κB system. PLoS One 2: e930.
11. Pandey SC, Ugale R, Zhang H, Tang L, Prakash A, (2008). Brain chromatin remodeling: a novel mechanism of alcoholism. J Neurosci 28: 3729-3737.
12. Pascual M, Baliño P, Alfonso-Loeches S, Aragõn CM, Guerri C, (2011). Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage. Brain Behav Immun 25: S80-S91.
13. Wu Y, Lousberg EL, Moldenhauer LM, Hayball JD, Robertson SA, Coller JK, et al,. (2011). Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment. Brain Behav Immun 25: S155-S164.
14. Wu Y, Lousberg EL, Moldenhauer LM, Hayball JD, Coller JK, Rice KC, et al,. (2012). Inhibiting the TLR4-MyD88 signaling cascade by genetic or pharmacologic strategies reduces acute alcohol dose-induced sedation and motor impairment in mice. Br J Pharmacol 165: 1319-1329.