Withdrawal of proliferation signal inhibitors due to adverse events in the maintenance phase of heart transplantation

Journal of Heart and Lung Transplantation

Volumn 31, Issue 3, 2012, Pages 288-295

  Gonzalez Vilchez, Francisco ^a   Vazquez De Prada, Jos Antonio ^a   Almenar, Luis ^b   Arizon Del Prado, Jos Mara ^c   Mirabet, Sonia ^d   Diaz Molina, Beatriz ^e   Delgado, Juan Francisco ^f   Gomez Bueno, Manuel ^g   Paniagua, Mara Jess ^h   Perez Villa, Flix ⁱ   Roig, Eulalia ^d   Martnez Dolz, Luis ^b   Brossa, Vicens ^d   Lambert, Jos Luis ^e   Segovia, Javier ^g   Crespo Leiro, Mara Generosa ^h   Ruiz Cano, Mara Jess ^f  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^d HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^e HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^f HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^g HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^h University Hospital de la Corua   (Spain)

ⁱ HOSPITAL CLÍNIC   (Spain)

Author keywords

adverse events; everolimus; heart transplantation; proliferation signal inhibitors; sirolimus

Indexed keywords

AZATHIOPRINE; EVEROLIMUS; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN;

ACUTE KIDNEY FAILURE; ADULT; ARTHRALGIA; BLOOD TOXICITY; DERMATITIS; DRUG WITHDRAWAL; DYSLIPIDEMIA; DYSPNEA; EDEMA; FEMALE; GASTROINTESTINAL TOXICITY; GRAFT REJECTION; HEART TRANSPLANTATION; HUMAN; INCIDENCE; KIDNEY FUNCTION; LYMPHOMA; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PERICARDIAL EFFUSION; PLEURA EFFUSION; PNEUMONIA; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; STOMATITIS; WOUND HEALING IMPAIRMENT;

EID: 84857065080     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2011.10.011     Document Type: Article

References (19)

1. F. Gustafsson, H.J. Ross Proliferation signal inhibitors in cardiac transplantation Curr Opin Cardiol 22 2007 111 116 (Pubitemid 46220265)
2. G. Stallone, B. Infante, G. Grandaliano, L. Gesualdo Management of side effects of sirolimus therapy Transplantation 87 2009 S23 S26
3. L. Gullestad, M. Iversen, S.A. Mortensen Everolimus with reduced calcineurin inhibitor in thoracic transplant recipients with renal dysfunction: a multicenter, randomized trial Transplantation 89 2010 864 872
4. C.A. Gleissner, A. Doesch, P. Ehlermann Cyclosporine withdrawal improves renal function in heart transplant patients on reduced-dose cyclosporine therapy Am J Transplant 6 2006 2750 2758 (Pubitemid 44571697)
5. J. Groetzner, I. Kaczmarek, U. Schulz VENINAHTx-Investigators Mycophenolate and sirolimus as calcineurin inhibitor-free immunosuppression improves renal function better than calcineurin inhibitor-reduction in late cardiac transplant recipients with chronic renal failure Transplantation 87 2009 726 733
6. D. Mancini, S. Pinney, D. Burkhoff Use of rapamycin slows progression of cardiac transplantation vasculopathy Circulation 108 2003 48 53 (Pubitemid 36859019)
7. J. Groetzner, B. Meiser, P. Landwehr Mycophenolate mofetil and sirolimus as calcineurin inhibitor-free immunosuppression for late cardiac transplant recipients with chronic renal failure Transplantation 77 2004 568 574 (Pubitemid 38282814)
8. J. Hunt, M. Lerman, M. Magee, T.M. Dewey, M. Herbert, M.J. Mack Improvement of renal dysfunction by conversion from calcineurin inhibitors to sirolimus after heart transplantation J Heart Lung Transplant 24 2005 1863 1867 (Pubitemid 41641863)
9. S.S. Kushwaha, Z. Khalpey, R.P. Frantz Sirolimus in cardiac transplantation: use as a primary immunosuppressant in calcineurin inhibitorinduced nephrotoxicity J Heart Lung Transplant 24 2005 2129 2136 (Pubitemid 41814736)
10. E. Raichlin, Z. Khalpey, W. Kremers Replacement of CNIs with sirolimus as primary immunosuppression in stable cardiac transplant recipients Transplantation 84 2007 467 474 (Pubitemid 47312156)
11. F. Gustafsson, H.J. Ross, M.S. Delgado, G. Bernabeo, D.H. Delgado Sirolimus-based immunosuppression after cardiac transplantation: Predictors of recovery from calcineurin inhibitor-induced renal dysfunction J Heart Lung Transplant 26 2007 998 1003 (Pubitemid 47494663)
12. A.Z. Aliabadi, E. Pohanka, G. Seebacher Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patients Am J Transplant 8 2008 854 861 (Pubitemid 351347752)
13. J.A. Moro, L. Almenar, L. Martnez-Dolz, I. Snchez-Lzaro, J. Agero, A. Salvador Tolerance profile of the proliferation signal inhibitors everolimus and sirolimus in heart transplantation Transplant Proc 40 2008 3034 3036
14. M.A. Engelen, S. Amler, H. Welp Prospective study of everolimus with calcineurin inhibitor-free immunosuppression in maintenance heart transplant patients: results at 2 years Transplantation 91 2011 1159 1165
15. J.A. Moro Lopez, L. Almenar, L. Martines-Dolz Progression of renal dysfunction in cardiac transplantation after the introduction of everolimus in the immunosuppressive regime Transplantation 87 2009 538 541
16. L. Almenar, J. Segovia, M.G. Crespo-Leiro Spanish Heart Transplantation Teams Spanish Heart Transplantation Registry. 21th official report of the Spanish Society of cardiology working group on heart failure and heart transplantation (1984-2009) Rev Esp Cardiol 63 2010 1317 1328
17. J.F. Delgado, J. Torres, M.J. Ruiz-Cano Sirolimus-associated interstitial pneumonitis in 3 heart transplant recipients J Heart Lung Transplant 25 2006 1171 1174 (Pubitemid 44311530)
18. V. Expsito, J.A. Vzquez de Prada, J.J. Gmez-Romn Everolimus-related Pulmonary Toxicity in Heart Transplant Recipients J Heart Lung Transpl 27 2008 797 800
19. J.M. Kovarik, S. Hartmann, M. Hubert Phamacokynetic and pharmacodynamic assessments of HMG-CoA reductase inhibitors when coadministered with everolimus J Clin Pharmacol 42 2002 222 228 (Pubitemid 34101356)