Odorant receptor modulation: Ternary paradigm for mode of action of insect repellents

Neuropharmacology

Volumn 62, Issue 5-6, 2012, Pages 2086-2095

  Bohbot, Jonathan D ^a   Dickens, Joseph C ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

Aedes aegypti; Agonist; Insect repellent; Insurmountable antagonist; Mosquito; Odorant receptor; Olfaction; OrcoRAM; VUAA1

Indexed keywords

1 OCTEN 3 OL; 3 (N BUTYL N ACETYL)AMINOPROPIONIC ACID ETHYL ESTER; INSECT REPELLENT; N (4 ETHYLPHENYL) 2 [[4 ETHYL 5 (3 PYRIDINYL) 4H 1,2,4 TRIAZOL 3 YL]THIO]ACETAMIDE; N (4 ETHYLPHENYL) 2 [[4 ETHYL 5 (4 PYRIDINYL) 4H 1,2,4 TRIAZOL 3 YL]THIO]ACETAMIDE; N,N DIETHYL 3 METHYLBENZAMIDE; PHEROMONE; SKATOLE; UNCLASSIFIED DRUG;

AEDES AEGYPTI; ANALYSIS OF VARIANCE; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME SPECIFICITY; LIGAND BINDING; MODULATION; MOLECULAR DYNAMICS; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SMELLING; XENOPUS;

AEDES; ANIMALS; DEET; INSECT REPELLENTS; PROPIONATES; RECEPTORS, ODORANT;

EID: 84857051291     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.01.004     Document Type: Article

References (56)

