Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synapticpotential and locomotor activity

Phytomedicine

Volumn 19, Issue 3-4, 2012, Pages 311-316

  Nasir, M N ^a,b   Abdullah, J ^a   Habsah, M ^c   Ghani, R I ^a   Rammes, G ^d,e  

^a SCHOOL OF MEDICAL SCIENCES   (Malaysia)

^b UNIVERSITI SULTAN ZAINAL ABIDIN   (Malaysia)

^c UNIVERSITI MALAYSIA TERENGGANU   (Malaysia)

^d MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Acetylcholinesterase; Asiatic acid; Centella asiatica; Excitatory postsynaptic potential; Locomotor activity

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; ACETYLCHOLINESTERASE; ASIATIC ACID; BICUCULLINE; PHACLOFEN; SCOPOLAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTELLA ASIATICA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ISOLATION; ENZYME INHIBITION; HIPPOCAMPUS; LOCOMOTION; MALE; NONHUMAN; OPEN FIELD BEHAVIOR; PLANT LEAF; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

ACETYLCHOLINESTERASE; ANIMALS; BACLOFEN; BEHAVIOR, ANIMAL; BICUCULLINE; CENTELLA; CHOLINESTERASE INHIBITORS; ELECTROPHYSIOLOGY; GABA-B RECEPTOR AGONISTS; HIPPOCAMPUS; MALE; MOTOR ACTIVITY; PENTACYCLIC TRITERPENES; PLANT LEAVES; POSTSYNAPTIC POTENTIAL SUMMATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-B; SCOPOLAMINE HYDROBROMIDE;

CENTELLA ASIATICA;

EID: 84857051939     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.10.004     Document Type: Article

References (31)

