Sirolimus-associated Interstitial Pneumonitis in 3 Heart Transplant Recipients

Journal of Heart and Lung Transplantation

Volumn 25, Issue 9, 2006, Pages 1171-1174

  Delgado, Juan F ^a   Torres, Juan ^a   José Ruiz Cano, Maria ^a   Sánchez, Violeta ^a   Escribano, Pilar ^a   Borruel, Susana ^a   María Cortina, Jose ^a   de la Calzada, Carlos S ^a  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; RAPAMYCIN;

ADULT; ARTICLE; COUGHING; DISEASE SEVERITY; DRUG SAFETY; DYSPNEA; FEMALE; GRAFT RECIPIENT; GRAFT REJECTION; HEART FAILURE; HEART GRAFT; HUMAN; HYPOXEMIA; INTERSTITIAL PNEUMONIA; LUNG INFILTRATE; LUNG INJURY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; PATHOGENESIS; PRIORITY JOURNAL;

AGED; DIAGNOSIS, DIFFERENTIAL; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INCIDENCE; LUNG DISEASES, INTERSTITIAL; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; SIROLIMUS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 33748129890     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2006.05.013     Document Type: Article

References (22)

1. Snell G.I., Levvey B.J., Chin W., et al. Sirolimus allows renal recovery in lung and heart transplant recipients with chronic renal impairment. J Heart Lung Transplant 21 (2002) 540-546
2. Groetzner J., Kaczmarek I., Meiser B., Muller M., Daebritz S., and Reichart B. Sirolimus and mycophenolate mofetil as calcineurin inhibitor-free immunosuppression in a cardiac transplant patient with chronic renal failure. J Heart Lung Transplant 23 (2004) 770-773
3. Mancini D., Pinney S., Burkhoff D., et al. Use of rapamycin slows progression of cardiac transplantation vasculopathy. Circulation 108 (2003) 48-53
4. Stallone G., Schena A., Infante B., et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med 352 (2005) 1317-1323
5. Delgado J.F., Crespo M.G., Manito N., et al. Sirolimus in heart transplantation: preliminary results of a multicenter registry in Spain (RAPACOR Study). Am J Transplant 5 suppl (2005) S172
6. Keogh A., Richardson M., Ruygrok P., et al. Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial. Circulation 110 (2004) 2694-2700
7. Taylor D.O., Edwards L.B., Boucek M.M., et al. Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult heart transplant report-2005. J Heart Lung Transplant 24 (2005) 945-955
8. Mahalati K., Murphy D., and West M. Bronchiolitis obliterans and organizing pneumonia in renal transplant recipients. Transplantation 69 (2000) 1531
9. Garrean S., Massad M.G., Tshibaka M., Hanhan Z., Caines A.E., and Benedetti E. Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients. Clin Transplant 19 (2005) 698-703
10. Hamour I.M., Mittal T.K., Bell A.D., and Banner N.R. Reversible sirolimus-associated pneumonitis after heart transplantation. J Heart Lung Transplant 25 (2006) 241-244
11. Haydar A.A., Denton M., West A., Rees J., and Goldsmith D.J.A. Sirolimus-induced pneumonitis: three cases and a review of the literature. Am J Transplant 4 (2004) 137-139
12. Lennon A., Finan K., Fitzgerald M.X., and McCormick P.A. Interstitial pneumonitis associated with sirolimus (rapamycin) therapy after liver transplantation. Transplantation 72 (2001) 1166-1167
13. Lindenfeld J.A., Simon S.F., Zamora M.R., et al. BOOP is common in cardiac transplant recipients switched from a calcineurin inhibitor to sirolimus. Am J Transplant 5 (2005) 1392-1396
14. Manito N., Kaplinsky E.J., Bernat R., et al. Fatal interstitial pneumonitis associated with sirolimus therapy in a heart transplant recipient. J Heart Lung Transplant 23 (2004) 780-782
15. Morelon E., Stern M., Israel-Biet D., et al. Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients. Transplantation 72 (2001) 787-790
16. Morelon E., Stern M., and Kreis H. Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients. N Engl J Med 343 (2000) 225-226
17. Pham P.T., Pham P.C., Danovitch G.M., et al. Sirolimus-associated pulmonary toxicity. Transplantation 77 (2004) 1215-1220
18. Singer S.J., Tiernan R., and Sullivan E.J. Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients. N Engl J Med 343 (2000) 1815-1816
19. MacDonald A.S. A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts. Transplantation 71 (2001) 271-280
20. Johnson R.W., Kreis H., Oberbauer R., Brattstrom C., Claesson K., and Eris J. Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure. Transplantation 72 (2001) 777-786
21. Kahan B.D., and The Rapamune US Study Group. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study. Lancet 356 (2000) 194-202
22. McWilliams T.J., Levvey B.J., Russell P.A., Milne D.G., and Snell G.I. Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation. J Heart Lung Transplant 22 (2003) 210-213