1. O. Arunlakshana, and H.O. Schild Some quantitative uses of drug antagonists Br. J. Pharmacol. Chemother. 14 1959 48 58
2. R. Benton, S. Sachse, S.W. Michnick, and L.B. Vosshall Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo PLoS Biol. 4 2006 240 257 (Pubitemid 43275854)
3. A. Blackwell, and S.N. Johnson Electrophysiological investigation of larval water and potential oviposition chemo-attractants for Anopheles gambiae s.s Ann. Trop. Med. Parasitol. 94 2000 389 398 (Pubitemid 30410182)
4. J.D. Bohbot, and J.C. Dickens Characterization of an enantioselective odorant receptor in the yellow fever mosquito Aedes aegypti PLoS ONE 4 2009 e7032
5. J.D. Bohbot, and J.C. Dickens Insect repellents: modulators of mosquito odorant receptor activity PLoS ONE 5 2010 e12138
6. J.D. Bohbot, L. Fu, T.C. Le, K.R. Chauhan, C.L. Cantrell, and J.C. Dickens Multiple activities of insect repellents on odorant receptors in mosquitoes Med. Vet. Entomol. 2011 10.1111/j.1365-2915.2011.00949.x
7. J.D. Bohbot, P.L. Jones, G. Wang, R.J. Pitts, G.M. Pask, and L.J. Zwiebel Conservation of indole responsive odorant receptors in mosquitoes reveals an ancient olfactory trait Chem. Senses 36 2010 149 160
8. A.F. Carey, G. Wang, C. Su, L.J. Zwiebel, and J.R. Carlson Odorant reception in the malaria mosquito Anopheles gambiae Nature 464 2010 66 71
9. J.P. Changeux 50th Anniversary of the word "allosteric" Protein Sci. 20 2011 1119 1124
10. A. Christopoulos, and T. Kenakin G protein-coupled receptor allosterism and complexing Pharmacol. Rev. 54 2002 323 374 (Pubitemid 34575719)
11. J.I. Cook, S. Majeed, R. Ignell, J.A. Pickett, M.A. Birkett, and J.G. Logan Enantiomeric selectivity in behavioural and electrophysiological responses of Aedes aegypti and Culex quinquefasciatus mosquitoes Bull. Entomol. Res. 101 2011 541 550
12. E.E. Davis, and P.G. Sokolove Lactic acid-sensitive receptors on the antennae of the mosquito, Aedes aegypti J. Comp. Physiol. A 105 1976 43 54
13. M. Ditzen, M. Pellegrino, and L.B. Vosshall Insect odorant receptors are molecular targets of the insect repellent DEET Science 319 2008 1838 1842
14. E.B. Dogan, J.W. Ayres, and P.A. Rossignol Behavioural mode of action of deet: inhibition of lactic acid attraction Med. Vet. Entomol. 13 1999 97 100 (Pubitemid 29125985)
15. Y.J. Du, and J.G. Millar Electroantennogram and oviposition bioassay responses of Culex quinquefasciatus and Culex tarsalis (Diptera: Culicidae) to chemicals in odors from Bermuda grass infusions J. Med. Entomol. 36 1999 158 166 (Pubitemid 129547363)
16. T. Elmore, R. Ignell, J.R. Carlson, and D.P. Smith Targeted mutation of a Drosophila odor receptor defines receptor requirement in a novel class of sensillum J. Neurosci. 23 2003 9906 9912 (Pubitemid 37371605)
17. J.H. Gaddum, K.A. Hameed, D.E. Hathway, and F.F. Stephens Quantitative studies of antagonists for 5-hydroxytryptamine Q. J. Exp. Physiol. Cogn. Med. Sci. 40 1955 49 74
18. A.J. Grant, and J.C. Dickens Functional characterization of the octenol receptor neuron on the maxillary palps of the yellow fever mosquito, Aedes aegypti PLoS ONE 6 2011 e21785
19. E. Hallem, M.G. Ho, and J.R. Carlson The molecular basis of odor coding in the Drosophila antenna Cell 117 2004 965 979 (Pubitemid 38798861)
20. E.A. Hallem, and J.R. Carlson Coding of odors by a receptor repertoire Cell 125 2006 143 160
21. S.R. Hill, B.S. Hansson, and R. Ignell Characterization of antennal trichoid sensilla from female southern house mosquito, Culex quinquefasciatus Say Chem. Senses 34 2009 231 252
22. D.T. Hughes, J. Pelletier, C.W. Luetje, and W.S. Leal Odorant receptor from the southern house mosquito narrowly tuned to the oviposition attractant skatole J. Chem. Ecol. 36 2010 797 800
23. P.L. Jones, G.M. Pask, D.C. Rinker, and L.J. Zwiebel Functional agonism of insect odorant receptor ion channels Proc. Natl. Acad. Sci. U.S.A. 108 2011 8821 8825
24. U.B. Kaupp Olfactory signalling in vertebrates and insects: differences and commonalities Nat. Rev. Neurosci. 11 2010 188 200
25. D.L. Kline, S.A. Allan, U.R. Bernier, and C.H. Welch Evaluation of the enantiomers of 1-octen-3-ol and 1-octyn-3-ol as attractants for mosquitoes associated with a freshwater swamp in Florida, U.S.A Med. Vet. Entomol. 21 2007 323 331 (Pubitemid 350293918)
26. J.M. Lindh, A. Kannaste, B.G.J. Knols, I. Faye, and A.K. Borg-Karlson Oviposition responses of Anopheles gambiae s.s (Diptera: Culicidae) and identification of volatiles from bacteria containing species J. Med. Entomol. 45 2008 1039 1049
27. C. Liu, R.J. Pitts, J.D. Bohbot, P.L. Jones, G. Wang, and L.J. Zwiebel Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae PLoS Biol. 8 2010 e1000467
28. T. Lu, Y.T. Qiu, G. Wang, J.Y. Kwon, M. Rutzler, H.W. Kwon, R.J. Pitts, J.J. Van Loon, W. Takken, J.R. Carlson, and L.J. Zwiebel Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiae Curr. Biol. 17 2007 1533 1544 (Pubitemid 47385989)
29. C. Lundin, L. Kall, S.A. Kreher, K. Kapp, E.L. Sonnhammer, J.R. Carlson, G. Heijne, and I. Nilsson Membrane topology of the Drosophila OR83b odorant receptor FEBS Lett. 581 2007 5601 5604 (Pubitemid 350186005)
30. J. Meijerink, M.A. Braks, and J.J. Van Loon Olfactory receptors on the antennae of the malaria mosquito Anopheles gambiae are sensitive to ammonia and other sweat-borne components J. Insect. Physiol. 47 2001 455 464 (Pubitemid 32220487)