1. S. Anja, D. Jan, W. Wolfgang, Z. Walter, and R. Gerhard Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity Neuroscience Letter 416 2007 82 86
2. Z.A. Aziz, M.R. Davey, J.B. Power, P. Anthony, R.M. Smith, and K.C. Lowe Production of asiaticoside and madecassoside in Centella asiatica in vitro and in vivo Biologia Plantarum 51 1 2007 34 42 (Pubitemid 46464782)
3. B receptors and their significance in mammalian pharmacology Trends in Pharmacological Sciences 10 1989 401 407 (Pubitemid 19244476)
4. B receptors: a site of therapeutic benefit Current Opinion in Pharmacology 6 2006 37 43 (Pubitemid 43103818)
5. Y.H. Cheng, X.L. Cheng, Z. Radić, and J.A. McCammon Acetylcholinesterase: mechanisms of covalent inhibiton of H447I mutant determined by computational analyses Chemico Biological Interactions 175 1-3 2008 196 199
6. J.P. Colletier, D. Fournier, H.M. Greenblatt, J. Stojan, J.L. Sussman, G. Zaccai, I. Silman, and M. Weik Structural insights into substrate traffic and inhibition in acetylcholinesterase The EMBO Journal 25 2006 2746 2756 (Pubitemid 43980382)
7. G. Colombo, S. Melisb, G. Brunettib, S. Serrab, G. Vaccab, M.A.M. Caraib, and G.L. Gessaa GABAB receptor inhibition causes locomotor stimulation in mice European Journal of Pharmacology 433 1 2001 101 104 14 (Pubitemid 34038086)
8. De Souza, N.D.; Shah, V.; Desai, P.D.; Inamdar, P.K.; D'Sa, A.; Ammonaman-chi, R.; Dohadwalla, A.N.; Lakdawala, A.D.; Mandrekar, S.S.; Blum-bach, J.; 1992. 2,3,23-Trihydroxyurs-12-ene and its derivatives, processes for their preparation and their use. European Patent 03, pp. 83-171.
9. P. Dutar, and R.A. Nicoll Classification of muscarinic responses in hippocampus in terms of receptors subtypes and second messenger systems: electrophysiological studies in vitro Journal of Neuroscience 8 1988 4214 4224 (Pubitemid 19017404)
10. T. Ghous, and A. Townshend Flow injection determination of neostigmine and galanthamine by immobilized AChE inhibition Analytica Chimica Acta 371 1998 379 386 (Pubitemid 28428892)
11. J.J. Jackson, and M.R. Soliman Effects of tacrine (THA) on spatial reference memory and cholinergic enzymes in specific rat brain regions Life Sciences 58 1996 47 54
12. K. Krüger, N. Binding, H. Straub, and U. Musshoff Effects of arsenite on long-term potentiation in hippocampal slices from young and adult rats Toxicology Letter 165 2 2006 167 173
13. J.L. Liang, F. Chen, E. Krstew, M.S. Cowen, F.Y. Carroll, D. Crawford, P.M. Beart, and A.J. Lawrence The GABA (B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self administration of ethanol in alcohol-preferring rats Neuropharmacology 50 2006 632 639
14. A. Marston, J. Kissling, and K. Hostettmann A rapid TLC bioautographic method for the detection of acetylcholinesterase and butyrylcholinesterase inhibitors in plants Phytochemical Analysis 13 2002 51 54 (Pubitemid 34126614)
15. R.R. Matsumoto GABA receptors: are cellular differences reflected in function Brain Research Reviews 14 1989 203 225 (Pubitemid 19247335)
16. P.K. Mukherjee, V. Kumar, M. Mal, and P.J. Houghton Acetylcholinesterase inhibitors from plants Phytomedicine 14 2007 289 300 (Pubitemid 46415622)
17. Y. Nakagawa, I. Yoshinori, Y. Toshio, and T. Eijori Involvement of cholinergic systems in the deficit of place learning in Morris water maze task induced by baclofen in rats Brain Research 683 1995 209 214
18. M.N. Nasir, M. Habsah, I. Zamzuri, G. Rammes, J. Hasnan, and J. Abdullah Effects of asiatic acid on passive and active avoidance task in male Spraque-Dawley rats Journal of Ethnopharmacology 134 2010 203 209
19. I. Orhan, M. Kartal, Q. Naz, G. Yilmaz, Y. Kan, and B. Konuklugil Antioxidant and anticholinesterase evaluation of selected Turkish Salvia species Food Chemistry 103 2007 1247 1254 (Pubitemid 46467116)
20. T. Phensri High-performance liquid chromatographic determination of asiatic acid in human plasma Thai Journal of Pharmaceutical Sciences 32 2008 10 16
21. N. Pitsikas, A.E. Rigamonti, S.G. Cella, and E.E. Muller The GABAB receptor and recognition memory: possible modulation of its behavioral effects by the nitrergic system Neuroscience 118 4 2003 1121 1127 (Pubitemid 36561198)
22. W. Qi, D. Ding, and R.J. Salvi Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures Hearing Research 236 1-2 2008 52 60
23. S.U. Savelev, E.J. Okello, and E.K. Perry Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents Phytotheraphy Research 18 4 2004 315 324 (Pubitemid 38619534)
24. B receptors and analgesia N.G. Bowery, H. Bittiger, H.-R. Olpe, GABAB Receptors in Mammalian Function 1990 John Willey and Sons West Sussex, England 369 383
25. B(1) Neuron 31 2001 47 58 (Pubitemid 32757088)
26. J.H. Sienkiewicz, M. Piotr, K. Pawel, C. Agnieszka, S. Janusz, B. Andrzej, K. Wojeiech, and P. Adam The effects of central administration of physostigmine in two models of anxiety Pharmacology, Biochemistry and Behavior 75 2003 491 496
27. T. Sushma, S. Shinjini, P. Kishor, G. Sangeeta, and I.S. Gambhir Effect of Centella asiatica on mild cognitive impairment (MCI) and other common age-related clinical problems Journal of Nanomaterials and Biostructures 3 4 2008 215 220
28. A. Stuchlik, and K. Vales Baclofen dose-dependently disrupts learning in a place avoidance task requiring cognitive coordination Physiology & Behavior 97 2009 507 511
29. S.M. Thompson Modulation of inhibitory synaptic transmission in the hippocampus Progress in Neurobiology 42 1994 575 609 (Pubitemid 24194930)
30. P. Wijeweera, J.T. Arnason, D. Koszycki, and Z. Merali Evaluation of anxiolytic properties of Gotukola - (Centella asiatica) extracts and asiaticoside in rat behavioral models Phytomedicine 13 9-10 2006 668 676 (Pubitemid 44666404)
31. Q.L. Yu, Q. Hong, T. Yoshihisa, and Y.G. Wen A novel triterpene from Centella asiatica Molecules 11 2006 661 665