Primary human sinonasal epithelial cell culture model for topical drug delivery in patients with chronic rhinosinusitis with nasal polyposis

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 3, 2012, Pages 449-456

  Bleier, Benjamin S ^a   Mulligan, Ryan M ^b   Schlosser, Rodney J ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

chronic rhinosinusitis; in vitro model; nasal polyposis; primary human sinonasal epithelial cell culture; topical drug delivery

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE;

ARTICLE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DEPENDENT VARIABLE; DRUG DELIVERY SYSTEM; DRUG EFFECT; EPITHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; NOSE POLYP; RHINOSINUSITIS; TOPICAL TREATMENT;

ADMINISTRATION, TOPICAL; CASE-CONTROL STUDIES; CELLS, CULTURED; CHRONIC DISEASE; CILIA; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GLUCOCORTICOIDS; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; MODELS, BIOLOGICAL; NASAL MUCOSA; NASAL POLYPS; PHENOTYPE; RHINITIS; SINUSITIS;

EID: 84857064591     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01409.x     Document Type: Article

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