31. J. Meijerink, M.A.H. Braks, A.A. Brack, W. Adam, T. Dekker, M.A. Posthumus, T.A.V. Beek, and J.J.A. Loon Identification of olfactory stimulants for Anopheles gambiae from human sweat samples J. Chem. Ecol. 26 6 2000 1367 1382 (Pubitemid 30421918)
32. J.G. Millar, J.D. Chaney, and M.S. Mulla Identification of oviposition attractants for Culex quinquefasciatus from fermented Bermuda grass infusions J. Am. Mosq. Control Assoc. 8 1992 11 17
33. P. Mombaerts Molecular biology of odorant receptors in vertebrates Annu. Rev. Neurosci. 22 1999 487 509 (Pubitemid 29144895)
34. J. Monod, J. Wyman, and J.P. Changeux On the nature of allosteric transitions: a plausible model J. Mol. Biol. 12 1965 88 118
35. T. Nakagawa, T. Sakurai, T. Nishioka, and K. Touhara Insect sex-pheromone signals mediated by specific combinations of olfactory receptors Science 307 2005 1638 1642 (Pubitemid 40354748)
36. R.R. Neubig, M. Spedding, T. Kenakin, and A. Christopoulos International union of pharmacology committee on receptor nomenclature and drug classification. XXXVIII. Update on terms and symbols in quantitative pharmacology Pharmacol. Rev. 55 2003 597 606 (Pubitemid 37500521)
37. E.M. Neuhaus, G. Gisselmann, W. Zhang, R. Dooley, K. Stortkuhl, and H. Hatt Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster Nat. Neurosci. 8 2005 15 17 (Pubitemid 41236723)
38. A.S. Nichols, S. Chen, and C.W. Luetje Subunit contributions to insect olfactory receptor function: channel block and odorant recognition Chem. Senses 2011 10.1093/chemse/bjr053
39. J. Pelletier, D.T. Hughes, C.W. Luetje, and W.S. Leal An odorant receptor from the southern house mosquito Culex pipiens quinquefasciatus sensitive to oviposition attractants PLoS ONE 5 2010 e10090
40. M. Pellegrino, N. Steinbach, M.C. Stensmyr, B.S. Hansson, and L.B. Vosshall A natural polymorphism alters odour and DEET sensitivity in an insect odorant receptor Nature 2011 10.1038/nature10438
41. V. Sargsyan, M.N. Getahun, S.L. Llanos, S.B. Olsson, B.S. Hansson, and D. Wicher Phosphorylation via PKC regulates the function of the Drosophila odorant co-receptor Front Cell Neurosci. 5 2011 5
42. K. Sato, M. Pellegrino, T. Nakagawa, T. Nakagawa, L.B. Vosshall, and K. Touhara Insect olfactory receptors are heteromeric ligand-gated ion channels Nature 452 2008 1002 1006 (Pubitemid 351589615)
43. K.P. Siju, S.R. Hill, B.S. Hansson, and R. Ignell Influence of blood meal on the responsiveness of olfactory receptor neurons in antennal sensilla trichodea of the yellow fever mosquito, Aedes aegypti J. Insect Physiol. 56 2010 659 665
44. R. Smart, A. Kiely, M. Beale, E. Vargas, C. Carraher, A.V. Kralicek, D.L. Christie, C. Chen, R.D. Newcomb, and C.G. Warr Drosophila odorant receptors are novel seven transmembrane domain proteins that can signal independently of heterotrimeric G proteins Insect Biochem. Mol. Biol. 38 2008 770 780
45. M. Spehr, and S.D. Munger Olfactory receptors: G protein-coupled receptors and beyond J. Neurochem. 109 2009 1570 1583
46. K. Sumikawa, M. Houghton, J.S. Emtage, B.M. Richards, and E.A. Barnard Active multi-subunit ACh receptor assembled by translation of heterologous mRNA in Xenopus oocytes Nature 292 1981 862 864 (Pubitemid 11015507)
47. Z. Syed, and W.S. Leal Maxillary palps are broad spectrum odorant detectors in Culex quinquefasciatus Chem. Senses 32 2007 727 738 (Pubitemid 47578171)
48. Z. Syed, and W.S. Leal Mosquitoes smell and avoid the insect repellent DEET Proc. Natl. Acad. Sci. U.S.A. 105 2008 13598 13603
49. Z. Syed, and W.S. Leal Acute olfactory response of Culex mosquitoes to a human- and bird-derived attractant Proc. Natl. Acad. Sci. U.S.A. 106 2009 18803 18808
50. W. Takken, J.J. van Loon, and W. Adam Inhibition of host-seeking response and olfactory responsiveness in Anopheles gambiae following blood feeding J. Insect Physiol. 47 2001 303 310 (Pubitemid 32157335)
51. P. Tsitoura, E. Andronopoulou, D. Tsikou, A. Agalou, M.P. Papakonstantinou, G.A. Kotzia, V. Labropoulou, L. Swevers, Z. Georgoussi, and K. Iatrou Expression and membrane topology of Anopheles gambiae odorant receptors in lepidopteran insect cells PLoS ONE 5 2010 e15428
52. G. Wang, A.F. Carey, J.R. Carlson, and L.J. Zwiebel Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae Proc. Natl. Acad. Sci. U.S.A. 107 2010 4418 4423
53. K.W. Wanner, A.S. Nichols, J.E. Allen, P.L. Bunger, S.F. Garczynski, C.E. Linn, H.M. Robertson, and C.W. Luetje Sex pheromone receptor specificity in the European corn borer moth, Ostrinia nubilalis PLoS ONE 5 2010 e8685
54. K.W. Wanner, A.S. Nichols, K.K. Walden, A. Brockmann, C.W. Luetje, and H.M. Robertson A honey bee odorant receptor for the queen substance 9-oxo-2-decenoic acid Proc. Natl. Acad. Sci. U.S.A. 104 2007 14383 14388 (Pubitemid 350003270)
55. D. Wicher, R. Schafer, R. Bauernfeind, M.C. Stensmyr, R. Heller, S.H. Heinemann, and B.S. Hansson Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels Nature 452 2008 1007 1011 (Pubitemid 351589619)
56. Y. Xia, G. Wang, D. Buscariollo, J.R. Pitts, H. Wenger, and L. Zwiebel The molecular basis of olfactory-based behavior in Anopheles gambiae larvae Proc. Natl. Acad. Sci. U.S.A. 105 2008 6433 6438 (Pubitemid 351758363)